Title:
NEW CATALYTIC SYSTEM FOR SCALABLE PREPARATION OF INDOXACARB
Document Type and Number:
WIPO Patent Application WO/2018/178982
Kind Code:
A8
Abstract:
It is an object of the present invention to provide a novel and advantageous process for commercially preparing of indoxacarb which is racemic or enantiomerically enriched at chiral center from its amide precursor using a new catalytic system. More particularly, it relates to an efficient method of preparation of indoxacarb which is racemic or enantiomerically enriched at chiral center from methyl-7-chloro-2,5-dihydro-2-[[[(4-trifluoromethoxy) phenyl]amino]carbonyl]-indeno[1,2-e][1,3,4]oxadiazine-4a(3H) carboxylate represented as formula (I) using methoxycarbonylation agent and metal salt of methylsulfinylmethylide in hydrocarbon solvent in the presence of organic base and phase transfer catalyst.
Inventors:
VENKATARAMANA RAJURI (IN)
BICIDI JAYAPAL REDDY (IN)
PILLAI BIJUKUMAR GOPINATHAN (IN)
MANNAM SREEDEVI (IN)
BICIDI JAYAPAL REDDY (IN)
PILLAI BIJUKUMAR GOPINATHAN (IN)
MANNAM SREEDEVI (IN)
Application Number:
PCT/IL2018/050356
Publication Date:
November 01, 2018
Filing Date:
March 27, 2018
Export Citation:
Assignee:
ADAMA MAKHTESHIM LTD (IL)
International Classes:
C07D273/04
Attorney, Agent or Firm:
EHRLICH, Gal et al. (IL)
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