NEW BIS-PLATINUM COMPLEXES WITH POLYAMINE LIGANDS AS ANTITUMOR AGENTS

Title:

NEW BIS-PLATINUM COMPLEXES WITH POLYAMINE LIGANDS AS ANTITUMOR AGENTS

Document Type and Number:

WIPO Patent Application WO1998003519

Kind Code:

A3

Abstract:

Bis-platinum(II) complexes with polyamine ligands, the method of making bis-platinum(II) complexes and the use thereof for the treatment of tumors in mammals, are disclosed. The method of making the polyamine ligands, and the use of a new compound VII(c) as an intermediate in the synthesis of polyamine ligands, are also disclosed.

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Inventors:

FARRELL NICHOLAS P (US)
MENTA ERNESTO (IT)
DI DOMENICO ROBERTO (IT)
SPINELLI SILVANO (IT)

Application Number:

PCT/US1997/012553

Publication Date:

April 17, 2003

Filing Date:

July 22, 1997

Export Citation:

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Assignee:

HOFFMANN LA ROCHE (CH)
UNIV VIRGINIA COMMONWEALTH (US)
FARRELL NICHOLAS P (US)
MENTA ERNESTO (IT)
DI DOMENICO ROBERTO (IT)
SPINELLI SILVANO (IT)

International Classes:

A61K31/282; C07C209/50; A61P35/00; C07C237/10; C07C269/04; C07F15/00; C07C211/09; C07C211/14; C07C271/16; (IPC1-7): C07F15/00; A61K31/28; C07C209/50; C07C269/06

Domestic Patent References:

WO1988000947A1	1988-02-11
WO1991003482A1	1991-03-21
WO1995026968A1	1995-10-12

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