Title:
NEW PHARMACEUTICAL USE AND PHARMACEUTICAL COMPOSITION OF PYRROLOQUINOLINE QUINONE, DERIVATIVE AND/OR SALTS THEREOF
Document Type and Number:
WIPO Patent Application WO/2016/173435
Kind Code:
A1
Abstract:
Disclosed are a use of a pyrroloquinoline quinone (PQQ), derivative and/or salt thereof in the preparation of drugs for the treatment and/or prevention of adenomyosis, ovarian chocolate cysts and deep infiltrating endometriosis and other types of endometriosis; and a use of antioxidants in the preparation of drugs for the inhibition endometrial stromal cell proliferation, oxidative stress state, migration and invasion, the antioxidants are selected from the following: N-acetyl-L-cysteine (NAC), resveratrol, epigallocatechin, epigallocatechin gallate vinegar, one or more of vitamin E or vitamin C; PQQ in combination with NAC have a significant synergy of inhibition cell proliferation: in vitro significantly inhibiting the proliferation of endometrial stromal cells, in vivo significantly reducing the size of endometriosis injuries, significantly reducing infiltration of endometrial stroma and glands, and significantly reducing the use dosage of NAC; PQQ contributes to fertility, and increases the chance of pregnancy; and PQQ or PQQ in combination with NAC as a drug, almost has no side effects and will not interfere with pregnancy.
Inventors:
WEN CHUANJUN (CN)
SUN FENYONG (CN)
SUN FENYONG (CN)
Application Number:
PCT/CN2016/079709
Publication Date:
November 03, 2016
Filing Date:
April 20, 2016
Export Citation:
Assignee:
NANJING SHUPENG LIFESCIENCE CO LTD (CN)
International Classes:
C07D471/04; A61K31/4745; A61P15/00
Domestic Patent References:
| WO2006138347A2 | 2006-12-28 |
Foreign References:
| CN104856996A | 2015-08-26 | |||
| CN102665707A | 2012-09-12 |
Other References:
RUCKER, R. ET AL.: "Potential Physiological Importance of Pyrroloquinoline Quinone", ALTERNATIVE MEDICINE REVIEW, vol. 14, no. 3, 31 December 2009 (2009-12-31), pages 268 - 277, XP055325799
DURAK, Y ET AL.: "Effect of Vitamin C on the Growth of Experimentally Induced Endometriotic Cysts", OBSTETRICS AND GYNAECOLOGY RESEARCH, vol. 39, no. 7, 31 July 2013 (2013-07-31), pages 1253 - 1258, XP055325865
NGO, C. ET AL.: "Reactive Oxygen Species Controls Endometriosis Progression", THE AMERICAN JOURNAL OF PATHOLOGY, vol. 175, no. 1, 31 July 2009 (2009-07-31), pages 225 - 234, XP009127152
DURAK, Y ET AL.: "Effect of Vitamin C on the Growth of Experimentally Induced Endometriotic Cysts", OBSTETRICS AND GYNAECOLOGY RESEARCH, vol. 39, no. 7, 31 July 2013 (2013-07-31), pages 1253 - 1258, XP055325865
NGO, C. ET AL.: "Reactive Oxygen Species Controls Endometriosis Progression", THE AMERICAN JOURNAL OF PATHOLOGY, vol. 175, no. 1, 31 July 2009 (2009-07-31), pages 225 - 234, XP009127152
Attorney, Agent or Firm:
SHENZHEN ARK INTELLECTUAL PROPERTY AGENT LLP (CN)
深圳壹舟知识产权代理事务所（普通合伙） (CN)
深圳壹舟知识产权代理事务所（普通合伙） (CN)
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