Title:
NEW INHIBITORS OF CYCLOPHILINS AND USES THEREOF
Document Type and Number:
WIPO Patent Application WO/2011/076784
Kind Code:
A3
Abstract:
The present invention relates to a compound of formula (I): Formula (I), wherein: - n is 0, 1 or 2; - A is in particular CH or N; - X is in particular CO, SO2, CS, and R1 is in particular H, - R2 is a group of formula NR3R4 or OR5, R3 and R4 being in particular H, and R5 an alkyl group, - R6 is in particular H or an alkyl group, and - R7 is in particular an aryl group, substituted with at least one NH2 group for its use in the prevention and/or the treatment of viral pathologies or infections.
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Inventors:
GUICHOU JEAN-FRANCOIS (FR)
COLLIANDRE LIONEL (FR)
AHMED-BELKACEM HAKIM (FR)
PAWLOTSKY JEAN-MICHEL (FR)
COLLIANDRE LIONEL (FR)
AHMED-BELKACEM HAKIM (FR)
PAWLOTSKY JEAN-MICHEL (FR)
Application Number:
PCT/EP2010/070359
Publication Date:
November 10, 2011
Filing Date:
December 21, 2010
Export Citation:
Assignee:
INST NAT SANTE RECH MED (FR)
GUICHOU JEAN-FRANCOIS (FR)
COLLIANDRE LIONEL (FR)
AHMED-BELKACEM HAKIM (FR)
PAWLOTSKY JEAN-MICHEL (FR)
GUICHOU JEAN-FRANCOIS (FR)
COLLIANDRE LIONEL (FR)
AHMED-BELKACEM HAKIM (FR)
PAWLOTSKY JEAN-MICHEL (FR)
International Classes:
C07C275/24; A61K31/17; A61K31/18; A61K31/4166; A61K31/42; A61K31/44; A61K31/4706; A61K31/535; A61K31/5375; A61P31/12; C07C307/06; C07C335/12; C07D213/40; C07D285/135; C07D295/00
Domestic Patent References:
| WO2009073719A1 | 2009-06-11 | |||
| WO2007002639A2 | 2007-01-04 | |||
| WO2009096609A1 | 2009-08-06 |
Foreign References:
| US20040204340A1 | 2004-10-14 | |||
| US6593362B2 | 2003-07-15 | |||
| EP0484281A2 | 1992-05-06 |
Other References:
C. CAMPÀS ET AL: "DEBIO-025", DRUGS OF THE FUTURE, vol. 33, no. 12, 2008, pages 1012 - 1017, XP002581090
J.-F. GUICHOU: "Structure-based design, synthesis, and biological evaluation of novel inhibitors of human cyclophilin A", J.MED.CHEM., vol. 49, no. 3, 1 October 2006 (2006-10-01), pages 900 - 910, XP002581091
J.-F. GUICHOU: "Structure-based design, synthesis, and biological evaluation of novel inhibitors of human cyclophilin A", J.MED.CHEM., vol. 49, no. 3, 1 October 2006 (2006-10-01), pages 900 - 910, XP002581091
Attorney, Agent or Firm:
DOMENEGO, Bertrand et al. (2 Place d'Estienne d'Orves, Paris Cedex 09, FR)
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