Title:
NEW METHOD FOR IMPROVING QUALITY OF PLATELETS
Document Type and Number:
WIPO Patent Application WO/2023/083361
Kind Code:
A1
Abstract:
Disclosed is a new method for improving the quality of platelets. It is disclosed for the first time that the molecular of carnitine palmitoyl transferase II (CPT2) of the platelet mitochondrial inner membrane is critical to the survival, preparation and storage of platelets, the reduction of CPT2 protein expression and/or activity seriously affects the quality of platelets, and the normal or high expression of the protein improves the quality of platelets. By means of directly and indirectly influencing or modifying CPT2 protein, the effect of CPT2 on platelets is verified at multiple angles, and a pathway and endogenous or exogenous molecules having a key effect of maintaining activity of platelets are disclosed. Therefore, the CPT2 itself or an up-regulator thereof can be used for maintaining the activity of platelets, and maintaining or improving the storage quality of platelets, and can also be used for screening substances capable of maintaining the activity of platelets or improving the storage quality thereof on the basis of the CPT2 or the signal pathway involving same and using same as a target.
Inventors:
LIU JUNLING (CN)
FAN XUEMEI (CN)
FAN XUEMEI (CN)
Application Number:
PCT/CN2022/131812
Publication Date:
May 19, 2023
Filing Date:
November 15, 2022
Export Citation:
Assignee:
SHANGHAI SYNVIDA BIOTECHNOLOGY CO LTD (CN)
International Classes:
A01N1/02; A61K45/00; C12Q1/48
Foreign References:
| CN108366551A | 2018-08-03 | |||
| CN1698430A | 2005-11-23 |
Other References:
FAN XUEMEI, WANG YANG, CAI XIAOHONG, SHEN YINGZHI, XU TONGRAN, XU YANYAN, CHENG JINKE, WANG XUEFENG, ZHANG LIN, DAI JING, LIN SHUH: "CPT2 K79 acetylation regulates platelet life span", BLOOD ADVANCES, vol. 6, no. 17, 13 September 2022 (2022-09-13), pages 4924 - 4935, XP093065633, ISSN: 2473-9529, DOI: 10.1182/bloodadvances.2021006687
DEYHIM, M. R. ET AL.: "L-carnitine effectively improves the metabolism and quality of platelet concentrates during storage.", ANN HEMATOL., vol. 94, 18 November 2014 (2014-11-18), XP035462070, DOI: 10.1007/s00277-014-2243-5
KNOTTNERUS, S. J. G. ET AL.: "Disorders of mitochondrial long-chain fatty acid oxidation and the carnitine shuttle.", ENDOCRINE AND METABOLIC DISORDERS., vol. 19, 20 June 2018 (2018-06-20), XP036624097, DOI: 10.1007/s11154-018-9448-1
LIU LIN; XIE BOWEN; FAN MING; CANDAS-GREEN DEMET; JIANG JOY X.; WEI RYAN; WANG YINSHENG; CHEN HONG-WU; HU YIYANG; LI JIAN JIAN: "Low-Level Saturated Fatty Acid Palmitate Benefits Liver Cells by Boosting Mitochondrial Metabolism via CDK1-SIRT3-CPT2 Cascade", DEVELOPMENTAL CELL, CELL PRESS, US, vol. 52, no. 2, 19 December 2019 (2019-12-19), US , pages 196, XP086016559, ISSN: 1534-5807, DOI: 10.1016/j.devcel.2019.11.012
LEPROPRE SOPHIE, SHAKEEL KAUTBALLY, MARIE OCTAVE, AUDREY GINION, MARIE-BLANCHE ONSELAER, GREGORY R. STEINBERG, BRUCE E. KEMP, ALE: "AMPK-ACC signaling modulates platelet phospholipids and potentiates thrombus formation", BLOOD, vol. 132, no. 11, 13 September 2018 (2018-09-13), pages 1180 - 1192, XP093065644
DEYHIM, M. R. ET AL.: "L-carnitine effectively improves the metabolism and quality of platelet concentrates during storage.", ANN HEMATOL., vol. 94, 18 November 2014 (2014-11-18), XP035462070, DOI: 10.1007/s00277-014-2243-5
KNOTTNERUS, S. J. G. ET AL.: "Disorders of mitochondrial long-chain fatty acid oxidation and the carnitine shuttle.", ENDOCRINE AND METABOLIC DISORDERS., vol. 19, 20 June 2018 (2018-06-20), XP036624097, DOI: 10.1007/s11154-018-9448-1
LIU LIN; XIE BOWEN; FAN MING; CANDAS-GREEN DEMET; JIANG JOY X.; WEI RYAN; WANG YINSHENG; CHEN HONG-WU; HU YIYANG; LI JIAN JIAN: "Low-Level Saturated Fatty Acid Palmitate Benefits Liver Cells by Boosting Mitochondrial Metabolism via CDK1-SIRT3-CPT2 Cascade", DEVELOPMENTAL CELL, CELL PRESS, US, vol. 52, no. 2, 19 December 2019 (2019-12-19), US , pages 196, XP086016559, ISSN: 1534-5807, DOI: 10.1016/j.devcel.2019.11.012
LEPROPRE SOPHIE, SHAKEEL KAUTBALLY, MARIE OCTAVE, AUDREY GINION, MARIE-BLANCHE ONSELAER, GREGORY R. STEINBERG, BRUCE E. KEMP, ALE: "AMPK-ACC signaling modulates platelet phospholipids and potentiates thrombus formation", BLOOD, vol. 132, no. 11, 13 September 2018 (2018-09-13), pages 1180 - 1192, XP093065644
Attorney, Agent or Firm:
SHANGHAI PATENT & TRADEMARK LAW OFFICE, LLC (CN)
Download PDF:
Previous Patent: MANUFACTURING METHOD FOR LEAD FRAME, AND LEAD FRAME STRUCTURE
Next Patent: DRUG FOR TREATING TUMORS
Next Patent: DRUG FOR TREATING TUMORS