Title:
NEW ARTIFICIAL NUCLEIC ACID, PRODUCTION METHOD THEREFOR, AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2020/203896
Kind Code:
A1
Abstract:
The present invention addresses the problem of providing a new artificial nucleic acid, a production method therefor, and a use thereof. The problem can be solved by an artificial nucleic acid having a unit derived from a compound represented by formula (1) or a salt thereof (in the formula, Base represents an aromatic heterocyclic ring group optionally having a substituent or an aromatic hydrocarbon ring group optionally having a substituent, A1 represents a straight-chain alkylene group, A2 represents a single bond or an alkylene group, X represents an alkylene group optionally having a substituent, R1 and R2 are the same or different from each other and each represent a hydrogen atom, an alkyl group optionally having a substituent, an alkenyl group optionally having a substituent, a cycloalkyl group optionally having a substituent, a cycloalkenyl group optionally having a substituent, an aryl group optionally having a substituent, a protecting group of a hydroxyl group, a phosphino group having a substituent, a dihydroxyphosphinyl group optionally having a substituent, or a hydroxymercaptophosphinyl group optionally having a substituent, or R1 and R2, together with two oxygen atoms respectively adjacent thereto and carbon atoms at positions 3-5 of a furanose, form a ring optionally having a substituent, and R3 represents an amino group optionally having a substituent).
Inventors:
BAN IKUYA (JP)
YOSHIKAWA HARUHISA (JP)
ORITA AYAKO (JP)
IMANISHI TAKESHI (JP)
YOSHIKAWA HARUHISA (JP)
ORITA AYAKO (JP)
IMANISHI TAKESHI (JP)
Application Number:
PCT/JP2020/014332
Publication Date:
October 08, 2020
Filing Date:
March 27, 2020
Export Citation:
Assignee:
SYSMEX CORP (JP)
International Classes:
A61K48/00; A61K31/7088; A61P31/00; A61P31/12; A61P35/00; C07H19/067; C07H19/167; C07H21/02; C12N15/11; C12N15/113; C12Q1/6844; C12Q1/6876
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Other References:
RAHMAN, S. M. ET AL.: "Design, Synthesis, and Properties of 2', 4'-BNANC: A Bridged Nucleic Acid Analogue", JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, vol. 130, no. 14, 2008, pages 4886 - 4896, XP055031784, DOI: 10.1021/ja710342q
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See also references of EP 3967328A4
ACC. CHEM. RES., vol. 32, 1999, pages 624 - 630
CHEM. COMMUN., 2009, pages 1225 - 12271
SAMBROOK, J: "Molecular Cloning: A Laboratory Manual", 1998, COLD SPRING HARBOR LABORATORY PRESS
TETRAHEDRON LETTERS, vol. 56, 2015, pages 4990 - 4992
ANAL CHEM., vol. 85, no. 18, 2013, pages 1 - 17
J. ORG. CHEM., vol. 76, 2011, pages 6967 - 6971
See also references of EP 3967328A4
Attorney, Agent or Firm:
SAEGUSA & PARTNERS (JP)
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