NEW CAR CONSTRUCTS COMPRISING TNFR2 DOMAINS - SANGAMO THERAPEUTICS FRANCE

Title:

NEW CAR CONSTRUCTS COMPRISING TNFR2 DOMAINS

Document Type and Number:

WIPO Patent Application WO/2020/030979

Kind Code:

A8

Abstract:

The present invention relates to a chimeric antigen receptor (CAR) comprising a human TNFR2 transmembrane domain (TM) or a fragment or variant thereof and/or a human TNFR2 costimulatory intracellular signaling domain or a fragment or variant thereof, and to an immune cell expressing said CAR. The present invention further relates to therapeutic methods comprising the administration of an immune cell expressing a chimeric antigen receptor (CAR) comprising a human TNFR2 transmembrane domain (TM) or a fragment or variant thereof and/or a human TNFR2 costimulatory intracellular signaling domain or a fragment or variant thereof.

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Inventors:

ABEL TOBIAS (FR)
FENARD DAVID (FR)
GERTNER-DARDENNE JULIE (FR)
MEYER FRANÇOIS (FR)

Application Number:

PCT/IB2019/000907

Publication Date:

May 22, 2020

Filing Date:

August 09, 2019

Export Citation:

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Assignee:

SANGAMO THERAPEUTICS FRANCE (FR)

International Classes:

A61P37/00; A61K35/17; C07K16/00; C12N5/0783

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