Title:
NEW CRYSTAL FORM OF TENOFOVIR ALAFENAMIDE SALT, PREPARATION METHOD AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2017/211325
Kind Code:
A1
Abstract:
Disclosed are a new polymorph II, crystal form A and B of 9-[(R)-2-[[(S)-[[(S)-1-(isopropoxycarbonyl)ethyl]amino]phenoxyphosphinyl]methoxy]propyl]adenine fumarate, and preparation methods and pharmaceutical use thereof. The crystal form II is a hemi-fumarate; the crystal form A is a mono-fumarate; and the crystal form B is a sesqui-fumarate. Compared with the existing crystal form, the new crystal forms have obvious advantages in solubility, stability and preparation process.
Inventors:
MENG XIAOMING (CN)
Application Number:
PCT/CN2017/088538
Publication Date:
December 14, 2017
Filing Date:
June 15, 2017
Export Citation:
Assignee:
SHANGHAI BEGREAT PHARMATECH (CN)
MENG XIAOMING (CN)
MENG XIAOMING (CN)
International Classes:
C07F9/6561; A61K31/675; A61P31/18; A61P31/20
Foreign References:
| CN103732594A | 2014-04-16 | |||
| CN104817593A | 2015-08-05 | |||
| CN1443189A | 2003-09-17 | |||
| CN105085571A | 2015-11-25 |
Download PDF:
Previous Patent: ADAPTER, PORTABLE POWER SYSTEM, AND POWER SYSTEM
Next Patent: PERIODONTAL PHYSICAL TREATMENT DEVICE
Next Patent: PERIODONTAL PHYSICAL TREATMENT DEVICE