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Title:
NEW METHOD FOR MANUFACTURING PITAVASTATIN HEMICALCIUM USING NEW INTERMEDIATE
Document Type and Number:
WIPO Patent Application WO/2011/105649
Kind Code:
A1
Abstract:
The present invention is useful as a HMG-Co A reductase inhibitor and relates to a new method for manufacturing pitavastatin hemicalcium which is used as a treatment for hyperlipidemia. More specifically, a new method for manufacturing pitavastatin hemicalcium using a new intermediate is disclosed. The present invention has the following advantages: the usage of the new intermediate for manufacturing pitavastatin provides a more effective method for manufacturing pitavastatin; an alcohol protecting group, which is one of the new intermediates, easily protects dialcohol within one to two hours under acid catalyst and mild reaction conditions; the deprotection reaction of dialcohol is completed within thirty minutes to one hour under very mild reaction conditions of 0 to 25 degrees celsius, which reduces the formation of isomers to the extent possible. Also, the present invention is able to obtain a high yield of high purity pitavastatin hemicalcium despite consecutively executing a hydrolytic reaction and a pitavastatin hemicalcium reaction, without an isolation reaction after the deprotection reaction.

Inventors:
CHO, Dong ock (8 Dawol Village Jeongja-dong, Jangan-guSuwon-si, Kyeonggi-do 440-300, 440-300, KR)
조동옥 (경기도 수원시 장안구 정자동 대월마을, 440-300 Kyeonggi-do, 440-300, KR)
KIM, Seung ki (3 Dugyen Village Woobang Apt, 887-1 Jeongja-dong,Jangan-g, Suwon-si Kyeonggi-do 440-300, 440-300, KR)
Application Number:
KR2010/001302
Publication Date:
September 01, 2011
Filing Date:
March 03, 2010
Export Citation:
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Assignee:
MEDICHEM KOREA LIMITED COMPANY (304 Fitech New Technology Business Center, 111-7 Kuun-dong,Kwonsun-g, Suwon-si Kyeonggi-do 441-814, 441-814, KR)
(주)메디켐코리아 (경기도 수원시 권선구 구운동 111-7 화이텍신기술창업보육센터 304호, 441-814 Kyeonggi-do, 441-814, KR)
CHO, Dong ock (8 Dawol Village Jeongja-dong, Jangan-guSuwon-si, Kyeonggi-do 440-300, 440-300, KR)
조동옥 (경기도 수원시 장안구 정자동 대월마을, 440-300 Kyeonggi-do, 440-300, KR)
International Classes:
C07D215/14; A61K31/47; A61P3/06; C07D319/06
Domestic Patent References:
WO2007132482A2
WO2005054207A1
WO2005063728A2
Foreign References:
KR20090104253A
Attorney, Agent or Firm:
TAEDONG INTERNATIONAL PATENT&LAW OFFICE (1120, Castle Tower Ingye-dong,Paldal-g, Suwon-si Kyeonggi-do 442-835, 442-835, KR)
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Claims: