NEW BENZIMIDAZOLE DERIVATIVE AND PHARMACEUTICAL USE THEREOF

WIPO Patent Application WO/2016/117647

A1

Provided is a prophylactic or therapeutic drug for diseases involving Nav1.7, more specifically diseases such as neuropathic pain, nociceptive pain, inflammatory pain, small-fiber neuropathy, erythromelalgia, paroxysmal extreme pain disorder, dysuria, and multiple sclerosis. The present invention provides a compound represented by formula (1) or a pharmaceutically acceptable salt thereof. (In the formula, R1a, R1b, R1c and R1d each represent hydrogen, a cyanide, a C1-4 alkyl, a C1-4 alkoxy, a C3-7 cycloalkyl, a C3-7 cycloalkoxy, a C3-7 cycloalkyl amino, a C6-10 aryl, or the like; R2 and R3 each represent hydrogen, a C1-6 alkyl, a C3-10 cycloalkyl, a 3-7 membered heterocyclic ring, or the like; L represents CR4R5; R4 and R5 each represent hydrogen, a hydroxyl, a C1-4 alkyl, a C1-4 alkoxy, a C3-7 cycloalkyl, or the like, and m represents 1, 2, or 3.)

SAWAYAMA YUSUKE (JP)
ADACHI KEIJI (JP)
YAMAI YUSUKE (JP)
IWAMOTO KOHEI (JP)
KIYOSHIGE SAORI (JP)

PCT/JP2016/051713

July 28, 2016

January 21, 2016

Click for automatic bibliography generation  

SUMITOMO DAINIPPON PHARMA CO LTD (JP)

C07D235/06; A61K31/4184; A61K31/454; A61K31/5377; A61K45/00; A61P13/02; A61P25/00; A61P25/04; C07D235/08; C07D401/06; C07D403/06; C07D405/04; C07D405/12

WO2014100695A1	2014-06-26
WO2014100764A2	2014-06-26
WO2013134415A1	2013-09-12
WO2012172043A1	2012-12-20
WO2007116866A1	2007-10-18
WO2013101926A1	2013-07-04
WO2012116440A1	2012-09-07
WO2015140717A1	2015-09-24

JP2010500345A	2010-01-07
JP2009521431A	2009-06-04
JP2008513443A	2008-05-01
JP2006528971A	2006-12-28
JP2009514930A	2009-04-09
JP2009514928A	2009-04-09
JPH0680666A	1994-03-22

TAKASHIMA, HAJIME (JP)
Takashima 1 (JP)

View/Download PDF      PDF Help

Previous Patent: ADHESIVE COMPOSITION, ADHESIVE SHEET, AND METHOD FOR PRODUCING SAME

Next Patent: HEXAGONAL PLATE-SHAPED FERRITE POWDER, METHOD FOR PRODUCING SAME, AND RESIN COMPOSITION AND MOLDED A...