Title:
NEW CONJUGATES OF MONTELUKAST AND PEPTIDES
Document Type and Number:
WIPO Patent Application WO/2020/052677
Kind Code:
A1
Abstract:
There is provided a peptide-containing compound that comprises a peptide component which is an amino acid sequence of from 2 to 45 amino acids, which peptide component is covalently bonded to one or more compounds of the formula (I), wherein: R1 is selected from the group consisting of -C(CH3)2OH, -COCH3, -C(CH3)=CH2 and -C(CH3)2H; and n is 0, 1 or 2, as well as regioisomers, stereoisomers, and pharmaceutically-or cosmetically-acceptable salts of said peptide-containing compound. The compound of formula I is preferably montelukast, montelukast styrene or hydrogenated montelukast styrene. The peptide-containing compound is particularly useful in the treatment of inflammation, including wounds, hemorrhoids, burns, psoriasis, acne, atopic dermatitis, allergic rhinitis, allergic conjunctivitis, chronic obstructive pulmonary disease, inflammatory bowel disease (such as. ulcerative colitis). The peptide-containing compound is also useful in the treatment of idiopathic pulmonary fibrosis.
Inventors:
SAMUELSSON BENGT INGEMAR (SE)
GU MING (CN)
GU MING (CN)
Application Number:
PCT/CN2019/105832
Publication Date:
March 19, 2020
Filing Date:
September 14, 2019
Export Citation:
Assignee:
JIANGYIN USUN PHARMACEUTICAL CO LTD (CN)
International Classes:
A61K47/64; A61P17/00; A61P29/00; C07K2/00
Domestic Patent References:
| WO2017011982A1 | 2017-01-26 | |||
| WO2006046123A2 | 2006-05-04 |
Foreign References:
| CN110312513A | 2019-10-08 | |||
| US20050107612A1 | 2005-05-19 | |||
| EP3326639A1 | 2018-05-30 |
Other References:
SENER, G. ET AL.: "Leukotriene receptor blocker montelukast protects against burn-induced oxidative injury of the skin and remote organs", BURNS, vol. 31, no. 5, 31 December 2005 (2005-12-31), pages 587 - 596, XP004964262, DOI: 10.1016/j.burns.2005.01.012
WAITE, J. H.: "Nature 's underwater adhesive specialist", INTJ.ADHESLON AND ADHESIVES, vol. 7, no. 1, 31 January 1987 (1987-01-31), pages 9 - 14, XP055691927
AHN JUNG-MO ET AL., IMMUNOLOGICAL INVESTIGATIONS, 2018, pages 1 - 13
SENER ET AL., BURNS, vol. 31, 2005, pages 587 - 596
See also references of EP 3678705A4
WAITE, J. H.: "Nature 's underwater adhesive specialist", INTJ.ADHESLON AND ADHESIVES, vol. 7, no. 1, 31 January 1987 (1987-01-31), pages 9 - 14, XP055691927
AHN JUNG-MO ET AL., IMMUNOLOGICAL INVESTIGATIONS, 2018, pages 1 - 13
SENER ET AL., BURNS, vol. 31, 2005, pages 587 - 596
See also references of EP 3678705A4
Attorney, Agent or Firm:
WU, FENG & ZHANG (CN)
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