Title:
NEW DUAL CHIMERIC ANTIGEN RECEPTOR-T CELL WHICH CAN BE REGULATED, CONSTRUCTION METHOD THEREFOR AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2019/062518
Kind Code:
A1
Abstract:
Provided are a new dual chimeric antigen receptor-T cell which can be regulated, a construction method therefor and the use thereof, which fall within the field of cellular immunotherapy for tumours. The dual chimeric antigen receptor is composed of a first chimeric antigen receptor for MSLN and a second chimeric antigen receptor for FITC. A dual-targeted functional T cell regulated by specific exogenous bifunctional molecules is constructed, and the exogenous molecules are used to preliminarily discuss the in vivo and in vitro activity of the dual chimeric antigen receptor-T cell. By means of in vitro and in vivo tests, it is confirmed that the activation mode of the constructed CAR-T cell is under the combined control of an endogenous tumour antigen and exogenous bifunctional molecules, and the combined regulation mode can significantly improve the safe application of CAR-T cell immunotherapy.
Inventors:
XU HANMEI (CN)
ZHANG ERHAO (CN)
ZHANG ERHAO (CN)
Application Number:
PCT/CN2018/104579
Publication Date:
April 04, 2019
Filing Date:
September 07, 2018
Export Citation:
Assignee:
NANJING ANJI BIOLOGICAL TECH CO LTD (CN)
International Classes:
A61K48/00; C07K14/705; C07K16/28
Domestic Patent References:
| WO2014127261A1 | 2014-08-21 |
Foreign References:
| CN1830487A | 2006-09-13 | |||
| CN106755023A | 2017-05-31 | |||
| CN105814083A | 2016-07-27 | |||
| CN105026429A | 2015-11-04 | |||
| CN106459989A | 2017-02-22 |
Other References:
ZHANG, E.H.: "A new insight in chimeric antigen receptor-engineered T cells for cancer immunotherapy", JOURNAL OF HEMATOLOGY & ONCOLOGY., vol. 10, no. 1, 3 January 2017 (2017-01-03), XP055565362
ZHANG, E.H.: "Accurate control of dual-receptor engineered T cell activity through a bifunctional anti-angiogenic peptide", JOURNAL OF HEMATOLOGY & ONCOLOGY, vol. 11, no. 44, 20 March 2018 (2018-03-20), pages 1 - 14, XP055587960
ZHANG, E.H.: "Accurate control of dual-receptor engineered T cell activity through a bifunctional anti-angiogenic peptide", JOURNAL OF HEMATOLOGY & ONCOLOGY, vol. 11, no. 44, 20 March 2018 (2018-03-20), pages 1 - 14, XP055587960
Attorney, Agent or Firm:
RAYTO PARTNERS, P.C (CN)
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