Title:
NEW METHOD FOR PREPARING BRIVARACETAM
Document Type and Number:
WIPO Patent Application WO/2018/152950
Kind Code:
A1
Abstract:
Provided is a method for preparing brivaracetam, comprising using optically pure (R)-4-n-propyl-dihydrofuran-2(3H)-one as the raw material, and subjecting same to steps such as ring opening, halogenation, condensation and ring closure to prepare the high-purity brivaracetam. The preparation method of the invention has readily available raw materials, low costs, a high total yield, a high optical purity of the obtained product, and simple reaction conditions and operation processes.
More Like This:
| WO/2023/021363 | SYNTHESIS OF BRIVARACETAM |
| WO/2005/070877 | DIAMINO ALCOHOLS AND THEIR USE AS RENIN INHIBITORS |
Inventors:
MA LIANG (CN)
Application Number:
PCT/CN2017/081557
Publication Date:
August 30, 2018
Filing Date:
April 23, 2017
Export Citation:
Assignee:
BEIJING ABLEPHARMTECH CO LTD (CN)
International Classes:
C07D207/27
Domestic Patent References:
| WO2016191435A1 | 2016-12-01 |
Foreign References:
| CN101263113A | 2008-09-10 |
Other References:
YU, CHENGGONG ET AL.: "Graphical Synthetic Routes of Brivaracetam", CHINESE JOURNAL OF PHARMACEUTICALS, vol. 47, no. 12, 31 December 2016 (2016-12-31), pages 1600 - 1603, DOI: 10.16522/j.cnki.cjph.2016.12.023
Attorney, Agent or Firm:
BEIJING ZHAOJUN UNION INTELLECTUAL PROPERTY LAW FIRM (CN)
Download PDF: