Title:
NEW MONOCLONAL ANTIBODY
Document Type and Number:
WIPO Patent Application WO/2015/076425
Kind Code:
A1
Abstract:
Provided is a drug for preventing or treating various malignant tumors such as solid tumors that are presently intractable, and that comprises, as an active ingredient, new antibodies that are able to bind with human CD44v9 and that specifically induce antibody-dependent cellular cytotoxicity in cancer cells. Provided is an antibody to human CD44v9 and a drug for preventing or treating tumours that contains said antibody.
Inventors:
NIWA SHINICHIRO (JP)
HAYASHI HIDEMI (JP)
OGURA DAI (JP)
SHINDOU TAKAYUKI (JP)
HAYASHI HIDEMI (JP)
OGURA DAI (JP)
SHINDOU TAKAYUKI (JP)
Application Number:
PCT/JP2014/081674
Publication Date:
May 28, 2015
Filing Date:
November 25, 2014
Export Citation:
Assignee:
LINK GENOMICS INC (JP)
International Classes:
C07K16/28; A61K31/136; A61K31/166; A61K31/17; A61K31/198; A61K31/203; A61K31/255; A61K31/282; A61K31/337; A61K31/407; A61K31/4188; A61K31/4745; A61K31/475; A61K31/513; A61K31/519; A61K31/52; A61K31/6615; A61K31/675; A61K31/69; A61K31/7008; A61K31/704; A61K31/7048; A61K31/7056; A61K31/7064; A61K31/7068; A61K31/7076; A61K33/243; A61K39/395; A61K45/00; A61K49/00; A61P35/00; C07K14/705; C12N1/15; C12N1/19; C12N1/21; C12N5/10; C12N15/00; C12P21/08; C12Q1/04; G01N33/574
Domestic Patent References:
| WO2011007853A1 | 2011-01-20 | |||
| WO2013018886A1 | 2013-02-07 | |||
| WO2011145629A2 | 2011-11-24 |
Foreign References:
| JP2013518848A | 2013-05-23 | |||
| JPH05276987A | 1993-10-26 | |||
| JP2011525359A | 2011-09-22 | |||
| JPH11127861A | 1999-05-18 |
Other References:
SEKI, K. ET AL.: "Inhibition of liver metastasis formation by anti- CD 44 variant exon 9 monoclonal antibody", INTERNATIONAL JOURNAL OF ONCOLOGY, vol. 11, 1997, pages 1257 - 1261, XP009124463
KIMURA, Y. ET AL.: "CD 44variant exon 9 plays an important role in colon cancer initiating cells", ONCOTARGET, vol. 4, no. 5, 6 June 2013 (2013-06-06), pages 785 - 791
OKADA, S. ET AL.: "Expression of CD 44 Variant 9 Contributes to 5-Fluorouracil Resistance in Gastric Cancer Through Anti-Oxidative Stress Mechanism", GASTROENTEROLOGY, vol. 144, no. 5, May 2013 (2013-05-01), pages S460 - S461
MIELGO, A. ET AL.: "A novel antiapoptotic mechanism based on interference of Fas signaling by CD 44 variant isoforms", CELL DEATH AND DIFFERENTIATION, vol. 13, 2006, pages 465 - 477
KIMURA, Y. ET AL.: "CD 44variant exon 9 plays an important role in colon cancer initiating cells", ONCOTARGET, vol. 4, no. 5, 6 June 2013 (2013-06-06), pages 785 - 791
OKADA, S. ET AL.: "Expression of CD 44 Variant 9 Contributes to 5-Fluorouracil Resistance in Gastric Cancer Through Anti-Oxidative Stress Mechanism", GASTROENTEROLOGY, vol. 144, no. 5, May 2013 (2013-05-01), pages S460 - S461
MIELGO, A. ET AL.: "A novel antiapoptotic mechanism based on interference of Fas signaling by CD 44 variant isoforms", CELL DEATH AND DIFFERENTIATION, vol. 13, 2006, pages 465 - 477
Attorney, Agent or Firm:
KOBAYASHI, Hiroshi et al. (JP)
Kobayashi 浩 (JP)
Kobayashi 浩 (JP)
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