Title:
NEW MUTANT OF RECOMBINANT GANODERMA LUCIDUM IMMUNOREGULATORY PROTEIN AND APPLICATION THEREOF
Document Type and Number:
WIPO Patent Application WO/2023/016419
Kind Code:
A1
Abstract:
The present invention relates to a recombinant protein, the recombinant protein comprising a spacer peptide and a recombinant Ganoderma lucidum immunoregulatory protein mutant (rLZ-8 mutant); compared with the amino acid sequence shown in SEQ ID NO: 10, the amino acid sequence of the rLZ-8 mutant contains at least one amino acid mutation. It also relates to an application of the recombinant protein in the treatment of diseases.
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Inventors:
ZHANG XIN (CN)
SONG GONGMING (CN)
JIA WEI (CN)
ZHANG XITIAN (CN)
SONG GONGMING (CN)
JIA WEI (CN)
ZHANG XITIAN (CN)
Application Number:
PCT/CN2022/110916
Publication Date:
February 16, 2023
Filing Date:
August 08, 2022
Export Citation:
Assignee:
CHANGCHUN INTELLICROWN PHARMACEUTICAL CO LTD (CN)
SHANGHAI INTELLICROWN BIOTECHNOLOGY CO LTD (CN)
SHANGHAI INTELLICROWN BIOTECHNOLOGY CO LTD (CN)
International Classes:
C07K19/00; A61K38/16; A61P35/00
Domestic Patent References:
| WO2015158177A1 | 2015-10-22 |
Foreign References:
| CN103524628A | 2014-01-22 | |||
| CN107118263A | 2017-09-01 | |||
| CN111748543A | 2020-10-09 |
Other References:
SHI YING-FEI, JING KE-JU, LING XUE-PING, LU YING-HUA: "Codon Optimization of Human Proinsulin and Expression in Pichia pastoris", XIAMEN DAXUE XUEBAO (ZIRAN KEXUE BAN) - XIAMEN UNIVERSITY.JOURNAL (NATURAL SCIENCE EDITION) - ACTA SCIENTIARUMUNIVERSITATIS AMOIENSIS, vol. 51, no. 1, 31 January 2012 (2012-01-31), CN , pages 101 - 106, XP009522307, ISSN: 0438-0479
LIN TUNG-YI, HSU HSIEN-YEH, SUN WEI-HSUAN, WU TSUNG-HAN, TSAO SHU-MING: "Induction of Cbl-dependent epidermal growth factor receptor degradation in Ling Zhi-8 suppressed lung cancer : LZ-8 induces EGFR degradation", INTERNATIONAL JOURNAL OF CANCER, vol. 140, no. 11, 1 June 2017 (2017-06-01), US , pages 2596 - 2607, XP093035166, ISSN: 0020-7136, DOI: 10.1002/ijc.30649
KINO ET AL., GANODERMA LUCIDUM MYCELIUM EXTRACT, 1989
"UniProtKB", Database accession no. P14945
LIN TUNG-YI, HSU HSIEN-YEH, SUN WEI-HSUAN, WU TSUNG-HAN, TSAO SHU-MING: "Induction of Cbl-dependent epidermal growth factor receptor degradation in Ling Zhi-8 suppressed lung cancer : LZ-8 induces EGFR degradation", INTERNATIONAL JOURNAL OF CANCER, vol. 140, no. 11, 1 June 2017 (2017-06-01), US , pages 2596 - 2607, XP093035166, ISSN: 0020-7136, DOI: 10.1002/ijc.30649
KINO ET AL., GANODERMA LUCIDUM MYCELIUM EXTRACT, 1989
"UniProtKB", Database accession no. P14945
Attorney, Agent or Firm:
SHANGHAI DIANSHI PARTNERS, P.C. (CN)
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