Title:
NEW NORBORNENE-BASED AMPHIPATHIC COMPOUND AND UTILIZATION THEREOF
Document Type and Number:
WIPO Patent Application WO/2018/139698
Kind Code:
A1
Abstract:
The present invention relates to a newly developed norbornene-based amphipathic compound, a method for producing the same, and a method for extracting, solubilizing, stabilizing, crystallizing or analyzing a membrane protein by using the same. In addition, compared to existing compounds, this compound enables efficient extraction of membrane proteins having various structures and characteristics from cell membranes, and stable storage of the same in an aqueous solution for a long period of time, and thus can be utilized for functional analysis and structural analysis thereof. Analysis of structures and functions of membrane proteins has a close relationship with the development of new drug and therefore, is one of the most interested fields in current biology and chemistry
Inventors:
CHAE PIL SEOK (KR)
DAS MANABENDRA (KR)
DAS MANABENDRA (KR)
Application Number:
PCT/KR2017/001486
Publication Date:
August 02, 2018
Filing Date:
February 10, 2017
Export Citation:
Assignee:
IUCF HYU ERICA CAMPUS (KR)
International Classes:
C07H15/203; C07K1/113; C07K1/14; C07K1/30; C07K14/705; G01N33/68
Foreign References:
| US20130001465A1 | 2013-01-03 | |||
| US20040242897A1 | 2004-12-02 |
Other References:
ILKER, M. F.: "Modular norbornene derivatives for the preparation of well-defined amphiphilic polymers: Study of the lipid membrane disruption activities", MACROMOLECULES, vol. 37, no. 3, March 2004 (2004-03-01), pages 694 - 700, XP055536713
CHAE, P. S.: "Tripod amphiphiles for membrane protein manipulation", MOLECULAR BIOSYSTEMS, vol. 6, 2010, pages 89 - 94, XP055536722
CHAE, P. S.: "Glucose-neopentyl glycol (GNG) amphiphiles for membrane protein study", CHEMICAL COMMUNICATIONS, 21 March 2013 (2013-03-21), pages 2287 - 2289, XP055536723
CHAE, P. S.: "Tripod amphiphiles for membrane protein manipulation", MOLECULAR BIOSYSTEMS, vol. 6, 2010, pages 89 - 94, XP055536722
CHAE, P. S.: "Glucose-neopentyl glycol (GNG) amphiphiles for membrane protein study", CHEMICAL COMMUNICATIONS, 21 March 2013 (2013-03-21), pages 2287 - 2289, XP055536723
Attorney, Agent or Firm:
DANA PATENT LAW FIRM (KR)
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