Title:
NEW POLYPEPTIDE RESISTANT TO HIV INFECTION AND USES THEREOF
Document Type and Number:
WIPO Patent Application WO/2015/106673
Kind Code:
A1
Abstract:
The present invention relates to the biomedical field, and provides polypeptide for inhibiting HIV infection. The polypeptide comprises an amino acid sequence as expressed by SEQ ID NO: 1-10. The present invention also provides uses of the polypeptide in the preparation of drugs for resisting to HIV infection or preventing or treating aids. The polypeptide of the present invention is a monomer fusion inhibitor directly derived from NHR, has an activity higher than that of an original sequence, and needs low synthesis cost.
Inventors:
LIU KELIANG (CN)
CAI LIFENG (CN)
ZHENG BAOHUA (CN)
ZHANG GUIYING (CN)
CAO DEQIANG (CN)
JIANG XIFENG (CN)
CAI LIFENG (CN)
ZHENG BAOHUA (CN)
ZHANG GUIYING (CN)
CAO DEQIANG (CN)
JIANG XIFENG (CN)
Application Number:
PCT/CN2015/070570
Publication Date:
July 23, 2015
Filing Date:
January 13, 2015
Export Citation:
Assignee:
INST PHARM & TOXICOLOGY AMMS (CN)
International Classes:
C07K14/16; A61K38/16; A61K48/00; A61P31/18; C12N1/15; C12N1/19; C12N1/21; C12N15/49; C12N15/63
Domestic Patent References:
| WO2005089796A1 | 2005-09-29 |
Foreign References:
| CN102427829A | 2012-04-25 |
Other References:
CAI LF ET AL.: "Biochemistry and Biophysics of HIV-1 gp41-membrane interactions: Implications for HIV-1 Envelope Protein Mediated Viral- Cell Fusion and Fusion Inhibitor Design", CURR TOP MED CHEM, vol. 11, no. 24, 1 December 2011 (2011-12-01), pages 2959 - 2984
Attorney, Agent or Firm:
CCPIT PATENT AND TRADEMARK LAW OFFICE (CN)
中国国际贸易促进委员会专利商标事务所 (CN)
中国国际贸易促进委员会专利商标事务所 (CN)
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