Title:
A NEW BACILLUS SUBTILIS STRAIN AND ITS USE IN PREPARING MEDICINE FOR TREATING THROMBOSIS
Document Type and Number:
WIPO Patent Application WO/2006/116949
Kind Code:
A1
Abstract:
A new bacillus subtilis strain and its use in preparing medicine for treating thrombosis are provided.Particularly, the use of fibrinolytic enzyme produced by bacillus subtilis in preparing medicine for treating thrombosis is provided.The present invention also discloses a method for producing said fibrinolytic enzyme(nattokinase).It is efficient and convenient to prepare nattokinase by using the new bacillus subtilis strain of the invention.
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Inventors:
CHEN JUN (CN)
WEI QI (CN)
JIANG FEI (CN)
LIU ZHONGRONG (CN)
LAI YANA (CN)
HE JUNRONG (CN)
LI BOGANG (CN)
WEI QI (CN)
JIANG FEI (CN)
LIU ZHONGRONG (CN)
LAI YANA (CN)
HE JUNRONG (CN)
LI BOGANG (CN)
Application Number:
PCT/CN2006/000892
Publication Date:
November 09, 2006
Filing Date:
April 30, 2006
Export Citation:
Assignee:
CHENGDU DI AO JIUHONG PHARMACE (CN)
CHEN JUN (CN)
WEI QI (CN)
JIANG FEI (CN)
LIU ZHONGRONG (CN)
LAI YANA (CN)
HE JUNRONG (CN)
LI BOGANG (CN)
CHEN JUN (CN)
WEI QI (CN)
JIANG FEI (CN)
LIU ZHONGRONG (CN)
LAI YANA (CN)
HE JUNRONG (CN)
LI BOGANG (CN)
International Classes:
A61K38/48; A61K35/742; A61P9/00; C12N1/20
Foreign References:
| CN1100142C | 2003-01-29 | |||
| CN1451745A | 2003-10-29 | |||
| CN1177039C | 2004-11-24 | |||
| KR20030084098A | 2003-11-01 | |||
| JP2004067538A | 2004-03-04 | |||
| JPH06261744A | 1994-09-20 | |||
| CN1451745A | 2003-10-29 | |||
| CN1273274A | 2000-11-15 |
Other References:
MEI LEHE; HU SHENG; XU JING ET AL.: "Screening of Bacillus subtilis natto and optimization of nattokinase fermentation", JOURNAL OF ZHCJIANG UNIVERSITY (ENGINEERING SCIENCE, vol. 38, no. 10, 2004, pages 1355 - 1360
XIONG XIAOHUI; LIANG JIANGUANG; XIONG QIANG: "Optimization of Nattokinase Production Using Liquid Fermentation", FOOD AND FERMENTATION INDUSTRIES, vol. 30, no. 1, 2004, pages 62 - 66
XIE QIULING; GUO YONG: "The optimization offermentation conditions ofnattokinase.", JOURNAL OF SOUTH CHINA UNIVERSITY OF TECHNOLOGY (NATURAL SCIENCE, vol. 27, no. 5, 1999, pages 127 - 131
BAO YANXIA; CHEN JUN; QIAN ZHIYU ET AL.: "Optimization of the technique of solid fermentation ofnattokinase", JOURNAL OF SHENYANG PHARMACEUTICAL UNIVERSITY, vol. 21, no. 6, 2004, pages 468 - 471
LI LIMIN; HUI HONGWEN; WANG MINGFANG: "Study on purification of nattokinase from the B. natto fermented broth (liquor)", JOURNAL OF INNCR MONGOLIA AGRICULTURAL UNIVERSITY, vol. 24, no. 4, 2003, pages 51 - 54
LU YING; ZHANG LU; FENG LEI ET AL.: "Purification and Characterization of Nattokinase from Bacillus subtilis", FOOD AND FERMENTATION INDUSTRIES, vol. 30, no. 3, 2004, pages 122 - 124
BAI ZHEN; XU MEI; HAN SIQIN ET AL.: "Purification and characterization of Nattokinase", JOURNAL OF NORTHEAST AGRICULTURAL UNIVERSITY, vol. 35, no. 6, 2004, pages 667 - 673
FUJITA M; HONG K; ITO Y ET AL.: "Transport of nattokinase across the rat intestinal tract.", BIOL. PHARM. BULL., vol. 18, no. 9, 1995, pages 1194 - 6, XP008103671
See also references of EP 1927365A4
XIONG XIAOHUI; LIANG JIANGUANG; XIONG QIANG: "Optimization of Nattokinase Production Using Liquid Fermentation", FOOD AND FERMENTATION INDUSTRIES, vol. 30, no. 1, 2004, pages 62 - 66
XIE QIULING; GUO YONG: "The optimization offermentation conditions ofnattokinase.", JOURNAL OF SOUTH CHINA UNIVERSITY OF TECHNOLOGY (NATURAL SCIENCE, vol. 27, no. 5, 1999, pages 127 - 131
BAO YANXIA; CHEN JUN; QIAN ZHIYU ET AL.: "Optimization of the technique of solid fermentation ofnattokinase", JOURNAL OF SHENYANG PHARMACEUTICAL UNIVERSITY, vol. 21, no. 6, 2004, pages 468 - 471
LI LIMIN; HUI HONGWEN; WANG MINGFANG: "Study on purification of nattokinase from the B. natto fermented broth (liquor)", JOURNAL OF INNCR MONGOLIA AGRICULTURAL UNIVERSITY, vol. 24, no. 4, 2003, pages 51 - 54
LU YING; ZHANG LU; FENG LEI ET AL.: "Purification and Characterization of Nattokinase from Bacillus subtilis", FOOD AND FERMENTATION INDUSTRIES, vol. 30, no. 3, 2004, pages 122 - 124
BAI ZHEN; XU MEI; HAN SIQIN ET AL.: "Purification and characterization of Nattokinase", JOURNAL OF NORTHEAST AGRICULTURAL UNIVERSITY, vol. 35, no. 6, 2004, pages 667 - 673
FUJITA M; HONG K; ITO Y ET AL.: "Transport of nattokinase across the rat intestinal tract.", BIOL. PHARM. BULL., vol. 18, no. 9, 1995, pages 1194 - 6, XP008103671
See also references of EP 1927365A4
Attorney, Agent or Firm:
LECOME INTELLECTUAL PROPERTY AGENT LTD. (Tower BINDO Mansion,No. 48-JIA Zhichun Road,Haidian District, Beijing 8, CN)
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