The present invention relates to pyridine compounds and the N-oxides and the salts thereof for combating phytopathogenic fungi, and to the use and methods for combating phytopathogenic fungi and to seeds coated with at least one such compound. The invention also relates to pro- cesses for preparing these compounds, intermediates, processes for preparing such intermedi- ates, and to compositions comprising at least one compound I.

In many cases, in particular at low application rates, the fungicidal activity of the known fungi- cidal compounds is unsatisfactory. Based on this, it was an object of the present invention to provide compounds having improved activity and/or a broader activity spectrum against phyto- pathogenic harmful fungi.

Surprisingly, this object is achieved by the use of the inventive pyridine compounds of formula I having favorable fungicidal activity against phytopathogenic fungi.

Accordingly, the present invention relates to use of the compounds of formula I

wherein

X is O, S, NH

R ¹ is in each case independently selected from hydrogen, halogen, OH, CN, COOH,

CONH ₂ , N0 ₂ , SH, NH _2, NH(Ci-C ₄ -alkyl), N(Ci-C ₄ -alkyl) ₂ , NH-S0 ₂ -R ^x , Ci-C ₆ -alkyl, C ₂ -C ₆ - alkenyl, C2-C6-alkynyl, Ci-C ₆ -alkoxy, C3-C6-cycloalkyl, five- or six-membered heteroaryl and aryl; wherein the heteroaryl contains one, two or three heteroatoms selected from N, O and S; and wherein

R ^x is Ci-C ₄ -alkyl, Ci-C ₄ -halogenalkyl, unsubstituted aryl or aryl that is substituted by 1 , 2, 3, 4 or 5 substituents R ^x1 independently selected from Ci-C ₄ -alkyl, halogen, OH, CN, Ci-C ₄ -halogenalkyl, Ci-C ₄ -alkoxy and Ci-C ₄ -halogenalkoxy;

wherein the acyclic moieties of R ¹ are unsubstituted or substituted with identical or differ- ent groups R ^1a which independently of one another are selected from:

R ^1a halogen, OH, CN, COOH, CONH2, Ci-C ₆ -alkoxy, C3-C6-cycloalkyl, C3-C6- halogencycloalkyl, Ci-C ₄ -halogenalkoxy, Ci-C ₆ -alkylthio, aryl and phenoxy, wherein the aryl group is unsubstituted or carries 1 , 2, 3, 4 or 5 substituents R ^11a selected from the group consisting of halogen, OH, Ci-C ₄ -alkyl, Ci-C ₄ -halogen- alkyl, Ci-C ₄ -alkoxy and Ci-C ₄ -halogenalkoxy;

wherein the carbocyclic, heteroaryl and aryl moieties of R ¹ are not further substituted or carry 1 , 2, 3, 4, 5 or up to the maximum number of identical or different groups R ^1b which independently of one another are selected from: R ^1b halogen, OH, CN, COOH, CONH ₂ , Ci-C ₄ -alkyl, CrC ₄ -alkoxy, Ci-C ₄ -halogenalkyl, C3-C6-cycloalkyl, C3-C6-halogencycloalkyl, Ci-C ₄ -halogenalkoxy and Ci-C ₆ -al- kylthio;

R ² is in each case independently selected from halogen, OH, CN, COOH, CONH2, NO2, SH, NH _2, NH(Ci-C ₄ -alkyl), N(Ci-C ₄ -alkyl) ₂ , NH(C ₂ -C ₄ -alkenyl), N(C ₂ -C ₄ -alkenyl) ₂ , NH(C ₂ -C ₄ -al- kynyl), N(C2-C ₄ -alkynyl)2, NH(C3-C6-cycloalkyl), N(C3-C6-cycloalkyl)2, N(Ci-C ₄ -alkyl)(C2-C ₄ - alkenyl), N(Ci-C ₄ -alkyl)(C2-C ₄ -alkynyl), N(Ci-C ₄ -alkyl)(C3-C6-cycloalkyl), N(C2-C ₄ - alkenyl)(C2-C ₄ -alkynyl), N(C2-C ₄ -alkenyl)(C3-C6-cycloalkyl), N(C2-C ₄ -alkynyl)(C3-C6-cyclo- alkyl), NH(C(=0)C _r C ₄ -alkyl), N(C(=0)CrC ₄ -alkyl) _2, NH-S0 ₂ -R ^x , S(0) _n -Ci-C ₆ -alkyl, S(0) _n - aryl, Ci-C ₆ -cycloalkylthio, S(0) _n -C ₂ -C ₆ -alkenyl, S(0) _n -C ₂ -C ₆ -alkynyl, CH(=0), C(=0)Ci-C ₆ - alkyl, C(=0)C ₂ -C ₆ -alkenyl, C(=0)C ₂ -C ₆ -alkynyl, C(=0)C ₃ -C ₆ -cycloalkyl, C(=0)NH(C _I -C ₆ - alkyl), CH(=S), C(=S)Ci-C ₆ -alkyl, C(=S)C ₂ -C ₆ -alkenyl, C(=S)C ₂ -C ₆ -alkynyl, C(=S)C ₃ -C ₆ - cycloalkyl, C(=S)0(C ₂ -C ₆ -alkenyl) _, C(=S)0(C ₂ -C ₆ -alkynyl) _, C(=S)0(C ₃ -C ₇ -cycloalkyl) _, C(=S)NH(Ci-C ₆ -alkyl), C(=S)NH(C ₂ -C ₆ -alkenyl) _, C(=S)NH(C ₂ -C ₆ -alkynyl) _, C(=S)NH(C ₃ -C ₇ - cycloalkyl),C(=S)N(Ci-C ₆ -alkyl) ₂ , C(=S)N(C ₂ -C ₆ -alkenyl) _2, C(=S)N(C ₂ -C ₆ -alkynyl) _2,

C(=S)N(C ₃ -C ₇ -cycloalkyl) _2, CrC ₆ -alkyl, Ci-C ₆ -halogenalkyl, C2-C6-alkenyl, C2-C6-alkynyl, OR ^Y , C3-C6-cycloalkyl, five- or six-membered heteroaryl and aryl; wherein the heteroaryl contains one, two or three heteroatoms selected from N, O and S; wherein

R ^x is as defined above;

R ^Y is Ci-C ₆ -alkyl, Ci-C ₆ -halogenalkyl, C2-C6-alkenyl, C2-C6-halogenalkenyl, C2-C6- alkynyl, C2-C6-halogenalkynyl, C3-C6-cycloalkyl, C3-C6-halogencycloalkyl, phenyl and phenyl-Ci-C ₆ -alkyl; wherein the phenyl groups are unsubstituted or carry one, two, three, four or five substituents selected from the group consisting of CN, halogen, OH, Ci-C ₄ -alkyl, Ci-C ₄ -halogenalkyl, Ci-C ₄ -alkoxy and CrC ₄ -halo- genalkoxy;

wherein the acyclic moieties of R ² are unsubstituted or substituted by groups R ^2a which independently of one another are selected from:

R ^2a halogen, OH, CN, COOH, CONH2, Ci-C ₆ -alkoxy, C3-C6-cycloalkyl, C3-C6- halogencycloalkyl, Ci-C ₄ -halogenalkoxy, Ci-Ce-alkylthio and phenoxy, wherein the phenyl group is unsubstituted or substituted by substituents R ^91a selected from the group consisting of halogen, OH, Ci-C ₄ -alkyl, Ci-C ₄ -halogenalkyl, Ci-C ₄ - alkoxy and Ci-C ₄ -halogenalkoxy;

wherein the carbocyclic, heteroaryl and aryl moieties of R ² are unsubstituted or substituted by groups R ^3b which independently of one another are selected from:

R ^2b halogen, OH, CN, COOH, CONH2, Ci-C ₄ -alkyl, Ci-C ₄ -alkoxy, Ci-C ₄ -halogenalkyl, C3-C6-cycloalkyl, C3-C6-halogencycloalkyl, Ci-C ₄ -halogenalkoxy and Ci-C ₆ -al- kylthio;

and wherein n is defined as above;

R ³ is in each case independently selected from the substituents as defined for R ² , wherein the possible substituents for R ³ are R ^3a and R ^3b , respectively, which correspond to R ^2a and R ^2b , respectively; R ² , R ³ together with the carbon atoms to which they are bound form a five- , six-, or seven- membered carbo-, heterocyclic or heteroaromatic ring; wherein the heterocyclic or heteroaromatic ring contains 1 , 2, 3 or 4 heteroatoms selected from N, O and S, wherein N may carry one substituent R ^N selected from Ci-C4-alkyl, Ci-C ₄ -halogen- alkyl and SC>2Ph, wherein Ph is unsubstituted or substituted by substituents selected from Ci-C4-alkyl, halogen, Ci-C4-halogenalkyl, Ci-C4-alkoxy, Ci-C4-halogenalkoxy, and CN; and wherein S may be in the form of its oxide SO or S0 ₂ ; and wherein in each case one or two CH ₂ groups of the carbo- or heterocycle may be replaced by a group independently selected from C(=0) and C(=S); and wherein the carbo-, heter- ocyclic or heteroaromatic ring is substituent by (R ²³ ) _m , wherein m is 0, 1 , 2, 3 or 4;

R ²³ is in each case independently selected from halogen, OH, CN, COOH, CONH ₂ , N0 ₂ , SH, NH _2, NH(Ci-C ₄ -alkyl), N(Ci-C ₄ -alkyl) ₂ , NH-S0 ₂ -R ^x , Ci-C ₆ -alkyl, C ₂ -C ₆ -alkenyl, C ₂ -C ₆ -al- kynyl, Ci-C ₆ -alkoxy, C3-C6-cycloalkyl, saturated or partially unsaturated three-, four-, five-, six-, seven-, eight-, nine-, or ten-membered carbo- and heterocycle, five- or six-membered heteroaryl and aryl; wherein the heterocycle and heteroaryl contains 1 , 2 or 3 heteroatoms selected from N, O and S; and wherein in each case one or two CH ₂ groups of the carbo- or heterocycle may be replaced by a group independently selected from C(=0) and C(=S); and wherein

R ^x is as defined above;

wherein the acyclic moieties of R ²³ are unsubstituted or carry 1 , 2, 3 or up to the maximum pos- sible number of identical or different groups R ^23a which independently of one another are se- lected from:

R ^23a halogen, OH, CN, COOH, CONH ₂ , Ci-C ₆ -alkoxy, C3-C6-cycloalkyl, C3-C6- halogencycloalkyl, CrC4-halogenalkoxy, Ci-Ce-alkylthio and phenoxy, wherein the phenyl group is unsubstituted or unsubstituted or substituted with R ^91a se- lected from the group consisting of halogen, OH, Ci-C4-alkyl, Ci-C4-halogenalkyl, Ci-C4-alkoxy, Ci-C4-halogenalkoxy, CN, C3-C6-cycloalkyl, C3-C6-halogencycloal- kyl, Ci-C4-alkylthio;

wherein the carbocyclic, heterocyclic, heteroaryl and aryl moieties of R ²³ are unsubstituted or substituted with identical or different groups R ^23b which independently of one another are se- lected from:

R ^23b halogen, OH, CN, COOH, CONH ₂ , Ci-C4-alkyl, CrC4-alkoxy, Ci-C4-halogenalkyl, C3-C6-cycloalkyl, C3-C6-halogencycloalkyl, CrC4-halogenalkoxy, and CrC ₆ -al- kylthio;

R ⁴ is in each case independently selected from hydrogen, halogen, OH, CN, COOH,

CON H ₂ , N0 _2I SH, NH _2, NH(Ci-C ₄ -alkyl), N(Ci-C ₄ -alkyl) ₂ , NH-S0 ₂ -R ^x , Ci-C ₆ -alkyl, C ₂ -C ₆ - alkenyl, C ₂ -C ₆ -alkynyl, Ci-C ₆ -alkoxy, C3-C6-cycloalkyl, five- or six-membered heteroaryl and aryl; wherein the heteroaryl contains one, two or three heteroatoms selected from N, O and S; and wherein

R ^x is as defined above wherein the aliphatic moieties of R ⁴ are unsubstituted or substituted with identical or dif- ferent groups R ^2a which independently of one another are selected from:

R ^4a halogen, OH, CN, COOH, CONH ₂ , Ci-C ₆ -alkoxy, C ₃ -C ₆ -cycloalkyl, C ₃ -C ₆ - halogencycloalkyl, Ci-C ₄ -halogenalkoxy, Ci-Ce-alkylthio, aryl and phenoxy, wherein the aryl group is unsubstituted or carries 1 , 2, 3, 4 or 5 substituents R ^41a selected from the group consisting of halogen, OH, Ci-C ₄ -alkyl, Ci-C ₄ -halogen- alkyl, Ci-C ₄ -alkoxy and Ci-C ₄ -halogenalkoxy;

wherein the cycloalkyl, heteroaryl and aryl moieties of R ⁴ are not further substituted or carry 1 , 2, 3, 4, 5 or up to the maximum number of identical or different groups R ^4b which independently of one another are selected from:

R ^4b halogen, OH, CN, COOH, CONH ₂ , Ci-C ₄ -alkyl, Ci-C ₄ -alkoxy, Ci-C ₄ -halogenalkyl, C ₃ -C ₆ -cycloalkyl, C ₃ -C ₆ -halogencycloalkyl, Ci-C ₄ -halogenalkoxy and Ci-C6-al- kylthio;

R ⁵ is in each case independently selected from hydrogen, OH, CH(=0), C(=0)Ci-C ₆ -alkyl, C(=0)C ₂ -C ₆ -alkenyl, C(=0)C ₂ -C ₆ -alkynyl, C(=0)C ₃ -C ₆ -cycloalkyl, Ci-C ₆ -alkyl, Ci-C ₄ -halo- genalkyl, C ₃ -C ₆ -cycloalkyl, C ₃ -C ₆ -halogencycloalkyl, Ci-C ₄ -alkoxy, CrC ₄ -halogenalkoxy, OR ^Y , C ₂ -C ₆ -alkenyl, C ₂ -C ₆ -halogenalkenyl C ₂ -C ₆ -alkynyl, C ₂ -C ₆ -halogenalkynyl, five- or six-membered heteroaryl and aryl; wherein the heteroaryl contains one, two or three het- eroatoms selected from N, O and S; wherein the aryl groups are unsubstituted or carry one, two, three, four or five substituents selected from the group consisting of CN, halo- gen, OH, Ci-C ₄ -alkyl, Ci-C ₄ -halogenalkyl, Ci-C ₄ -alkoxy and Ci-C ₄ -halogenalkoxy;

R ^Y is defined as above;

wherein the acyclic moieties of R ⁵ are not further substituted or carry one, two, three or up to the maximum possible number of identical or different groups R ^5a which independently of one another are selected from:

R ^5a halogen, OH, CN, COOH, CONH ₂ , Ci-C ₆ -alkoxy, C ₃ -C ₆ -cycloalkyl, C ₃ -C ₆ -cycloal- kenyl, C ₃ -C ₆ -halogencycloalkyl, C ₃ -C ₆ -halogencycloalkenyl, Ci-C ₄ -halogenalkoxy, Ci-C ₆ -alkylthio, five- or six-membered heteroaryl, phenyl and phenoxy, wherein the heteroaryl, phenyl and phenoxy group is unsubstituted or carries one, two, three, four or five substituents R ^78a’ selected from the group consisting of halogen, OH, Ci- C ₄ -alkyl, Ci-C ₄ -halogenalkyl, Ci-C ₄ -alkoxy and Ci-C ₄ -halogenalkoxy;

wherein the alicyclic, phenyl, heterocyclic and heteroaryl moieties of R ¹² are not further substituted or carry one, two, three, four, five or up to the maximum number of identical or different groups R ^12b which independently of one another are selected from:

R ^5b halogen, OH, CN, COOH, CONH ₂ , Ci-C ₄ -alkyl, Ci-C ₄ -alkoxy, Ci-C ₄ -halogenalkyl, C ₃ -C ₆ -cycloalkyl, C ₃ -C ₆ -halogencycloalkyl, Ci-C ₄ -halogenalkoxy and Ci-Ce-alkylthio; R ⁶ is independently selected from hydrogen, halogen, OH, CN, COOH, CONH ₂ , N0 ₂ , SH, CrCe-alkylthio, NH _2, NH(Ci-C ₄ -alkyl), N(Ci-C ₄ -alkyl) ₂ , NH-S0 ₂ -R ^x , Ci-C ₆ -alkyl, Ci-C ₆ -hal- ogenalkyl, C ₂ -C ₆ -alkenyl, C ₂ -C ₆ -halogenalkenyl, C ₂ -C ₆ -alkynyl, C ₂ -C ₆ -halogenalkynyl, Ci- C ₆ -alkoxy, Ci-C ₆ -halogenalkoxy, C ₂ -C ₆ -alkenyloxy, C ₂ -C ₆ -alkynyloxy, aryloxy, het- eroaryloxy, arylamino, heteroarylamino, arylthio, heteroarylthio, CH(=0), C(=0)Ci-C6- alkyl, C(=0)0(Ci-C ₆ -alkyl), C(=0)NH(Ci-C ₆ -alkyl), C(=0)N(Ci-C ₆ -alkyl) ₂ , CR’=NOR”, a saturated or partially unsaturated three-, four-, five-, six-, seven-, eight-, nine-, or ten- membered carbocycle or heterocycle, a five- or six-membered heteroaryl or aryl; wherein in each case one or two CH ₂ groups of the carbo- and heterocycle may be replaced by a group independently selected from C(=0) and C(=S), and wherein the heterocycle and the heteroaryl contain independently one, two, three or four heteroatoms selected from N, O and S; and wherein R’ and R” are independently selected from H, Ci-C ₄ -alkyl, C ₂ - C ₆ -alkenyl, C ₂ -C ₆ -alkynyl, saturated or partially unsaturated three-, four-, five-, six-, seven-, eight-, nine-, or ten-membered carbo- and heterocycle, five- or six-membered heteroaryl or aryl; wherein the heterocycle or heteroaryl contains one, two or three het- eroatoms selected from N, O and S, and wherein R’ and R” are independently unsubsti- tuted or substituted by R’” which is independently selected from halogen, OH, CN, N0 ₂ , SH, NH _2, NH(Ci-C ₄ -alkyl), N(Ci-C ₄ -alkyl) ₂ , NH-S0 ₂ -R ^x , Ci-C ₆ -alkyl, Ci-C ₆ -halogenalkyl, C ₂ -C ₆ -alkenyl, C ₂ -C ₆ -halogenalkenyl, C ₂ -C ₆ -alkynyl, C ₂ -C ₆ -halogenalkynyl, Ci-C ₆ -alkoxy, Ci-C ₆ -halogenalkoxy, C3-C6-cycloalkyl, C3-C6-halogencycloalkyl and phenyl; or wherein the aliphatic moieties of and R ⁶ are independently not further substituted or carry 1 , 2, 3 or up to the maximum possible number of identical or different groups R ^6a , respectively, which independently of one another are selected from:

R ^6a halogen, OH, CN, COOH, CONH ₂ , N0 ₂ , SH, NH ₂ , NH(C C ₄ -alkyl), N(Ci-C ₄ -al- kyl) ₂ , NH-aryl, N(aryl) ₂ , NH(C(=0)C _r C ₄ -alkyl), N(C(=0)C C ₄ -alkyl) ₂ , NH-S0 ₂ -R ^x , Ci-C ₆ -alkoxy, C3-C6-halogencycloalkyl, Ci-C ₄ -halogenalkoxy, Ci-Ce-alkylthio, Ci- C ₆ -halogenalkylthio, S(0) _n -Ci-C ₆ -alkyl, S(0) _n -aryl, CH(=0), C(=0)Ci-C ₆ -alkyl, C(=0)0(Ci-C ₆ -aikyl), C(=0)NH(Ci-C ₆ -aikyl), C(=0)N(Ci-C ₆ -aikyl) ₂ , CR’=NOR”, a saturated or partially unsaturated three-, four-, five-, six-, seven-, eight-, nine-, or ten-membered carbocycle or heterocycle, aryl, phenoxy, a five-, six- or ten-mem- bered heteroaryl; wherein in each case one or two CH ₂ groups of the carbo- and heterocycle may be replaced by a group independently selected from C(=0) and C(=S), five- or six-membered heteroaryl and aryl; wherein the heterocycle and the heteroaryl contain independently 1 , 2, 3 or 4 heteroatoms selected from N, O and S; wherein in each case one or two CH ₂ groups of the carbo- and heterocy- cle may be replaced by a group independently selected from C(=0) and C(=S); wherein the carbocyclic, heterocyclic, aryl and phenyl groups are independently unsubstituted or carry one, two, three, four or five substituents selected from the group consisting of halogen, OH, CN, N0 ₂ , SH, NH ₂ , NH(Ci-C ₄ -alkyl), N(C _I -C ₄ - alkyl) ₂ , NH(C(=0)Ci-C ₄ -aikyl), N(C(=0)Ci-C ₄ -aikyl) ₂ , NH-S0 ₂ -R ^x , C _r C ₆ -alkylthio, Ci-C ₄ -alkyl, Ci-C ₄ -halogenalkyl, Ci-C ₄ -alkoxy, Ci-C ₄ -halogenalkoxy, and S(0) _n - Ci-C ₆ -alkyl; and wherein R ^x , R’, R” and R” are as defined above

wherein the carbocyclic, heterocyclic, heteroaryl and aryl moieties of R ⁶ are independently not further substituted or carry 1 , 2, 3, 4, 5 or up to the maximum number of identical or different groups R ^6b , respectively, which independently of one another are selected from:

R ^6b halogen, OH, CN, COOH, CONH ₂ , N0 ₂ , SH, NH _2, NH(Ci-C ₄ -alkyl), N(Ci-C ₄ -al- kyl) ₂ , NH(C(=0)Ci-C ₄ -aikyl), N(C(=0)Ci-C ₄ -aikyl) ₂ , NH-S0 ₂ -R ^x , Ci-C ₄ -alkyl, Cr C ₄ -alkoxy, Ci-C ₄ -halogenalkyl, C3-C6-cycloalkyl, C3-C6-halogencycloalkyl, C1-C4- halogenalkoxy, Ci-C ₆ -alkylthio, Ci-C ₆ -halogenalkylthio, S(0) _n -Ci-C ₆ -alkyl, C1-C4- alkoxy-Ci-C4-alkyl, phenyl and phenoxy, wherein the phenyl groups are unsubsti- tuted or substituted with substituents selected from the group consisting of halo- gen, OH, Ci-C ₄ -alkyl, Ci-C ₄ -halogenalkyl, CrC4-alkoxy and CrC4-halogenalkoxy; and wherein R ^x is as defined above; or

n is 0, 1 , 2

R ⁷ is independently selected from

halogen, OH, CN, COOH, CONH ₂ , N0 ₂ , SH, Ci-C ₆ -alkylthio, NH _2, NH(Ci-C ₄ -alkyl), N(Ci- C ₄ -alkyl) ₂ , NH-S0 ₂ -R ^x , Ci-C ₆ -alkyl, Ci-C ₆ -halogenalkyl, C ₂ -C ₆ -alkenyl, C ₂ -C ₆ -halogen- alkenyl, C ₂ -C ₆ -alkynyl, C ₂ -C ₆ -halogenalkynyl, Ci-C ₆ -alkoxy, Ci-C ₆ -halogenalkoxy, 0 ₂ -O _Q - alkenyloxy, C ₂ -C ₆ -alkynyloxy, aryloxy, heteroaryloxy, arylamino, heteroarylamino, ar- ylthio, heteroarylthio, CH(=0), C(=0)Ci-C ₆ -aikyl, C(=0)0(Ci-C ₆ -aikyl), C(=0)NH(Ci-C ₆ - alkyl), C(=0)N(Ci-C ₆ -alkyl) ₂ , CR’=NOR”, a saturated or partially unsaturated three-, four- , five-, six-, seven-, eight-, nine-, or ten-membered carbocycle or heterocycle, a five- or six-membered heteroaryl or aryl; wherein in each case one or two CH ₂ groups of the carbo- and heterocycle may be replaced by a group independently selected from C(=0) and C(=S), and wherein the heterocycle and the heteroaryl contain independently one, two, three or four heteroatoms selected from N, O and S; and wherein R’ and R” are in- dependently selected from H, Ci-C ₄ -alkyl, C ₂ -C ₆ -alkenyl, C ₂ -C ₆ -alkynyl, saturated or par- tially unsaturated three-, four-, five-, six-, seven-, eight-, nine-, or ten-membered carbo- and heterocycle, five- or six-membered heteroaryl or aryl; wherein the heterocycle or heteroaryl contains one, two or three heteroatoms selected from N, O and S, and wherein R’ and R” are independently unsubstituted or substituted by R’” which is inde- pendently selected from halogen, OH, CN, N0 ₂ , SH, NH _2, NH(Ci-C ₄ -alkyl), N(Ci-C ₄ -al- kyl) ₂ , NH-S0 ₂ -R ^x , Ci-C ₆ -alkyl, Ci-C ₆ -halogenalkyl, C ₂ -C ₆ -alkenyl, C ₂ -C ₆ -halogenalkenyl, C ₂ -C ₆ -alkynyl, C ₂ -C ₆ -halogenalkynyl, Ci-C ₆ -alkoxy, Ci-C ₆ -halogenalkoxy, C3-C6-cycloal- kyl, C3-C6-halogencycloalkyl and phenyl; or

wherein the aliphatic moieties of and R ⁷ are independently not further substituted or carry 1 , 2, 3 or up to the maximum possible number of identical or different groups R ^7a , respectively, which independently of one another are selected from:

R ^7a

halogen, OH, CN, COOH, CONH ₂ , N0 ₂ , SH, NH ₂ , NH(Ci-C ₄ -alkyl), N(Ci-C ₄ -alkyl) ₂ , NH- aryl, N(aryl) ₂ , NH(C(=0)Ci-C ₄ -aikyl), N(C(=0)Ci-C ₄ -aikyl) ₂ , NH-S0 ₂ -R ^x , Ci-C ₆ - alkoxy, C3-C6-halogencycloalkyl, Ci-C4-halogenalkoxy, Ci-C ₆ -alkylthio, Ci-C ₆ -halo- genalkylthio, S(0) _n -Ci-C ₆ -alkyl, S(0) _n -aryl, CH(=0), C(=0)C C ₆ -alkyl, C(=0)0(C _r Ce-alkyl), C(=0)NH(Ci-C ₆ -aikyl), C(=0)N(Ci-C ₆ -aikyl) ₂ , CR’=NOR”, a saturated or partially unsaturated three-, four-, five-, six-, seven-, eight-, nine-, or ten-membered carbocycle or heterocycle, aryl, phenoxy, a five-, six- or ten-membered heteroaryl; wherein in each case one or two CH ₂ groups of the carbo- and heterocycle may be replaced by a group independently selected from C(=0) and C(=S), five- or six- membered heteroaryl and aryl; wherein the heterocycle and the heteroaryl contain independently 1 , 2, 3 or 4 heteroatoms selected from N, O and S; wherein in each case one or two CH ₂ groups of the carbo- and heterocycle may be replaced by a group independently selected from C(=0) and C(=S); wherein the carbocyclic, heter- ocyclic, aryl and phenyl groups are independently unsubstituted or carry one, two, three, four or five substituents selected from the group consisting of halogen, OH, CN, N0 ₂ , SH, NH _2I NH(Ci-C ₄ -alkyl), N(Ci-C ₄ -alkyl) ₂ , NH(C(=0)Ci-C ₄ -aikyl),

N(C(=0)Ci-C ₄ -aikyl) ₂ , NH-S0 ₂ -R ^x , Ci-Ce-alkylthio, Ci-C ₄ -alkyl, Ci-C ₄ -halogenalkyl, Ci-C ₄ -alkoxy, Ci-C ₄ -halogenalkoxy, and S(0) _n -Ci-C ₆ -alkyl; and wherein R ^x , R’, R” and R” are as defined above

wherein the carbocyclic, heterocyclic, heteroaryl and aryl moieties of R ⁷ are independently not further substituted or carry 1 , 2, 3, 4, 5 or up to the maximum number of identical or different groups R ^7b , respectively, which independently of one another are selected from:

R ^7b halogen, OH, CN, COOH, CONH ₂ , N0 ₂ , SH, NH _2, NH(Ci-C ₄ -alkyl), N(Ci-C ₄ -al- kyl) ₂ , NH(C(=0)Ci-C ₄ -aikyl), N(C(=0)Ci-C ₄ -aikyl) ₂ , NH-S0 ₂ -R ^x , Ci-C ₄ -alkyl, Cr C ₄ -alkoxy, Ci-C ₄ -halogenalkyl, C3-C6-cycloalkyl, C3-C6-halogencycloalkyl, Ci-C ₄ - halogenalkoxy, Ci-C ₆ -alkylthio, Ci-C ₆ -halogenalkylthio, S(0) _n -Ci-C ₆ -alkyl, Ci-C ₄ - alkoxy-Ci-C ₄ -alkyl, phenyl and phenoxy, wherein the phenyl groups are unsubsti- tuted or substituted with substituents selected from the group consisting of halo- gen, OH, Ci-C ₄ -alkyl, Ci-C ₄ -halogenalkyl, CrC ₄ -alkoxy and Ci-C ₄ -halogenalkoxy; and wherein R ^x is as defined above;

n is 0, 1 , 2

R ⁸ is independently selected from CN, COOH, CONH ₂ , Ci-C ₆ -alkyl, Ci-C ₆ -halogenalkyl, C ₂ - C ₆ -alkenyl, C ₂ -C ₆ -halogenalkenyl, C ₂ -C ₆ -alkynyl, C ₂ -C ₆ -halogenalkynyl, CH(=0), C(=0)Ci-C ₆ -alkyl, C(=0)0(Ci-C ₆ -alkyl), C(=0)NH(Ci-C ₆ -aikyl), C(=0)N(Ci-C ₆ -aikyl) ₂ , CR’=NOR”, a saturated or partially unsaturated three-, four-, five-, six-, seven-, eight-, nine-, or ten-membered carbocycle or heterocycle, a five- or six-membered heteroaryl or aryl; wherein in each case one or two CH ₂ groups of the carbo- and heterocycle may be replaced by a group independently selected from C(=0) and C(=S), and wherein the het- erocycle and the heteroaryl contain independently one, two, three or four heteroatoms selected from N, O and S, and wherein heterocycle and heteroaryl are connected via C atom; and wherein R’ and R” are independently selected from H, Ci-C ₄ -alkyl, 0 ₂ -O _Q - alkenyl, C ₂ -C ₆ -alkynyl, saturated or partially unsaturated three-, four-, five-, six-, seven-, eight-, nine-, or ten-membered carbo- and heterocycle, five- or six-membered heteroaryl or aryl; wherein the heterocycle or heteroaryl contains one, two or three heteroatoms se- lected from N, O and S, and wherein R’ and R” are independently unsubstituted or sub- stituted by R’” which is independently selected from halogen, OH, CN, N0 ₂ , SH, NH _2, NH(Ci-C ₄ -alkyl), N(Ci-C ₄ -alkyl) ₂ , NH-S0 ₂ -R ^x , Ci-C ₆ -alkyl, Ci-C ₆ -halogenalkyl, C ₂ -C ₆ - alkenyl, C ₂ -C ₆ -halogenalkenyl, C ₂ -C ₆ -alkynyl, C ₂ -C ₆ -halogenalkynyl, CrC ₆ -alkoxy, O _I -O _Q - halogenalkoxy, C ₃ -C ₆ -cycloalkyl, C ₃ -C ₆ -halogencycloalkyl and phenyl; or

wherein the aliphatic moieties of and R ⁸ are independently not further substituted or carry 1 , 2, 3 or up to the maximum possible number of identical or different groups R ^8a , respectively, which independently of one another are selected from:

R ^8a halogen, OH, CN, COOH, CONH ₂ , N0 ₂ , SH, NH ₂ , NH(Ci-C ₄ -alkyl), N(Ci-C ₄ -al- kyl) ₂ , NH(C(=0)Ci-C ₄ -aikyl), N(C(=0)Ci-C ₄ -alkyl) ₂ , NH-S0 ₂ -R ^x , Ci-C ₆ -alkoxy, C3-C6-halogencycloalkyl, Ci-C4-halogenalkoxy, Ci-C ₆ -alkylthio, CrC ₆ -halogen- alkylthio, S(0) _n -Ci-C ₆ -alkyl, S(0) _n -aryl, CH(=0), C(=0)Ci-C ₆ -alkyl, C(=0)0(C _r Ce-alkyl), C(=0)NH(Ci-C ₆ -alkyl), C(=0)N(Ci-C ₆ -alkyl) ₂ , CR’=NOR”, a saturated or partially unsaturated three-, four-, five-, six-, seven-, eight-, nine-, or ten-mem- bered carbocycle or heterocycle, aryl, phenoxy, a five-, six- or ten-membered het- eroaryl; wherein in each case one or two CH2 groups of the carbo- and heterocy- cle may be replaced by a group independently selected from C(=0) and C(=S), five- or six-membered heteroaryl and aryl; wherein the heterocycle and the het- eroaryl contain independently 1 , 2, 3 or 4 heteroatoms selected from N, O and S; wherein in each case one or two CH ₂ groups of the carbo- and heterocycle may be replaced by a group independently selected from C(=0) and C(=S); wherein the carbocyclic, heterocyclic, aryl and phenyl groups are independently unsubsti- tuted or carry one, two, three, four or five substituents selected from the group consisting of halogen, OH, CN, NO2, SH, NH2, NH(Ci-C ₄ -alkyl), N(Ci-C ₄ -alkyl)2, NH(C(=0)Ci-C ₄ -aikyl), N(C(=0)Ci-C ₄ -aikyl) ₂ , NH-S0 ₂ -R ^x , Ci-C ₆ -alkylthio, Ci-C ₄ - alkyl, Ci-C ₄ -halogenalkyl, Ci-C ₄ -alkoxy, Ci-C ₄ -halogenalkoxy, and S(0) _n -Ci-C ₆ - alkyl; and wherein R ^x , R’, R” and R” are as defined above

wherein the carbocyclic, heterocyclic, heteroaryl and aryl moieties of R ⁸ are independently not further substituted or carry 1 , 2, 3, 4, 5 or up to the maximum number of identical or different groups R ^8b , respectively, which independently of one another are selected from:

R ^8b halogen, OH, CN, COOH, CONH ₂ , N0 ₂ , SH, NH _2, NH(Ci-C ₄ -alkyl), N(Ci-C ₄ -al- kyl) ₂ , NH(C(=0)Ci-C ₄ -aikyl), N(C(=0)Ci-C ₄ -aikyl) ₂ , NH-S0 ₂ -R ^x , Ci-C ₄ -alkyl, Cr C ₄ -alkoxy, Ci-C ₄ -halogenalkyl, C ₃ -C ₆ -cycloalkyl, C ₃ -C ₆ -halogencycloalkyl, Ci-C ₄ - halogenalkoxy, Ci-C ₆ -alkylthio, Ci-C ₆ -halogenalkylthio, S(0) _n -Ci-C ₆ -alkyl, Ci-C ₄ - alkoxy-Ci-C ₄ -alkyl, phenyl and phenoxy, wherein the phenyl groups are unsubsti- tuted or substituted with substituents selected from the group consisting of halo- gen, OH, Ci-C ₄ -alkyl, Ci-C ₄ -halogenalkyl, Ci-C ₄ -alkoxy and Ci-C ₄ -halogenalkoxy; and wherein R ^x is as defined above;

n is 0, 1 , 2

and the N-oxides and the agriculturally acceptable salts thereof as fungicides.

The numbering of the ring members and substituents in the compounds of the present invention is as given in formula I above. A skilled person will realize that compounds of formula I can be accessed via an amide coupling reaction of 3-aminopyridines of type II with carboxylic acids of type III. Among various reported methods for such amide coupling reactions, a robust method involves the treatment of carboxylic acids of type III with thionyl chloride or oxalyl chloride or dicyclohexylcarbodiimide in solvents like tetrahydrofurane, dimethylformamide or dichloromethane at room temperature. Subsequent ad- dition of amines of type II in the presence of a base like triethylamine at room temperature gives the target compounds of type I (see: Chem. Soc. Rev. 2009, 606-631 , or Tetrahedron 2005, 10827-10852).

The compounds oft he formula II and III are commercial available.

The N-oxides may be prepared from the inventive compounds according to conventional oxida- tion methods, e. g. by treating compounds I with an organic peracid such as metachloroper- benzoic acid (cf. WO 03/64572 or J. Med. Chem. 38(1 1 ), 1892-903, 1995); or with inorganic oxi- dizing agents such as hydrogen peroxide (cf. J. Heterocyc. Chem. 18(7), 1305-8, 1981 ) or ox- one (cf. J. Am. Chem. Soc. 123(25), 5962-5973, 2001 ). The oxidation may lead to pure mono- N-oxides or to a mixture of different N-oxides, which can be separated by conventional methods such as chromatography.

In the following, the intermediate compounds are further described. A skilled person will readily understand that the preferences for the substituents, also in particular the ones given in the ta- bles below for the respective substituents, given herein in connection with compounds I apply for the intermediates accordingly. Thereby, the substituents in each case have independently of each other or more preferably in combination the meanings as defined herein.

If the synthesis yields mixtures of isomers, a separation is generally not necessarily required since in some cases the individual isomers can be interconverted during work-up for use or dur- ing application (e. g. under the action of light, acids or bases). Such conversions may also take place after use, e. g. in the treatment of plants in the treated plant, or in the harmful fungus to be controlled.

In the definitions of the variables given above, collective terms are used which are generally representative for the substituents in question. The term "C _n -C _m " indicates the number of carbon atoms possible in each case in the substituent or substituent moiety in question.

The term "halogen" refers to fluorine, chlorine, bromine and iodine.

The term "Ci-C ₆ -alkyl" refers to a straight-chained or branched saturated hydrocarbon group having 1 to 6 carbon atoms, e.g. methyl, ethyl, propyl, 1-methylethyl, butyl, 1 -methylpropyl, 2- methylpropyl, 1 , 1 -dimethylethyl, pentyl, 1 -methylbutyl, 2-methylbutyl, 3-methylbutyl, 2,2-dime- thylpropyl, 1-ethylpropyl, 1 ,1-dimethylpropyl, 1 ,2-dimethylpropyl, hexyl, 1-methylpentyl, 2- methylpentyl, 3-methylpentyl, 4-methylpentyl, 1 ,1 -dimethylbutyl, 1 ,2-dimethylbutyl, 1 ,3-dimethyl- butyl, 2,2-dimethylbutyl, 2,3-dimethylbutyl, 3,3-dimethylbutyl, 1-ethylbutyl, 2-ethylbutyl, 1 ,1 ,2-tri- methyl propyl , 1 ,2,2-trimethylpropyl, 1 -ethyl-1 -methylpropyl and 1 -ethyl-2-methylpropyl. Likewise, the term "C2-C4-alkyl" refers to a straight-chained or branched alkyl group having 2 to 4 carbon atoms, such as ethyl, propyl (n-propyl), 1-methylethyl (iso-propoyl), butyl, 1 -methylpropyl (sec.- butyl), 2-methylpropyl (iso-butyl), 1 , 1 -dimethylethyl (tert.-butyl).

The term "CrC ₆ -halogenalkyl" refers to an alkyl group having 1 or 6 carbon atoms as defined above, wherein some or all of the hydrogen atoms in these groups may be replaced by halogen atoms as mentioned above. Examples are "CrC2-halogenalkyl" groups such as chloromethyl, bromomethyl, dichloromethyl, trichloromethyl, fluoromethyl, difluoromethyl, trifluoromethyl, chlor- ofluoromethyl, dichlorofluoromethyl, chlorodifluoromethyl, 1 -chloroethyl, 1 -bromoethyl, 1 -fluoro- ethyl, 2-fluoroethyl, 2 ,2-d ifluoroethyl , 2,2,2-trifluoroethyl, 2-chloro-2-fluoroethyl, 2-chloro-

2.2-difluoroethyl, 2,2-dichloro-2-fluoroethyl, 2,2,2-trichloroethyl or pentafluoroethyl.

The term "CrC ₆ -hydroxyalkyl" refers to an alkyl group having 1 or 6 carbon atoms as defined above, wherein some or all of the hydrogen atoms in these groups may be replaced by OH groups.

The term "Ci-C4-alkoxy-Ci-C4-alkyl" refers to alkyl having 1 to 4 carbon atoms (as defined above), whereAccording to one hydrogen atom of the alkyl radical is replaced by a Ci-C4-alkoxy group (as defined above). Likewise, the term "Ci-C6-alkoxy-Ci-C4-alkyl" refers to alkyl having 1 to 4 carbon atoms (as defined above), whereAccording to one hydrogen atom of the alkyl radi cal is replaced by a Ci-C ₆ -alkoxy group (as defined above).

The term "C2-C6-alkenyl" refers to a straight-chain or branched unsaturated hydrocarbon radical having 2 to 6 carbon atoms and a double bond in any position. Examples are "C2-C4-alkenyl" groups, such as ethenyl, 1 -propenyl, 2-propenyl (allyl), 1 -methylethenyl, 1 -butenyl, 2-butenyl, 3-butenyl, 1 -methyl-1 -propenyl, 2-methyl-1 -propenyl, 1 -methyl-2-propenyl, 2-methyl-2-propenyl.

The term "C2-C6-alkynyl" refers to a straight-chain or branched unsaturated hydrocarbon radical having 2 to 6 carbon atoms and containing at least one triple bond. Examples are "C2-C4-al- kynyl" groups, such as ethynyl, prop-1 -ynyl, prop-2 -ynyl (propargyl), but-1-ynyl, but-2-ynyl, but- 3-ynyl, 1 -methyl-prop-2-ynyl.

The term "CrC ₆ -alkoxy" refers to a straight-chain or branched alkyl group having 1 to 6 carbon atoms which is bonded via an oxygen, at any position in the alkyl group. Examples are "C1-C4- alkoxy" groups, such as methoxy, ethoxy, n-propoxy, 1-methylethoxy, butoxy, 1 -methyhprop- oxy, 2-methylpropoxy or 1 ,1-dimethylethoxy.

The term "Ci-C ₆ -halogenalkoxy" refers to a Ci-C ₆ -alkoxy radical as defined above, wherein some or all of the hydrogen atoms in these groups may be replaced by halogen atoms as men- tioned above. Examples are "Ci-C4-halogenalkoxy" groups, such as OCH2F, OCHF2, OCF ₃ , OCH2CI, OCHCI2, OCCI3, chlorofluoromethoxy, dichlorofluoromethoxy, chlorodifluoromethoxy, 2-fluoroethoxy, 2-chlorothoxy, 2-bromoethoxy, 2-iodoethoxy, 2,2-difluoroethoxy, 2,2,2-trifluoro- ethoxy, 2-chloro-2-fluoroethoxy, 2-chloro-2,2-difluoroethoxy, 2,2-dichloro-2-fluoroethoxy, 2,2,2- trichloroethoxy, OC2F5, 2-fluoropropoxy, 3-fluoropropoxy, 2,2-difluoropropoxy,

2.3-difluoro ^~, propoxy, 2 chloropropoxy, 3-chloropropoxy, 2,3-dichloropropoxy, 2-bromopropoxy, 3 bromopropoxy, 3,3,3-trifluoropropoxy, 3,3,3-trichloropropoxy, OCH2-C2F5, OCF2-C2F5, 1 -fluo- romethyl-2-fluoroethoxy, 1 -chloromethyl-2-chloroethoxy, 1 -bromomethyl-2-bromoethoxy, 4-fluorobutoxy, 4-chlorobutoxy, 4-bromobutoxy or nonafluorobutoxy.

The term "C2-C6-alkenyloxy" refers to a straight-chain or branched alkenyl group having 2 to 6 carbon atoms which is bonded via an oxygen, at any position in the alkenyl group. Examples are "C2-C4-alkenyloxy" groups.

The term "C2-C6-alkynyloxy" refers to a straight-chain or branched alkynyl group having 2 to 6 carbon atoms which is bonded via an oxygen, at any position in the alkynyl group. Examples are "C2-C4-alkynyloxy" groups.

The term "C3-C6-cycloalkyl" refers to monocyclic saturated hydrocarbon radicals having 3 to 6 carbon ring members, such as cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl. Accordingly, a saturated three-, four-, five-, six-, seven-, eight-, nine or ten-membered carbocyclyl or carbo- cycle is a "C3-Cio-cycloalkyl".

The term "C3-C6-cycloalkenyl" refers to a monocyclic partially unsaturated 3-, 4- 5- or 6-mem- bered carbocycle having 3 to 6 carbon ring members and at least one double bond, such as cy- clopentenyl, cyclopentadienyl, cyclohexadienyl. Accordingly, a partially unsaturated three-, four- , five-, six-, seven-, eight-, nine or ten-membered carbocyclyl or carbocycle is a "C3-Cio-cycloal- kenyl".

The term "C3-C8-cycloalkyl-Ci-C4-alkyl" refers to alkyl having 1 to 4 carbon atoms (as defined above), whereAccording to one hydrogen atom of the alkyl radical is replaced by a cycloalkyl radical having 3 to 8 carbon atoms (as defined above).

The term "Ci-C ₆ -alkylthio" as used herein refers to straight-chain or branched alkyl groups hav- ing 1 to 6 carbon atoms (as defined above) bonded via a sulfur atom. Accordingly, the term "C1- C ₆ -halogenalkylthio" as used herein refers to straight-chain or branched halogenalkyl group hav- ing 1 to 6 carbon atoms (as defined above) bonded through a sulfur atom, at any position in the halogenalkyl group.

The term "C(=0)-Ci-C ₆ -alkyl” refers to a radical which is attached through the carbon atom of the group C(=0) as indicated by the number valence of the carbon atom. The number of va- lence of carbon is 4, that of nitrogen is 3. Likewise the following terms are to be construed: NH(Ci-C ₄ -alkyl), N(Ci-C ₄ -alkyl) ₂ , NH(C ₃ -C ₆ -cycloalkyl), N(C ₃ -C ₆ -cycloalkyl) ₂ , C(=0)-NH(Ci-C ₆ - alkyl), C(=0)-N(Ci-C ₆ -alkyl) ₂ .

The term“saturated or partially unsaturated three-, four-, five-, six-, seven-, eight-, nine or ten- membered heterocyclyl or heterocycle, wherein the heterocyclyl or heterocycle contains 1 , 2, 3 or 4 heteroatoms selected from N, O and S” is to be understood as meaning both saturated and partially unsaturated heterocycles, wherein the ring member atoms of the heterocycle include besides carbon atoms 1 , 2, 3 or 4 heteroatoms independently selected from the group of O, N and S. For example:

a 3- or 4-membered saturated heterocycle which contains 1 or 2 heteroatoms from the group consisting of O, N and S as ring members such as oxirane, aziridine, thiirane, oxetane, azet- idine, thiethane, [1 ,2]dioxetane, [1 ,2]dithietane, [1 ,2]diazetidine; and a 5- or 6-membered saturated or partially unsaturated heterocycle which contains 1 , 2 or 3 het- eroatoms from the group consisting of O, N and S as ring members such as 2-tetrahydrofuranyl, 3-tetrahydrofuranyl, 2-tetrahydrothienyl, 3-tetrahydrothienyl, 2-pyrrolidinyl, 3-pyrrolidinyl, 3-isox- azolidinyl, 4-isoxazolidinyl, 5-isoxazolidinyl, 3-isothiazolidinyl, 4-isothiazolidinyl, 5-isothiazoli- dinyl, 3-pyrazolidinyl, 4-pyrazolidinyl, 5-pyrazolidinyl, 2-oxazolidinyl, 4-oxazolidinyl, 5-oxazoli- dinyl, 2-thiazolidinyl, 4-thiazolidinyl, 5-thiazolidinyl, 2-imidazolidinyl, 4-imidazolidinyl,

1 ,2,4-oxadiazolidin-3-yl, 1 ,2,4-oxadiazolidin-5-yl, 1 ,2,4-thiadiazolidin-3-yl, 1 ,2,4-thiadiazolidin-5- yl, 1 ,2,4-triazolidin-3-yl, 1 ,3,4-oxadiazolidin-2-yl, 1 ,3,4-thiadiazolidin-2-yl, 1 ,3,4-triazolidin-2-yl, 2,3-dihydrofur-2-yl, 2,3-dihydrofur-3-yl, 2,4-dihydrofur-2-yl, 2,4-dihydrofur-3-yl, 2,3-dihydrothien-

2-yl, 2,3-dihydrothien-3-yl, 2,4-dihydrothien-2-yl, 2,4-dihydrothien-3-yl, 2-pyrrolin-2-yl, 2-pyrrolin-

3-yl, 3-pyrrolin-2-yl, 3-pyrrolin-3-yl, 2-isoxazolin-3-yl, 3-isoxazolin-3-yl, 4-isoxazolin-3-yl, 2-isoxa- zolin-4-yl, 3-isoxazolin-4-yl, 4-isoxazolin-4-yl, 2-isoxazolin-5-yl, 3-isoxazolin-5-yl, 4-isoxazolin-5- yl, 2-isothiazolin-3-yl, 3-isothiazolin-3-yl, 4-isothiazolin-3-yl, 2-isothiazolin-4-yl, 3-isothiazolin-4- yl, 4-isothiazolin-4-yl, 2-isothiazolin-5-yl, 3-isothiazolin-5-yl, 4-isothiazolin-5-yl, 2,3-dihydropyra- zol-1-yl, 2,3-dihydropyrazol-2-yl, 2,3-dihydropyrazol-3-yl, 2,3-dihydropyrazol-4-yl, 2,3-dihydropy- razol-5-yl, 3,4-dihydropyrazol-1-yl, 3,4-dihydropyrazol-3-yl, 3,4-dihydropyrazol-4-yl, 3,4-dihydro- pyrazol-5-yl, 4,5-dihydropyrazol-1-yl, 4,5-dihydropyrazol-3-yl, 4,5-dihydropyrazol-4-yl, 4,5-dihy- dropyrazol-5-yl, 2,3-dihydrooxazol-2-yl, 2,3-dihydrooxazol-3-yl, 2,3-dihydrooxazol-4-yl, 2,3-dihy- drooxazol-5-yl, 3,4-dihydrooxazol-2-yl, 3,4-dihydrooxazol-3-yl, 3,4-dihydrooxazol-4-yl, 3,4-dihy- drooxazol-5-yl, 3,4-dihydrooxazol-2-yl, 3,4-dihydrooxazol-3-yl, 3,4-dihydrooxazol-4-yl, 2-piperidi- nyl, 3-piperidinyl, 4-piperidinyl, 1 ,3-dioxan-5-yl, 2-tetrahydropyranyl, 4-tetrahydropyranyl, 2-tet- rahydrothienyl, 3-hexahydropyridazinyl, 4-hexahydropyridazinyl, 2-hexahydropyrimidinyl, 4-hex- ahydropyrimidinyl, 5-hexahydropyrimidinyl, 2-piperazinyl, 1 ,3,5-hexahydrotriazin-2-yl and 1 ,2,4- hexahydrotriazin-3-yl and also the corresponding -ylidene radicals; and

a 7-membered saturated or partially unsaturated heterocycle such as tetra- and hexahydroaze- pinyl, such as 2,3,4,5-tetrahydro[1 H]azepin-1-,-2-,-3-,-4-,-5-,-6- or-7-yl, 3,4,5,6-tetrahy- dro[2H]azepin-2-,-3-,-4-,-5-,-6- or-7-yl, 2,3,4,7-tetrahydro[1 H]azepin-1-,-2-,-3-,-4-,-5-,-6- or-7-yl,

2.3.6.7-tetrahydro[1 H]azepin-1-,-2-,-3-,-4-,-5-,-6- or-7-yl, hexahydroazepin-1-,-2-,-3- or-4-yl, tetra- and hexahydrooxepinyl such as 2,3,4,5-tetrahydro[1 H]oxepin-2-,-3-,-4-,-5-,-6- or-7-yl,

2.3.4.7-tetrahydro[1 H]oxepin-2-,-3-,-4-,-5-,-6- or-7-yl, 2,3,6,7-tetrahydro[1 H]oxepin-2-, -3-, -4-, -5- ,-6- or-7-yl, hexahydroazepin-1-,-2-,-3- or-4-yl, tetra- and hexahydro-1 ,3-diazepinyl, tetra- and hexahydro-1 ,4-diazepinyl, tetra- and hexahydro-1 ,3-oxazepinyl, tetra- and hexahydro-1 ,4-oxa- zepinyl, tetra- and hexahydro-1 ,3-dioxepinyl, tetra- and hexahydro-1 ,4-dioxepinyl and the corre- sponding -ylidene radicals.

The term“substituted” refers to substitued with 1 , 2, 3 or up to the maximum possible number of substituents.

The term“5-or 6-membered heteroaryl” or“5-or 6-membered heteroaromatic” refers to aromatic ring systems incuding besides carbon atoms, 1 , 2, 3 or 4 heteroatoms independently selected from the group consisting of N, O and S, for example,

a 5-membered heteroaryl such as pyrrol-1 -yl, pyrrol-2-yl, pyrrol-3-yl, thien-2-yl, thien-3-yl, furan- 2-yl, furan-3-yl, pyrazol-1-yl, pyrazol-3-yl, pyrazol-4-yl, pyrazol-5-yl, imidazol-1-yl, imidazol-2-yl, imidazol-4-yl, imidazol-5-yl, oxazol-2-yl, oxazol-4-yl, oxazol-5-yl, isoxazol-3-yl, isoxazol-4-yl, isoxazol-5-yl, thiazol-2-yl, thiazol-4-yl, thiazol-5-yl, isoth iazol-3-yl , isothiazol-4-yl, isothiazol-5-yl, 1.2.4-triazolyl-1 -yl, 1 ,2,4-triazol-3-yl 1 ,2,4-triazol-5-yl, 1 ,2,4-oxadiazol-3-yl, 1 ,2,4-oxadiazol-5-yl and 1 ,2,4-thiadiazol-3-yl, 1 ,2,4-thiadiazol-5-yl; or

a 6-membered heteroaryl, such as pyridin-2-yl, pyridin-3-yl, pyridin-4-yl, pyridazin-3-yl, pyri- dazin-4-yl, pyrimidin-2-yl, pyrimidin-4-yl, pyrimidin-5-yl, pyrazin-2-yl and 1 ,3,5-triazin-2-yl and

1.2.4-triazin-3-yl.

Agriculturally acceptable salts of the inventive compounds encompass especially the salts of those cations or the acid addition salts of those acids whose cations and anions, respectively, have no adverse effect on the fungicidal action of said compounds. Suitable cations are thus in particular the ions of the alkali metals, preferably sodium and potassium, of the alkaline earth metals, preferably calcium, magnesium and barium, of the transition metals, preferably manga- nese, copper, zinc and iron, and also the ammonium ion which, if desired, may carry one to four Ci-C ₄ -alkyl substituents and/or one phenyl or benzyl substituent, preferably diisopropylammo- nium, tetramethylammonium, tetrabutylammonium, trimethylbenzylammonium, furthermore phosphonium ions, sulfonium ions, preferably tri(Ci-C4-alkyl)sulfonium, and sulfoxonium ions, preferably tri(Ci-C4-alkyl)sulfoxonium. Anions of useful acid addition salts are primarily chloride, bromide, fluoride, hydrogensulfate, sulfate, dihydrogenphosphate, hydrogenphosphate, phos- phate, nitrate, bicarbonate, carbonate, hexafluorosilicate, hexafluorophosphate, benzoate, and the anions of Ci-C4-alkanoic acids, preferably formate, acetate, propionate and butyrate. They can be formed by reacting such inventive compound with an acid of the corresponding anion, preferably of hydrochloric acid, hydrobromic acid, sulfuric acid, phosphoric acid or nitric acid.

The inventive compounds can be present in atropisomers arising from restricted rotation about a single bond of asymmetric groups. They also form part of the subject matter of the present in- vention.

Depending on the substitution pattern, the compounds of formula I and their N-oxides may have one or more centers of chirality, in which case they are present as pure enantiomers or pure di- astereomers or as enantiomer or diastereomer mixtures. Both, the pure enantiomers or dia- stereomers and their mixtures are subject matter of the present invention.

In the following, particular embodiments of the inventive compounds are described. Therein, specific meanings of the respective substituents are further detained, wherein the meanings are in each case on their own but also in any combination with one another, particular embodiments of the present invention.

Furthermore, in respect of the variables, generally, the embodiments of the compounds I also apply to the intermediates.

R ¹ according to the invention is in each case independently selected from hydrogen, halogen, OH, CN, N0 ₂ , SH, NH _2, NH(Ci-C ₄ -alkyl), N(Ci-C ₄ -alkyl) ₂ , NH-S0 ₂ -R ^x , Ci-C ₆ -alkyl, C ₂ -C ₆ -alkenyl, C ₂ -C ₆ -alkynyl, Ci-C ₆ -alkoxy, C3-C6-cycloalkyl, five- or six-membered heteroaryl and aryl;

wherein the heteroaryl contains one, two or three heteroatoms selected from N, O and S; and wherein

R ^x is Ci-C4-alkyl, CrC4-halogenalkyl, unsubstituted aryl or aryl that is substituted with one, two, three, four or five substituents R ^x1 independently selected from CrC4-alkyl, halogen, OH, CN, Ci-C4-halogenalkyl, CrC4-alkoxy and CrC4-halogenalkoxy; wherein the acyclic moieties of R ¹ are unsubstituted or substituted with identical or different groups R ^1a which independently of one another are selected from:

R ^1a halogen, OH, CN, Ci-C6-alkoxy, C ₃ -C ₆ -cycloalkyl, C ₃ -C ₆ -halogencycloalky, Ci-C ₄ -halogen- alkoxy, Ci-Ce-alkylthio, aryl and phenoxy, wherein the aryl and phenoxy group is unsubstituted or unsubstituted or substituted with R ^11a selected from the group consisting of halogen, OH, Ci- C ₄ -alkyl, Ci-C ₄ -halogenalkyl, Ci-C ₄ -alkoxy and Ci-C ₄ -halogenalkoxy;

wherein the carbocyclic, heteroaryl and aryl moieties of R ¹ are unsubstituted or substituted with identical or different groups R ^1b which independently of one another are selected from:

R ^1b halogen, OH, CN, Ci-C ₄ -alkyl, Ci-C ₄ -alkoxy, Ci-C ₄ -halogenalkyl, C ₃ -C ₆ -cycloalkyl, C ₃ -C ₆ - halogencycloalkyl, Ci-C ₄ -halogenalkoxy and Ci-Ce-alkylthio.

For every R ¹ that is present in the inventive compounds, the following embodiments and preferences apply independently of the meaning of any other R ¹ that may be present in the ring.

According to one embodiment of formula I, R ¹ is H, halogen or Ci-C6-alkyl, in particular H, CH ₃ , Et, F, Cl, more specifically H, CH ₃ , F or Cl most preferred H, F or Cl.

According to another embodiment of formula I, R ¹ is hydrogen.

According to still another embodiment of formula I, R ¹ is halogen, in particular Br, F or Cl, more specifically F or Cl.

According to another embodiment of formula I, R ¹ is F

According to another embodiment of formula I, R ¹ is Cl

According to another embodiment of formula I, R ¹ is Br.

According to still another embodiment of formula I, R ¹ is OH.

According to still another embodiment of formula I, R ¹ is COOH.

According to still another embodiment of formula I, R ¹ is CONH ₂ .

According to still another embodiment of formula I, R ¹ is CN.

According to still another embodiment of formula I, R ¹ is NO ₂ .

According to still another embodiment of formula I, R ¹ is SH.

According to still another embodiment of formula I R ¹ is NH _2, NH(Ci-C ₄ -alkyl), N(Ci-C ₄ -alkyl) ₂ or NH-SC> ₂ -R ^x , wherein R ^x is Ci-C ₄ -alkyl, Ci-C ₄ -halogenalkyl, unsubstituted aryl or aryl that is sub- stituted with one, two, three, four or five substituents R ^x1 independently selected from Ci-C ₄ -al- kyl, halogen, OH, CN, Ci-C ₄ -halogenalkyl, Ci-C ₄ -alkoxy, or Ci-C ₄ -halogenalkoxy. In particular Ci-C ₄ -alkyl, such as NHCH ₃ and N(CH ₃ ) ₂ . In particular R ^x is Ci-C ₄ -alkyl, and phenyl that is sub- stituted with one CH ₃ , more specifically S02-R ^x is CH ₃ and tosyl group (“Ts”).

According to still another embodiment of formula I, R ¹ is Ci-C6-alkyl, in particular Ci-C ₄ -alkyl, such as CH3 or CH2CH3.

According to still another embodiment of formula I, R ¹ is Ci-C6-halogenalkyl, in particular Ci-C ₄ - halogenalkyl, such as CF ₃ , CHF ₂ , CH ₂ F, CCI ₃ , CHCI ₂ , CH ₂ CI, CF3CH2, CCI3CH2 or CF ₂ CHF ₂ .

According to still another embodiment of formula I, R ¹ is C ₂ -C ₆ -alkenyl or C ₂ -C ₆ -halogenalkenyl, in particular C ₂ -C ₄ -alkenyl or C ₂ -C ₄ -halogenalkenyl, such as CH=CH ₂ , C(CH ₃ )=CH _2, CH=CCl ₂ ,

According to still another embodiment of formula I, R ¹ is C ₂ -C ₆ -alkynyl or C ₂ -C ₆ -halogenalkynyl, in particular C ₂ -C ₄ -alkynyl or C ₂ -C ₄ -halogenalkynyl, such as CECH, CECCI, CECF. CH ₂ CECH, CH ₂ CºCCI, or CH ₂ CºCF.

According to still another embodiment of formula I, R ¹ is CrC ₆ -alkoxy, in particular CrC ₄ -alkoxy, more specifically Ci-C ₂ -alkoxy such as OCH ₃ or OCH ₂ CH ₃ .

According to still another embodiment of formula I, R ¹ is Ci-C ₆ -halogenalkoxy, in particular Ci- C ₄ -halogenalkoxy, more specifically Ci-C ₂ -halogenalkoxy such as OCF ₃ , OCHF ₂ , OCH ₂ F,

OCCI ₃ , OCHC or OCH2CI, in particular OCF ₃ , OCHF ₂ , OCCI ₃ or OCHCI ₂ .

According to still another embodiment of formula I R ¹ is C ₃ -C ₆ -cycloalkyl, in particular cyclopro- pyi-

According to still another embodiment of formula I, R ¹ is C ₃ -C ₆ -cycloalkyl, for example cyclopro- pyl, substituted with one, two, three or up to the maximum possible number of identical or differ- ent groups R ^1b as defined and preferably herein.

According to still another embodiment of formula I, R ¹ is C ₃ -C ₆ -halogencycloalkyl. In a special embodiment R ¹ is fully or partially halogenated cyclopropyl.

According to still another embodiment of formula I, R ¹ is unsubstituted aryl or aryl that is substituted with one, two, three or four R ^1b , as defined herein. In particular, R ¹ is unsubstituted phenyl or phenyl that is substituted with one, two, three or four R ^1b , as defined herein.

According to still another embodiment of formula I, R ¹ is unsubstituted 5- or 6-membered heteroaryl. According to still a further embodiment, R ¹ is 5- or 6-membered heteroaryl that is substituted with one, two or three R ^1b , as defined herein.

According to still another embodiment of formula l,R ¹ is in each case independently selected from hydrogen, halogen, OH, CN, N0 ₂ , SH, NH _2, NH(Ci-C ₄ -alkyl), N(Ci-C ₄ -alkyl) ₂ , NH-S0 ₂ -R ^x , Ci-C ₆ -alkyl, C ₂ -C ₆ -alkenyl, C ₂ -C ₆ -alkynyl, Ci-C ₆ -alkoxy and C ₃ -C ₆ -cycloalkyl; wherein the acyclic moieties of R ¹ are not further substituted or carry one, two, three, four or five identical or differ- ent groups R ^1a as defined below and wherein the carbocyclic, heteroaryl and aryl moieties of R ¹ are not further substituted or carry one, two, three, four or five identical or different groups R ^1b as defined below.

According to still another embodiment of formula I, R ¹ is independently selected from hydrogen, halogen, CN, OH, Ci-C ₆ -alkyl,Ci-C ₆ -alkoxy, C ₆ -alkenyl, C ₂ -C ₆ -alkynyl, C ₃ -C ₆ -cycloalkyl, wherein the acyclic and cyclic moieties of R ¹ are unsubtitted or substituted by halogen.

According to still another embodiment of formula I, R ¹ is independently selected from hydrogen, halogen, CN, OH, Ci-C ₆ -alkyl, Ci-C ₆ -halogenalkyl, Ci-C ₆ -alkoxy and Ci-C ₆ -halogenalkoxy, in particular independently selected from H, F, Cl, Br, CN, OH, Ci-C ₄ -alkyl, Ci-C ₄ -halogenalkyl, C ₁ - C ₄ -alkoxy and Ci-C ₄ -halogenalkoxy.

According to still another embodiment of formula I, R ¹ is independently selected from H, CN, halogen or Ci-C ₆ -alkyl, in particular H, CN, CH ₃ , Et, F, Cl, more specifically H, CN, CH ₃ , F or Cl most preferred H, CH _3, F or Cl.

R ^1a are the possible substituents for the acyclic moieties of R ¹ .

R ^1a according to the invention is independently selected from halogen, OH, CN, Ci-C ₆ -alkoxy, C ₃ -C ₆ -cycloalkyl, C ₃ -C ₆ -halogencycloalkyl, Ci-C ₄ -halogenalkoxy, Ci-C ₆ -alkylthio, aryl and phe- noxy, wherein the aryl group is unsubstituted or unsubstituted or substituted with R ^11a selected from the group consisting of halogen, OH, Ci-C ₄ -alkyl, Ci-C ₄ -halogenalkyl, Ci-C ₄ -alkoxy and Ci- C ₄ -halogenalkoxy, in particular selected from halogen, Ci-C ₂ -alkyl, Ci-C ₂ -halogenalkyl, C ₁ -C ₂ - alkoxy and Ci-C ₂ -halogenalkoxy, more specifically selected from halogen, such as F, Cl and Br.

In to one embodiment R ^1a is independently selected from halogen, OH, CN, Ci-C ₂ -alkoxy, C ₃ - C ₆ -cycloalkyl, C ₃ -C ₆ -halogencycloalkyl and Ci-C ₂ -halogenalkoxy. Specifically, R ^1a is

independently selected from F, Cl, OH, CN, Ci-C ₂ -alkoxy, cyclopropyl, 1-F-cyclopropyl, 1 -CI- cyclopropyl, 1 ,1 -F ₂ -cyclopropyl, 1 ,1-Cl ₂ -cyclopropyl and Ci-C ₂ -halogenalkoxy.

According to one embodiment R ^1a is independently selected from halogen, such as F, Cl, Br and I, more specifically F, Cl and Br.

According to still another embodiment of formula I, R ^1a is independently selected from OH, C ₃ - C ₆ -cycloalkyl, C ₃ -C ₆ -halogencycloalkyl and Ci-C ₂ -halogenalkoxy. Specifically, R ^1a is

independently selected from OH, cyclopropyl and Ci-C ₂ -halogenalkoxy.

According to still another embodiment of formula I, R ^1a is independently selected from aryl and phenoxy, wherein the aryl group is unsubstituted or substituted with R ^11a selected from the group consisting of halogen, OH, Ci-C ₄ -alkyl, Ci-C ₄ -halogenalkyl, Ci-C ₄ -alkoxy and Ci-C ₄ -halo- genalkoxy, in particular selected from halogen, Ci-C ₂ -alkyl, Ci-C ₂ -halogenalkyl, Ci-C ₂ -alkoxy and Ci-C ₂ -halogenalkoxy, more specifically selected from halogen, such as F, Cl and Br.

R ^1b are the possible substituents for the carbocyclic, heteroaryl and aryl moieties of R ¹ .

R ^1b according to the invention is independently selected from halogen, OH, CN, Ci-C ₄ -alkyl, C ₁ - C ₄ -alkoxy, Ci-C ₄ -halogenalkyl, C ₃ -C ₆ -cycloalkyl, C ₃ -C ₆ -halogencycloalkyl, Ci-C ₄ -halogenalkoxy and Ci-C6-alkylthio;

According to one embodiment thereof R ^1b is independently selected from halogen, CN, C ₁ -C ₂ - alkyl, Ci-C ₂ -alkoxy, Ci-C ₂ -halogenalkyl, C ₃ -C ₆ -cycloalkyl, C ₃ -C ₆ -halogencycloalkyl and C ₁ -C ₂ - halogenalkoxy. Specifically, R ^1b is independently selected from F, Cl, Br, OH, CN, CH ₃ , OCH _3, CHF ₂ , OCHF ₂ , cyclopropyl, 1-F-cyclopropyl, 1-CI-cyclopropyl, 1 ,1-F ₂ -cyclopropyl, 1 , 1 -CI ₂ - cyclopropyl, OCF3, and OCHF2.

According to still another embodiment thereof R ^1b is independently selected from halogen, C-i- C ₂ -alkyl, CrC ₂ -alkoxy, Ci-C ₂ -halogenalkyl, C ₃ -C ₆ -cycloalkyl, C ₃ -C ₆ -halogencycloalkyl and C ₁ -C ₂ - halogenalkoxy. Specifically, R ^1b is independently selected from halogen, CN, OH, CH ₃ , CHF ₂ , OCHF ₂ , OCF ₃ , OCH ₃ , cyclopropyl, 1-F-cyclopropyl, 1 -CI-cyclopropyl, 1 ,1-F ₂ -cyclopropyl, 1 , 1 -CI ₂ - cyclopropyl and halogenmethoxy, more specifically independently selected from F, Cl, OH, CH ₃ , OCH _3, CHF ₂ , OCH ₃ , cyclopropyl, 1 -F-cyclopropyl, 1 -CI-cyclopropyl, 1 ,1-F ₂ -cyclopropyl, 1 , 1 -CI ₂ - cyclopropyl, OCHF ₂ and OCF ₃ .

R ^x in the substituent NH-S0 ₂ -R ^X is in each case independently selected from Ci-C ₄ -alkyl, Ci-C ₄ - halogenalkyl, unsubstituted aryl and aryl that is substituted with one, two, three, four or five substituents R ^x1 independently selected from Ci-C ₄ -alkyl, halogen, OH, CN, Ci-C ₄ -halogenalkyl, Ci-C ₄ -alkoxy and CrC4-halogenalkoxy. In particular, R ^x is in each case independently selected from Ci-C4-alkyl, halogen, OH, CN and phenyl that is substituted with one, two or three R ^x1 independently selected from Ci-C2-alkyl, more specifically R ^x is in each case independently selected from Ci-C4-alkyl and phenyl that is substituted with one CH ₃ , more specifically S0 ₂ -R ^x is the tosyl group (“Ts”).

Particularly preferred embodiments of R ¹ according to the invention are in Table P1 below, wherein each line of lines P1-1 to P1-16 corresponds to one particular embodiment of the inven- tion. Thereby, for every R ¹ that is present in the inventive compounds, these specific

embodiments and preferences apply independently of the meaning of any other R ¹ that may be present in the ring:

Table P1 :

Ts” in the table stands for the tosylgroup SC>2-(p-CH3)phenyl.

R ² is in each case independently selected from H, halogen, COOH, CONH ₂ , OH, CN, NO ₂ , SH, NH _2, NH(Ci-C ₄ -alkyl), N(Ci-C ₄ -alkyl) ₂ , NH(C ₂ -C ₄ -alkenyl), N(C ₂ -C ₄ -alkenyl) ₂ , NH(C ₂ -C ₄ - alkynyl), N(C2-C ₄ -alkynyl)2, NH(C3-C6-cycloalkyl), N(C3-C6-cycloalkyl)2, N(C2-C ₄ -alkyl)(C2-C ₄ - alkenyl), N(C ₂ -C ₄ -alkyl)(C ₂ -C ₄ -alkynyl), N(C ₂ -C ₄ -alkyl)(C ₃ -C ₆ -cycloalkyl), N(C ₂ -C ₄ -alkenyl)(C ₂ -C ₄ - alkynyl), N(C ₂ -C ₄ -alkenyl)(C ₃ -C ₆ -cycloalkyl), N(C ₂ -C ₄ -alkynyl)(C ₃ -C ₆ -cycloalkyl), NH(C(=0)Ci-C ₄ - alkyl), N(C(=0)Ci-C ₄ -alkyl) _2, NH-S0 ₂ -R ^X , S(0) _n -Ci-C ₆ -alkyl, S(0) _n -aryl, Ci-C ₆ -cycloalkylthio, S(0) _n -C ₂ -C ₆ -alkenyl, S(0) _n -C ₂ -C ₆ -alkynyl, CH(=0), C(=0)Ci-C ₆ -alkyl, C(=0)C ₂ -C ₆ -alkenyl, C(=0)C ₂ -C ₆ -alkynyl, C(=0)C ₃ -C ₆ -cycloalkyl, C(=0)NH(C _r C ₆ -alkyl), CH(=S), C(=S)Ci-C ₆ -alkyl, C(=S)C ₂ -C ₆ -alkenyl, C(=S)C ₂ -C ₆ -alkynyl, C(=S)C ₃ -C ₆ -cycloalkyl, (=S)0(C ₂ -C ₆ -alkenyl) _,

C(=S)0(C ₂ -C ₆ -alkynyl) _, C(=S)0(C ₃ -C ₇ -cycloalkyl) _, C(=S)NH(Ci-C ₆ -alkyl), C(=S)NH(C ₂ -C ₆ - alkenyl), C(=S)NH(C ₂ -C ₆ -alkynyl), C(=S)NH(C3-C7-cycloalkyl),C(=S)N(Ci-C ₆ -alkyl)2, C(=S)N(C ₂ - C6-alkenyl)2, C(=S)N(C2-C6-alkynyl)2, C(=S)N(C3-C7-cycloalkyl)2, Ci-C6-alkyl, C2-C6-alkenyl, C2- C ₆ -alkynyl, OR ^Y , C ₃ -C ₆ -cycloalkyl, five- or six-membered heteroaryl and aryl; wherein the heteroaryl contains one, two or three heteroatoms selected from N, O and S; wherein

R ^x is as defined above;

R ^Y is Ci-C ₆ -alkyl, Ci-C ₆ -halogenalkyl, C ₂ -C ₆ -alkenyl, C ₂ -C ₆ -halogenalkenyl, C ₂ -C ₆ - alkynyl, C ₂ -C ₆ -halogenalkynyl, C ₃ -C ₆ -cycloalkyl, C ₃ -C ₆ -halogencycloalkyl; phenyl and phenyl-Ci-C ₆ -alkyl; wherein the phenyl group is unsubstituted or substituted with substituents selected from the group consisting of halogen, CN, OH, O-I-OQ- alkyl, Ci-C ₆ -halogenalkyl, Ci-C ₆ -alkoxy and Ci-C ₆ -halogenalkoxy; wherein the acyclic moieties of R ² are unsubstituted or substituted with groups R ^2a which independently of one another are selected from:

R ^2a halogen, OH, CN, CrC ₆ -alkoxy, C ₃ -C ₆ -cycloalkyl, C ₃ -C ₆ -halogencycloalkyl, CrC ₄ - halogenalkoxy, Ci-Ce-alkylthio, aryl and phenoxy, wherein the aryl and phenoxy group is unsubstituted or substituted with substituents R ^21a selected from the group consisting of halogen, OH, Ci-C ₄ -alkyl, Ci-C ₄ -halogenalkyl, Ci-C ₄ -alkoxy and Ci-C ₄ -halogenalkoxy;

wherein the carbocycle, heteroaryl and aryl moieties of R ² are unsubstituted or substituted with groups R ^2b which independently of one another are selected from:

R ^2b halogen, OH, CN, Ci-C ₄ -alkyl, CrC ₄ -alkoxy, Ci-C ₄ -halogenalkyl, C ₃ -C ₆ -cycloalkyl, C ₃ -C ₆ -halogencycloalkyl, Ci-C ₄ -halogenalkoxy and Ci-Ce-alkylthio.

According to one embodiment of formula I, R ² is selected from the group consisting of halogen, CN, Ci-C ₆ -alkyl, Ci-C ₆ -halogenalkyl, C ₂ -C ₆ -alkenyl, C ₂ -C ₆ -halogenalkenyl, C ₂ -C ₆ -alkynyl, C ₂ -C ₆ - halogenalkynyl, Ci-C ₆ -alkoxy, Ci-C ₆ -halogenalkoxy, C ₃ -C ₆ -cycloalkyl, C ₃ -C ₆ -halogencycloalkyl, and OR ^Y .

According to still another embodiment of formula I, R ² is halogen, in particular F, Cl, Br or I, more specifically F, Cl or Br, in particular F or Cl.

According to still another embodiment of formula I, R ² is F.

According to still another embodiment of formula I, R ² is Cl.

According to still another embodiment of formula I, R ² is Br. According to still another embodiment of formula I, R ² is COOH.

According to still another embodiment of formula I, R ² is CONH ₂ .

According to still another embodiment of formula I, R ² is OH.

According to still another embodiment of formula I, R ² is CN.

According to still another embodiment of formula I, R ² is NO ₂ .

According to still another embodiment of formula I, R ² is SH.

According to still another embodiment of formula I, R ² is NH ₂ .

According to still another embodiment of formula I, R ² is _, NH(Ci-C ₄ -alkyl), in particular NH(CH3),

NH(C ₂ H ₅ ).

According to still another embodiment of formula I, R ² is _, N(Ci-C4-alkyl)2, in particular NH(CH ₃ ) ₂ , NH(C ₂ H ₅ ) ₂ .

According to still another embodiment of formula I, R ² is _, NH(C ₂ -C ₄ -alkenyl), in particular NH(CH=CH ₂ ), NH(CH ₂ CH=CH ₂ ).

According to still another embodiment of formula I, R ² is _, N(C ₂ -C ₄ --alkenyl) ₂ , in particular N(CH=CH ₂ ) ₂ , N(CH ₂ CH=CH ₂ ) ₂ .

According to still another embodiment of formula I, R ² is _, NH(C ₂ -C ₄ -alkynyl), in particular NH(C= CH), NH(CH ₂ CºCH).

According to still another embodiment of formula I, R ² is _, N(C ₂ -C4-alkynyl)2, in particular N(C= CH) ₂ , N(CH ₂ CºCH) ₂ .

According to still another embodiment of formula I, R ² is _, NH(C ₃ -C ₆ -cycloalkyl), in particular NH(C ₃ H ₇ ), NH(C ₄ H ₂ ).

According to still another embodiment of formula I, R ² is _, N(C ₃ -C ₆ -cycloalkyl) ₂ , in particular N(C ₃ H ₇ ) ₂ , N(C ₄ H ₂ ) ₂ .

According to still another embodiment of formula I, R ² is N(Ci-C ₄ -alkyl)(C ₂ -C ₄ -alkenyl), in particular N(CH ₃ )(CH=CH ₂ ), N(CH3)(CH ₂ CH=CH ₂ ), N(C ₂ H5)(CH=CH ₂ ), N(C ₂ H5)(CH ₂ CH=CH2).

According to still another embodiment of formula I, R ² is N(Ci-C ₄ -alkyl)(C ₂ -C ₄ -alkynyl), in particular N(CH ₃ )(CºCH), N(CH ₃ )(CH ₂ CºCH), N(C ₂ H ₅ )(CºCH), N(C ₂ H ₅ )(CH ₂ CºCH).

According to still another embodiment of formula I, R ² is N(Ci-C ₄ -alkyl)(C ₃ -C ₆ -cycloalkyl), in particular N(CH ₃ )(C ₃ H ₇ ), N(CH3)(C ₄ H ₂ ), N(C ₂ H ₅ )(C ₃ H ₇ ), N(CH ₃ )(C ₄ H ₂ ).

According to still another embodiment of formula I, R ² is N(C ₂ -C ₄ -alkenyl)(C ₂ -C ₄ -alkynyl), in particular N(CH=CH ₂ )(CºCH), N(CH ₂ CH=CH ₂ )(CH ₂ CºCH), N(CH=CH ₂ )(CºCH),

N(CH ₂ CH=CH ₂ )(CH ₂ CºCH).

According to still another embodiment of formula I, R ² is N(C ₂ -C ₄ -alkenyl)(C ₃ -C ₆ -cycloalkyl), in particular N(CH=CH ₂ )(C ₃ H ₇ ), N(CH ₂ CH=CH ₂ )(C ₄ H ₂ ), N(CH=CH ₂ )(C ₃ H ₇ ), N(CH ₂ CH=CH ₂ )(C ₄ H ₂ ).

According to still another embodiment of formula I, R ² is N(C ₂ -C ₄ -alkynyl)(C ₃ -C ₆ -cycloalkyl), in particular N(CºCH)(C ₃ H ₇ ), N(CH ₂ CºCH)(C ₄ H ₂ ), N(CºCH)(C ₃ H ₇ ), N(CH ₂ CºCH)(C ₄ H ₂ ). According to still another embodiment of formula I, R ² is _, NH(C(=0)(Ci-C ₄ -alkyl), in particular NH(C(=0)(CH ₃ ), NH(C(=0)(C ₂ H ₅ ).

According to still another embodiment of formula I, R ² is N(C(=0)(Ci-C ₄ -alkyl) ₂ , in particular N(C(=0)(CH ₃ ) ₂ , N(C(=0)(C ₂ H ₅ ) ₂ .

According to a further specific embodiment of formula I, R ² is NH-S0 ₂ -R ^X such as NH-SO ₂ -CH ₃ , NH-SO2-CH2-CH3, NH-S0 ₂ -CF _3I NH-S0 ₂ -TS.

According to still another embodiment of formula I, R ² is S(0)n-Ci-C ₆ -alkyl such as SCH ₃ , S(=0) CH ₃ , S(0) ₂ CH ₃ .

According to still another embodiment of formula I, R ² is S(0)n-aryl such as S-phenyl, S(=0) phenyl, S(0) ₂ phenyl.

According to still another embodiment of formula I, R ² is S(0)n-C ₂ -C ₆ -alkenyl such as

According to still another embodiment of formula I, R ² is S(0)n-C ₂ -C ₆ -alkynyl such as SC CH, S(=0)CºCH, S(0) ₂ CºCH, SCH ₂ CºCH, S(=0)CH ₂ CºCH, S(0) ₂ CH ₂ CºCH.

According to a further specific embodiment of formula I, R ² is CH(=0).

According to a further specific embodiment of formula I, R ² is C(=0)Ci-C ₆ -alkyl, C(=0)0(Ci-C ₆ - alkyl) or C(=0)NH(Ci-C ₆ -alkyl), wherein alkyl is CH3, C ₂ H ₅ , n-propyl, i-propyl, n-butyl, i-butyl, tert-butyl, n-pentyl or i-pentyl.

According to a further specific embodiment of formula I, R ² is C(=0)C ₂ -C ₆ -alkenyl, C(=0)0(C ₂ - C ₆ -alkenyl) or (=0)NH(C ₂ -C ₆ -alkenyl) wherein alkenyl is CH=CH2 _, CH2CH=CH2.

According to a further specific embodiment of formula I, R ² is C(=0)C ₂ -C ₆ -alkynyl, C(=0)0(C ₂ - C ₆ -alkynyl) orC(=0)NH(C ₂ -C ₆ -alkynyl)„ wherein alkynyl is C CH _, CI-hC CH.

According to a further specific embodiment of formula I, R ² is C(=0)C ₃ -C ₆ -cycloalkyl,

C(=0)0(C ₃ -C ₆ -cycloalkyl) or C(=0)NH(C ₃ -C ₆ -cycloalkyl), wherein cycloalkyl is cyclopropyl (C3H7) or cyclobutyl (C4H2).

According to a further specific embodiment of formula I, R ² is CH(=S).

According to a further specific embodiment of formula I, R ² is C(=S)Ci-C ₆ -alkyl, C(=S)OCi-C ₆ - alkyl, C(=S)NH(Ci-C ₆ -alkyl) or C(=S)NH(Ci-C ₆ -alkyl), wherein alkyl is CH3, C ₂ H ₅ , n-propyl, i-pro- pyl, n-butyl, i-butyl, tert-butyl, n-pentyl or i-pentyl.

According to a further specific embodiment of formula I, R ² is C(=S)C2-C6-alkenyl, C(=S)OC2-C6- alkenyl, C(=S)NH(C2-C6-alkenyl) or C(=S)N(C2-C6-alkenyl) ₂ , wherein alkenyl is CH=CH _2, CH ₂ CH=CH ₂ .

According to a further specific embodiment of formula I, R ² is C(=S)C2-C6-alkynyl, _, C(=S)0(C ₂ - C ₆ -alkynyl), C(=S)NH(C2-C6-alkynyl) or C(=S)N(C2-C6-alkynyl)2 _, wherein alkynyl is C CH _, CI-hC CH. According to a further specific embodiment of formula I, R ² is C(=S)C ₃ -C ₆ -cycloalkyl, _,

C(=S)0(C ₃ -C ₇ -cycloalkyl), C(=S)NH(C ₃ -C ₇ -cycloalkyl) or _, C(=S)N(C ₃ -C ₇ -cycloalkyl) ₂ , wherein cycloalkyl is cyclopropyl (C ₃ H ₇ ) or cyclobutyl (C ₄ H ₂ ).

According to still another embodiment of formula I, R ² is Ci-C ₆ -alkyl, in particular Ci-C4-alkyl, such as CH ₃ . or C ₂ H ₅ , in particular CH ₃ or CH ₂ CH ₃ .

According to still another embodiment of formula I, R ² is Ci-C ₆ -halogenalkyl, in particular C ₁ -C ₄ - halogenalkyl, such as CF ₃ , CCI ₃ , FCH ₂ , CICH ₂ , F ₂ CH, CI ₂ CH, CF3CH2, CCI3CH2 or CF ₂ CHF ₂ . According to still a further embodiment of formula I, R ² is C ₂ -C ₆ -alkenyl, in particular C ₂ -C ₄ -alk- enyl, such as CH=CH ₂ , C(CH ₃ )=CH ₂ , CH ₂ CH=CH ₂ .

According to a further specific embodiment of formula I, R ² is C ₂ -C ₆ -halogenalkenyl, in particular C ₂ -C ₄ -halogenalkenyl, more specifically C ₂ -C ₃ -halogenalkenyl such as CH=CHF, CH=CHCI,

According to still a further embodiment of formula I, R ² is C ₂ -C ₆ -alkynyl or C ₂ -C ₆ -halogenalkynyl, in particular C ₂ -C ₄ -alkynyl or C ₂ -C ₄ -halogenalkynyl, such as C CH, CFhC CH, C CCI,

CH ₂ CºCCI, or CCI ₂ CºCCI.

According to a further specific embodiment of formula I, R ² is OR ^Y wherein R ^Y is Ci-C6-alkyl, Cr C6-halogenalkyl, C ₂ -C ₆ -alkenyl, C ₂ -C ₆ -halogenalkenyl, C ₂ -C ₆ -alkynyl, C ₂ -C ₆ -halogenalkynyl, C ₃ - C6-cycloalkyl, C ₃ -C ₆ -halogencycloalkyl.

According to a further specific embodiment of formula I, R ² is OR ^Y wherein R ^Y is Ci-C6-alkyl, in particular Ci-C ₄ -alkyl, more specifically Ci-C ₂ -alkoxy. R ² is such as OCH ₃ or OCH ₂ CH ₃ .

According to a further specific embodiment of formula I, R ² is OR ^Y wherein R ^Y is Ci-C6-halogen- alkyl, in particular Ci-C ₄ -halogenalkyl, more specifically Ci-C ₂ -halogenalkyl. R ² is such as OCF ₃ , OCHF _2I OCH ₂ F, OCCI ₃ , OCHC or OCH ₂ CI, in particular OCF ₃ , OCHF ₂ , OCCI ₃ or OCHCI ₂ .

According to a further specific embodiment of formula I, R ² is OR ^Y wherein R ^Y C ₂ -C ₆ -alkenyl, in particular C ₂ -C ₄ -alkenyl, more specifically Ci-C ₂ -alkenyl. R ² is such as OCH=CH ₂ ,

OCH ₂ CH=CH ₂ .

According to a further specific embodiment of formula I, R ² is OR ^Y wherein R ^Y C ₂ -C ₆ -halogen- alkenyl, in particular C ₂ -C ₄ -halogenalkenyl, more specifically Ci-C ₂ -halogenalkenyl.

According to a further specific embodiment of formula I, R ² is OR ^Y wherein R ^Y C ₂ -C ₆ -alkynyl, in particular C ₂ -C ₆ -alkynyl, in particular C ₂ -C ₄ -alkynyl, more specifically Ci-C ₂ -alkynyl. R ² is such as OC CH,

According to a further specific embodiment of formula I, R ² is OR ^Y wherein R ^Y C ₂ -C ₆ -halogen- alkynyl, in particular C ₂ -C ₆ -halogenalkynyl, in particular C ₂ -C ₄ -halogenalkynyl, more specifically Ci-C ₂ -halogenalkynyl. R ² is such as OC CCI, OCFhC CCI, or OCChC CCI.

According to still another embodiment of formula I, R ² is is OR ^Y wherein R ^Y C ₃ -C ₆ -cycloalkenyl, in particular cyclopropenyl.

According to still another embodiment of formula I, R ² is C ₃ -C ₆ -cycloalkyl, in particular cyclopro- pyi- According to still another embodiment of formula I, R ² is C3-C6-halogencycloalkyl. In a special embodiment R ^2b is fully or partially halogenated cyclopropyl, such as 1 -F-cyclopropyl, 1 -CI- cyclopropyl, 1 ,1 -F ₂ -cyclopropyl, 1 ,1-Cl ₂ -cyclopropyl .

According to still another embodiment of formula I, R ² is phenyl-Ci-C ₆ -alkyl, such as phenyl- CH2, wherein the phenyl moiety in each case is unsubstituted or substituted by one, two or three identical or different groups R ^2b which independently of one another are selected from halogen, Ci-C2-alkyl, Ci-C2-alkoxy, Ci-C2-halogenalkyl and Ci-C2-halogenalkoxy, in particular F, Cl, Br, CHs, OCH ₃ , CF ₃ and OCF ₃ .

According to still another embodiment of formula I, R ² is aryl, in particular phenyl, wherein the aryl or phenyl moiety in each case is unsubstituted or substituted with identical or different groups R ^2b which independently of one another are selected from CN, halogen, Ci-C2-alkyl, C1- C2-alkoxy, Ci-C2-halogenalkyl and Ci-C2-halogenalkoxy, in particular CN, F, Cl, Br, CH3, OCH3, CHF2, OCHF2 _, CF3 and OCF3. According to one embodiment, R ² is unsubstituted phenyl. Ac- cording to another embodiment, R ² is phenyl, that is substituted with one, two or three, in partic- ular one, halogen, in particular selected from F, Cl and Br, more specifically selected from F and Cl.

According to still another embodiment of formula I, R ² is a 5-membered heteroaryl such as pyr- rol-1-yl, pyrrol-2-yl, pyrrol-3-yl, thien-2-yl, thien-3-yl, furan-2-yl, furan-3-yl, pyrazol-1-yl, pyrazol- 3-yl, pyrazol-4-yl, pyrazol-5-yl, imidazol-1-yl, imidazol-2-yl, imidazol-4-yl, imidazol-5-yl, oxazol-2- yl, oxazol-4-yl, oxazol-5-yl, isoxazol-3-yl, isoxazol-4-yl, isoxazol-5-yl, thiazol-2-yl, thiazol-4-yl, thiazol-5-yl, isothiazol-3-yl, isoth iazol-4-yl , isothiazol-5-yl, 1 ,2,4-triazolyl-1 -yl, 1 ,2,4-triazol-3-yl 1 ,2,4-triazol-5-yl, 1 ,2,4-oxadiazol-3-yl, 1 ,2,4-oxadiazol-5-yl and 1 ,2,4-thiadiazol-3-yl, 1 ,2,4-thia- diazol-5-yl.

According to still another embodiment of formula I, R ² is a 6-membered heteroaryl such as pyri- din-2-yl, pyridin-3-yl, pyridin-4-yl, pyridazin-3-yl, pyridazin-4-yl, pyrimidin-2-yl, pyrimidin-4-yl, py- rimidin-5-yl, pyrazin-2-yl and 1 ,3,5-triazin-2-yl and 1 ,2,4-triazin-3-yl.

According to still another embodiment of formula I, R ² is in each case independently selected from halogen, CN, Ci-C ₆ -alkyl, Ci-C ₆ -halogenalkyl, C2-C6-alkenyl, C2-C6-alkynyl, Ci-C ₆ -alkoxy, Ci-C ₆ -halogenalkoxy, C3-C6-alkenyloxy, C3-C6-alkynyloxy, C3-C6-cycloalkyl and C3-C6-halogen- cycloalkyl, wherein the acyclic moieties of R ² are unsubstituted or substituted with identical or different groups R ^2a as defined and preferably defined herein, and wherein the carbocyclic, phe- nyl and heteroaryl moieties of R ² are unsubstituted or substituted with identical or different groups R ^2b as defined and preferably defined herein.

According to still another embodiment of formula I, R ² is in each case independently selected from halogen, CN, Ci-C ₆ -alkyl, Ci-C ₆ -halogenalkyl, C2-C6-alkenyl, C2-C6-alkynyl, Ci-C ₆ -alkoxy, Ci-C ₆ -halogenalkoxy; wherein the acyclic moieties of R ² are unsubstituted or substituted with identical or different groups R ^2a as defined and preferably defined herein.

According to still another embodiment of formula I, R ² is in each case independently selected from CN, halogen, Ci-C ₆ -alkyl, Ci-C ₆ -halogenalkyl, C2-C6-alkynyl, OR ^Y , C3-C6-cycloalkyl;

wherein R ^Y is Ci-C ₆ -alkyl, Ci-C ₆ -halogenalkyl, C2-C6-alkenyl or C2-C6-alkynyl.

R ^2a are the possible substituents for the acyclic moieties of R ² . According to one embodiment R ^2a is independently selected from halogen, OH, CN, C ₁ -C ₆ - alkoxy, C ₃ -C ₆ -cycloalkyl, C ₃ -C ₆ -halogencycloalkyl, Ci-C ₄ -halogenalkoxy, Ci-C ₆ -alkylthio, aryl and phenoxy, wherein the aryl and phenyl group is unsubstituted or substituted with substitu- ents R ^21a selected from the group consisting of halogen, OH, Ci-C ₄ -alkyl, Ci-C ₄ -halogenalkyl, Ci-C ₄ -alkoxy and Ci-C ₄ -halogenalkoxy.

According to one embodiment R ^2a is independently selected from halogen, CrC ₆ -alkoxy, C ₃ -C ₆ - cycloalkyl, C ₃ -C ₆ -halogencycloalkyl and Ci-C ₄ -halogenalkoxy. Specifically, R ^2a is independently selected from F, Cl, Br, I, Ci-C ₂ -alkoxy, cyclopropyl, 1-F-cyclopropyl, 1-CI-cyclopropyl, 1 ,1-F ₂ - cyclopropyl, 1 ,1-Cl ₂ -cyclopropyl and Ci-C ₂ -halogenalkoxy.

According to still another embodiment of formula I, R ^2a is independently halogen, in particular selected from F, Cl, Br and I, more specifically F, Cl and Br.

R ^2b are the possible substituents for the carbocyclic, heteroaryl and phenyl moieties of R ² . R ^2b according to the invention is independently selected from halogen, OH, CN, Ci-C ₄ -alkyl, C ₁ -C ₄ - alkoxy, Ci-C ₄ -halogenalkyl, C ₃ -C ₆ -cycloalkyl, C ₃ -C ₆ -halogencycloalkyl, Ci-C ₄ -halogenalkoxy and Ci-C ₆ -alkylthio.

According to one embodiment thereof R ^2b is independently selected from halogen, CN, C ₁ -C ₄ - alkyl, CrC ₄ -alkoxy, CrC ₄ -halogenalkyl and Ci-C ₄ -halogenalkoxy, in particular halogen, C ₁ -C ₄ - alkyl and Ci-C ₄ -alkoxy. Specifically, R ^2b is independently selected from F, Cl, CN, CH ₃ , OCH ₃ and halogenmethoxy.

Particularly preferred embodiments of R ² according to the invention are in Table P2 below, wherein each line of lines P2-1 to P2-41 corresponds to one particular embodiment of the inven- tion, wherein P2-1 to P2-41 are also in any combination with one another a preferred embodi- ment of the present invention. The connection point to the carbon atom, to which R ² is bound is marked with“#” in the drawings.

Table P2:

R ³ is in each case independently selected fromhalogen, OH, COOH, CONH ₂ , CN, N0 ₂ , SH, NH _2, NH(Ci-C ₄ -alkyl), N(CrC ₄ -alkyl) ₂ , NH(C ₂ -C ₄ -alkenyl), N(C ₂ -C ₄ -alkenyl) ₂ , NH(C ₂ -C ₄ -alkynyl), N(C ₂ -C ₄ -alkynyl) ₂ , NH(C3-C6-cycloalkyl), N(C3-C6-cycloalkyl) ₂ , N(C ₂ -C ₄ -alkyl)(C ₂ -C ₄ -alkenyl), N(C ₂ -C ₄ -alkyl)(C ₂ -C ₄ -alkynyl), N(C ₂ -C ₄ -alkyl)(C3-C6-cycloalkyl), N(C ₂ -C ₄ -alkenyl)(C ₂ -C ₄ -alkynyl), N(C ₂ -C ₄ -alkenyl)(C3-C6-cycloalkyl), N(C ₂ -C ₄ -alkynyl)(C3-C6-cycloalkyl), NH(C(=0)Ci-C ₄ -alkyl), N(C(=0)Ci-C ₄ -alkyl) _2, NH-S0 ₂ -R ^x , S(0) _n -Ci-C ₆ -alkyl, S(0) _n -aryl, Ci-C ₆ -cycloalkylthio, S(0) _n -C ₂ - C ₆ -alkenyl, S(0) _n -C ₂ -C ₆ -alkynyl, CH(=0), C(=0)Ci-C ₆ -alkyl, C(=0)C ₂ -C ₆ -alkenyl, C(=0)C ₂ -C ₆ - alkynyl, C(=0)C ₃ -C ₆ -cyclpalkyl, C(=0)NH(C C ₆ -alkyl), CH(=S), C(=S)Ci-C ₆ -alkyl, C(=S)C ₂ -C ₆ - alkenyl, C(=S)C ₂ -C ₆ -alkynyl, C(=S)C ₃ -C ₆ -cyclpalkyl, C(=S)0(C ₂ -C ₆ -alkenyl) _, C(=S)0(C ₂ -C ₆ - alkynyl) _, C(=S)0(C ₃ -C ₇ -cycloalkyl) _, C(=S)NH(Ci-C ₆ -alkyl), C(=S)NH(C ₂ -C ₆ -alkenyl) _, C(=S)NH(C ₂ - Ce-alkynyl), C(=S)NH(C ₃ -C ₇ -cycloalkyl),C(=S)N(Ci-C ₆ -alkyl) ₂ , C(=S)N(C ₂ -C ₆ -alkenyl) _2,

C(=S)N(C2-C6-alkynyl)2, C(=S)N(C ₃ -C ₇ -cycloalkyl)2, Ci-C6-alkyl, C2-C6-alkenyl, C2-C6-alkynyl,

OR ^Y , C ₃ -C ₆ -cycloalkyl, five- or six-membered heteroaryl and aryl; wherein the heteroaryl contains one, two or three heteroatoms selected from N, O and S; wherein

R ^x is as defined above;

R ^Y is as defined above;

wherein the acyclic moieties of R ³ are unsubstituted or substituted with groups R ^3a which independently of one another are selected from:

R ^3a halogen, OH, CN, Ci-C ₆ -alkoxy, C ₃ -C ₆ -cycloalkyl, C ₃ -C ₆ -halogencycloalkyl, Ci-C ₄ - halogenalkoxy, Ci-Ce-alkylthio, aryl and phenoxy, wherein the aryl and phenyl group is unsubstituted or substituted with substituents R ^31a selected from the group consisting of halogen, OH, Ci-C ₄ -alkyl, Ci-C ₄ -halogenalkyl, Ci-C ₄ -alkoxy and CrC ₄ -halogenalkoxy;

wherein the carbocyclic, heteroaryl and aryl moieties of R ³ are unsubstituted or

substituted with groups R ^3b which independently of one another are selected from:

R ^3b halogen, OH, CN, Ci-C ₄ -alkyl, Ci-C ₄ -alkoxy, Ci-C ₄ -halogenalkyl, C ₃ -C ₆ -cycloalkyl, C ₃ -C ₆ -halogencycloalkyl, Ci-C ₄ -halogenalkoxy and Ci-Ce-alkylthio.

According to one embodiment of formula I, R ³ is selected from the group consisting of halogen, CN, Ci-C ₆ -alkyl, Ci-C ₆ -halogenalkyl, C ₂ -C ₆ -alkenyl, C ₂ -C ₆ -halogenalkenyl, C ₂ -C ₆ -alkynyl, C ₂ -C ₆ - halogenalkynyl, Ci-C ₆ -alkoxy, Ci-C ₆ -halogenalkoxy and OR ^Y .

R ³ is secected from the group consisting of halogen, CN, Ci-C6-alkyl, Ci-C6-halogenalkyl, C ₂ -C ₆ - alkenyl, C ₂ -C ₆ -halogenalkenyl, C ₂ -C ₆ -alkynyl, C ₂ -C ₆ -halogenalkynyl, CrC6-alkoxy, Ci-C6-halo- genalkoxy and OR ^Y .

According to still another embodiment of formula I R ³ is halogen, in particular F, Cl, Br or I, more specifically F, Cl or Br, in particular F or Cl.

According to stil another embodiment of formula R ³ s F.

According to stil another embodiment of formula R ³ s Cl.

According to stil another embodiment of formula R ³ s Br.

According to stil another embodiment of formula R ³ s OH.

According to stil another embodiment of formula R ² s COOH.

According to stil another embodiment of formula R ² s CONH2.

According to stil another embodiment of formula R ³ s CN.

According to stil another embodiment of formula R ³ s N0 ₂ .

According to stil another embodiment of formula R ³ s SH. According to still another embodiment of formula I, R ³ is Nhh.

According to still another embodiment of formula I, R ³ is _, NH(Ci-C ₄ -alkyl), in particular NH(CH3), NH(C ₂ H ₅ ).

According to still another embodiment of formula I, R ³ is _, N(Ci-C4-alkyl)2, in particular NH(CH ₃ ) ₂ , NH(C ₂ H ₅ ) ₂ .

According to still another embodiment of formula I, R ³ is _, NH(C ₂ -C ₄ -alkenyl), in particular NH(CH=CH ₂ ), NH(CH ₂ CH=CH ₂ ).

According to still another embodiment of formula I, R ³ is _, N(C2-C4--alkenyl)2, in particular N(CH=CH ₂ ) ₂ , N(CH ₂ CH=CH ₂ ) ₂ .

According to still another embodiment of formula I, R ³ is _, NH(C ₂ -C ₄ -alkynyl), in particular NH(C= CH), NH(CH ₂ CºCH).

According to still another embodiment of formula I, R ³ is _, N(C2-C4-alkynyl)2, in particular N(C= CH) ₂ , N(CH ₂ CºCH) ₂ .

According to still another embodiment of formula I, R ³ is _, NH(C ₃ -C ₆ -cycloalkyl), in particular NH(C ₃ H ₇ ), NH(C ₄ H ₉ ).

According to still another embodiment of formula I, R ³ is _, N(C3-C6-cycloalkyl)2, in particular N(C ₃ H ₇ )2, N(C ₄ H ₉ ) ₂ .

According to still another embodiment of formula I, R ³ is N(Ci-C ₄ -alkyl)(C ₂ -C ₄ -alkenyl), in particular N(CH ₃ )(CH=CH ₂ ), N(CH3)(CH ₂ CH=CH ₂ ), N(C ₂ H5)(CH=CH ₂ ), N(C ₂ H5)(CH ₂ CH=CH2).

According to still another embodiment of formula I, R ³ is N(Ci-C ₄ -alkyl)(C ₂ -C ₄ -alkynyl), in particular N(CH ₃ )(CºCH), N(CH ₃ )(CH ₂ CºCH), N(C ₂ H ₅ )(CºCH), N(C ₂ H ₅ )(CH ₂ CºCH).

According to still another embodiment of formula I, R ³ is N(CrC ₄ -alkyl)(C ₃ -C ₆ -cycloalkyl), in particular N(CH ₃ )(C ₃ H ₇ ), N(CH ₃ )(C ₄ H ₉ ), N(C ₂ H ₅ )(C ₃ H ₇ ), N(CH ₃ )(C ₄ H ₉ ).

According to still another embodiment of formula I, R ³ is N(C ₂ -C ₄ -alkenyl)(C ₂ -C ₄ -alkynyl), in particular N(CH=CH ₂ )(CºCH), N(CH ₂ CH=CH ₂ )(CH ₂ CºCH), N(CH=CH ₂ )(CºCH),

N(CH ₂ CH=CH ₂ )(CH ₂ CºCH).

According to still another embodiment of formula I, R ³ is N(C ₂ -C ₄ -alkenyl)(C ₃ -C ₆ -cycloalkyl), in particular N(CH=CH ₂ )(C ₃ H ₇ ), N(CH ₂ CH=CH ₂ )(C ₄ H ₉ ), N(CH=CH ₂ )(C ₃ H ₇ ), N(CH ₂ CH=CH ₂ )(C ₄ H ₉ ).

According to still another embodiment of formula I, R ³ is N(C ₂ -C ₄ -alkynyl)(C ₃ -C ₆ -cycloalkyl), in particular N(CºCH)(C ₃ H ₇ ), N(CH ₂ CºCH)(C ₄ H ₉ ), N(CºCH)(C ₃ H ₇ ), N(CH ₂ CºCH)(C ₄ H ₉ ).

According to still another embodiment of formula I, R ³ is _, NH(C(=0)(CrC4-alkyl), in particular NH(C(=0)(CH ₃ ), NH(C(=0)(C ₂ H ₅ ).

According to still another embodiment of formula I, R ³ is N(C(=0)(Ci-C4-alkyl)2, in particular N(C(=0)(CH ₃ ) ₂ , N(C(=0)(C ₂ H ₅ ) ₂ .

According to a further specific embodiment of formula I, R ³ is NH-SC>2-R ^X such as NH-SO2-CH3, NH-SO2-CH2-CH3, NH-S0 ₂ -CF _3I NH-S0 ₂ -TS.

According to still another embodiment of formula I, R ³ is S(0)n-Ci-C ₆ -alkyl such as SCH3, S(=0) CH _3I S(0) ₂ CH ₃ . According to still another embodiment of formula I, R ³ is S(0)n-aryl such as S-phenyl, S(=0) phenyl, S(0) ₂ phenyl.

According to still another embodiment of formula I, R ³ is S(0)n-C ₂ -C ₆ -alkenyl such as

According to still another embodiment of formula I, R ³ is S(0)n-C ₂ -C ₆ -alkynyl such as SC CH, S(=0)CºCH, S(0) ₂ CºCH, SCH ₂ CºCH, S(=0)CH ₂ CºCH, S(0) ₂ CH ₂ CºCH.

According to a further specific embodiment of formula I, R ³ is CH(=0).

According to a further specific embodiment of formula I, R ³ is C(=0)Ci-C ₆ -alkyl, C(=0)0(Ci-C ₆ - alkyl) or C(=0)NH(Ci-C ₆ -alkyl), wherein alkyl is CH3, C ₂ H ₅ , n-propyl, i-propyl, n-butyl, i-butyl, tert-butyl, n-pentyl or i-pentyl.

According to a further specific embodiment of formula I, R ³ is C(=0)C ₂ -C ₆ -alkenyl, C(=0)0(C ₂ - Ce-alkenyl) or C(=0)NH(C ₂ -C ₆ -alkenyl), wherein alkenyl is CH=CH _2, C(CH ₃ )=CH ₂ , CH ₂ CH=CH ₂ .

According to a further specific embodiment of formula I, R ³ is C(=0)C ₂ -C ₆ -alkynyl, C(=0)0(C ₂ - C ₆ -alkynyl) or C(=0)NH(C ₂ -C ₆ -alkynyl), wherein alkynyl is C CH CFhC CH,

According to a further specific embodiment of formula I, R ³ is C(=0)C ₃ -C ₆ -cycloalkyl,

C(=0)0(C ₃ -C ₆ -cycloalkyl) or C(=0)NH(C ₃ -C ₆ -cycloalkyl), wherein cycloalkyl is cyclopropyl (C3H7) or cyclobutyl (C4H9).

According to a further specific embodiment of formula I, R ³ is CH(=S).

According to a further specific embodiment of formula I, R ³ is C(=S)Ci-C ₆ -alkyl, C(=S)OCi-C ₆ - alkyl, C(=S)NH(Ci-C ₆ -alkyl) or C(=S)NH(Ci-C ₆ -alkyl), wherein alkyl is CH3, C ₂ H ₅ , n-propyl, i-pro- pyl, n-butyl, i-butyl, tert-butyl, n-pentyl or i-pentyl.

According to a further specific embodiment of formula I, R ³ is C(=S)C2-C6-alkenyl, C(=S)OC2-C6- alkenyl, C(=S)NH(C2-C6-alkenyl) or C(=S)N(C2-C6-alkenyl) ₂ , wherein alkenyl is CH=CH _2, CH ₂ CH=CH ₂ .

According to a further specific embodiment of formula I, R ³ is C(=S)C2-C6-alkynyl, C(=S)0(C ₂ - C ₆ -alkynyl), C(=S)NH(C2-C6-alkynyl) or C(=S)N(C2-C6-alkynyl), wherein alkynyl is C CH CFhC CH.

According to a further specific embodiment of formula I, R ³ is C(=S)C3-C6-cycloalkyl,

C(=S)0(C ₃ -C ₇ -cycloalkyl), C(=S)NH(C3-C7-cycloalkyl) or _, C(=S)N(C ₃ -C ₇ -cycloalkyl) _2, wherein cy- cloalkyl is cyclopropyl (C3H7) or cyclobutyl (C ₄ H ₉ ).

According to still another embodiment of formula I, R ³ is Ci-C ₆ -alkyl, in particular Ci-C4-alkyl, such as CH ₃ . or C ₂ H ₅ , in particular CH ₃ or CH ₂ CH ₃ .

According to still another embodiment of formula I, R ³ is Ci-C ₆ -halogenalkyl, in particular C1-C4- halogenalkyl, such as CF ₃ , CCI ₃ , FCH ₂ , CICH ₂ , F ₂ CH, CI ₂ CH, CF3CH2, CCI3CH2 or CF ₂ CHF ₂ . According to still a further embodiment of formula I, R ³ is C2-C6-alkenyl, in particular C2-C4-alk- enyl, such as CH=CH2.

According to a further specific embodiment of formula I, R ³ is C2-C6-halogenalkenyl, in particular C2-C4-halogenalkenyl, more specifically C2-C3-halogenalkenyl such as CH=CHF, CH=CHCI,

According to still a further embodiment of formula I, R ³ is C ₂ -C ₆ -alkynyl or C ₂ -C ₆ -halogen- alkynyl, in particular C ₂ -C ₄ -alkynyl or C ₂ -C4-halogenalkynyl, such as C CH, CH ₂ C CH, C CCI, CH ₂ CºCCI, or CCI ₂ CºCCI.

According to a further specific embodiment of formula I, R ³ is OR ^Y wherein R ^Y is Ci-C ₆ -alkyl, Ci-C ₆ -halogenalkyl, C ₂ -C ₆ -alkenyl, C ₂ -C ₆ -halogenalkenyl, C ₂ -C ₆ -alkynyl, C ₂ -C ₆ -halogenalkynyl, C3-C6-cycloalkyl, C3-C6-halogencycloalkyl.

According to a further specific embodiment of formula I, R ³ is OR ^Y wherein R ^Y is Ci-C ₆ -alkyl, in particular Ci-C4-alkyl, more specifically Ci-C ₂ -alkoxy. R ³ is such as OCH ₃ or OCFhCFh.

According to a further specific embodiment of formula I, R ³ is OR ^Y wherein R ^Y is Ci-C ₆ -halogen- alkyl, in particular Ci-C4-halogenalkyl, more specifically Ci-C ₂ -halogenalkyl. R ³ is such as OCF ₃ , OCHF ₂ , OCH ₂ F, OCCI ₃ , OCHC or OCH ₂ CI, in particular OCF ₃ , OCHF ₂ , OCCI ₃ or OCHCI ₂ .

According to a further specific embodiment of formula I, R ³ is OR ^Y wherein R ^Y C ₂ -C ₆ -alkenyl, in particular C ₂ -C4-alkenyl, more specifically Ci-C ₂ -alkenyl. R ³ is such as OCH=CH ₂ ,

OCH ₂ CH=CH ₂ .

According to a further specific embodiment of formula I, R ³ is OR ^Y wherein R ^Y C ₂ -C ₆ -alkynyl, in particular C ₂ -C ₆ -alkynyl, in particular C ₂ -C4-alkynyl, more specifically Ci-C ₂ -alkynyl. R ³ is such as OCºCH, OCºCCI, OCH ₂ CºCCI, or OCCI ₂ CºCCI

According to still another embodiment of formula I R ³ is OR ^Y wherein R ^Y is C3-C6-cycloalkyl, in particular cyclopropyl.

According to still another embodiment of formula I, R ³ is OR ^Y wherein R ^Y is C3-C6-halogencyclo- alkyl. In a special embodiment R ¹ is fully or partially halogenated cyclopropyl.

According to still another embodiment of formula I, R ³ is is OR ^Y wherein R ^Y C3-C6-cycloalkenyl, in particular cyclopropenyl.

According to still another embodiment of formula I, R ³ is C3-C6-cycloalkyl, in particular cyclopro- pyl.

According to still another embodiment of formula I, R ³ is C3-C6-halogencycloalkyl. In a special embodiment R ^3b is fully or partially halogenated cyclopropyl, such as 1 -F-cyclopropyl, 1 -CI- cyclopropyl, 1 ,1 -F ₂ -cyclopropyl, 1 ,1-CI ₂ -cyclopropyl

According to still another embodiment of formula I, R ³ is phenyl-Ci-C ₆ -alkyl, such as phenyl- CH ₂ , wherein the phenyl moiety in each case is unsubstituted or substituted by one, two or three identical or different groups R ^3b which independently of one another are selected from halogen, Ci-C ₂ -alkyl, Ci-C ₂ -alkoxy, Ci-C ₂ -halogenalkyl and Ci-C ₂ -halogenalkoxy, in particular F, Cl, Br, CHs, OCH3, CFs and OCF ₃ .

According to still another embodiment of formula I, R ³ is aryl, in particular phenyl, wherein the aryl or phenyl moiety in each case is unsubstituted or substituted with identical or different groups R ^3b which independently of one another are selected from CN, halogen, Ci-C ₂ -alkyl, C1- C ₂ -alkoxy, CrC ₂ -halogenalkyl and CrC ₂ -halogenalkoxy, in particular CN, F, Cl, Br, CH ₃ , OCH ₃ , CHF ₂ , OCHF _2, CF ₃ and OCF ₃ . According to one embodiment, R ³ is unsubstituted phenyl. Ac- cording to another embodiment, R ³ is phenyl, that is substituted with one, two or three, in partic- ular one, halogen, in particular selected from F, Cl and Br, more specifically selected from F and Cl.

According to still another embodiment of formula I, R ³ is a 5-membered heteroaryl such as pyr- rol-1-yl, pyrrol-2-yl, pyrrol-3-yl, thien-2-yl, thien-3-yl, furan-2-yl, furan-3-yl, pyrazol-1-yl, pyrazol- 3-yl, pyrazol-4-yl, pyrazol-5-yl, imidazol-1-yl, imidazol-2-yl, imidazol-4-yl, imidazol-5-yl, oxazol-2- yl, oxazol-4-yl, oxazol-5-yl, isoxazol-3-yl, isoxazol-4-yl, isoxazol-5-yl, thiazol-2-yl, thiazol-4-yl, thiazol-5-yl, isoth iazol-3-yl , isothiazol-4-yl, isoth iazol-5-y 1 , 1 ,2,4-triazolyl-1 -yl, 1 ,2,4-triazol-3-yl 1 ,2,4-triazol-5-yl, 1 ,2,4-oxadiazol-3-yl, 1 ,2,4-oxadiazol-5-yl and 1 ,2,4-thiadiazol-3-yl, 1 ,2,4-thia- diazol-5-yl.

According to still another embodiment of formula I, R ³ is a 6-membered heteroaryl such as pyri- din-2-yl, pyridin-3-yl, pyridin-4-yl, pyridazin-3-yl, pyridazin-4-yl, pyrimidin-2-yl, pyrimidin-4-yl, py- rimidin-5-yl, pyrazin-2-yl and 1 ,3,5-triazin-2-yl and 1 ,2,4-triazin-3-yl.

According to still another embodiment of formula I, R ³ is in each case independently selected fromhalogen, CN, Ci-C ₆ -alkyl, Ci-C ₆ -halogenalkyl, C ₂ -C ₆ -alkenyl, C ₂ -C ₆ -alkynyl, CrC ₆ -alkoxy, Ci-C ₆ -halogenalkoxy,C ₃ -C ₆ -alkenyloxy, C ₃ -C ₆ -alkynyloxy, C ₃ -C ₆ -cycloalkyl and C ₃ -C ₆ -halogen- cycloalkyl, wherein the acyclic moieties of R ³ are unsubstituted or substituted with identical or different groups R ^3a as defined and preferably defined herein, and wherein the carbocyclic, phe- nyl and heteroaryl moieties of R ³ are unsubstituted or substituted with identical or different groups R ^3b as defined and preferably defined herein.

According to still another embodiment of formula I, R ³ is in each case independently selected from halogen, CN, Ci-C ₆ -alkyl, Ci-C ₆ -halogenalkyl, C ₂ -C ₆ -alkenyl, C ₂ -C ₆ -alkynyl, Ci-C ₆ -alkoxy, Ci-C ₆ -halogenalkoxy; wherein the acyclic moieties of R ³ are unsubstituted or substituted with identical or different groups R ^3a as defined and preferably defined herein.

According to still another embodiment of formula I, R ³ is in each case independently selected from CN, halogen, Ci-C ₆ -alkyl, Ci-C ₆ -halogenalkyl, C ₂ -C ₆ -alkynyl, OR ^Y , C ₃ -C ₆ -cycloalkyl;

wherein R ^Y is Ci-C ₆ -alkyl, Ci-C ₆ -halogenalkyl, C ₂ -C ₆ -alkenyl or C ₂ -C ₆ -alkynyl.

R ^3a are the possible substituents for the acyclic moieties of R ³ .

According to one embodiment R ^3a is independently selected from halogen, OH, CN, C1-C6- alkoxy, C ₃ -C ₆ -cycloalkyl, C ₃ -C ₆ -halogencycloalkyl, Ci-C ₄ -halogenalkoxy, Ci-C ₆ -alkylthio, aryl and phenoxy, wherein the aryl and phenyl group is unsubstituted or substituted with substitu- ents R ^31a selected from the group consisting of halogen, OH, CrC4-alkyl, CrC4-halogenalkyl, Ci-C4-alkoxy and Ci-C4-halogenalkoxy.

According to one embodiment R ^3a is independently selected from halogen, Ci-C ₆ -alkoxy, C ₃ -C ₆ - cycloalkyl, C ₃ -C ₆ -halogencycloalkyl and Ci-C4-halogenalkoxy. Specifically, R ^3a is independently selected from F, Cl, Br, I, Ci-C ₂ -alkoxy, cyclopropyl, 1 -F-cyclopropyl, 1-CI-cyclopropyl, 1 ,1 -F ₂ - cyclopropyl, 1 ,1 -CI ₂ -cyclopropyl and Ci-C ₂ -halogenalkoxy.

According to still another embodiment of formula I, R ^3a is independently halogen, in particular selected from F, Cl, Br and I, more specifically F, Cl and Br.

R ^3b are the possible substituents for the carbocyclic, heteroaryl and phenyl moieties of R ³ . R ^3b according to the invention is independently selected from halogen, OH, CN, Ci-C4-alkyl, C1-C4- alkoxy, Ci-C4-halogenalkyl, C3-C6-cycloalkyl, C3-C6-halogencycloalkyl, Ci-C4-halogenalkoxy and Ci-C ₆ -alkylthio.

According to one embodiment thereof R ^3b is independently selected from halogen, CN, C1-C4- alkyl, Ci-C4-alkoxy, Ci-C4-halogenalkyl and Ci-C4-halogenalkoxy, in particular halogen, C1-C4- alkyl and Ci-C4-alkoxy. Specifically, R ^3b is independently selected from F, Cl, CN, CH ₃ , OCH ₃ and halogenmethoxy.

Particularly preferred embodiments of R ³ according to the invention are in Table P3 below, wherein each line of lines P3-1 to P3-41 corresponds to one particular embodiment of the inven- tion, wherein P3-1 to P3-41 are also in any combination with one another a preferred embodi- ment of the present invention. The connection point to the carbon atom, to which R ³ is bound is marked with“#” in the drawings.

Table P3:

According to still another embodiment of formula I, R ² , R ³ together with the carbon atoms to which they are bound form a five- , six-, or seven- membered carbo-, heterocyclic or heteroaro- matic ring; wherein the heterocyclic or heteroaromatic ring contains 1 , 2, 3 or 4 heteroatoms se- lected from N, O and S, wherein N may carry one substituent R ^N selected from Ci-C4-alkyl, Ci- C ₄ -halogenalkyl and S0 ₂ Ph, wherein Ph is unsubstituted or substituted by substituents selected from Ci-C ₄ -alkyl, halogen, Ci-C ₄ -halogenalkyl, Ci-C ₄ -alkoxy, Ci-C ₄ -halogenalkoxy, and CN; and wherein S may be in the form of its oxide SO or SO ₂ ; and wherein in each case one or two CH ₂ groups of the carbo- or heterocycle may be replaced by a group independently selected from C(=0) and C(=S); and wherein the carbo-, heterocyclic or heteroaromatic ring is substituent by (R ²³ ) _m , wherein m is 0, 1 , 2, 3 or 4;

R ²³ is in each case independently selected from halogen, OH, CN, COOH,

CONH ₂ , N0 ₂ , SH, NH _2, NH(Ci-C ₄ -alkyl), N(CrC ₄ -alkyl) ₂ , NH-S0 ₂ -R ^x , C _r C ₆ -alkyl, C ₂ - C ₆ -alkenyl, C ₂ -C ₆ -alkynyl, CrC ₆ -alkoxy, C ₃ -C ₆ -cycloalkyl, saturated or partially un- saturated three-, four-, five-, six-, seven-, eight-, nine-, or ten-membered carbo- and heterocycle, five- or six-membered heteroaryl and aryl; wherein the heterocycle and heteroaryl contains 1 , 2 or 3 heteroatoms selected from N, O and S; and wherein in each case one or two CH ₂ groups of the carbo- or heterocycle may be replaced by a group independently selected from C(=0) and C(=S); and wherein

R ^x is as defined above;

wherein the acyclic moieties of R ²³ are unsubstituted or carry 1 , 2, 3 or up to the maximum pos- sible number of identical or different groups R ^23a which independently of one another are se- lected from:

R ^23a halogen, OH, CN, COOH, CONH ₂ , Ci-C ₆ -alkoxy, C ₃ -C ₆ -cycloalkyl, C ₃ -C ₆ - halogencycloalkyl, Ci-C ₄ -halogenalkoxy, Ci-Ce-alkylthio and phenoxy, wherein the phenyl group is unsubstituted or unsubstituted or substituted with R ^91a se- lected from the group consisting of halogen, OH, Ci-C ₄ -alkyl, Ci-C ₄ -halogenalkyl, Ci-C ₄ -alkoxy, Ci-C ₄ -halogenalkoxy, CN, C ₃ -C ₆ -cycloalkyl, C ₃ -C ₆ -halogencycloal- kyl, CrC ₄ -alkylthio;

wherein the carbocyclic, heterocyclic, heteroaryl and aryl moieties of R ²³ are unsubstituted or substituted with identical or different groups R ^23b which independently of one another are se- lected from:

R ^23b halogen, OH, CN, COOH, CONH ₂ , Ci-C ₄ -alkyl, Ci-C ₄ -alkoxy, Ci-C ₄ -halogenalkyl, C ₃ -C ₆ -cycloalkyl, C ₃ -C ₆ -halogencycloalkyl, Ci-C ₄ -halogenalkoxy, and Ci-C ₆ -al- kylthio.

According to still another embodiment of formula I, R ² , R ³ together with the carbon atoms to which they are bound form a five- , six-, or seven- membered carbo-, heterocyclic or heteroaro- matic ring; wherein the heterocyclic or heteroaromatic ring contains 1 , 2, 3 or 4 heteroatoms se- lected from N, O and S, wherein N may carry one substituent R ^N selected from Ci-C ₄ -alkyl, Ci- C ₄ -halogenalkyl and S0 ₂ Ph, wherein Ph is unsubstituted or substituted with substituents se- lected from Ci-C ₄ -alkyl, halogen, Ci-C ₄ -halogenalkyl, Ci-C ₄ -alkoxy and Ci-C ₄ -halogenalkoxy, and CN; and wherein S may be in the form of its oxide SO or SO ₂ ; and wherein in each case one or two CH ₂ groups of the carbo- or heterocycle may be replaced by a group independently selected from C(=0) and C(=S); and wherein the carbo-, heterocyclic or heteroaromatic ring is substituent by (R ²³ ) _m wherein m is 0, 1 , 2, 3 or 4;

R ^N is the substituent of the heteroatom N that is contained in the heterocycle formed by R ² and R ³ in some of the inventive compounds. R ^N is selected from Ci-C ₄ -alkyl, Ci-C ₄ -halogenalkyl and SC>2Ph, wherein Ph is unsubstituted phenyl or phenyl that is substituted with one, two or three substituents selected from Ci-C ₄ -alkyl. In one preferred embodiment, R ^N is in each case inde- pendently selected from Ci-C2-alkyl, Ci-C2-halogenalkyl and SC>2Ph, wherein Ph is unsubsti- tuted phenyl or phenyl that is substituted with one methyl substituents. In one particular embodi- ment, R ^N is in each case independently selected from Ci-C2-alkyl, more particularly methyl. In one particular embodiment, R ^N is in each case independently selected from SC>2Ph, wherein Ph is unsubstituted phenyl or phenyl that is substituted with one methyl.

According to still another embodiment of formula I, R ² and R ³ together with the carbon atoms to which they are bound form a saturated or partially unsaturated five-, six-or seven -membered carbo- and heterocycle that is unsubstituted or substituted.

According to one embodiment, R ² and R ³ form a 3-membered saturated carbocycle. According to one embodiment thereof, the carbocycle is unsubstituted, i.e. it does not carry any substituent R ²³ . According to still another embodiment of formula I, it is substituted with R ²³ .

According to one embodiment, R ² and R ³ form a 4-membered saturated carbocycle. According to one embodiment thereof, the carbocycle is unsubstituted, i.e. it does not carry any substituent R ²³ . According to still another embodiment of formula I, it is substituted with R ²³ .

According to one embodiment, R ² and R ³ form a 5-membered saturated carbocycle. According to one embodiment thereof, the carbocycle is unsubstituted, i.e. it does not carry any substituent R ²³ . According to still another embodiment of formula I, it is substituted with R ²³ .

According to one embodiment, R ² and R ³ form a 6-membered saturated carbocycle. According to one embodiment thereof, the carbocycle is unsubstituted, i.e. it does not carry any substituent R ²³ . According to still another embodiment of formula I, it is substituted with R ²³ .

According to one embodiment, R ² and R ³ form a 7-membered saturated carbocycle. According to one embodiment thereof, the carbocycle is unsubstituted, i.e. it does not carry any substituent R ²³ . According to still another embodiment of formula I, it is substituted with R ²³ .

According to one embodiment, R ² and R ³ form a 3-membered saturated heterocycle. According to one embodiment thereof, the carbocycle is unsubstituted, i.e. it does not carry any substituent R ²³ . According to still another embodiment of formula I, it is substituted with R ²³ .

According to one embodiment, R ² and R ³ form a 4-membered saturated heterocycle. According to one embodiment thereof, the carbocycle is unsubstituted, i.e. it does not carry any substituent R ²³ . According to still another embodiment of formula I, it is substituted with R ²³ .

According to one embodiment, R ² and R ³ form a 5-membered saturated heterocycle. According to one embodiment thereof, the carbocycle is unsubstituted, i.e. it does not carry any substituent R ²³ . According to still another embodiment of formula I, it is substituted with R ²³ .

According to one embodiment, R ² and R ³ form a 6-membered saturated heterocycle. According to one embodiment thereof, the carbocycle is unsubstituted, i.e. it does not carry any substituent R ²³ . According to still another embodiment of formula I, it is substituted with R ²³ .

According to one embodiment, R ² and R ³ form a 7-membered saturated heterocycle. According to one embodiment thereof, the carbocycle is unsubstituted, i.e. it does not carry any substituent R ²³ . According to still another embodiment of formula I, it is substituted with R ²³ . According to one embodiment, R ² and R ³ form a 5-membered saturated heteroaryl. According to one embodiment thereof, the heteroaryl is unsubstituted, i.e. it does not carry any substituent R ²³ . According to still another embodiment of formula I, it is substituted with R ²³ .

According to one embodiment, R ² and R ³ form a 6-membered heteroaryl. According to one embodiment thereof, the heteroaryl is unsubstituted, i.e. it does not carry any substituent R ²³ . According to still another embodiment of formula I, it is substituted with R ²³ .

According to one embodiment, R ² and R ³ do not form a cyclic substituent.

R ²³ according to the invention is in each case independently selected from halogen, OH, CN, N0 ₂ , SH, NH _2, NH(Ci-C ₄ -alkyl), N(Ci-C ₄ -alkyl) ₂ , NH-S0 ₂ -R*, C C ₆ -alkyl, C ₂ -C ₆ -alkenyl, C ₂ -C ₆ - alkynyl, Ci-C ₆ -alkoxy, saturated or partially unsaturated three-, four-, five-, six-, seven-, eight-, nine-, or ten-membered carbo- and heterocycle, five- or six-membered heteroaryl and aryl; wherein the heterocycle and heteroaryl contains one, two or three heteroatoms selected from N, O and S; and wherein in each case one or two CH ₂ groups of the carbo- or heterocycle may be replaced by a group independently selected from C(=0) and C(=S); and wherein

R ^x is as defined above;

wherein the acyclic moieties of R ²³ are unsubstituted or substituted with identical or different groups R ^23a which independently of one another are selected from:

R ^23a halogen, OH, CN, Ci-C ₆ -alkoxy, C3-C6-cycloalkyl, C3-C6-halogencycloalkyl, Ci-C ₄ -halo- genalkoxy, Ci-Ce-alkylthio, aryl and phenoxy, wherein the aryl group is unsubstituted or unsub- stituted or substituted with R ^231a selected from the group consisting of halogen, OH, Ci-C ₄ -alkyl, Ci-C ₄ -halogenalkyl, Ci-C ₄ -alkoxy, Ci-C ₄ -halogenalkoxy, CN, C3-C6-cycloalkyl, C3-C6-halogency- cloalkyl, Ci-C ₄ -alkylthio;

wherein the carbocyclic, heterocyclic, heteroaryl and aryl of R ²³ are unsubstituted or substituted with identical or different groups R ^23b which independently of one another are selected from:

R ^23b halogen, OH, CN, Ci-C ₄ -alkyl, Ci-C ₄ -alkoxy, Ci-C ₄ -halogenalkyl, C3-C6-cycloalkyl, C3-C6- halogencycloalkyl, Ci-C ₄ -halogenalkoxy and Ci-Ce-alkylthio.

For every R ²³ that is present in the inventive compounds, the following embodiments and preferences apply independently of the meaning of any other R ²³ that may be present in the ring.

According to one embodiment of formula I, wherein m is 0, 1 , 2, 3 or 4.

According to still another embodiment of formula l,m is 0.

According to still another embodiment of formula I, m is 1 .

According to still another embodiment of formula I, m is 2 or 3. According to one specific embodiment thereof, m is 2. According to still another embodiment of formula I, m is 3.

According to one embodiment of formula I, R ²³ is halogen, Ci-C ₆ -alkyl, Ci-C ₆ -halogenalkyl, Ci- C ₆ -alkoxy or , Ci-C ₆ -halogenalkoxy, in particular CH ₃ , Et, CHF ₂ , OCH ₃ , OCHF ₂ , OCF ₃ , F, Cl, more specifically H, CH ₃ , F or Cl most preferred F or Cl.

According to still another embodiment of formula I, R ²³ is halogen, in particular Br, F or Cl, more specifically F or Cl. According to still another embodiment of formula I, R ²³ is OH.

According to still another embodiment of formula I, R ²³ is CN.

According to still another embodiment of formula I R ²³ is NH _2, NH(Ci-C ₄ -alkyl), N(Ci-C ₄ -alkyl) ₂ or NH-S0 ₂ -R ^x , wherein R ^x is Ci-C ₄ -alkyl, Ci-C ₄ -halogenalkyl, unsubstituted aryl or aryl that is sub- stituted with one, two, three, four or five substituents R ^x23 independently selected from C ₁ -C ₄ - alkyl.

According to still another embodiment of formula I, R ²³ is Ci-C ₆ -alkyl, in particular Ci-C ₄ -alkyl, such as CH ₃ .

According to still another embodiment of formula I, R ²³ is Ci-C ₆ -halogenalkyl, in particular C ₁ -C ₄ - halogenalkyl, such as CF ₃ , CHF ₂ , CH ₂ F, CCI ₃ , CHCI ₂ or CH ₂ CI.

According to still another embodiment of formula I, R ²³ is C ₂ -C ₆ -alkenyl or C ₂ -C ₆ -halogenalkenyl, in particular C ₂ -C ₄ -alkenyl or C ₂ -C ₄ -halogenalkenyl, such as CH=CH ₂ , C(CH3)=CH2,

According to still another embodiment of formula I, R ²³ is C ₂ -C ₆ -alkynyl or C ₂ -C ₆ -halogenalkynyl, in particular C ₂ -C ₄ -alkynyl or C ₂ -C ₄ -halogenalkynyl, such as C CH, CH ₂ C=CH, C C-CI, C C- CH ₃ , CH ₂ CºCH, CH ₂ CºCCI or CH ₂ CºC-CH ₃ .

According to still another embodiment of formula I, R ²³ is Ci-C6-alkoxy, in particular C ₁ -C ₄ - alkoxy, more specifically Ci-C ₂ -alkoxy such as OCH ₃ or OCH ₂ CH ₃ .

According to still another embodiment of formula I, R ²³ is Ci-C ₆ -halogenalkoxy, in particular C ₁ - C ₄ -halogenalkoxy, more specifically Ci-C ₂ -halogenalkoxy such as OCF ₃ , OCHF ₂ , OCH ₂ F,

OCCI3, OCHCh or OCH2CI, in particular OCF ₃ , OCHF ₂ , OCCI ₃ or OCHCI ₂ .

According to still another embodiment of formula I R ²³ is C ₃ -C ₆ -cycloalkyl, in particular cyclopro- pyi-

According to still another embodiment of formula I, R ²³ is C ₃ -C ₆ -cycloalkyl, for example cyclopro- pyl, substituted with one, two, three or up to the maximum possible number of identical or differ- ent groups R ^23b as defined and preferably herein.

According to still another embodiment of formula I, R ²³ is C ₃ -C ₆ -halogencycloalkyl. In a special embodiment R ²³ is fully or partially halogenated cyclopropyl.

According to still another embodiment of formula I, R ²³ is unsubstituted aryl or aryl that is substituted with one, two, three or four R ^23b , as defined herein. In particular, R ²³ is unsubstituted phenyl or phenyl that is substituted with one, two, three or four R ^23b , as defined herein.

According to still another embodiment of formula I, R ²³ is unsubstituted 5- or 6-membered heteroaryl. According to still a further embodiment, R ²³ is 5- or 6-membered heteroaryl that is substituted with one, two or three R ^23b , as defined herein.

According to still another embodiment of formula I, R ²³ is in each case independently selected from halogen, OH, CN, N0 ₂ , SH, NH _2, NH(Ci-C ₄ -alkyl), N(Ci-C ₄ -alkyl) ₂ , NH-S0 ₂ -R ^x , Ci-C ₆ -alkyl, C ₂ -C ₆ -alkenyl, C ₂ -C ₆ -alkynyl, Ci-C ₆ -alkoxy and C ₃ -C ₆ -cycloalkyl; wherein the acyclic moieties of R ²³ are not further substituted or carry one, two, three, four or five identical or different groups R ^23a as defined below and wherein the carbocyclic, heterocyclic and heteroaryl moieties of R ²³ are not further substituted or carry one, two, three, four or five identical or different groups R ^23b as defined below.

According to still another embodiment of formula I, R ²³ is independently selected from halogen, OH, Ci-C ₆ -alkyl, Ci-C ₆ -halogenalkyl, Ci-C ₆ -alkoxy and Ci-C ₆ -halogenalkoxy, in particular inde- pendently selected from F, Cl, Br, CN, OH, Ci-C ₄ -alkyl, Ci-C ₄ -halogenalkyl, Ci-C ₄ -alkoxy and Ci-C ₄ -halogenalkoxy.

R ^23a are the possible substituents for the acyclic moieties of R ²³ .

R ^23a according to the invention is independently selected from halogen, OH, CN, Ci-C ₆ -alkoxy, C ₃ -C ₆ -cycloalkyl, C ₃ -C ₆ -halogencycloalkyl, Ci-C ₄ -halogenalkoxy, Ci-C ₆ -alkylthio, aryl and phe- noxy, wherein the aryl and phenyl group is unsubstituted or unsubstituted or substituted with R ^231a selected from the group consisting of halogen, OH, Ci-C ₄ -alkyl, Ci-C ₄ -halogenalkyl, Ci-C ₄ - alkoxy, Ci-C ₄ -halogenalkoxy, CN, C ₃ -C ₆ -cycloalkyl, C ₃ -C ₆ -halogencycloalkyl, Ci-C ₄ -alkylthio.

R ^23a according to the invention is independently selected from halogen, OH, CN, Ci-C ₆ -alkoxy, C ₃ -C ₆ -cycloalkyl, C ₃ -C ₆ -halogencycloalkyl, Ci-C ₄ -halogenalkoxy, CrC ₆ -alkylthio, aryl and phe- noxy, wherein the aryl and phenyl group is unsubstituted or unsubstituted or substituted with R ^231a selected from the group consisting of halogen, OH, Ci-C ₄ -alkyl, Ci-C ₄ -halogenalkyl, Ci-C ₄ - alkoxy and Ci-C ₄ -halogenalkoxy, in particular selected from halogen, Ci-C ₂ -alkyl, Ci-C ₂ -halo- genalkyl, Ci-C ₂ -alkoxy, Ci-C ₂ -halogenalkoxy, more specifically selected from halogen, such as F, Cl and Br.

In to one embodiment R ^23a is independently selected from halogen, OH, CN, CrC ₂ -alkoxy, C ₃ - C ₆ -cycloalkyl, C ₃ -C ₆ -halogencycloalkyl and Ci-C ₂ -halogenalkoxy. Specifically, R ^23a is

independently selected from F, Cl, OH, CN, Ci-C ₂ -alkoxy, cyclopropyl, 1-F-cyclopropyl, 1 -CI- cyclopropyl, 1 ,1 -F ₂ -cyclopropyl, 1 ,1-Cl ₂ -cyclopropyl and Ci-C ₂ -halogenalkoxy.

According to one embodiment R ^23a is independently selected from halogen, such as F, Cl, Br and I, more specifically F, Cl and Br.

According to still another embodiment of formula I, R ^23a is independently selected from OH, C ₃ - C ₆ -cycloalkyl, C ₃ -C ₆ -halogencycloalkyl and Ci-C ₂ -halogenalkoxy. Specifically, R ^23a is

independently selected from OH, cyclopropyl and Ci-C ₂ -halogenalkoxy.

R ^23b are the possible substituents for the carbocyclic, heterocyclic and heteroaryl moieties of R ²³ .

R ^23b according to the invention is independently selected from halogen, OH, CN, Ci-C ₄ -alkyl, C ₁ - C ₄ -alkoxy, Ci-C ₄ -halogenalkyl, C ₃ -C ₆ -cycloalkyl, C ₃ -C ₆ -halogencycloalkyl and Ci-C ₄ -halogen- alkoxy.

According to one embodiment thereof R ^23b is independently selected from halogen, CN, C ₁ -C ₂ - alkyl, Ci-C ₂ -alkoxy, Ci-C ₂ -halogenalkyl, C ₃ -C ₆ -cycloalkyl, C ₃ -C ₆ -halogencycloalky and Ci-C ₂ -hal- ogenalkoxy. Specifically, R ^23b is independently selected from F, Cl, OH, CN, CH ₃ , OCH _3, cyclopropyl, 1-F-cyclopropyl, 1-CI-cyclopropyl, 1 ,1-F ₂ -cyclopropyl, 1 ,1-Cl ₂ -cyclopropyl and halogenmethoxy. According to still another embodiment thereof R ^23b is independently selected from Ci-C2-alkyl, Ci-C2-alkoxy, Ci-C2-halogenalkyl, C3-C6-cycloalkyl, C3-C6-halogencycloalkyl and Ci-C2-halogen- alkoxy. Specifically, R ^23b is independently selected from OH, CH3, OCH3, cyclopropyl, 1-F- cyclopropyl, 1-CI-cyclopropyl, 1 ,1-F ₂ -cyclopropyl, 1 ,1-Cl ₂ -cyclopropyl and halogenmethoxy, more specifically independently selected from OH, CH3, OCH3 _, cyclopropyl, 1-F-cyclopropyl, 1- Cl-cyclopropyl, 1 ,1-F ₂ -cyclopropyl, 1 ,1-Cl ₂ -cyclopropyl cyclopropyl and OCHF2.

Particularly preferred embodiments of combinations of R ² and R ³ according to the invention are in Table P35 below, wherein each line of lines P35-1 to P35-305 corresponds to one particular embodiment of the invention, wherein P35-1 to P35-305 are also in any combination with one another a preferred embodiment of the present invention. The carbon atom, to which R ² bound is marked with ^* in the drawings and the carbon atom, to which R ³ is bound is marked with # in the drawings. cPr stands for cyclopropyl.

Table P23:

R ⁴ according to the invention is in each case independently selected from hydrogen, halogen, OH, CN, N0 ₂ , SH, NH _2, NH(Ci-C ₄ -alkyl), N(Ci-C ₄ -alkyl) ₂ , NH-S0 ₂ -R ^x , Ci-C ₆ -alkyl, C ₂ -C ₆ -alkenyl, C ₂ -C ₆ -alkynyl, Ci-C ₆ -alkoxy, C3-C6-cycloalkyl, five- or six-membered heteroaryl and aryl;

wherein the heteroaryl contains one, two or three heteroatoms selected from N, O and S; and wherein

R ^x is Ci-C ₄ -alkyl, Ci-C ₄ -halogenalkyl, unsubstituted aryl or aryl that is substituted with one, two, three, four or five substituents R ^x4 independently selected from CrC ₄ -alkyl, halogen, OH, CN, Ci-C ₄ -halogenalkyl, Ci-C ₄ -alkoxy and Ci-C ₄ -halogenalkoxy;

wherein the acyclic moieties of R ⁴ are unsubstituted or substituted with identical or different groups R ^4a which independently of one another are selected from:

R ^4a halogen, OH, CN, Ci-C ₆ -alkoxy, C3-C6-cycloalkyl, C3-C6-halogencycloalky, Ci-C ₄ -halogen- alkoxy, Ci-Ce-alkylthio, aryl and phenoxy, wherein the aryl and phenoxy group is unsubstituted or unsubstituted or substituted with R ^44a selected from the group consisting of halogen, OH, Ci- C ₄ -alkyl, Ci-C ₄ -halogenalkyl, CrC ₄ -alkoxy and Ci-C ₄ -halogenalkoxy;

wherein the carbocyclic, heteroaryl and aryl moieties of R ⁴ are unsubstituted or substituted with identical or different groups R ^4b which independently of one another are selected from:

R ^4b halogen, OH, CN, Ci-C ₄ -alkyl, Ci-C ₄ -alkoxy, Ci-C ₄ -halogenalkyl, C ₃ -C ₆ -cycloalkyl, C ₃ -C ₆ - halogencycloalkyl, Ci-C ₄ -halogenalkoxy and Ci-Ce-alkylthio.

For every R ⁴ that is present in the inventive compounds, the following embodiments and preferences apply independently of the meaning of any other R ⁴ that may be present in the ring.

According to one embodiment of formula I, R ⁴ is H, halogen or Ci-C6-alkyl, in particular H, CH ₃ , Et, F, Cl, more specifically H, CH ₃ , F or Cl most preferred H, F or Cl.

According to another embodiment of formula I, R ⁴ is hydrogen.

According to still another embodiment of formula I, R ⁴ is halogen, in particular Br, F or Cl, more specifically F or Cl.

According to another embodiment of formula I, R ⁴ is F

According to another embodiment of formula I, R ⁴ is Cl

According to another embodiment of formula I, R ⁴ is Br.

According to still another embodiment of formula I, R ⁴ is OH.

According to still another embodiment of formula I, R ⁴ is COOH.

According to still another embodiment of formula I, R ⁴ is CONH ₂ .

According to still another embodiment of formula I, R ⁴ is CN.

According to still another embodiment of formula I, R ⁴ is NO ₂ .

According to still another embodiment of formula I, R ⁴ is SH.

According to still another embodiment of formula I R ⁴ is NH _2, NH(Ci-C ₄ -alkyl), N(Ci-C ₄ -alkyl) ₂ or NH-SC> ₂ -R ^x , wherein R ^x is Ci-C ₄ -alkyl, Ci-C ₄ -halogenalkyl, unsubstituted aryl or aryl that is sub- stituted with one, two, three, four or five substituents R ^x4 independently selected from Ci-C ₄ -al- kyl, halogen, OH, CN, Ci-C ₄ -halogenalkyl, Ci-C ₄ -alkoxy, or Ci-C ₄ -halogenalkoxy. In particular Ci-C ₄ -alkyl, such as NHCH ₃ and N(CH ₃ ) ₂ . In particular R ^x is Ci-C ₄ -alkyl, and phenyl that is sub- stituted with one CH ₃ , more specifically S02-R ^x is CH ₃ and tosyl group (“Ts”).

According to still another embodiment of formula I, R ⁴ is Ci-C6-alkyl, in particular Ci-C ₄ -alkyl, such as CH3 or CH2CH3.

According to still another embodiment of formula I, R ⁴ is Ci-C6-halogenalkyl, in particular CrC ₄ - halogenalkyl, such as CF ₃ , CHF ₂ , CH ₂ F, CCI ₃ , CHCI ₂ , CH ₂ CI, CF3CH2, CCI3CH2 or CF ₂ CHF ₂ .

According to still another embodiment of formula I, R ⁴ is C ₂ -C ₆ -alkenyl or C ₂ -C ₆ -halogenalkenyl, in particular C ₂ -C ₄ -alkenyl or C ₂ -C ₄ -halogenalkenyl, such as CH=CH ₂ , C(CH ₃ )=CH _2, CH=CCl ₂ ,

CH=CF ₂ , CCI=CCI ₂ , CF=CF ₂ , CH=CH ₂ , CH ₂ CH=CCI ₂ , CH ₂ CH=CF ₂ , CH ₂ CCI=CCI ₂ , CH ₂ CF=CF ₂ ,

CCI ₂ CH=CCI ₂ , CF ₂ CH=CF ₂ , CCI ₂ CCI=CCI ₂ , or CF ₂ CF=CF ₂ .

According to still another embodiment of formula I, R ⁴ is C ₂ -C ₆ -alkynyl or C ₂ -C ₆ -halogenalkynyl, in particular C ₂ -C ₄ -alkynyl or C ₂ -C ₄ -halogenalkynyl, such as CECH, CECCI, CECF. CH ₂ CECH, CH ₂ CºCCI, or CH ₂ CºCF.

According to still another embodiment of formula I, R ⁴ is Ci-C6-alkoxy, in particular Ci-C ₄ -alkoxy, more specifically Ci-C ₂ -alkoxy such as OCH ₃ or OCH ₂ CH ₃ .

According to still another embodiment of formula I, R ⁴ is Ci-C ₆ -halogenalkoxy, in particular C1- C4-halogenalkoxy, more specifically Ci-C2-halogenalkoxy such as OCF3, OCHF2, OCH2F,

OCCI3, OCHCh or OCH2CI, in particular OCF ₃ , OCHF ₂ , OCCI ₃ or OCHCI ₂ .

According to still another embodiment of formula I R ⁴ is C ₃ -C ₆ -cycloalkyl, in particular cyclopro- pyi-

According to still another embodiment of formula I, R ⁴ is C3-C6-cycloalkyl, for example cyclopro- pyl, substituted with one, two, three or up to the maximum possible number of identical or differ- ent groups R ^4b as defined and preferably herein.

According to still another embodiment of formula I, R ⁴ is C3-C6-halogencycloalkyl. In a special embodiment R ⁴ is fully or partially halogenated cyclopropyl.

According to still another embodiment of formula I, R ⁴ is unsubstituted aryl or aryl that is substituted with one, two, three or four R ^4b , as defined herein. In particular, R ⁴ is unsubstituted phenyl or phenyl that is substituted with one, two, three or four R ^4b , as defined herein.

According to still another embodiment of formula I, R ⁴ is unsubstituted 5- or 6-membered heteroaryl. According to still a further embodiment, R ⁴ is 5- or 6-membered heteroaryl that is substituted with one, two or three R ^4b , as defined herein.

According to still another embodiment of formula l,R ⁴ is in each case independently selected from hydrogen, halogen, OH, CN, N0 ₂ , SH, NH _2, NH(Ci-C ₄ -alkyl), N(Ci-C ₄ -alkyl) ₂ , NH-S0 ₂ -R ^x , Ci-C ₆ -alkyl, C2-C6-alkenyl, C2-C6-alkynyl, Ci-C ₆ -alkoxy and C3-C6-cycloalkyl; wherein the acyclic moieties of R ⁴ are not further substituted or carry one, two, three, four or five identical or differ- ent groups R ^4a as defined below and wherein the carbocyclic, heteroaryl and aryl moieties of R ⁴ are not further substituted or carry one, two, three, four or five identical or different groups R ^4b as defined below.

According to still another embodiment of formula I, R ⁴ is independently selected from hydrogen, halogen, CN, OH, Ci-C ₆ -alkyl,Ci-C ₆ -alkoxy, C ₆ -alkenyl, C2-C6-alkynyl, C3-C6-cycloalkyl, wherein the acyclic and cyclic moieties of R ⁴ are unsubtitted or substituted by halogen.

According to still another embodiment of formula I, R ⁴ is independently selected from hydrogen, halogen, CN, OH, Ci-C ₆ -alkyl, Ci-C ₆ -halogenalkyl, Ci-C ₆ -alkoxy and Ci-C ₆ -halogenalkoxy, in particular independently selected from H, F, Cl, Br, CN, OH, Ci-C4-alkyl, Ci-C4-halogenalkyl, Cr C4-alkoxy and Ci-C4-halogenalkoxy.

According to still another embodiment of formula I, R ⁴ is independently selected from H, CN, halogen or Ci-C ₆ -alkyl, in particular H, CN, CH3, Et, F, Cl, more specifically H, CN, CH3, F or Cl most preferred H, CH3, F or Cl.

R ^4a are the possible substituents for the acyclic moieties of R ⁴ .

R ^4a according to the invention is independently selected from halogen, OH, CN, CrC ₆ -alkoxy, C ₃ -C ₆ -cycloalkyl, C ₃ -C ₆ -halogencycloalkyl, Ci-C ₄ -halogenalkoxy, CrC ₆ -alkylthio, aryl and phe- noxy, wherein the aryl group is unsubstituted or unsubstituted or substituted with R ^44a selected from the group consisting of halogen, OH, Ci-C ₄ -alkyl, Ci-C ₄ -halogenalkyl, Ci-C ₄ -alkoxy and Ci- C ₄ -halogenalkoxy, in particular selected from halogen, Ci-C ₂ -alkyl, Ci-C ₂ -halogenalkyl, C ₁ -C ₂ - alkoxy and Ci-C ₂ -halogenalkoxy, more specifically selected from halogen, such as F, Cl and Br.

In to one embodiment R ^4a is independently selected from halogen, OH, CN, CrC ₂ -alkoxy, C ₃ - C ₆ -cycloalkyl, C ₃ -C ₆ -halogencycloalkyl and Ci-C ₂ -halogenalkoxy. Specifically, R ^4a is

independently selected from F, Cl, OH, CN, Ci-C ₂ -alkoxy, cyclopropyl, 1-F-cyclopropyl, 1 -CI- cyclopropyl, 1 ,1 -F ₂ -cyclopropyl, 1 ,1-Cl ₂ -cyclopropyl and CrC ₂ -halogenalkoxy.

According to one embodiment R ^4a is independently selected from halogen, such as F, Cl, Br and I, more specifically F, Cl and Br.

According to still another embodiment of formula I, R ^4a is independently selected from OH, C ₃ - C ₆ -cycloalkyl, C ₃ -C ₆ -halogencycloalkyl and Ci-C ₂ -halogenalkoxy. Specifically, R ^4a is

independently selected from OH, cyclopropyl and Ci-C ₂ -halogenalkoxy.

According to still another embodiment of formula I, R ^4a is independently selected from aryl and phenoxy, wherein the aryl group is unsubstituted or substituted with R ^44a selected from the group consisting of halogen, OH, CrC ₄ -alkyl, CrC ₄ -halogenalkyl, CrC ₄ -alkoxy and CrC ₄ -halo- genalkoxy, in particular selected from halogen, Ci-C ₂ -alkyl, Ci-C ₂ -halogenalkyl, Ci-C ₂ -alkoxy and Ci-C ₂ -halogenalkoxy, more specifically selected from halogen, such as F, Cl and Br.

R ^4b are the possible substituents for the carbocyclic, heteroaryl and aryl moieties of R ⁴ .

R ^4b according to the invention is independently selected from halogen, OH, CN, Ci-C ₄ -alkyl, C ₁ - C ₄ -alkoxy, Ci-C ₄ -halogenalkyl, C ₃ -C ₆ -cycloalkyl, C ₃ -C ₆ -halogencycloalkyl, Ci-C ₄ -halogenalkoxy and Ci-C6-alkylthio;

According to one embodiment thereof R ^4b is independently selected from halogen, CN, C ₁ -C ₂ - alkyl, CrC ₂ -alkoxy, CrC ₂ -halogenalkyl, C ₃ -C ₆ -cycloalkyl, C ₃ -C ₆ -halogencycloalkyl and C ₁ -C ₂ - halogenalkoxy. Specifically, R ^4b is independently selected from F, Cl, Br, OH, CN, CH ₃ , OCH _3, CHF ₂ , OCHF ₂ , cyclopropyl, 1 -F-cyclopropyl, 1 -CI-cyclopropyl, 1 ,1-F ₂ -cyclopropyl, 1 , 1 -CI ₂ - cyclopropyl, OCF3, and OCHF2.

According to still another embodiment thereof R ^4b is independently selected from halogen, C-i- C ₂ -alkyl, Ci-C ₂ -alkoxy, Ci-C ₂ -halogenalkyl, C ₃ -C ₆ -cycloalkyl, C ₃ -C ₆ -halogencycloalkyl and C ₁ -C ₂ - halogenalkoxy. Specifically, R ^4b is independently selected from halogen, CN, OH, CH ₃ , CHF ₂ , OCHF ₂ , OCF ₃ , OCH ₃ , cyclopropyl, 1-F-cyclopropyl, 1 -CI-cyclopropyl, 1 ,1-F ₂ -cyclopropyl, 1 , 1 -CI ₂ - cyclopropyl and halogenmethoxy, more specifically independently selected from F, Cl, OH, CH ₃ , OCH _3, CHF ₂ , OCH ₃ , cyclopropyl, 1 -F-cyclopropyl, 1 -CI-cyclopropyl, 1 ,1-F ₂ -cyclopropyl, 1 , 1 -CI ₂ - cyclopropyl, OCHF ₂ and OCF ₃ .

R ^x in the substituent NH-S0 ₂ -R ^X is in each case independently selected from Ci-C ₄ -alkyl, Ci-C ₄ - halogenalkyl, unsubstituted aryl and aryl that is substituted with one, two, three, four or five substituents R ^x4 independently selected from Ci-C ₄ -alkyl, halogen, OH, CN, Ci-C ₄ -halogenalkyl, Ci-C ₄ -alkoxy and Ci-C ₄ -halogenalkoxy. In particular, R ^x is in each case independently selected from CrC ₄ -alkyl, halogen, OH, CN and phenyl that is substituted with one, two or three R ^x4 independently selected from Ci-C ₂ -alkyl, more specifically R ^x is in each case independently selected from Ci-C ₄ -alkyl and phenyl that is substituted with one CH ₃ , more specifically SC>2-R ^X is the tosyl group (“Ts”).

Particularly preferred embodiments of R ⁴ according to the invention are in Table P4 below, wherein each line of lines P4-1 to P4-16 corresponds to one particular embodiment of the inven- tion. Thereby, for every R ⁴ that is present in the inventive compounds, these specific

embodiments and preferences apply independently of the meaning of any other R ⁴ that may be present in the ring:

Table P4:

“Ts” in the table stands for the tosylgroup SC>2-(p-CH3)phenyl.

10

R ⁵ is in each case independently selected from hydrogen, OH, CH(=0), C(=0)Ci-C ₆ -alkyl, C(=0)C ₂ -C ₆ -alkenyl, C(=0)C ₃ -C ₆ -cycloalkyl, Ci-C ₆ -alkyl, Ci-C ₄ -halogenalkyl, C3-C6-cycloalkyl, C3-C6-halogencycloalkyl, Ci-C ₄ -alkoxy, Ci-C ₄ -halogenalkoxy, OR ^Y , C2-C6-alkenyl, C2-C6- halogenalkenyl C2-C6-alkynyl, C2-C6-halogenalkynyl, S(0)n-Ci-C ₆ -alkyl, S(0)n-CrC ₆ - halogenalkyl, five- or six-membered heteroaryl and aryl; wherein the heteroaryl contains one, two or three heteroatoms selected from N, O and S; wherein the aryl groups are unsubstituted or carry one, two, three, four or five substituents selected from the group consisting of CN, halo- gen, OH, Ci-C ₄ -alkyl, Ci-C ₄ -halogenalkyl, Ci-C ₄ -alkoxy and Ci-C ₄ -halogenalkoxy; wherein n and R ^Y are as defined above.

R ^5a is the subtituent of the acyclic moieties of R ⁵ . The acyclic moieties of R ⁵ are not further substituted or carry one, two, three or up to the maximum possible number of identical or different groups R ^5a which independently of one another are selected from halogen, OH, CN, CrC ₆ -alkoxy, C3-C6-cycloalkyl, C3-C6-cycloalkenyl, C3-C6-halogencycloalkyl, C3-C6- halogencycloalkenyl, Ci-C ₄ -halogenalkoxy, Ci-Ce-alkylthio, five- or six-membered heteroaryl, aryl and phenoxy, wherein the heteroaryl, aryl and phenoxy group is unsubstituted or carries one, two, three, four or five substituents R ^78a’ selected from the group consisting of halogen, OH, Ci-C ₄ -alkyl, Ci-C ₄ -halogenalkyl, Ci-C ₄ -alkoxy and Ci-C ₄ -halogenalkoxy;

R ^5b is the subtituyend of carbocyclic, phenyl, heterocyclic and heteroaryl moieties of R ⁵ . The carbocyclic, phenyl, heterocyclic and heteroaryl moieties of R ⁵ are not further substituted or carry one, two, three, four, five or up to the maximum number of identical or different groups R ^5b which independently of one another are selected from halogen, OH, CN, Ci-C ₄ -alkyl, Ci-C ₄ - alkoxy, Ci-C ₄ -halogenalkyl, C ₃ -C ₆ -cycloalkyl, C ₃ -C ₆ -halogencycloalkyl, Ci-C ₄ -halogenalkoxy and Ci-C6-alkylthio.

According to one embodiment of formula I, R ⁵ is H.

According to still another embodiment of formula I, R ⁵ is OH.

According to a further specific embodiment of formula I, R ⁵ is CH(=0).

According to a further specific embodiment of formula I, R ⁵ is C(=0)Ci-C6-alkyl, wherein alkyl is CH ₃ , C ₂ H ₅ , n-propyl, i-propyl, n-butyl, i-butyl, tert-butyl, n-pentyl or i-pentyl.

According to a further specific embodiment of formula I, R ⁵ is C(=0)C2-C6-alkenyl, wherein alkenyl is CH=CH _2, CH ₂ CH=CH ₂ .

According to a further specific embodiment of formula I, R ⁵ is C(=0)C2-C6-alkynylwherein al- kynyl is CºCH _, CH ₂ CºCH.

According to a further specific embodiment of formula I, R ⁵ is C(=0)C3-C6-cycloalkyl, wherein cycloalkyl is cyclopropyl (C ₃ H ₇ ) or cyclobutyl (C ₄ Hg).

According to still another embodiment of formula I, R ⁵ is Ci-C6-alkyl, such as CH ₃ , C ₂ H ₅ , n-pro- pyl, i-propyl, n-butyl, i-butyl, tert-butyl, n-pentyl or i-pentyl.

According to still another embodiment of formula I, R ⁵ is Ci-C6-alkyl, in particular Ci-C ₄ -alkyl, such as CH ₃ , C ₂ H ₅ , n-propyl, i-propyl.

According to still another embodiment of formula I, R ⁵ is Ci-C6-halogenalkyl, in particular Ci-C ₄ - halogenalkyl, such as CF ₃ , CCI ₃ , FCH ₂ , CICH ₂ , F ₂ CH, CI ₂ CH, CF3CH2, CCI3CH2 or CF ₂ CHF ₂ .

According to still another embodiment of formula I R ⁵ is C ₃ -C ₆ -cycloalkyl, in particular cyclopro- pyl.

According to still another embodiment of formula I, R ⁵ is C ₃ -C ₆ -halogencycloalkyl. In a special embodiment R ^5b is fully or partially halogenated cyclopropyl, such as 1-F-cyclopropyl, 1-CI- cyclopropyl, 1 ,1-F2-cyclopropyl, 1 ,1-Cl2-cyclopropyl .

According to still another embodiment of formula I, R ⁵ is Ci-C ₄ -alkoxy and Ci-C ₄ -halogenalkoxy, in particular Ci-C ₃ -alkoxy, Ci-C ₃ -halogenalkoxy, such as CH ₂ OCH ₃ , CH ₂ OCF ₃ or CH ₂ OCHF ₂ .

According to a further specific embodiment of formula I, R ⁵ is OR ^Y wherein R ^Y is Ci-C6-alkyl, C ₁ - C6-halogenalkyl, C ₂ -C ₆ -alkenyl, C ₂ -C ₆ -halogenalkenyl, C ₂ -C ₆ -alkynyl, C ₂ -C ₆ -halogenalkynyl, C ₃ - C6-cycloalkyl, C ₃ -C ₆ -halogencycloalkyl, phenyl and phenyl-Ci-C6-alkyl; wherein the phenyl groups are unsubstituted or carry one, two, three, four or five substituents selected from the group consisting of CN, halogen, OH, Ci-C ₄ -alkyl, Ci-C ₄ -halogenalkyl, CrC ₄ -alkoxy and CrC ₄ - halogenalkoxy;

According to a further specific embodiment of formula I, R ⁵ is OR ^Y wherein R ^Y is Ci-C6-alkyl, in particular Ci-C ₄ -alkyl, more specifically Ci-C ₂ -alkyl. R ⁵ is such as OCH ₃ or OCH ₂ CH ₃ .

According to a further specific embodiment of formula I, R ⁵ is OR ^Y wherein R ^Y is Ci-C6-halogen- alkyl, in particular Ci-C ₄ -halogenalkyl, more specifically Ci-C ₂ -halogenalkyl. R ⁵ is such as OCF ₃ , OCHF _2I OCH ₂ F, OCCI _S , OCHCI ₂ or OCH ₂ CI, in particular OCF ₃ , OCHF ₂ , OCCI ₃ or OCHCI ₂ .

According to a further specific embodiment of formula I, R ⁵ is OR ^Y wherein R ^Y C ₂ -C ₆ -alkenyl, in particular C ₂ -C4-alkenyl, more specifically Ci-C ₂ -alkenyl. R ⁵ is such as OCH=CH ₂ ,

OCH ₂ CH=CH ₂ .

According to a further specific embodiment of formula I, R ⁵ is OR ^Y wherein R ^Y C ₂ -C ₆ -alkynyl, in particular C ₂ -C ₆ -alkynyl, in particular C ₂ -C ₄ -alkynyl, more specifically Ci-C ₂ -alkynyl. R ⁵ is such as OCºCH

According to still another embodiment of formula I, R ⁵ is OR ^Y wherein R ^Y is C ₃ -C ₆ -halogencyclo- alkyl. In a special embodiment R ¹ is fully or partially halogenated cyclopropyl.

According to still another embodiment of formula I, R ⁵ is is OR ^Y wherein R ^Y and phenyl; wherein the phenyl groups are unsubstituted or carry one, two, three, four or five substituents selected from the group consisting of CN, halogen, OH, Ci-C ₄ -alkyl, Ci-C ₄ -halogenalkyl, Ci-C ₄ -alkoxy and Ci-C ₄ -halogenalkoxy.

According to still another embodiment of formula I, R ⁵ is is OR ^Y wherein R ^Y phenyl-Ci-C ₆ -alkyl, such as phenyl-CH ₂ , herein the phenyl groups are unsubstituted or carry one, two, three, four or five substituents selected from the group consisting of CN, halogen, OH, Ci-C ₄ -alkyl, CrC ₄ -hal- ogenalkyl, CrC ₄ -alkoxy and Ci-C ₄ -halogenalkoxy. R ⁵ is such as OCH ₂ Ph.

According to still a further embodiment of formula I, R ⁵ is C ₂ -C ₆ -alkenyl, in particular C ₂ -C ₄ -alk- enyl, such as CH=CH ₂ , C(CH ₃ )=CH ₂ , CH ₂ CH=CH ₂ .

According to a further specific embodiment of formula I, R ⁵ is C ₂ -C ₆ -halogenalkenyl, in particular C ₂ -C ₄ -halogenalkenyl, more specifically C ₂ -C ₃ -halogenalkenyl such as CH=CHF, CH=CHCI, CH=CF ₂ , CH=CCI ₂ , CH ₂ CH=CHF, CH ₂ CH=CHCI, CH ₂ CH=CF _2I CH ₂ CH=CCI ₂ , CF ₂ CH=CF _2I CCI ₂ CH=CCI ₂ , CF ₂ CF=CF ₂ , CCI ₂ CCI=CCI ₂ .

According to still a further embodiment of formula I, R ⁵ is C ₂ -C ₆ -alkynyl or C ₂ -C ₆ -halogenalkynyl, in particular C ₂ -C ₄ -alkynyl or C ₂ -C ₄ -halogenalkynyl, such as OXOH, OH ₂ OXOH.

According to still another embodiment of formula I, R ⁵ is phenyl-Ci-C ₆ -alkyl, such as phenyl- CH ₂ , wherein the phenyl moiety in each case is unsubstituted or substituted by one, two or three identical or different groups R ^5b which independently of one another are selected from halogen, Ci-C ₂ -alkyl, Ci-C ₂ -alkoxy, Ci-C ₂ -halogenalkyl and Ci-C ₂ -halogenalkoxy, in particular F, Cl, Br, CH ₃ , OCH _S , CF ₃ and OCF ₃ .

According to still another embodiment of formula I, R ⁵ is aryl, in particular phenyl, wherein the aryl or phenyl moiety in each case is unsubstituted or substituted by identical or different groups R ^5b which independently of one another are selected from halogen, Ci-C ₂ -alkyl, CrC ₂ -alkoxy, Ci-C ₂ -halogenalkyl and Ci-C ₂ -halogenalkoxy, in particular F, Cl, Br, CH ₃ , OCH ₃ , CF ₃ and OCF ₃ . According to one embodiment, R ⁵ is unsubstituted phenyl. According to another embodiment,

R ⁵ is phenyl, that is substituted by one, two or three, in particular one, halogen, in particular se- lected from F, Cl and Br, more specifically selected from F and Cl.

According to still another embodiment of formula I, R ⁵ is a 5-membered heteroaryl such as pyr- rol-1-yl, pyrrol-2-yl, pyrrol-3-yl, thien-2-yl, thien-3-yl, furan-2-yl, furan-3-yl, pyrazol-1-yl, pyrazol- 3-yl, pyrazol-4-yl, pyrazol-5-yl, imidazol-1-yl, imidazol-2-yl, imidazol-4-yl, imidazol-5-yl, oxazol-2- yl, oxazol-4-yl, oxazol-5-yl, isoxazol-3-yl, isoxazol-4-yl, isoxazol-5-yl, thiazol-2-yl, thiazol-4-yl, thiazol-5-yl, isoth iazol-3-yl , isothiazol-4-yl, isoth iazol-5-y 1 , 1 ,2,4-triazolyl-1-yl, 1 ,2,4-triazol-3-yl 1 ,2,4-triazol-5-yl, 1 ,2,4-oxadiazol-3-yl, 1 ,2,4-oxadiazol-5-yl and 1 ,2,4-thiadiazol-3-yl, 1 ,2,4-thia- diazol-5-yl.

According to still another embodiment of formula I, R ⁵ is a 6-membered heteroaryl such as pyri- din-2-yl, pyridin-3-yl, pyridin-4-yl, pyridazin-3-yl, pyridazin-4-yl, pyrimidin-2-yl, pyrimidin-4-yl, py- rimidin-5-yl, pyrazin-2-yl and 1 ,3,5-triazin-2-yl and 1 ,2,4-triazin-3-yl.

According to still another embodiment of formula I, R ⁵ is in each case independently selected from H, halogen, OH, CN, Ci-C ₆ -alkyl, Ci-C ₆ -halogenalkyl, C2-C6-alkenyl, C2-C6-alkynyl, O _I -O _Q - alkoxy, Ci-C ₆ -halogenalkoxy, C3-C6-alkenyloxy, C3-C6-alkynyloxy and C3-C6-cycloalkyl wherein the acyclic moieties of R ⁵ are unsubstituted or substituted with identical or different groups R ^5a as defined and preferably defined herein, and wherein the carbocyclic, phenyl and heteroaryl moieties of R ⁵ are unsubstituted or substituted with identical or different groups R ^5b as defined and preferably defined herein.

According to still another embodiment of formula I, R ⁵ is in each case independently selected from H, halogen, OH, CN, Ci-C ₆ -alkyl, C2-C6-alkenyl, C2-C6-alkynyl, Ci-C ₆ -alkoxy, C3-C6- alkenyloxy, C3-C6-alkynyloxy and C3-C6-cycloalkyl, wherein the acyclic moieties of R ⁵ are unsub- stituted or substituted with identical or different groups R ^5a as defined and preferably defined herein, and wherein the cycloalkyl moieties of R ⁵ are unsubstituted or substituted with identical or different groups R ^5b as defined and preferably defined herein.

According to still another embodiment of formula I, R ⁵ is in each case independently selected from H and OR ^Y , wherein R ^Y is most preferably Ci-C ₆ -alkyl, Ci-C ₆ -halogenalkyl, C2-C6-alkenyl, C2-C6-halogenalkenyl, C2-C6-alkynyl, C2-C6-halogenalkynyl, phenyl and phenyl-Ci-C ₆ -alkyl; wherein the phenyl groups are unsubstituted or carry one, two, three, four or five substituents selected from the group consisting of CN, halogen, OH, Ci-C4-alkyl, Ci-C4-halogenalkyl, C1-C4- alkoxy and Ci-C4-halogenalkoxy.

According to still another embodiment of formula I, R ⁵ is in each case independently selected from H and OR ^Y , wherein R ^Y is most preferably C2-C6-alkenyl, C2-C6-alkynyl, phenyl and phenyl- Ci-C ₆ -alkyl; wherein the phenyl groups are unsubstituted or carry one, two, three, four or five substituents selected from the group consisting of CN, halogen, Ci-C4-alkyl, Ci-C4-halogenalkyl, Ci-C4-alkoxy and Ci-C4-halogenalkoxy.

According to still another embodiment of formula I, R ⁵ is in each case independently selected from H, CH(=0), C(=0)Ci-C ₆ -alkyl, , wherein the acyclic moieties of R ⁵ are unsubstituted or substituted with identical or different groups R ^5a as defined and preferably defined herein, and wherein the cycloalkyl moieties of R ⁵ are unsubstituted or substituted with identical or different groups R ^5b as defined and preferably defined herein.

According to one embodiment R ^5a is independently selected from halogen, Ci-C ₆ -alkoxy, C3-C6- cycloalkyl, C3-C6-halogencycloalkyl and Ci-C4-halogenalkoxy. Specifically, R ^5a is independently selected from F, Cl, Br, I, Ci-C2-alkoxy, cyclopropyl, 1-F-cyclopropyl, 1-CI-cyclopropyl, 1 ,1 -F2- cyclopropyl, 1 ,1-Cl ₂ -cyclopropyl and Ci-C2-halogenalkoxy.

According to still another embodiment of formula I, R ^5a is independently halogen, in particular selected from F, Cl, Br and I, more specifically F, Cl and Br. R ^5b are the possible substituents for the cycloalkyl, heteroaryl and phenyl moieties of R ⁵ . R ^5b according to the invention is independently selected from halogen, OH, CN, Ci-C ₄ -alkyl, C1-C4- alkoxy, Ci-C ₄ -halogenalkyl, C3-C6-cycloalkyl, C3-C6-halogencycloalkyl, Ci-C ₄ -halogenalkoxy and Ci-C ₆ -alkylthio.

According to one embodiment thereof R ^5b is independently selected from halogen, CN, Ci-C ₄ - alkyl, Ci-C ₄ -alkoxy, Ci-C ₄ -halogenalkyl and Ci-C ₄ -halogenalkoxy, in particular halogen, Ci-C ₄ - alkyl and Ci-C ₄ -alkoxy. Specifically, R ^5b is independently selected from F, Cl, CN, CH3, CHF2, CF ₃ OCH ₃ and halogenmethoxy.

Particularly preferred embodiments of R ⁵ according to the invention are in Table P5 below, wherein each line of lines P5-1 to P5-32 corresponds to one particular embodiment of the inven- tion, wherein P5-1 to P5-32 are also in any combination with one another a preferred embodi- ment of the present invention. The connection point to the carbon atom, to which R ⁵ is bound is marked with“#” in the drawings.

Table P5:

15 R ⁶ is independently selected from H, halogen, OH, CN, N0 ₂ , SH, CrC ₆ -alkylthio, NH _2, NH(Cr C ₄ -alkyl), N(Ci-C ₄ -alkyl) ₂ , NH-S0 ₂ -R ^x , Ci-C ₆ -alkyl, Ci-C ₆ -halogenalkyl, C ₂ -C ₆ -alkenyl, C ₂ -C ₆ -hal- ogenalkenyl, C ₂ -C ₆ -alkynyl, C ₂ -C ₆ -halogenalkynyl, Ci-C ₆ -alkoxy, Ci-C ₆ -halogenalkoxy, 0 ₂ -O _Q - alkenyloxy, C ₂ -C ₆ -alkynyloxy, aryloxy, heteroaryloxy, arylamino, heteroarylamino, arylthio, het- eroarylthio, CH(=0), C(=0)Ci-C ₆ -alkyl, C(=0)0(Ci-C ₆ -alkyl), C(=0)NH(Ci-C ₆ -alkyl), C(=0)N(Cr C ₆ -alkyl) ₂ , CR’=NOR”, a saturated or partially unsaturated three-, four-, five-, six-, seven-, eight- , nine-, or ten-membered carbocycle or heterocycle, a five- or six-membered heteroaryl or aryl; wherein in each case one or two CH ₂ groups of the carbo- and heterocycle may be replaced by a group independently selected from C(=0) and C(=S), and wherein the heterocycle and het- eroaryl contain independently one, two, three or four heteroatoms selected from N, O and S; and wherein R’ and R” are independently selected from H, Ci-C ₄ -alkyl, C ₂ -C ₆ -alkenyl, C ₂ -C ₆ -al- kynyl, saturated or partially unsaturated three-, four-, five-, six-, seven-, eight-, nine-, or ten- membered carbo- and heterocycle, five- or six-membered heteroaryl or aryl; wherein the hetero- cycle or heteroaryl contains one, two or three heteroatoms selected from N, O and S, and wherein R’ and R” are independently unsubstituted or substituted with R’” which is inde- pendently selected from halogen, OH, CN, N0 ₂ , SH, NH _2, NH(Ci-C ₄ -alkyl), N(Ci-C ₄ -alkyl) ₂ , NH- S0 ₂ -R ^x , CrC ₆ -alkyl, Ci-C ₆ -halogenalkyl, C ₂ -C ₆ -alkenyl, C ₂ -C ₆ -halogenalkenyl, C ₂ -C ₆ -alkynyl, C ₂ - C ₆ -halogenalkynyl, Ci-C ₆ -alkoxy, Ci-C ₆ -halogenalkoxy, C3-C6-cycloalkyl, C3-C6-halogencycloal- kyl and phenyl;

wherein R ^x is as defined above;

wherein the acyclic moieties of R ⁶ are independently not further substituted or carry one, two, three or up to the maximum possible number of identical or different groups R ^6a , which inde- pendently of one another are selected from:

R ^6a halogen, OH, CN, N0 ₂ , SH, NH ₂ , NH(Ci-C ₄ -alkyl), N(Ci-C ₄ -alkyl) ₂ , NH(C(=0)Ci-C ₄ -aikyl), N(C(=0)Ci-C ₄ -aikyl) ₂ , NH-S0 ₂ -R ^x , CrC ₆ -alkoxy, Ci-C4-halogenalkoxy, C3-C6-cycloalkyl, C3-C6- halogencycloalkyl, Ci-C ₆ -alkylthio, Ci-C ₆ -halogenalkylthio, S(0) _n -Ci-C ₆ -alkyl, S(0) _n -aryl,

CH(=0), C(=0)Ci-C ₆ -alkyl, C(=0)0(Ci-C ₆ -aikyl), C(=0)NH(Ci-C ₆ -aikyl), C(=0)N(Ci-C ₆ -aikyl) ₂ , CR’=NOR”, a saturated or partially unsaturated three-, four-, five-, six-, seven-, eight-, nine-, or ten-membered carbo- or heterocycle, a five-, six- or ten-membered heteroaryl, aryl or phenoxy, wherein in each case one or two CH ₂ groups of the carbo- and heterocycle may be replaced by a group independently selected from C(=0) and C(=S), and wherein the heterocycle and het- eroaryl contains independently one, two, three or four heteroatoms selected from N, O and S; wherein the carbo-, heterocyclic, heteroaryl and phenyl groups are independently unsubstituted or carry one, two, three, four or five substituents selected from the group consisting of halogen, OH, CN, N0 ₂ , SH, NH ₂ , NH(Ci-C ₄ -alkyl), N(Ci-C ₄ -alkyl) ₂ , NH(C(=0)Ci-C ₄ -aikyl), N(C(=0)Ci-C ₄ - alkyl) ₂ , NH-S0 ₂ -R ^x , Ci-C ₆ -alkylthio, Ci-C ₄ -alkyl, Ci-C ₄ -halogenalkyl, Ci-C ₄ -alkoxy, Ci-C ₄ -halo- genalkoxy, and S(0)n-Ci-C ₆ -alkyl; and wherein R ^x , R’ and R” are as defined above; n is 0, 1 , 2; and

wherein the carbo-, heterocyclic, heteroaryl and aryl moieties of R ⁶ are independently unsubsti- tuted or substituted with identical or different groups R ^6b , which independently of one another are selected from:

R ^6b halogen, OH, CN, N0 ₂ , SH, NH _2, NH(Ci-C ₄ -alkyl), N(Ci-C ₄ -alkyl) ₂ , NH(C(=0)Ci-C ₄ -alkyl), N(C(=0)Ci-C ₄ -alkyl) ₂ , NH-SC>2-R ^X , CrC4-alkyl, Ci-C ₄ -alkoxy, Ci-C4-halogenalkyl, C ₃ -C ₆ -cycloal- kyl, C3-C6- alogencycloalkyl, Ci-C4-halogenalkoxy, Ci-C ₆ -alkylthio, Ci-C ₆ -halogenalkylthio, S(0) _n -Ci-C ₆ -alkyl, Ci-C4-alkoxy-Ci-C4-alkyl, phenyl and phenoxy, wherein the phenyl groups are unsubstituted or carry one, two, three, four or five substituents selected from the group consist- ing of halogen, OH, Ci-C4-alkyl, Ci-C4-halogenalkyl, Ci-C4-alkoxy and Ci-C4-halogenalkoxy; and wherein R ^x and n are as defined above.

According to one embodiment of formula I, R ⁶ is independently selected from H, halogen, OH, CN, N0 ₂ , SH, CrCe-alkylthio, NH _2, NH(Ci-C ₄ -alkyl), N(Ci-C ₄ -alkyl) ₂ , NH-S0 ₂ -R ^x , substituted C C ₆ -alkyl, CrC ₆ -halogenalkyl, C ₂ -C ₆ -alkenyl, C ₂ -C ₆ -halogenalkenyl, C ₂ -C ₆ -alkynyl, C ₂ -C ₆ -halo- genalkynyl, Ci-C ₆ -alkoxy, Ci-C ₆ -halogenalkoxy, C ₂ -C ₆ -alkenyloxy, C ₂ -C ₆ -alkynyloxy, CH(=0), C(=0)Ci-C ₆ -aikyl, C(=0)0(Ci-C ₆ -aikyl), C(=0)NH(Ci-C ₆ -aikyl), C(=0)N(Ci-C ₆ -aikyl) ₂ ,

CR’=NOR”, a saturated or partially unsaturated three-, four-, five-, six-, seven-, eight-, nine-, or ten-membered carbocycle or heterocycle, a five- or six-membered heteroaryl or aryl; wherein in each case one or two CH ₂ groups of the carbo- and heterocycle may be replaced by a group in- dependently selected from C(=0) and C(=S), and wherein the heterocycle and the heteroaryl contain independently one, two, three or four heteroatoms selected from N, O and S; and wherein R’ and R” are independently selected from H, Ci-C4-alkyl, C ₂ -C ₆ -alkenyl, C ₂ -C ₆ -alkynyl, saturated or partially unsaturated three-, four-, five-, six-, seven-, eight-, nine-, or ten-membered carbo- and heterocycle, five- or six-membered heteroaryl or aryl; wherein the heterocycle or het- eroaryl contains one, two or three heteroatoms selected from N, O and S, and wherein R’ and R” are independently unsubstituted or substituted by R’” which is independently selected from halogen, OH, CN, N0 ₂ , SH, NH _2, NH(Ci-C ₄ -alkyl), N(Ci-C ₄ -alkyl) ₂ , NH-S0 ₂ -R ^x , Ci-C ₆ -alkyl, Ci- C ₆ -halogenalkyl, C ₂ -C ₆ -alkenyl, C ₂ -C ₆ -halogenalkenyl, C ₂ -C ₆ -alkynyl, C ₂ -C ₆ -halogenalkynyl, Ci- C ₆ -alkoxy, Ci-C ₆ -halogenalkoxy, C3-C6-cycloalkyl, C3-C6-halogencycloalkyl and phenyl; or wherein the aliphatic moieties of R ⁶ are independently not further substituted or carry 1 , 2, 3 or up to the maximum possible number of identical or different groups R ^6a , respectively, which in- dependently of one another are selected from:

R ^6a halogen, OH, CN, N0 ₂ , SH, NH ₂ , NH(Ci-C ₄ -alkyl), N(Ci-C ₄ -alkyl) ₂ , NH-aryl, N(aryl) ₂ ,

NH(C(=0)Ci-C ₄ -alkyl), N(C(=0)Ci-C ₄ -alkyl) ₂ , Ci-C ₆ -alkoxy, C3-C6-halogencycloalkyl, Ci- C4-halogenalkoxy, Ci-Ce-alkylthio, Ci-C ₆ -halogenalkylthio, S(0) _n -Ci-C ₆ -alkyl, S(0) _n -aryl, CH(=0), C(=0)Ci-C ₆ -aikyl, C(=0)0(Ci-C ₆ -aikyl), C(=0)NH(Ci-C ₆ -aikyl), C(=0)N(Ci-C ₆ - alkyl) ₂ , CR’=NOR”, a saturated or partially unsaturated three-, four-, five-, six-, seven-, eight-, nine-, or ten-membered carbocycle or heterocycle, aryl, phenoxy, a five-, six- or ten-membered heteroaryl; wherein in each case one or two CH ₂ groups of the carbo- and heterocycle may be replaced by a group independently selected from C(=0) and C(=S), five- or six-membered heteroaryl and aryl; wherein the heterocycle and the heteroaryl con- tain independently 1 , 2, 3 or 4 heteroatoms selected from N, O and S; wherein in each case one or two CH ₂ groups of the carbo- and heterocycle may be replaced by a group independently selected from C(=0) and C(=S); wherein the carbocyclic, heterocyclic, aryl and phenyl groups are independently unsubstituted or carry one, two, three, four or five substituents selected from the group consisting of halogen, OH, CN, N0 ₂ , SH, NH ₂ , NH(Ci-C ₄ -alkyl), N(Ci-C ₄ -alkyl) ₂ , NH(C(=0)Ci-C ₄ -aikyl), N(C(=0)Ci-C ₄ -aikyl) ₂ , NH-S0 ₂ -R ^x , Ci-C ₆ -alkylthio, Ci-C4-alkyl, Ci-C4-halogenalkyl, Ci-C4-alkoxy, Ci-C4-halogenalkoxy, and S(0) _n -Ci-C ₆ -alkyl; and wherein R ^x , R’, R” and R” are as defined above wherein the carbocyclic, heterocyclic, heteroaryl and aryl moieties of R ⁶ are independently not further substituted or carry 1 , 2, 3, 4, 5 or up to the maximum number of identical or different groups R ^6b , respectively, which independently of one another are selected from:

R ^6b halogen, OH, CN, N0 ₂ , SH, NH _2, NH(Ci-C ₄ -alkyl), N(Ci-C ₄ -alkyl) ₂ , NH(C(=0)Ci-C ₄ -aikyl), N(C(=0)Ci-C ₄ -aikyl) ₂ , NH-S0 ₂ -R ^x , Ci-C ₄ -alkyl, Ci-C4-alkoxy, Ci-C ₄ -halogenalkyl, C3-C6- cycloalkyl, C3-C6-halogencycloalkyl, Ci-C4-halogenalkoxy, Ci-C ₆ -alkylthio, Ci-C ₆ -halogen- alkylthio, S(0) _n -Ci-C ₆ -alkyl, Ci-C4-alkoxy-Ci-C4-alkyl, phenyl and phenoxy, wherein the phenyl groups are unsubstituted or substituted with substituents selected from the group consisting of halogen, OH, Ci-C4-alkyl, CrC4-halogenalkyl, CrC4-alkoxy and Ci-C4-halo- genalkoxy.

According to one embodiment of formula I, R ⁶ is selected from substituted H, Ci-C ₆ -alkyl, O-I-OQ- halogenalkyl, C ₂ -C ₆ -halogenalkyl, C ₂ -C ₆ -alkenyl, C ₂ -C ₆ -halogenalkenyl, C3-C6-cycloalkenyl, C ₂ - C ₆ -alkynyl, C ₂ -C ₆ -halogenalkynyl, C3-C6-cycloalkynyl, Ci-C ₆ -alkoxy, aryloxy, heteroaryloxy, ar- ylamino, heteroarylamino, arylthio, heteroarylthio, CN, CH(=0), C(=0)C ₂ -C ₆ -alkyl, C(=0)0(C ₂ - C ₆ -alkyl), CR’=NOR”, C3-C6-cycloalkyl, C3-C6-halogencycloalkyl, Ci-C ₆ -alkyl-five- and six-mem- bered heteroaryl ,a five- or six-membered heteroaryl, benzyl, aryl; wherein R’ and R” are de- fined below; and wherein the acyclic moieties of R ⁶ are unsubstituted or substituted with identi cal or different groups R ^6a as defined below and wherein wherein the carbocycle, heterocycle and heteroaryl and aryl moieties are unsubstituted or substituted with substituents R ^6b as de- fined below.

According to one embodiment of formula I, R ⁶ is selected from H, Ci-C ₆ -alkyl substituted with halogen, CN, Ci-C ₆ -alkoxy, aryloxy, arylamino, arylthio, Ci-C4-halogenalkoxy, Ci-C ₆ -alkylthio, S(0) _n -Ci-C ₆ -aikyl, NH-S0 ₂ -R ^x , N(Ci-C ₆ -alkyl) ₂ , NH-S0 ₂ -R ^x , NH(Ci-C ₆ -alkyl), N(Ci-C ₆ -alkyl) ₂ , CH(=0), C(=0)Ci-C ₆ -alkyl, C(=0)0(Ci-C ₆ -alkyl), a saturated three-, four-, five-, six-, membered carbo- or heterocycle, aryl, a five- or six-membered heteroaryl; wherein R ^x is defined below; and wherein the acyclic moieties of R ⁶ are unsubstituted or substituted with identical or different groups R ^6a as defined below and wherein wherein the carbocycle, heterocycle and heteroaryl and aryl moieties are unsubstituted or substituted with substituents R ^6b as defined below.

According to another embodiment of formula I, R ⁶ is H.

According to another embodiment of formula I, R ⁶ is F.

According to another embodiment of formula I, R ⁶ is Cl.

According to another embodiment of formula I, R ⁶ is Br.

According to still another embodiment of formula I, R ⁶ is OH.

According to still another embodiment of formula I, R ⁶ is CN.

According to still another embodiment of formula I, R ⁶ is N0 ₂ .

According to still another embodiment of formula I, R ⁶ is SH.

According to still another embodiment of formula I, R ⁶ is Ci-C ₆ -alkylthio, such as SCH3, SC ₂ Hs, S-n-propyl, S-i-propyl, S-n-butyl, S-i-butyl, S-tert-butyl, S-n-pentyl, S-i-pentyl, CH ₂ SCH ₃ or CH ₂ SCH ₂ CH ₃ . According to still another embodiment of formula I, R ⁶ is Ci-C6-halogenalkylthio, such as SCF ₃ , SCCI3, CH2SCF3 or CH2SCF3.

According to still another embodiment of formula I, R ⁶ is selected from CN, substituted C ₁ -C ₆ - alkyl, Ci-C6-halogenalkyl or Ci-C6-alkyl which is substituted, Ci-C6-halogenalkyl, phenyl, halogenphenyl and three-, four-, five- or six-membered carbo- and heterocycle, wherein the carbo- and heterocycle is unsubstituted or is substituted with substituents R ^6b as defined below. According to one embodiment thereof, the carbocycle is unsubstituted. In a particular embodi- ment, R ⁶ is selected from Ci-C6-halogenalkyl, phenyl-CH ₂ , halogenphenyl-CH ₂ , phenyl, halogenphenyl and three-, four-, five- or six-membered carbo- and heterocycle, wherein the carbo- and heterocycle is unsubstituted or is substituted with substituents R ^6b as defined below.

According to still another embodiment of formula I, R ⁶ is selected from H, CN, substituted C ₁ -C ₆ - alkyl, Ci-C6-halogenalkyl or Ci-C6-alkyl which is substituted, Ci-C6-halogenalkyl, phenyl, halogenphenyl, aryloxy, heteroaryloxy, arylamino, heteroarylamino, arylthio, heteroarylthio and three-, four-, five- or six-membered carbo- and heterocycle, wherein the carbo- and heterocycle is unsubstituted or substituted bysubstituents R ^6b as defined below. According to one embodi- ment thereof, the carbo- and heterocycle is unsubstituted. In a particular embodiment, R ⁶ is se- lected from substituted Ci-C6-halogenalkyl, phenyl, halogenphenyl and three-, four-, five- or six- membered carbo- and heterocycle, wherein the carbo- and heterocycle is unsubstituted or sub- stituted bysubstituents R ^6b as defined below.

According to another embodiment of formula I, R ⁶ is selected from H, CN, substituted Ci-C6-al- kyl, Ci-C6-halogenalkyl, C ₂ -C ₆ -alkenyl, C ₂ -C ₆ -halogenalkenyl, C ₂ -C ₆ -alkynyl, C ₂ -C ₆ -halogen- alkynyl, C ₃ -C ₆ -cycloalkyl, C ₃ -C ₆ -halogencycloalkyl, Ci-C6-alkylaryl, aryloxy, arylamino, ar- ylthio,five- or six-membered heteroaryl or aryl which is unsubstituted or substituted with halogen or Ci-C6-halogenalkyl, and wherein the acyclic moieties of R ⁶ are unsubstituted or substituted with identical or different groups R ^6a as defined below and wherein wherein the carbocycle, het- erocycle and heteroaryl and aryl moieties are unsubstituted or substituted with substituents R ^6b as defined below.

According to still another embodiment of formula I, R ⁶ is selected from H, CN, substituted C ₁ -C ₆ - alkyl, Ci-C6-halogenalkyl, CN, C ₂ -C ₆ -alkenyl, C ₂ -C ₆ -halogenalkenyl, C ₂ -C ₆ -alkynyl, C ₂ -C ₆ -halo- genalkynyl, C ₃ -C ₆ -cycloalkyl, C ₃ -C ₆ -halogencycloalkyl, Ci-C6-alkylaryl, phenyl, pyridine, pyrimi- dine, thiophene, imidazole, triazol, oxadiazol wherein the acyclic moieties of R ⁶ are unsubsti- tuted or substituted with identical or different groups R ^6a as defined below and wherein wherein the carbocycle, heterocycle and heteroaryl and aryl moieties are unsubstituted or substituted with substituents R ^6b as defined below.

According to still another embodiment of formula I, R ⁶ is selected from CN, substituted C ₁ -C ₆ - alkyl, Ci-C6-halogenalkyl, CN, C ₂ -C ₆ -alkenyl, C ₂ -C ₆ -halogenalkenyl, C ₂ -C ₆ -alkynyl, C ₂ -C ₆ -halo- genalkynyl, C ₃ -C ₆ -cycloalkyl, C ₃ -C ₆ -halogencycloalkyl, Ci-C6-alkylaryl, phenyl, pyridine, pyrimi- dine, thiophene, imidazole, triazol, oxadiazol wherein the acyclic moieties of R ⁶ are unsubsti- tuted or substituted with identical or different groups R ^6a as defined below and wherein wherein the carbocycle, heterocycle and heteroaryl and aryl moieties are unsubstituted or substituted with substituents R ^6b as defined below. According to still another embodiment of formula I, R ⁶ is Ci-C ₆ -alkyl such as CH ₃ , C2H5, n-pro- pyl, i-propyl, n-butyl, i-butyl, tert-butyl, n-pentyl or i-pentyl.

According to still another embodiment of formula I, R ⁶ is Ci-C ₆ -alkyl such as CH ₃ .

According to still another embodiment of formula I, R ⁶ is Ci-C ₆ -alkyl such as C2H5.

According to still another embodiment of formula I, R ⁶ is Ci-C ₆ -alkyl such as CH ₃ , C2H5, n-pro- pyl, i-propyl, n-butyl, i-butyl, tert-butyl, n-pentyl or i-pentyl which is substituted with at least one group R ^6a , which independently of one another are selected from:

R ^6a halogen, OH, CN, N0 ₂ , SH, NH ₂ , NH(C C ₄ -alkyl), N(Ci-C ₄ -alkyl) ₂ , NH(C(=0)C C ₄ -alkyl), N(C(=0)CrC ₄ -alkyl) ₂ , NH-S0 ₂ -R ^X , CrC ₆ -alkoxy, CrC ₄ -halogenalkoxy, Ci-Ce-alkylthio, C1-C6- halogenalkylthio, S(0) _n -Ci-C ₆ -alkyl, S(0) _n -aryl, CH(=0), C(=0)Ci-C ₆ -alkyl, C(=0)0(Ci-C ₆ -alkyl), C(=0)NH(Ci-C ₆ -alkyl), C(=0)N(Ci-C ₆ -alkyl) ₂ , CR -NOR” a saturated or partially unsaturated three-, four-, five-, six-, seven-, eight-, nine-, or ten-membered carbocycle or heterocycle, five-, six- or ten-membered heteroaryl, aryl or phenoxy, wherein in each case one or two CH2 groups of the carbo- and heterocycle may be replaced by a group independently selected from C(=0) and C(=S), and wherein the heterocycle and heteroaryl contains independently one, two, three or four heteroatoms selected from N, O and S; wherein the carbocyclic, heterocyclic, heteroaryl, aryl groups are independently unsubstituted or carry one, two, three, four or five substituents selected from the group consisting of halogen, OH, CN, NO2, SH, NH2, NH(Ci-C ₄ -alkyl), N(Ci- C ₄ -alkyl) ₂ , NH(C(=0)Ci-C ₄ -aikyl), N(C(=0)Ci-C ₄ -aikyl) ₂ , NH-S0 ₂ -R ^x , Ci-C ₆ -alkylthio, Ci-C ₄ -alkyl, Ci-C ₄ -halogenalkyl, Ci-C ₄ -alkoxy, Ci-C ₄ -halogenalkoxy, and S(0)n-Ci-C ₆ -alkyl.

According to still another embodiment of formula I, R ⁶ is CH ₃ is substituted with at least one group R ^6a , which independently of one another are selected from:

R ^6a halogen, OH, CN, N0 ₂ , SH, NH ₂ , NH(Ci-C ₄ -alkyl), N(Ci-C ₄ -alkyl) ₂ , NH-aryl, N(aryl) ₂ , NH(C(=0)Ci-C ₄ -aikyl), N(C(=0)Ci-C ₄ -alkyl) ₂ , NH-S0 ₂ -R ^X , CrC ₆ -alkoxy, Ci-C ₄ -halogenalkoxy, CrC ₆ -alkylthio, Ci-C ₆ -halogenalkylthio, S(0) _n -Ci-C ₆ -alkyl, S(0) _n -aryl, CH(=0), C(=0)CrC ₆ -al- kyl, C(=0)0(Ci-C ₆ -alkyl), C(=0)NH(Ci-C ₆ -alkyl), C(=0)N(Ci-C ₆ -alkyl) ₂ , CR’=NOR”, a saturated or partially unsaturated three-, four-, five-, six-, seven-, eight-, nine-, or ten-membered carbocy- cle or heterocycle, five-, six- or ten-membered heteroaryl, an aryl or phenoxy, wherein in each case one or two CH2 groups of the carbo- and heterocycle may be replaced by a group inde- pendently selected from C(=0) and C(=S), and wherein the heterocycle and heteroaryl contains independently one, two, three or four heteroatoms selected from N, O and S; wherein the carbo- cyclic, heterocyclic, heteroaryl, heteroaryl and phenyl groups are independently unsubstituted or carry one, two, three, four or five substituents selected from the group consisting of halogen,

OH, CN, N0 ₂ , SH, NH ₂ , NH(Ci-C ₄ -alkyl), N(Ci-C ₄ -alkyl) ₂ , NH(C(=0)Ci-C ₄ -aikyl), N(C(=0)Ci-C ₄ - alkyl)2, NH-S0 ₂ -R ^X , Ci-Ce-alkylthio, Ci-C ₄ -alkyl, Ci-C ₄ -halogenalkyl, Ci-C ₄ -alkoxy, Ci-C ₄ -halo- genalkoxy, and S(0)n-Ci-C ₆ -alkyl.

According to still another embodiment of formula I, R ⁶ is C2H5 is substituted with at least one group R ^6a , which independently of one another are selected from:

R ^6a halogen, OH, CN, N0 ₂ , SH, NH ₂ , NH(Ci-C ₄ -alkyl), N(Ci-C ₄ -alkyl) ₂ , NH-aryl, N(aryl) ₂ , NH(C(=0)Ci-C ₄ -aikyl), N(C(=0)Ci-C ₄ -alkyl) ₂ , NH-S0 ₂ -R ^X , CrC ₆ -alkoxy, Ci-C ₄ -halogenalkoxy, CrC ₆ -alkylthio, Ci-C ₆ -halogenalkylthio, S(0) _n -Ci-C ₆ -alkyl, S(0) _n -aryl, CH(=0), C(=0)CrC ₆ -al- kyl, C(=0)0(Ci-C ₆ -aikyl), C(=0)NH(Ci-C ₆ -aikyl), C(=0)N(Ci-C ₆ -alkyl) _2, CR’=NOR”a saturated or partially unsaturated three-, four-, five-, six-, seven-, eight-, nine-, or ten-membered carbocy- cle or heterocycle, five-, six- or ten-membered heteroaryl, phenyl or phenoxy; wherein in each case one or two CH ₂ groups of the carbo- and heterocycle may be replaced by a group inde- pendently selected from C(=0) and C(=S), and wherein the heterocycle and heteroaryl contains independently one, two, three or four heteroatoms selected from N, O and S; wherein the carbo- cyclic, heterocyclic, heteroaryl, aryl and phenyl groups are independently unsubstituted or carry one, two, three, four or five substituents selected from the group consisting of halogen, OH, CN, N0 ₂ , SH, NH _2I NH(Ci-C ₄ -alkyl), N(Ci-C ₄ -alkyl) ₂ , NH(C(=0)Ci-C ₄ -aikyl), N(C(=0)Ci-C ₄ -aikyl) ₂ , NH-S0 ₂ -R ^x , Ci-C ₆ -alkylthio, Ci-C ₄ -alkyl, Ci-C ₄ -halogenalkyl, Ci-C ₄ -alkoxy, Ci-C ₄ -halogenalkoxy, and S(0)n-Ci-C ₆ -alkyl.

According to still another embodiment of formula I, R ⁶ is CH ₂ CN.

According to still another embodiment of formula I, R ⁶ is CH ₂ OH.

According to still another embodiment of formula I, R ⁶ is Ci-C ₆ -halogenalkyl, in particular Ci-C ₄ - halogenalkyl, more specifically Ci-C ₂ -halogenalkyl, such as CF ₃ , CCI ₃ , FCH ₂ , CICH ₂ , F ₂ CH,

CI ₂ CH, CF ₃ CH _2I CCI ₃ CH ₂ or CF ₂ CHF ₂ .

According to still another embodiment of formula I, R ⁶ is CH ₂ F.

According to still another embodiment of formula I, R ⁶ is CHF ₂ .

According to still another embodiment of formula I, R ⁶ is CF ₃ .

According to still a further embodiment of formula I, R ⁶ is C ₂ -C ₆ -alkenyl, in particular C ₂ -C ₄ -alk- enyl, such as CH=CH ₂ , CH ₂ CH=CH ₂ or C(CH ₃ )C=CH ₂ .

According to a further specific embodiment of formula I, R ⁶ is C ₂ -C ₆ -halogenalkenyl, in particular C ₂ -C ₄ -halogenalkenyl, more specifically C ₂ -C3-halogenalkenyl such as CH=CHF, CH=CHCI, CH=CF ₂ , CH=CCI _2I CF=CF _2I CCI=CCI ₂ , CH ₂ CH=CHF, CH ₂ CH=CHCI, CH ₂ CH=CF _2I

CH ₂ CH=CCI _2I CH ₂ CF=CF _2I CH ₂ CCI=CCI _2I CF ₂ CF=CF ₂ or CCI ₂ CCI=CCI ₂ .

According to still a further embodiment of formula I, R ⁶ is C ₂ -C ₆ -cycloalkenyl, in particular C ₂ -C ₄ - cycloalkenyl, such as CH=CH ₂ -cPr.

According to still a further embodiment of formula I, R ⁶ is C ₂ -C ₆ -alkynyl or C ₂ -C ₆ -halogenalkynyl, in particular C ₂ -C ₄ -alkynyl or C ₂ -C ₄ -halogenalkynyl, such as C CH, C C-CI, C=C-CH ₃ , CH ₂ - CºCH, CH ₂ -CºCCI or CH ₂ - CºC-CH ₃ .

According to still a further embodiment of formula I, R ⁶ is C ₂ -C ₆ -cycloalkynyl in particular C ₂ -C ₄ - cycloalkynyl, such as C C-cPr.

According to a further specific embodiment of formula I, R ⁶ is Ci-C ₆ -alkoxy, in particular Ci-C ₄ - alkoxy, more specifically Ci-C ₂ -alkoxy such as OCH ₃ , CH ₂ CH ₃ or CH ₂ OCH3.

According to a further specific embodiment of formula I, R ⁶ is Ci-C ₆ -alkyl-CrC ₆ -alkoxy, in particular Ci-C ₄ -alkyl-CrC ₄ -alkoxy, more specifically Ci-C ₂ -alkyl-CrC ₂ -alkoxy, such as

CH ₂ OCH ₃ or CH ₂ OCH ₂ CH _3.

According to a further specific embodiment of formula I, R ⁶ is C ₂ -C ₆ -alkenyloxy, in particular C ₂ - C ₄ -alkenyloxy, more specifically Ci-C ₂ -alkenyloxy such as OCH=CH ₂ , OCH ₂ CH=CH ₂

OC(CH ₃ )CH=CH ₂ , CH ₂ OCH=CH _2I or CH ₂ OCH ₂ CH=CH ₂ .

According to a further specific embodiment of formula I, R ⁶ is C ₂ -C ₆ -alkynyloxy, in particular C ₂ - C ₄ -alkynyloxy, more specifically Ci-C ₂ -alkynyloxy such as OC CH, OCH ₂ C=CH or CH ₂ OC=CH According to a further specific embodiment of formula I, R ⁶ is Ci-C ₆ -halogenalkoxy, in particular Ci-C4-halogenalkoxy, more specifically Ci-C2-halogenalkoxy such as OCF3, OCHF2, OCH2F, OCCIs, OCHCh or OCH2CI, in particular OCF ₃ , OCHF ₂ , OCCI ₃ or OCHCI ₂ .

According to a further specific embodiment of formula I, R ⁶ is Ci-C6-alkyl-Ci-C6-halogenalkoxy, in particular Ci-C ₄ -alkyl-Ci-C ₄ -halogenalkoxy, more specifically Ci-C ₂ -alkyl-Ci-C ₂ -halogenalkoxy such as CH ₂ OCF _3I CH ₂ OCHF _2I CH ₂ OCH ₂ F, CH2OCCI3, CH2OCHCI2 or CH2OCH2CI, in particular CH2OCF3, CH ₂ OCHF ₂ , CH2OCCI3 or CH2OCHCI2.

According to a further specific embodiment of formula I, R ⁶ is CH(=0), C(=0)Ci-C ₆ -alkyl, C(=0)0(Ci-C ₆ -aikyl), C(=0)NH(Ci-C ₆ -aikyl) or C(=0)N(Ci-C ₆ -alkyl) ₂ , wherein alkyl is CH ₃ , C ₂ H ₅ , n-propyl, i-propyl, n-butyl, i-butyl, tert-butyl, n-pentyl or i-pentyl.

According to a further specific embodiment of formula I, R ⁶ is Ci-C ₄ -alkyl-CH(=0), Ci-C4-alkyl- C(=0)Ci-C ₆ -alkyl, Ci-C ₄ -alkyl-C(=0)0(Ci-C ₆ -alkyl), Ci-C ₄ -alkyl-C(=0)NH(Ci-C ₆ -alkyl) or C1-C4- alkyl-C(=0)N(Ci-C ₆ -alkyl)2, especially CH ₂ CH(=0), CH ₂ C(=0)Ci-C ₆ -alkyl, CH ₂ C(=0)0(Ci-C ₆ - alkyl), CH ₂ C(=0)NH(Ci-C ₆ -alkyl) or CH ₂ C(=0)N(Ci-C ₆ -alkyl) ₂ wherein alkyl is CH ₃ , C ₂ H ₅ , n-pro- pyl, i-propyl, n-butyl, i-butyl, tert-butyl, n-pentyl or i-pentyl.

According to a further specific embodiment of formula I, R ⁶ is CR’=NOR” such as

C(CH ₃ )=NOCH ₃ , C(CH ₃ )=NOCH ₂ CH ₃ or C(CH ₃ )=NOCF ₃ .

According to a further specific embodiment of formula I, R ⁶ is Ci-C ₆ -alkyl-NH(Ci-C ₄ -alkyl) orCi- C ₆ -alkyl-N(Ci-C ₄ -alkyl) ₂ , wherein alkyl is CH ₃ , C ₂ H ₅ , n-propyl, i-propyl, n-butyl, i-butyl, tert-butyl, n-pentyl or i-pentyl.

According to a further specific embodiment of formula I, R ⁶ is Ci-C ₆ -alkylthio, in particular C1-C4- alkoxy, more specifically Ci-C3-alkylthio such as CH2SCH3 or CH2SCH2CH3 _.

According to a further specific embodiment of formula I, R ⁶ is Ci-C ₆ -alkyl-S(0) _n -Ci-C ₆ -alkyl, wherein alkyl is CH ₃ , C2H5, n-propyl, i-propyl, n-butyl, i-butyl, tert-butyl, n-pentyl or i-pentyl and n is 1 , 2 or 3.

According to a further specific embodiment of formula I, R ⁶ is Ci-C ₆ -alkyl-S(0) _n -Ci-C ₆ - halogenalkyl, wherein halogenalkyl is CF ₃ or CHF2 and n is 1 , 2 or 3.

According to a further specific embodiment of formula I, R ⁶ is Ci-C ₆ -alkyl-S(0) _n -aryl, wherein the aryl or phenyl moiety in each case is unsubstituted or substituted with identical or different groups R ^6b which independently of one another are selected from halogen, Ci-C2-alkyl, C1-C2- alkoxy, Ci-C2-halogenalkyl, Ci-C2-halogenalkoxy and S(0) _n -Ci-C ₆ -alkyl, in particular F, Cl, Br, CH ₃ , OCH _3I CF ₃ , CHF _2I OCHF _2I OCF ₃ . According to one embodiment, R ⁶ is unsubstituted phe- nyl. According to another embodiment, R ⁶ is phenyl, that is substituted with one, two or three, in particular one, halogen, in particular selected from F, Cl and Br, more specifically selected from F and Cl.

According to a further specific embodiment of formula I, R ⁶ is Ci-C ₆ -alkyl-NH-S0 ₂ -R ^x wherein R ^x is Ci-C4-alkyl, Ci-C4-halogenalkyl, unsubstituted aryl or aryl that is substituted with one, two, three, four or five substituents R ^x2 independently selected from Ci-C4-alkyl, halogen, OH, CN, Ci-C4-halogenalkyl, Ci-C4-alkoxy, or Ci-C4-halogenalkoxy, such as CH ₂ NHS0 ₂ CF ₃ or

CH2NHSO2CH3. According to still another embodiment of formula I, R ⁶ is selected from Ci-C ₆ -alkyl which is sub- stituted, a saturated three-, four-, five-, six-, seven-, eight-, nine-, or ten-membered carbocycle, in particular three-, four-, five- or six-membered, wherein the carbocycle is unsubstituted or sub- stituted with substituents R ^6b as defined below. According to one embodiment thereof, the car- bocycle is unsubstituted.

According to one embodiment, R ⁶ is selected from Ci-C ₆ -alkyl, especially CH ₂ which is substi- tuted with a 3-membered saturated carbocycle. According to one embodiment thereof, the carbocycle is unsubstituted, i.e. it does not carry any substituent R ^6b . According to still another embodiment of formula I, it is substituted with R ^6b .

According to one embodiment, R ⁶ is selected from Ci-C ₆ -alkyl, especially CH ₂ which is substi- tuted with a 4-membered saturated carbocycle. According to one embodiment thereof, the carbocycle is unsubstituted, i.e. it does not carry any substituent R ^6b . According to still another embodiment of formula I, it is substituted with R ^6b .

According to one embodiment, R ⁶ is selected from Ci-C ₆ -alkyl, especially CH ₂ which is substi- tuted with a 5-membered saturated carbocycle. According to one embodiment thereof, the carbocycle is unsubstituted, i.e. it does not carry any substituent R ^6b . According to still another embodiment of formula I, it is substituted with R ^6b .

According to one embodiment, R ⁶ is selected from Ci-C ₆ -alkyl, especially CH ₂ which is substi- tuted with a 6-membered saturated carbocycle. According to one embodiment thereof, the carbocycle is unsubstituted, i.e. it does not carry any substituent R ^6b . According to still another embodiment of formula I, it is substituted with R ^6b .

According to a further specific embodiment of formula I, R ⁶ is Ci-C ₆ -alkylheterocycle, especially CH ₂ substituted with a 4-membered saturated heterocycle which contains 1 or 2 heteroatoms, in particular 1 heteroatom, from the group consisting of N, O and S, as ring members. According to one embodiment, the heterocycle contains one O as heteroatom. For example, the formed heterocycle is oxetane. According to one embodiment thereof, the heterocycle is unsubstituted, i.e. it does not carry any substituent R ^6b . According to still another embodiment of formula I, it is substituted with R ^6b .

According to a further specific embodiment of formula I, R ⁶ is Ci-C ₆ -alkylheterocycle, especially CH ₂ substituted with a 5-membered saturated heterocycle which contains 1 , 2 or 3, in particular 1 or 2, heteroatoms from the group consisting of N, O and S, as ring members. According to one embodiment, the heterocycle contains one O as heteroatom. According to one embodiment thereof, the heterocycle is unsubstituted, i.e. it does not carry any substituent R ^6b . According to still another embodiment of formula I, it is substituted with R ^6b .

According to a further specific embodiment of formula I, R ⁶ is Ci-C ₆ -alkylheterocycle, especially CH ₂ subsitited by a 6-membered saturated heterocycle which contains 1 , 2 or 3, in particular 1 or 2, heteroatoms from the group consisting of N, O and S as ring members. According to one embodiment thereof, the heterocycle is unsubstituted, i.e. it does not carry any substituent R ^6b . According to still another embodiment of formula I, it is substituted with R ^6b . According to one specific embodiment thereof, said 6-membered saturated heterocycle contains 1 or 2, in particu- lar 1 , heteroatom(s) O. According to one embodiment thereof, the respective 6-membered heterocycle is unsubstituted, i.e. it does not carry any substituent R ^6b . According to still another embodiment of formula I, it is substituted with R ^6b .

According to a further specific embodiment of formula I, R ⁶ is Ci-C ₆ -alkylheterocycle, especially Chh substituted with a 5-membered saturated heterocycle which contains one N as ring mem- ber and optionally one or two groups CFh are replaced by C(=0).

According to still another embodiment of formula I, R ⁶ is a partially unsaturated three-, four-, five-, six-, seven-, eight-, nine-, or ten-membered carbocycle, in particular three-, four-, five- or six-membered, wherein the carbocycle is unsubstituted or substituted with substituents R ^6b as defined below. According to one embodiment thereof, the carbocycle is unsubstituted.

According to still another embodiment of formula I, R ⁶ is a partially unsaturated three-, four-, five-, six-, seven-, eight-, nine-, or ten-membered carbocycle or heterocycle, in particular three-, four-, five- or six-membered, wherein the heterocycle contains one, two, three or four heteroa- toms selected from N, O and S, and wherein the carbocycle and heterocycle are unsubstituted or substituted with substituents R ^6b as defined below. According to one embodiment thereof, the carbocycle or heterocycle is unsubstituted.

According to still a further embodiment, R ⁶ is a saturated three-, four-, five-, six-, seven-, eight-, nine-, or ten-membered carbocycle or heterocycle, in particular three-, four-, five- or six-mem- bered, wherein the heterocycle contains one, two, three or four heteroatoms selected from N, O and S, and wherein the carbocycle and heterocycle are unsubstituted or substituted with substit- uents R ^6b as defined below. According to one embodiment thereof, the carbocycle or heterocy- cle is unsubstituted.

According to still another embodiment of formula I, R ⁶ is a saturated three-, four-, five-, six-, seven-, eight-, nine-, or ten-membered carbocycle, in particular three-, four-, five- or six-mem- bered, wherein the carbocycle is unsubstituted or substituted with substituents R ^6b as defined below. According to one embodiment thereof, the carbocycle is unsubstituted.

According to one embodiment, R ⁶ is a 3-membered saturated carbocycle. According to one embodiment thereof, the carbocycle is unsubstituted, i.e. it does not carry any substituent R ^6b . According to still another embodiment of formula I, it is substituted with R ^6b .

According to one embodiment, R ⁶ is a 3-membered saturated carbocycle, which is

unsubstituted such as cyclopropyl.

According to one embodiment, R ⁶ is a 3-membered saturated carbocycle, which is substituted with halogen, more specifically by F, such as C ₃ H ₃ F2.

According to one embodiment, R ⁶ is a 3-membered saturated carbocycle, which is substituted with halogen. More specifically by Cl, such as C ₃ H ₃ CI2.

According to one embodiment, R ⁶ is a 4-membered saturated carbocycle. According to one embodiment thereof, the carbocycle is unsubstituted, i.e. it does not carry any substituent R ^6b . According to still another embodiment of formula I, it is substituted with R ^6b .

According to one embodiment, R ⁶ is a 5-membered saturated carbocycle. According to one embodiment thereof, the carbocycle is unsubstituted, i.e. it does not carry any substituent R ^6b . According to still another embodiment of formula I, it is substituted with R ^6b . According to one embodiment, R ⁶ is a 6-membered saturated carbocycle. According to one embodiment thereof, the carbocycle is unsubstituted, i.e. it does not carry any substituent R ^6b . According to still another embodiment of formula I, it is substituted with R ^6b .

According to still another embodiment of formula I, R ⁶ is a partially unsaturated three-, four-, five-, six-, seven-, eight-, nine-, or ten-membered heterocycle, in particular three-, four-, five- or six-membered, wherein the heterocycle contains one, two, three or four heteroatoms selected from N, O and S, and wherein the heterocycle is unsubstituted or substituted with substituents R ^6b as defined below. According to one embodiment thereof, the heterocycle is unsubstituted.

According to still another embodiment of formula I, R ⁶ is a saturated three-, four-, five-, six-, seven-, eight-, nine-, or ten-membered heterocycle, in particular three-, four-, five- or six-mem- bered, wherein the heterocycle contains one, two, three or four heteroatoms selected from N, O and S, and wherein the heterocycle is unsubstituted or substituted with substituents R ^6b as de- fined below. According to one embodiment thereof, the heterocycle is unsubstituted.

According to still another embodiment of formula I, in the embodiments of R ⁶ described above, the heterocycle contains preferably one, two or three, more specifically one or two heteroatoms selected from N, O and S. More specifically, the hetereocycle contains one heteroatom selected from N, O and S. In particular, the heterocycle contains one or two, in particular one O.

According to one embodiment, R ⁶ is a 4-membered saturated heterocycle which contains 1 or 2 heteroatoms, in particular 1 heteroatom, from the group consisting of N, O and S, as ring mem- bers. According to one embodiment, the heterocycle contains one O as heteroatom. For exam- pie, the formed heterocycle is oxetane. According to one embodiment thereof, the heterocycle is unsubstituted, i.e. it does not carry any substituent R ^6b . According to still another embodiment of formula I, it is substituted with R ^6b .

According to still another embodiment of formula I, R ⁶ is a 5-membered saturated heterocycle which contains 1 , 2 or 3, in particular 1 or 2, heteroatoms from the group consisting of N, O and S, as ring members. According to one embodiment, the heterocycle contains one O as heteroa- tom. According to one embodiment thereof, the heterocycle is unsubstituted, i.e. it does not carry any substituent R ^6b . According to still another embodiment of formula I, it is substituted with R ^6b .

According to still another embodiment of formula I, R ⁶ is a 6-membered saturated heterocycle which contains 1 , 2 or 3, in particular 1 or 2, heteroatoms from the group consisting of N, O and S as ring members. According to one embodiment thereof, the heterocycle is unsubstituted, i.e. it does not carry any substituent R ^6b . According to still another embodiment of formula I, it is substituted with R ^6b . According to one specific embodiment thereof, said 6-membered saturated heterocycle contains 1 or 2, in particular 1 , heteroatom(s) O. According to one embodiment thereof, the respective 6-membered heterocycle is unsubstituted, i.e. it does not carry any substituent R ^6b . According to still another embodiment of formula I, it is substituted with R ^6b .

According to still another embodiment of formula I, R ⁶ is phenyl-Ci-C ₆ -alkyl, such as phenyl- CH2, wherein the phenyl moiety in each case is unsubstituted or substituted with one, two or three identical or different groups R ^6b which independently of one another are selected from CN, halogen, Ci-C2-alkyl, CrC2-alkoxy, Ci-C2-halogenalkyl, Ci-C2-halogenalkoxy and S(0) _n -CrC ₆ - alkyl, in particular from CN, F, Cl, Br, CH3, OCH3, CF3, CHF2, OCHF2, OCF3 and S(0) ₂ CH ₃ . According to still another embodiment of formula I, R ⁶ is aryl, in particular phenyl, wherein the aryl or phenyl moiety in each case is unsubstituted or substituted with identical or different groups R ^6b which independently of one another are selected from CN, halogen, Ci-C2-alkyl, Ci- C2-alkoxy, Ci-C2-halogenalkyl, Ci-C2-halogenalkoxy and S(0) _n -Ci-C ₆ -alkyl, in particular from CN, F, Cl, Br, CH3, OCH3, CF3, CHF2, OCHF2, OCF3. According to one embodiment, R ⁶ is un- substituted phenyl. According to another embodiment, R ⁶ is phenyl, that is substituted with one, two or three, in particular one, halogen, in particular selected from F, Cl and Br, more specifi- cally selected from F and Cl.

According to still another embodiment of formula I, R ⁶ is a 5-membered heteroaryl such as pyr- rol-1-yl, pyrrol-2-yl, pyrrol-3-yl, thien-2-yl, thien-3-yl, furan-2-yl, furan-3-yl, pyrazol-1-yl, pyrazol- 3-yl, pyrazol-4-yl, pyrazol-5-yl, imidazol-1-yl, imidazol-2-yl, imidazol-4-yl, imidazol-5-yl, oxazol-2- yl, oxazol-4-yl, oxazol-5-yl, isoxazol-3-yl, isoxazol-4-yl, isoxazol-5-yl, thiazol-2-yl, thiazol-4-yl, thiazol-5-yl, isoth iazol-3-yl , isothiazol-4-yl, isoth iazol-5-y 1 , 1 ,2,4-triazolyl-1-yl, 1 ,2,4-triazol-3-yl 1 ,2,4-triazol-5-yl, 1 ,2,4-oxadiazol-3-yl, 1 ,2,4-oxadiazol-5-yl and 1 ,2,4-thiadiazol-3-yl, 1 ,2,4-thia- diazol-5-yl.

According to still another embodiment of formula I, R ⁶ is a 6-membered heteroaryl, such as pyri- din-2-yl, pyridin-3-yl, pyridin-4-yl, pyridazin-3-yl, pyridazin-4-yl, pyrimidin-2-yl, pyrimidin-4-yl, py- rimidin-5-yl, pyrazin-2-yl and 1 ,3,5-triazin-2-yl and 1 ,2,4-triazin-3-yl.

According to a further specific embodiment of formula I, R ⁶ is Ci-C ₆ -alkyl, especially CH2 subsitited by a 5-membered saturated heteroaryl which contains 1 , 2 or 3, in particular 1 or 2, heteroatoms from the group consisting of N, O and S as ring members. According to one embodiment thereof, the heteroaryl is unsubstituted, i.e. it does not carry any substituent R ^6b . According to still another embodiment of formula I, it is substituted by R ^6b .

According to a further specific embodiment of formula I, R ⁶ is Ci-C ₆ -alkyl, especially CH2 subsitited by a 5-membered saturated heteroaryl which contains one N as ring member.

According to one embodiment thereof, the heteroaryl is unsubstituted, i.e. it does not carry any substituent R ^6b . According to still another embodiment of formula I, it is substituted by R ^6b .

According to a further specific embodiment of formula I, R ⁶ is Ci-C ₆ -alkyl, especially CH2 subsitited by a 5-membered saturated heteroaryl which contains two N as ring members.

According to one embodiment thereof, the heteroaryl is unsubstituted, i.e. it does not carry any substituent R ^6b . According to still another embodiment of formula I, it is substituted by R ^6b .

According to a further specific embodiment of formula I, R ⁶ is Ci-C ₆ -alkyl, especially CH2 subsitited by a 5-membered saturated heteroaryl which contains three N as ring members. According to one embodiment thereof, the heteroaryl is unsubstituted, i.e. it does not carry any substituent R ^6b . According to still another embodiment of formula I, it is substituted by R ^6b .

According to one specific embodiment thereof, said 5-membered saturated heterocycle contains 1 or 2, in particular 1 , heteroatom(s) O.

According to a further specific embodiment of formula I, R ⁶ is Ci-C ₆ -alkyl, especially CH ₂ subsitited by a 5-membered saturated heteroaryl which contains one S as ring member.

According to one embodiment thereof, the heteroaryl is unsubstituted, i.e. it does not carry any substituent R ^6b . According to still another embodiment of formula I, it is substituted by R ^6b .

According to a further specific embodiment of formula I, R ⁶ is Ci-C ₆ -alkyl, especially CH2 subsitited by a 5-membered saturated heteroaryl which contains one S and one N as ring mem- bers. According to one embodiment thereof, the heteroaryl is unsubstituted, i.e. it does not carry any substituent R ^6b . According to still another embodiment of formula I, it is substituted by R ^6b .

According to a further specific embodiment of formula I, R ⁶ is Ci-C ₆ -alkyl, especially CH ₂ subsitited by a 5-membered saturated heteroaryl which contains one S and two N as ring mem- bers. According to one embodiment thereof, the heteroaryl is unsubstituted, i.e. it does not carry any substituent R ^6b . According to still another embodiment of formula I, it is substituted by R ^6b .

According to a further specific embodiment of formula I, R ⁶ is Ci-C ₆ -alkyl, especially CH ₂ subsitited by a 5-membered saturated heteroaryl which contains one oxygen and one N as ring members. According to one embodiment thereof, the heteroaryl is unsubstituted, i.e. it does not carry any substituent R ^6b . According to still another embodiment of formula I, it is substituted by R ^6b .

According to a further specific embodiment of formula I, R ⁶ is Ci-C ₆ -alkyl, especially CH ₂ subsitited by a 5-membered saturated heteroaryl which contains one oxygen and two N as ring members. According to one embodiment thereof, the heteroaryl is unsubstituted, i.e. it does not carry any substituent R ^6b . According to still another embodiment of formula I, it is substituted by R ^6b .

According to a further specific embodiment of formula I, R ⁶ is Ci-C ₆ -alkyl, especially CH ₂ subsitited by a 6-membered saturated heteroaryl which contains 1 , 2 or 3, in particular 1 or 2, heteroatoms from the group consisting of N, O and S as ring members. According to one embodiment thereof, the heteroaryl is unsubstituted, i.e. it does not carry any substituent R ^6b . According to still another embodiment of formula I, it is substituted by R ^6b .

According to a further specific embodiment of formula I, R ⁶ is Ci-C ₆ -alkyl, especially CH ₂ subsitited by a 6-membered saturated heteroaryl which one N as ring member. According to one embodiment thereof, the heteroaryl is unsubstituted, i.e. it does not carry any substituent R ^6b . According to still another embodiment of formula I, it is substituted by R ^6b .

According to a further specific embodiment of formula I, R ⁶ is Ci-C ₆ -alkyl, especially CH ₂ subsitited by a 6-membered saturated heteroaryl which two N as ring members. According to one embodiment thereof, the heteroaryl is unsubstituted, i.e. it does not carry any substituent R ^6b . According to still another embodiment of formula I, it is substituted by R ^6b .

According to a further specific embodiment of formula I, R ⁶ is Ci-C ₆ -alkyl, especially CH ₂ subsitited by a 10-membered saturated heteroaryl which contains 1 , 2 or 3, in particular 1 or 2, heteroatoms from the group consisting of N, O and S as ring members. According to one embodiment thereof, the heteroaryl is unsubstituted, i.e. it does not carry any substituent R ^6b . According to still another embodiment of formula I, it is substituted by R ^6b . According to one specific embodiment thereof, said 10-membered saturated heterocycle contains 1 or 2, in partic- ular 1 , heteroatom(s) N.

According to a further specific embodiment of formula I, R ⁶ is Ci-C ₆ -alkyl, especially CH ₂ subsitited by a 10-membered saturated heteroaryl which one N as ring members. According to one embodiment thereof, the heteroaryl is unsubstituted, i.e. it does not carry any substituent R ^6b . According to still another embodiment of formula I, it is substituted by R ^6b . According to still another embodiment of formula I, R ⁶ is Chh substituted by a 5-membered heteroaryl such as pyrrol-1 -yl, pyrrol-2-yl, pyrrol-3-yl, thien-2-yl, thien-3-yl, furan-2-yl, furan-3-yl, pyrazol-1-yl, pyrazol-3-yl, pyrazol-4-yl, pyrazol-5-yl, imidazol-1-yl, imidazol-2-yl, imidazol-4-yl, imidazol-5-yl, oxazol-2-yl, oxazol-4-yl, oxazol-5-yl, isoxazol-3-yl, isoxazol-4-yl, isoxazol-5-yl, thiazol-2-yl, thiazol-4-yl, thiazol-5-yl, isothiazol-3-yl, isothiazol-4-yl, isoth iazol-5-yl , 1 ,2,4-triazolyl- 1 -yl, 1 ,2,4-triazol-3-yl 1 ,2,4-triazol-5-yl, 1 ,2,4-oxadiazol-3-yl, 1 ,2,4-oxadiazol-5-yl and 1 ,2,4- thiadiazol-3-yl, 1 ,2,4-thiadiazol-5-yl.

According to still another embodiment of formula I, R ⁶ is CH ₂ substituted by a 6-membered het- eroaryl, such as pyridin-2-yl, pyridin-3-yl, pyridin-4-yl, pyridazin-3-yl, pyridazin-4-yl, pyrimidin-2- yl, pyrimidin-4-yl, pyrimidin-5-yl, pyrazin-2-yl and 1 ,3,5-triazin-2-yl and 1 ,2,4-triazin-3-yl.

According to a further particular embodiment, R ⁶ is selected from Ci-C ₆ -alkyl, Ci-C ₆ -halogen- alkyl, CN, C2-C6-alkenyl, C2-C6-halogenalkenyl, C3-C6-cycloalkenyl, C2-C6-alkynyl, C2-C6-halo- genalkynyl, Ci-C ₆ -alkoxy, C3-C6-cycloalkynyl, C(=0)Ci-C ₆ -alkyl, C(=0)0(Ci-C ₆ -alkyl),

CR’=NOR”, C3-C6-halogencycloalkyl a saturated three-, four-, five-, six-, membered carbocycle or heterocycle, a five- or six-membered heteroaryl or aryl;, and Ci-C ₆ -alkyl substituted by CN, CrC ₆ -alkoxy, Ci-C ₄ -halogenalkoxy, Ci-C ₆ -alkylthio, S(0) _n -Ci-C ₆ -alkyl, NH-SO2-RX, NH(C _I -C ₆ - alkyl), N(Ci-C ₆ -alkyl) ₂ , C(=0)Ci-C ₆ -alkyl, C(=0)0(Ci-C ₆ -alkyl), a saturated three-, four-, five-, six-, membered carbocycle, heterocycle, aryl or heteroaryl; wherein the carbocycle, heterocycle, aryl and heteroaryl is unsubstituted or carries one, two, three or four substituents R ^6b as defined below. According to one embodiment thereof, the carbocycle, heterocycle, heteroaryl and aryl are unsubstituted. In a particular embodiment, R ⁶ is selected from CN, Ci-C ₆ -alkyl, Ci-C ₆ -halo- genalkyl, C2-C6-alkenyl, C2-C6-halogenalkenyl, C2-C6-alkynyl, C2-C6-halogenalkynyl, C1-C6- alkoxy, a saturated three-, four-, five-, six-, membered carbocycle or heterocycle, a five- or six- membered heteroaryl or aryl; and Ci-C ₆ -alkyl substituted by a saturated three-, four-, five-, six-, membered carbocycle, heterocycle, aryl or heteroaryl; wherein the carbocycle, heterocacle, aryl and heteroaryl are unsubstituted or carries one, two, three or four substituents R ^6b as defined below.

According to a further particular embodiment, R ⁶ is selected from Ci-C ₆ -halogenalkyl, CN, C2- C ₆ -alkenyl, C2-C6-halogenalkenyl, C3-C6-cycloalkenyl, C2-C6-alkynyl, C2-C6-halogenalkynyl, C1- C ₆ -alkoxy, C3-C6-cycloalkynyl, C(=0)Ci-C ₆ -alkyl, C(=0)0(Ci-C ₆ -alkyl), CR’=NOR”, C3-C6- halogencycloalkyl a saturated three-, four-, five-, six-, membered carbocycle or heterocycle, a five- or six-membered heteroaryl or aryl;, and Ci-C ₆ -alkyl substituted by CN, CrC ₆ -alkoxy, Cr C ₄ -halogenalkoxy, Ci-Ce-alkylthio, S(0) _n -Ci-C ₆ -alkyl, NH-SO2-RX, NH(Ci-C ₆ -alkyl), N(CrC ₆ -al- kyl)2, C(=0)Ci-C ₆ -alkyl, C(=0)0(Ci-C ₆ -alkyl), a saturated three-, four-, five-, six-, membered carbocycle, heterocycle, aryl or heteroaryl; wherein the carbocycle, heterocycle, aryl and het- eroaryl is unsubstituted or carries one, two, three or four substituents R ^6b as defined below. Ac- cording to one embodiment thereof, the carbocycle, heterocycle, heteroaryl and aryl are unsub- stituted. In a particular embodiment, R ⁶ is selected from CN, Ci-C ₆ -alkyl, Ci-C ₆ -halogenalkyl, C2-C6-alkenyl, C2-C6-halogenalkenyl, C2-C6-alkynyl, C2-C6-halogenalkynyl, Ci-C ₆ -alkoxy, a satu- rated three-, four-, five-, six-, membered carbocycle or heterocycle, a five- or six-membered het- eroaryl or aryl; and Ci-C ₆ -alkyl substituted by a saturated three-, four-, five-, six-, membered carbocycle, heterocycle, aryl or heteroaryl; wherein the carbocycle, heterocacle, aryl and het- eroaryl are unsubstituted or carries one, two, three or four substituents R ^6b as defined below. Particularly preferred embodiments of R ⁶ according to the invention are in Table P6 below, wherein each line of lines P6-1 to P6-209 corresponds to one particular embodiment of the in- vention, wherein P6-1 to P6-209 are also in any combination with one another a preferred em- bodiment of the present invention. The connection point to the carbon atom, to which R ⁶ is bound is marked with“#” in the drawings.

Table P6 (py = pyridyl):

R ⁷ is independently selected from halogen, OH, CN, N0 ₂ , SH, Ci-Ce-alkylthio, NH _2, NH(CI-C ₄ - alkyl), N(Ci-C ₄ -alkyl) ₂ , NH-S0 ₂ -R ^x , Ci-C ₆ -alkyl, Ci-C ₆ -halogenalkyl, C ₂ -C ₆ -alkenyl, C ₂ -C ₆ -halo- genalkenyl, C ₂ -C ₆ -alkynyl, C ₂ -C ₆ -halogenalkynyl, Ci-C ₆ -alkoxy, Ci-C ₆ -halogenalkoxy, 0 ₂ -O _Q - alkenyloxy, C ₂ -C ₆ -alkynyloxy, aryloxy, heteroaryloxy, arylamino, heteroarylamino, arylthio, het- eroarylthio, CH(=0), C(=0)Ci-C ₆ -alkyl, C(=0)0(Ci-C ₆ -alkyl), C(=0)NH(Ci-C ₆ -alkyl), C(=0)N(Cr C ₆ -alkyl) ₂ , CR’=NOR”, a saturated or partially unsaturated three-, four-, five-, six-, seven-, eight- , nine-, or ten-membered carbocycle or heterocycle, a five- or six-membered heteroaryl or aryl; wherein in each case one or two CH ₂ groups of the carbo- and heterocycle may be replaced by a group independently selected from C(=0) and C(=S), and wherein the heterocycle and het- eroaryl contain independently one, two, three or four heteroatoms selected from N, O and S; and wherein R’ and R” are independently selected from H, Ci-C ₄ -alkyl, C ₂ -C ₆ -alkenyl, C ₂ -C ₆ -al- kynyl, saturated or partially unsaturated three-, four-, five-, six-, seven-, eight-, nine-, or ten- membered carbo- and heterocycle, five- or six-membered heteroaryl or aryl; wherein the hetero- cycle or heteroaryl contains one, two or three heteroatoms selected from N, O and S, and wherein R’ and R” are independently unsubstituted or substituted with R’” which is inde- pendently selected from halogen, OH, CN, N0 ₂ , SH, NH _2, NH(Ci-C ₄ -alkyl), N(Ci-C ₄ -alkyl) ₂ , NH- S0 ₂ -R ^x , CrC ₆ -alkyl, Ci-C ₆ -halogenalkyl, C ₂ -C ₆ -alkenyl, C ₂ -C ₆ -halogenalkenyl, C ₂ -C ₆ -alkynyl, C ₂ - C ₆ -halogenalkynyl, Ci-C ₆ -alkoxy, Ci-C ₆ -halogenalkoxy, C3-C6-cycloalkyl, C3-C6-halogencycloal- kyl and phenyl;

wherein R ^x is as defined above;

wherein the acyclic moieties of R ⁷ are independently not further substituted or carry one, two, three or up to the maximum possible number of identical or different groups R ^7a , which inde- pendently of one another are selected from:

R ^7a halogen, OH, CN, N0 ₂ , SH, NH ₂ , NH(Ci-C ₄ -alkyl), N(Ci-C ₄ -alkyl) ₂ , NH(C(=0)Ci-C ₄ -aikyl), N(C(=0)Ci-C ₄ -aikyl) ₂ , NH-S0 ₂ -R ^x , CrC ₆ -alkoxy, CrC4-halogenalkoxy, C3-C6-cycloalkyl, C3-C6- halogencycloalkyl, Ci-C ₆ -alkylthio, Ci-C ₆ -halogenalkylthio, S(0) _n -Ci-C ₆ -alkyl, S(0) _n -aryl,

CH(=0), C(=0)Ci-C ₆ -alkyl, C(=0)0(Ci-C ₆ -aikyl), C(=0)NH(Ci-C ₆ -aikyl), C(=0)N(Ci-C ₆ -aikyl) ₂ , CR’=NOR”, a saturated or partially unsaturated three-, four-, five-, six-, seven-, eight-, nine-, or ten-membered carbo- or heterocycle, a five-, six- or ten-membered heteroaryl, aryl or phenoxy, wherein in each case one or two CH ₂ groups of the carbo- and heterocycle may be replaced by a group independently selected from C(=0) and C(=S), and wherein the heterocycle and het- eroaryl contains independently one, two, three or four heteroatoms selected from N, O and S; wherein the carbo-, heterocyclic, heteroaryl and phenyl groups are independently unsubstituted or carry one, two, three, four or five substituents selected from the group consisting of halogen, OH, CN, N0 ₂ , SH, NH ₂ , NH(Ci-C ₄ -alkyl), N(Ci-C ₄ -alkyl) ₂ , NH(C(=0)Ci-C ₄ -aikyl), N(C(=0)Ci-C ₄ - alkyl) ₂ , NH-S0 ₂ -R ^x , Ci-C ₆ -alkylthio, Ci-C ₄ -alkyl, Ci-C ₄ -halogenalkyl, Ci-C ₄ -alkoxy, Ci-C ₄ -halo- genalkoxy, and S(0)n-Ci-C ₆ -alkyl; and wherein R ^x , R’ and R” are as defined above; n is 0, 1 , 2; and

wherein the carbo-, heterocyclic, heteroaryl and aryl moieties of R ⁷ are independently unsubsti- tuted or substituted with identical or different groups R ^7b , which independently of one another are selected from:

R ^7b halogen, OH, CN, N0 ₂ , SH, NH _2, NH(Ci-C ₄ -alkyl), N(Ci-C ₄ -alkyl) ₂ , NH(C(=0)Ci-C ₄ -alkyl), N(C(=0)Ci-C ₄ -alkyl) ₂ , NH-SC>2-R ^X , CrC4-alkyl, Ci-C ₄ -alkoxy, Ci-C4-halogenalkyl, C ₃ -C ₆ -cycloal- kyl, C3-C6- alogencycloalkyl, Ci-C4-halogenalkoxy, Ci-C ₆ -alkylthio, Ci-C ₆ -halogenalkylthio, S(0) _n -Ci-C ₆ -alkyl, Ci-C4-alkoxy-Ci-C4-alkyl, phenyl and phenoxy, wherein the phenyl groups are unsubstituted or carry one, two, three, four or five substituents selected from the group consist- ing of halogen, OH, Ci-C4-alkyl, Ci-C4-halogenalkyl, Ci-C4-alkoxy and Ci-C4-halogenalkoxy; and wherein R ^x and n are as defined above.

According to one embodiment of formula I, R ⁷ is independently selected from halogen, OH, CN, N0 ₂ , SH, Ci-Ce-alkylthio, NH _2, NH(Ci-C ₄ -alkyl), N(Ci-C ₄ -alkyl) ₂ , NH-S0 ₂ -R ^x , substituted C C ₆ - alkyl, CrC ₆ -halogenalkyl, C ₂ -C ₆ -alkenyl, C ₂ -C ₆ -halogenalkenyl, C ₂ -C ₆ -alkynyl, C ₂ -C ₆ -halogen- alkynyl, Ci-C ₆ -alkoxy, Ci-C ₆ -halogenalkoxy, C ₂ -C ₆ -alkenyloxy, C ₂ -C ₆ -alkynyloxy, CH(=0), C(=0)Ci-C ₆ -aikyl, C(=0)0(Ci-C ₆ -aikyl), C(=0)NH(Ci-C ₆ -aikyl), C(=0)N(Ci-C ₆ -aikyl) ₂ ,

CR’=NOR”, a saturated or partially unsaturated three-, four-, five-, six-, seven-, eight-, nine-, or ten-membered carbocycle or heterocycle, a five- or six-membered heteroaryl or aryl; wherein in each case one or two CH ₂ groups of the carbo- and heterocycle may be replaced by a group in- dependently selected from C(=0) and C(=S), and wherein the heterocycle and the heteroaryl contain independently one, two, three or four heteroatoms selected from N, O and S; and wherein R’ and R” are independently selected from H, Ci-C4-alkyl, C ₂ -C ₆ -alkenyl, C ₂ -C ₆ -alkynyl, saturated or partially unsaturated three-, four-, five-, six-, seven-, eight-, nine-, or ten-membered carbo- and heterocycle, five- or six-membered heteroaryl or aryl; wherein the heterocycle or het- eroaryl contains one, two or three heteroatoms selected from N, O and S, and wherein R’ and R” are independently unsubstituted or substituted by R’” which is independently selected from halogen, OH, CN, N0 ₂ , SH, NH _2, NH(Ci-C ₄ -alkyl), N(Ci-C ₄ -alkyl) ₂ , NH-S0 ₂ -R ^x , Ci-C ₆ -alkyl, Ci- C ₆ -halogenalkyl, C ₂ -C ₆ -alkenyl, C ₂ -C ₆ -halogenalkenyl, C ₂ -C ₆ -alkynyl, C ₂ -C ₆ -halogenalkynyl, Ci- C ₆ -alkoxy, Ci-C ₆ -halogenalkoxy, C3-C6-cycloalkyl, C3-C6-halogencycloalkyl and phenyl; or wherein the aliphatic moieties of R ⁷ are independently not further substituted or carry 1 , 2, 3 or up to the maximum possible number of identical or different groups R ^7a , respectively, which in- dependently of one another are selected from:

R ^7a halogen, OH, CN, N0 ₂ , SH, NH ₂ , NH(Ci-C ₄ -alkyl), N(Ci-C ₄ -alkyl) ₂ , NH-aryl, N(aryl) ₂ ,

NH(C(=0)Ci-C ₄ -alkyl), N(C(=0)Ci-C ₄ -alkyl) ₂ , Ci-C ₆ -alkoxy, C3-C6-halogencycloalkyl, Ci- C4-halogenalkoxy, Ci-Ce-alkylthio, Ci-C ₆ -halogenalkylthio, S(0) _n -Ci-C ₆ -alkyl, S(0) _n -aryl, CH(=0), C(=0)Ci-C ₆ -aikyl, C(=0)0(Ci-C ₆ -aikyl), C(=0)NH(Ci-C ₆ -aikyl), C(=0)N(Ci-C ₆ - alkyl) ₂ , CR’=NOR”, a saturated or partially unsaturated three-, four-, five-, six-, seven-, eight-, nine-, or ten-membered carbocycle or heterocycle, aryl, phenoxy, a five-, six- or ten-membered heteroaryl; wherein in each case one or two CH ₂ groups of the carbo- and heterocycle may be replaced by a group independently selected from C(=0) and C(=S), five- or six-membered heteroaryl and aryl; wherein the heterocycle and the heteroaryl con- tain independently 1 , 2, 3 or 4 heteroatoms selected from N, O and S; wherein in each case one or two CH ₂ groups of the carbo- and heterocycle may be replaced by a group independently selected from C(=0) and C(=S); wherein the carbocyclic, heterocyclic, aryl and phenyl groups are independently unsubstituted or carry one, two, three, four or five substituents selected from the group consisting of halogen, OH, CN, N0 ₂ , SH, NH ₂ , NH(Ci-C ₄ -alkyl), N(Ci-C ₄ -alkyl) ₂ , NH(C(=0)Ci-C ₄ -aikyl), N(C(=0)Ci-C ₄ -aikyl) ₂ , NH-S0 ₂ -R ^x , Ci-C ₆ -alkylthio, Ci-C4-alkyl, Ci-C4-halogenalkyl, Ci-C4-alkoxy, Ci-C4-halogenalkoxy, and S(0) _n -Ci-C ₆ -alkyl; and wherein R ^x , R’, R” and R” are as defined above wherein the carbocyclic, heterocyclic, heteroaryl and aryl moieties of R ⁷ are independently not further substituted or carry 1 , 2, 3, 4, 5 or up to the maximum number of identical or different groups R ^7b , respectively, which independently of one another are selected from:

R ^7b halogen, OH, CN, N0 ₂ , SH, NH _2, NH(Ci-C ₄ -alkyl), N(Ci-C ₄ -alkyl) ₂ , NH(C(=0)Ci-C ₄ -aikyl), N(C(=0)Ci-C ₄ -aikyl) ₂ , NH-S0 ₂ -R ^x , Ci-C ₄ -alkyl, Ci-C4-alkoxy, Ci-C ₄ -halogenalkyl, C3-C6- cycloalkyl, C3-C6-halogencycloalkyl, Ci-C4-halogenalkoxy, Ci-C ₆ -alkylthio, Ci-C ₆ -halogen- alkylthio, S(0) _n -Ci-C ₆ -alkyl, Ci-C4-alkoxy-Ci-C4-alkyl, phenyl and phenoxy, wherein the phenyl groups are unsubstituted or substituted with substituents selected from the group consisting of halogen, OH, Ci-C4-alkyl, CrC4-halogenalkyl, CrC4-alkoxy and Ci-C4-halo- genalkoxy.

According to one embodiment of formula I, R ⁷ is selected from substituted Ci-C ₆ -alkyl, O-I-OQ- halogenalkyl, C ₂ -C ₆ -halogenalkyl, C ₂ -C ₆ -alkenyl, C ₂ -C ₆ -halogenalkenyl, C3-C6-cycloalkenyl, C ₂ - C ₆ -alkynyl, C ₂ -C ₆ -halogenalkynyl, C3-C6-cycloalkynyl, Ci-C ₆ -alkoxy, aryloxy, heteroaryloxy, ar- ylamino, heteroarylamino, arylthio, heteroarylthio, CN, CH(=0), C(=0)C ₂ -C ₆ -alkyl, C(=0)0(C ₂ - C ₆ -alkyl), CR’=NOR”, C3-C6-cycloalkyl, C3-C6-halogencycloalkyl, Ci-C ₆ -alkyl-five- and six-mem- bered heteroaryl ,a five- or six-membered heteroaryl, benzyl, aryl; wherein R’ and R” are de- fined below; and wherein the acyclic moieties of R ⁷ are unsubstituted or substituted with identi cal or different groups R ^7a as defined below and wherein wherein the carbocycle, heterocycle and heteroaryl and aryl moieties are unsubstituted or substituted with substituents R ^7b as de- fined below.

According to one embodiment of formula I, R ⁷ is selected from Ci-C ₆ -alkyl substituted with halo- gen, CN, Ci-C ₆ -alkoxy, aryloxy, arylamino, arylthio, Ci-C4-halogenalkoxy, Ci-C ₆ -alkylthio, S(0) _n - CrCe-alkyl, NH-S0 ₂ -R ^x , N(Ci-C ₆ -alkyl) ₂ , NH-S0 ₂ -R ^x , NH(Ci-C ₆ -alkyl), N(Ci-C ₆ -alkyl) ₂ , CH(=0), C(=0)Ci-C ₆ -alkyl, C(=0)0(Ci-C ₆ -alkyl), a saturated three-, four-, five-, six-, membered carbo- or heterocycle, aryl, a five- or six-membered heteroaryl; wherein R ^x is defined below; and wherein the acyclic moieties of R ⁷ are unsubstituted or substituted with identical or different groups R ^7a as defined below and wherein wherein the carbocycle, heterocycle and heteroaryl and aryl moi- eties are unsubstituted or substituted with substituents R ^7b as defined below.

According to another embodiment of formula I, R ⁷ is F.

According to another embodiment of formula I, R ⁷ is Cl.

According to another embodiment of formula I, R ⁷ is Br.

According to still another embodiment of formula I, R ⁷ is OH.

According to still another embodiment of formula I, R ⁷ is CN.

According to still another embodiment of formula I, R ⁷ is N0 ₂ .

According to still another embodiment of formula I, R ⁷ is SH.

According to still another embodiment of formula I, R ⁷ is Ci-C ₆ -alkylthio, such as SCH3, SC ₂ Hs,

S-n-propyl, S-i-propyl, S-n-butyl, S-i-butyl, S-tert-butyl, S-n-pentyl, S-i-pentyl, CH ₂ SCH ₃ or CH ₂ SCH ₂ CH ₃ .

According to still another embodiment of formula I, R ⁷ is Ci-C ₆ -halogenalkylthio, such as SCF ₃ , SCCI ₃ , CH ₂ SCF ₃ or CH ₂ SCF ₃ . According to still another embodiment of formula I, R ⁷ is selected from CN, substituted C1-C ₆ - alkyl, Ci-C ₆ -halogenalkyl or Ci-C ₆ -alkyl which is substituted, Ci-C ₆ -halogenalkyl, phenyl, halogenphenyl and three-, four-, five- or six-membered carbo- and heterocycle, wherein the carbo- and heterocycle is unsubstituted or is substituted with substituents R ^7b as defined below. According to one embodiment thereof, the carbocycle is unsubstituted. In a particular embodi- ment, R ⁷ is selected from Ci-C ₆ -halogenalkyl, phenyl-Chh, halogenphenyl-Chh, phenyl, halogenphenyl and three-, four-, five- or six-membered carbo- and heterocycle, wherein the carbo- and heterocycle is unsubstituted or is substituted with substituents R ^7b as defined below.

According to still another embodiment of formula I, R ⁷ is selected from CN, substituted C1-C ₆ - alkyl, Ci-C ₆ -halogenalkyl or Ci-C ₆ -alkyl which is substituted, Ci-C ₆ -halogenalkyl, phenyl, halogenphenyl, aryloxy, heteroaryloxy, arylamino, heteroarylamino, arylthio, heteroarylthio and three-, four-, five- or six-membered carbo- and heterocycle, wherein the carbo- and heterocycle is unsubstituted or substituted bysubstituents R ^7b as defined below. According to one embodi- ment thereof, the carbo- and heterocycle is unsubstituted. In a particular embodiment, R ⁷ is se- lected from substituted Ci-C ₆ -halogenalkyl, phenyl, halogenphenyl and three-, four-, five- or six- membered carbo- and heterocycle, wherein the carbo- and heterocycle is unsubstituted or sub- stituted bysubstituents R ^7b as defined below.

According to another embodiment of formula I, R ⁷ is selected from CN, substituted Ci-C ₆ -alkyl, Ci-C ₆ -halogenalkyl, C2-C6-alkenyl, C2-C6-halogenalkenyl, C2-C6-alkynyl, C2-C6-halogenalkynyl, C3-C6-cycloalkyl, C3-C6-halogencycloalkyl, Ci-C ₆ -alkylaryl, aryloxy, arylamino, arylthio, five- or six-membered heteroaryl or aryl which is unsubstituted or substituted with halogen or Ci-C ₆ -hal- ogenalkyl, and wherein the acyclic moieties of R ⁷ are unsubstituted or substituted with identical or different groups R ^7a as defined below and wherein wherein the carbocycle, heterocycle and heteroaryl and aryl moieties are unsubstituted or substituted with substituents R ^7b as defined be- low.

According to still another embodiment of formula I, R ⁷ is selected from CN, substituted C1-C6- alkyl, Ci-C ₆ -halogenalkyl, CN, C2-C6-alkenyl, C2-C6-halogenalkenyl, C2-C6-alkynyl, C2-C6-halo- genalkynyl, C3-C6-cycloalkyl, C3-C6-halogencycloalkyl, Ci-C ₆ -alkylaryl, phenyl, pyridine, pyrimi- dine, thiophene, imidazole, triazol, oxadiazol wherein the acyclic moieties of R ⁷ are unsubsti- tuted or substituted with identical or different groups R ^7a as defined below and wherein wherein the carbocycle, heterocycle and heteroaryl and aryl moieties are unsubstituted or substituted with substituents R ^7b as defined below.

According to still another embodiment of formula I, R ⁷ is Ci-C ₆ -alkyl such as CH ₃ , C2H5, n-pro- pyl, i-propyl, n-butyl, i-butyl, tert-butyl, n-pentyl or i-pentyl.

According to still another embodiment of formula I, R ⁷ is Ci-C ₆ -alkyl such as CH ₃ .

According to still another embodiment of formula I, R ⁷ is Ci-C ₆ -alkyl such as C2H5.

According to still another embodiment of formula I, R ⁷ is Ci-C ₆ -alkyl such as CH ₃ , C2H5, n-pro- pyl, i-propyl, n-butyl, i-butyl, tert-butyl, n-pentyl or i-pentyl which is substituted with at least one group R ^7a , which independently of one another are selected from:

R ^7a halogen, OH, CN, N0 ₂ , SH, NH ₂ , NH(C C ₄ -alkyl), N(Ci-C ₄ -alkyl) ₂ , NH(C(=0)C C ₄ -aikyl), N(C(=0)Ci-C ₄ -alkyl)2, NH-S02-R ^X , Ci-C6-alkoxy, Ci-C ₄ -halogenalkoxy, Ci-Ce-alkylthio, C1-C6- halogenalkylthio, S(0) _n -Ci-C ₆ -alkyl, S(0) _n -aryl, CH(=0), C(=0)Ci-C ₆ -alkyl, C(=0)0(Ci-C ₆ -alkyl), C(=0)NH(CrC ₆ -alkyl), C(=0)N(Ci-C ₆ -alkyl) ₂ , CR -NOR” a saturated or partially unsaturated three-, four-, five-, six-, seven-, eight-, nine-, or ten-membered carbocycle or heterocycle, five-, six- or ten-membered heteroaryl, aryl or phenoxy, wherein in each case one or two CH ₂ groups of the carbo- and heterocycle may be replaced by a group independently selected from C(=0) and C(=S), and wherein the heterocycle and heteroaryl contains independently one, two, three or four heteroatoms selected from N, O and S; wherein the carbocyclic, heterocyclic, heteroaryl, aryl groups are independently unsubstituted or carry one, two, three, four or five substituents selected from the group consisting of halogen, OH, CN, N0 ₂ , SH, NH ₂ , NH(Ci-C4-alkyl), N(Ci- C ₄ -alkyl) ₂ , NH(C(=0)C _r C ₄ -alkyl), N(C(=0)C _r C ₄ -alkyl) ₂ , NH-S0 ₂ -R ^x , C C ₆ -alkylthio, C C ₄ -alkyl, Ci-C ₄ -halogenalkyl, Ci-C ₄ -alkoxy, Ci-C ₄ -halogenalkoxy, and S(0)n-Ci-C ₆ -alkyl.

According to still another embodiment of formula I, R ⁷ is CH3 is substituted with at least one group R ^7a , which independently of one another are selected from:

R ^7a halogen, OH, CN, N0 ₂ , SH, NH ₂ , NH(Ci-C ₄ -alkyl), N(Ci-C ₄ -alkyl) ₂ , NH-aryl, N(aryl) ₂ , NH(C(=0)Ci-C ₄ -aikyl), N(C(=0)Ci-C ₄ -aikyl) ₂ , NH-S0 ₂ -R ^x , Ci-C ₆ -alkoxy, Ci-C ₄ -halogenalkoxy, Ci-C ₆ -alkylthio, Ci-C ₆ -halogenalkylthio, S(0) _n -Ci-C ₆ -alkyl, S(0) _n -aryl, CH(=0), C(=0)Ci-C ₆ -al- kyl, C(=0)0(Ci-C ₆ -aikyl), C(=0)NH(C C ₆ -alkyl), C(=0)N(Ci-C ₆ -aikyl) ₂ , CR’=NOR”, a saturated or partially unsaturated three-, four-, five-, six-, seven-, eight-, nine-, or ten-membered carbocy- cle or heterocycle, five-, six- or ten-membered heteroaryl, an aryl or phenoxy, wherein in each case one or two CH ₂ groups of the carbo- and heterocycle may be replaced by a group inde- pendently selected from C(=0) and C(=S), and wherein the heterocycle and heteroaryl contains independently one, two, three or four heteroatoms selected from N, O and S; wherein the carbo- cyclic, heterocyclic, heteroaryl, heteroaryl and phenyl groups are independently unsubstituted or carry one, two, three, four or five substituents selected from the group consisting of halogen,

OH, CN, N0 ₂ , SH, NH ₂ , NH(Ci-C ₄ -alkyl), N(Ci-C ₄ -alkyl) ₂ , NH(C(=0)Ci-C ₄ -aikyl), N(C(=0)Ci-C ₄ - alkyl) ₂ , NH-S0 ₂ -R ^x , Ci-Ce-alkylthio, Ci-C ₄ -alkyl, Ci-C ₄ -halogenalkyl, CrC ₄ -alkoxy, CrC ₄ -halo- genalkoxy, and S(0)n-Ci-C ₆ -alkyl.

According to still another embodiment of formula I, R ⁷ is C ₂ Hs is substituted with at least one group R ^7a , which independently of one another are selected from:

R ^7a halogen, OH, CN, N0 ₂ , SH, NH ₂ , NH(Ci-C ₄ -alkyl), N(Ci-C ₄ -alkyl) ₂ , NH-aryl, N(aryl) ₂ , NH(C(=0)Ci-C ₄ -aikyl), N(C(=0)Ci-C ₄ -aikyl) ₂ , NH-S0 ₂ -R ^x , Ci-C ₆ -alkoxy, Ci-C ₄ -halogenalkoxy, Ci-C ₆ -alkylthio, Ci-C ₆ -halogenalkylthio, S(0) _n -Ci-C ₆ -alkyl, S(0) _n -aryl, CH(=0), C(=0)Ci-C ₆ -al- kyl, C(=0)0(Ci-C ₆ -aikyl), C(=0)NH(Ci-C ₆ -aikyl), C(=0)N(Ci-C ₆ -aikyl) _2, CR’=NOR”a saturated or partially unsaturated three-, four-, five-, six-, seven-, eight-, nine-, or ten-membered carbocy- cle or heterocycle, five-, six- or ten-membered heteroaryl, phenyl or phenoxy; wherein in each case one or two CH ₂ groups of the carbo- and heterocycle may be replaced by a group inde- pendently selected from C(=0) and C(=S), and wherein the heterocycle and heteroaryl contains independently one, two, three or four heteroatoms selected from N, O and S; wherein the carbo- cyclic, heterocyclic, heteroaryl, aryl and phenyl groups are independently unsubstituted or carry one, two, three, four or five substituents selected from the group consisting of halogen, OH, CN, N0 ₂ , SH, NH ₂ , NH(Ci-C ₄ -alkyl), N(C C ₄ -alkyl) ₂ , NH(C(=0)C C ₄ -alkyl), N(C(=0)C _r C ₄ -alkyl) ₂ , NH-S0 ₂ -R ^x , Ci-C ₆ -alkylthio, Ci-C ₄ -alkyl, Ci-C ₄ -halogenalkyl, CrC ₄ -alkoxy, Ci-C ₄ -halogenalkoxy, and S(0)n-Ci-C ₆ -alkyl.

According to still another embodiment of formula I, R ⁷ is CH ₂ CN. According to still another embodiment of formula I, R ⁷ is CH ₂ OH.

According to still another embodiment of formula I, R ⁷ is Ci-C6-halogenalkyl, in particular C ₁ -C ₄ - halogenalkyl, more specifically Ci-C ₂ -halogenalkyl, such as CF ₃ , CCI ₃ , FCH ₂ , CICH ₂ , F ₂ CH, CI2CH, CF3CH2, CCI3CH2 or CF2CHF2.

According to still another embodiment of formula I, R ⁷ is CH ₂ F.

According to still another embodiment of formula I, R ⁷ is CHF ₂ .

According to still another embodiment of formula I, R ⁷ is CF ₃ .

According to still a further embodiment of formula I, R ⁷ is C ₂ -C ₆ -alkenyl, in particular C ₂ -C ₄ -alk- enyl, such as CH=CH ₂ , CH ₂ CH=CH ₂ or C(CH ₃ )C=CH ₂ .

According to a further specific embodiment of formula I, R ⁷ is C ₂ -C ₆ -halogenalkenyl, in particular C ₂ -C ₄ -halogenalkenyl, more specifically C ₂ -C ₃ -halogenalkenyl such as CH=CHF, CH=CHCI,

According to still a further embodiment of formula I, R ⁷ is C ₂ -C ₆ -cycloalkenyl, in particular C ₂ -C ₄ - cycloalkenyl, such as CH=CH ₂ -cPr.

According to still a further embodiment of formula I, R ⁷ is C ₂ -C ₆ -alkynyl or C ₂ -C ₆ -halogenalkynyl, in particular C ₂ -C ₄ -alkynyl or C ₂ -C ₄ -halogenalkynyl, such as C CH, C C-CI, C=C-CH ₃ , CH ₂ - CºCH, CH ₂ -CºCCI or CH ₂ - CºC-CH ₃ .

According to still a further embodiment of formula I, R ⁷ is C ₂ -C ₆ -cycloalkynyl in particular C ₂ -C ₄ - cycloalkynyl, such as C C-cPr.

According to a further specific embodiment of formula I, R ⁷ is Ci-C6-alkoxy, in particular Ci-C ₄ - alkoxy, more specifically Ci-C ₂ -alkoxy such as OCH ₃ , CH ₂ CH ₃ or CH ₂ OCH ₃ .

According to a further specific embodiment of formula I, R ⁷ is Ci-C ₆ -alkyl-Ci-C ₆ -alkoxy, in particular Ci-C ₄ -alkyl-Ci-C ₄ -alkoxy, more specifically Ci-C ₂ -alkyl-Ci-C ₂ -alkoxy, such as

CH ₂ OCH ₃ or CH ₂ OCH ₂ CH _3.

According to a further specific embodiment of formula I, R ⁷ is C ₂ -C ₆ -alkenyloxy, in particular C ₂ - C ₄ -alkenyloxy, more specifically Ci-C ₂ -alkenyloxy such as OCH=CH ₂ , OCH ₂ CH=CH ₂

OC(CH ₃ )CH=CH ₂ , CH ₂ OCH=CH _2I or CH ₂ OCH ₂ CH=CH ₂ .

According to a further specific embodiment of formula I, R ⁷ is C ₂ -C ₆ -alkynyloxy, in particular C ₂ - C ₄ -alkynyloxy, more specifically Ci-C ₂ -alkynyloxy such as OC CH, OCFhC CH or CFhOC CH

According to a further specific embodiment of formula I, R ⁷ is Ci-C ₆ -halogenalkoxy, in particular Ci-C ₄ -halogenalkoxy, more specifically Ci-C ₂ -halogenalkoxy such as OCF ₃ , OCHF ₂ , OCH ₂ F, OCCI ₃ , OCHC or OCH ₂ CI, in particular OCF ₃ , OCHF ₂ , OCCI ₃ or OCHCI ₂ .

According to a further specific embodiment of formula I, R ⁷ is Ci-C6-alkyl-Ci-C6-halogenalkoxy, in particular Ci-C ₄ -alkyl-Ci-C ₄ -halogenalkoxy, more specifically Ci-C ₂ -alkyl-Ci-C ₂ -halogenalkoxy such as CH ₂ OCF _3I CH ₂ OCHF _2I CH ₂ OCH ₂ F, CH2OCCI3, CH2OCHCI2 or CH ₂ OCH ₂ CI, in particular CH2OCF3, CH ₂ OCHF ₂ , CH2OCCI3 or CH2OCHCI2. According to a further specific embodiment of formula I, R ⁷ is CH(=0), C(=0)Ci-C ₆ -alkyl, C(=0)0(Ci-C ₆ -alkyl), C(=0)NH(Ci-C ₆ -alkyl) or C(=0)N(Ci-C ₆ -aikyl) ₂ , wherein alkyl is CH ₃ , C ₂ H ₅ , n-propyl, i-propyl, n-butyl, i-butyl, tert-butyl, n-pentyl or i-pentyl.

According to a further specific embodiment of formula I, R ⁷ is Ci-C ₄ -alkyl-CH(=0), Ci-C ₄ -alkyl- C(=0)Ci-C ₆ -aikyl, Ci-C ₄ -alkyl-C(=0)0(Ci-C ₆ -alkyl), Ci-C ₄ -alkyl-C(=0)NH(Ci-C ₆ -alkyl) or C1-C4- alkyl-C(=0)N(Ci-C ₆ -alkyl) ₂ , especially CH ₂ CH(=0), CH ₂ C(=0)Ci-C ₆ -aikyl, CH ₂ C(=0)0(Ci-C ₆ - alkyl), CH ₂ C(=0)NH(Ci-C ₆ -aikyl) or CH ₂ C(=0)N(Ci-C ₆ -aikyl) ₂ wherein alkyl is CH ₃ , C ₂ H ₅ , n-pro- pyl, i-propyl, n-butyl, i-butyl, tert-butyl, n-pentyl or i-pentyl.

According to a further specific embodiment of formula I, R ⁷ is CR’=NOR” such as

C(CH ₃ )=NOCH ₃ , C(CH ₃ )=NOCH ₂ CH ₃ or C(CH ₃ )=NOCF ₃ .

According to a further specific embodiment of formula I, R ⁷ is Ci-C6-alkyl-NH(Ci-C4-alkyl) or Ci- C6-alkyl-N(Ci-C4-alkyl) ₂ , wherein alkyl is CH ₃ , C ₂ H ₅ , n-propyl, i-propyl, n-butyl, i-butyl, tert-butyl, n-pentyl or i-pentyl.

According to a further specific embodiment of formula I, R ⁷ is Ci-C ₆ -alkylthio, in particular C1-C4- alkoxy, more specifically Ci-C ₃ -alkylthio such as CH ₂ SCH ₃ or CH ₂ SCH ₂ CH _3.

According to a further specific embodiment of formula I, R ⁷ is Ci-C ₆ -alkyl-S(0) _n -Ci-C ₆ -alkyl, wherein alkyl is CH ₃ , C ₂ H ₅ , n-propyl, i-propyl, n-butyl, i-butyl, tert-butyl, n-pentyl or i-pentyl and n is 1 , 2 or 3.

According to a further specific embodiment of formula I, R ⁷ is Ci-C ₆ -alkyl-S(0) _n -Ci-C ₆ - halogenalkyl, wherein halogenalkyl is CF ₃ or CHF ₂ and n is 1 , 2 or 3.

According to a further specific embodiment of formula I, R ⁷ is Ci-C ₆ -alkyl-S(0) _n -aryl, wherein the aryl or phenyl moiety in each case is unsubstituted or substituted with identical or different groups R ^7b which independently of one another are selected from halogen, Ci-C ₂ -alkyl, Ci-C ₂ - alkoxy, Ci-C ₂ -halogenalkyl, Ci-C ₂ -halogenalkoxy and S(0) _n -Ci-C ₆ -alkyl, in particular F, Cl, Br, CH ₃ , OCH ₃ , CF ₃ , CHF ₂ , OCHF ₂ , OCF ₃ . According to one embodiment, R ⁷ is unsubstituted phe- nyl. According to another embodiment, R ⁷ is phenyl, that is substituted with one, two or three, in particular one, halogen, in particular selected from F, Cl and Br, more specifically selected from F and Cl.

According to a further specific embodiment of formula I, R ⁷ is Ci-C ₆ -alkyl-NH-S0 ₂ -R ^x wherein R ^x is Ci-C4-alkyl, Ci-C4-halogenalkyl, unsubstituted aryl or aryl that is substituted with one, two, three, four or five substituents R ^x2 independently selected from Ci-C4-alkyl, halogen, OH, CN, Ci-C4-halogenalkyl, Ci-C4-alkoxy, or CrC4-halogenalkoxy, such as CH ₂ NHS0 ₂ CF ₃ or

CH ₂ NHS0 ₂ CH ₃ .

According to still another embodiment of formula I, R ⁷ is selected from Ci-C ₆ -alkyl which is sub- stituted, a saturated three-, four-, five-, six-, seven-, eight-, nine-, or ten-membered carbocycle, in particular three-, four-, five- or six-membered, wherein the carbocycle is unsubstituted or sub- stituted with substituents R ^7b as defined below. According to one embodiment thereof, the car- bocycle is unsubstituted.

According to one embodiment, R ⁷ is selected from Ci-C ₆ -alkyl, especially CH ₂ which is substi- tuted with a 3-membered saturated carbocycle. According to one embodiment thereof, the carbocycle is unsubstituted, i.e. it does not carry any substituent R ^7b . According to still another embodiment of formula I, it is substituted with R ^7b .

According to one embodiment, R ⁷ is selected from Ci-C ₆ -alkyl, especially CH ₂ which is substi- tuted with a 4-membered saturated carbocycle. According to one embodiment thereof, the carbocycle is unsubstituted, i.e. it does not carry any substituent R ^7b . According to still another embodiment of formula I, it is substituted with R ^7b .

According to one embodiment, R ⁷ is selected from Ci-C ₆ -alkyl, especially CH ₂ which is substi- tuted with a 5-membered saturated carbocycle. According to one embodiment thereof, the carbocycle is unsubstituted, i.e. it does not carry any substituent R ^7b . According to still another embodiment of formula I, it is substituted with R ^7b .

According to one embodiment, R ⁷ is selected from Ci-C ₆ -alkyl, especially CH ₂ which is substi- tuted with a 6-membered saturated carbocycle. According to one embodiment thereof, the carbocycle is unsubstituted, i.e. it does not carry any substituent R ^7b . According to still another embodiment of formula I, it is substituted with R ^7b .

According to a further specific embodiment of formula I, R ⁷ is Ci-C ₆ -alkylheterocycle, especially CH ₂ substituted with a 4-membered saturated heterocycle which contains 1 or 2 heteroatoms, in particular 1 heteroatom, from the group consisting of N, O and S, as ring members. According to one embodiment, the heterocycle contains one O as heteroatom. For example, the formed heterocycle is oxetane. According to one embodiment thereof, the heterocycle is unsubstituted, i.e. it does not carry any substituent R ^7b . According to still another embodiment of formula I, it is substituted with R ^7b .

According to a further specific embodiment of formula I, R ⁷ is Ci-C ₆ -alkylheterocycle, especially CH ₂ substituted with a 5-membered saturated heterocycle which contains 1 , 2 or 3, in particular 1 or 2, heteroatoms from the group consisting of N, O and S, as ring members. According to one embodiment, the heterocycle contains one O as heteroatom. According to one embodiment thereof, the heterocycle is unsubstituted, i.e. it does not carry any substituent R ^7b . According to still another embodiment of formula I, it is substituted with R ^7b .

According to a further specific embodiment of formula I, R ⁷ is Ci-C ₆ -alkylheterocycle, especially CH ₂ subsitited by a 6-membered saturated heterocycle which contains 1 , 2 or 3, in particular 1 or 2, heteroatoms from the group consisting of N, O and S as ring members. According to one embodiment thereof, the heterocycle is unsubstituted, i.e. it does not carry any substituent R ^7b . According to still another embodiment of formula I, it is substituted with R ^7b . According to one specific embodiment thereof, said 6-membered saturated heterocycle contains 1 or 2, in particu- lar 1 , heteroatom(s) O. According to one embodiment thereof, the respective 6-membered heterocycle is unsubstituted, i.e. it does not carry any substituent R ^7b . According to still another embodiment of formula I, it is substituted with R ^7b .

According to a further specific embodiment of formula I, R ⁷ is Ci-C ₆ -alkylheterocycle, especially CH ₂ substituted with a 5-membered saturated heterocycle which contains one N as ring mem- ber and optionally one or two groups CH ₂ are replaced by C(=0).

According to still another embodiment of formula I, R ⁷ is a partially unsaturated three-, four-, five-, six-, seven-, eight-, nine-, or ten-membered carbocycle, in particular three-, four-, five- or six-membered, wherein the carbocycle is unsubstituted or substituted with substituents R ^7b as defined below. According to one embodiment thereof, the carbocycle is unsubstituted.

According to still another embodiment of formula I, R ⁷ is a partially unsaturated three-, four-, five-, six-, seven-, eight-, nine-, or ten-membered carbocycle or heterocycle, in particular three-, four-, five- or six-membered, wherein the heterocycle contains one, two, three or four heteroa- toms selected from N, O and S, and wherein the carbocycle and heterocycle are unsubstituted or substituted with substituents R ^7b as defined below. According to one embodiment thereof, the carbocycle or heterocycle is unsubstituted.

According to still a further embodiment, R ⁷ is a saturated three-, four-, five-, six-, seven-, eight-, nine-, or ten-membered carbocycle or heterocycle, in particular three-, four-, five- or six-mem- bered, wherein the heterocycle contains one, two, three or four heteroatoms selected from N, O and S, and wherein the carbocycle and heterocycle are unsubstituted or substituted with substit- uents R ^7b as defined below. According to one embodiment thereof, the carbocycle or heterocy- cle is unsubstituted.

According to still another embodiment of formula I, R ⁷ is a saturated three-, four-, five-, six-, seven-, eight-, nine-, or ten-membered carbocycle, in particular three-, four-, five- or six-mem- bered, wherein the carbocycle is unsubstituted or substituted with substituents R ^7b as defined below. According to one embodiment thereof, the carbocycle is unsubstituted.

According to one embodiment, R ⁷ is a 3-membered saturated carbocycle. According to one embodiment thereof, the carbocycle is unsubstituted, i.e. it does not carry any substituent R ^7b . According to still another embodiment of formula I, it is substituted with R ^7b .

According to one embodiment, R ⁷ is a 3-membered saturated carbocycle, which is

unsubstituted such as cyclopropyl.

According to one embodiment, R ⁷ is a 3-membered saturated carbocycle, which is substituted with halogen, more specifically by F, such as C ₃ H ₃ F2.

According to one embodiment, R ⁷ is a 3-membered saturated carbocycle, which is substituted with halogen. More specifically by Cl, such as C ₃ H ₃ CI2.

According to one embodiment, R ⁷ is a 4-membered saturated carbocycle. According to one embodiment thereof, the carbocycle is unsubstituted, i.e. it does not carry any substituent R ^7b . According to still another embodiment of formula I, it is substituted with R ^7b .

According to one embodiment, R ⁷ is a 5-membered saturated carbocycle. According to one embodiment thereof, the carbocycle is unsubstituted, i.e. it does not carry any substituent R ^7b . According to still another embodiment of formula I, it is substituted with R ^7b .

According to one embodiment, R ⁷ is a 6-membered saturated carbocycle. According to one embodiment thereof, the carbocycle is unsubstituted, i.e. it does not carry any substituent R ^7b . According to still another embodiment of formula I, it is substituted with R ^7b .

According to still another embodiment of formula I, R ⁷ is a partially unsaturated three-, four-, five-, six-, seven-, eight-, nine-, or ten-membered heterocycle, in particular three-, four-, five- or six-membered, wherein the heterocycle contains one, two, three or four heteroatoms selected from N, O and S, and wherein the heterocycle is unsubstituted or substituted with substituents R ^7b as defined below. According to one embodiment thereof, the heterocycle is unsubstituted.

According to still another embodiment of formula I, R ⁷ is a saturated three-, four-, five-, six-, seven-, eight-, nine-, or ten-membered heterocycle, in particular three-, four-, five- or six-mem- bered, wherein the heterocycle contains one, two, three or four heteroatoms selected from N, O and S, and wherein the heterocycle is unsubstituted or substituted with substituents R ^7b as de- fined below. According to one embodiment thereof, the heterocycle is unsubstituted.

According to still another embodiment of formula I, in the embodiments of R ⁷ described above, the heterocycle contains preferably one, two or three, more specifically one or two heteroatoms selected from N, O and S. More specifically, the hetereocycle contains one heteroatom selected from N, O and S. In particular, the heterocycle contains one or two, in particular one O.

According to one embodiment, R ⁷ is a 4-membered saturated heterocycle which contains 1 or 2 heteroatoms, in particular 1 heteroatom, from the group consisting of N, O and S, as ring mem- bers. According to one embodiment, the heterocycle contains one O as heteroatom. For exam- pie, the formed heterocycle is oxetane. According to one embodiment thereof, the heterocycle is unsubstituted, i.e. it does not carry any substituent R ^7b . According to still another embodiment of formula I, it is substituted with R ^7b .

According to still another embodiment of formula I, R ⁷ is a 5-membered saturated heterocycle which contains 1 , 2 or 3, in particular 1 or 2, heteroatoms from the group consisting of N, O and S, as ring members. According to one embodiment, the heterocycle contains one O as heteroa- tom. According to one embodiment thereof, the heterocycle is unsubstituted, i.e. it does not carry any substituent R ^7b . According to still another embodiment of formula I, it is substituted with R ^7b .

According to still another embodiment of formula I, R ⁷ is a 6-membered saturated heterocycle which contains 1 , 2 or 3, in particular 1 or 2, heteroatoms from the group consisting of N, O and S as ring members. According to one embodiment thereof, the heterocycle is unsubstituted, i.e. it does not carry any substituent R ^7b . According to still another embodiment of formula I, it is substituted with R ^7b . According to one specific embodiment thereof, said 6-membered saturated heterocycle contains 1 or 2, in particular 1 , heteroatom(s) O. According to one embodiment thereof, the respective 6-membered heterocycle is unsubstituted, i.e. it does not carry any substituent R ^7b . According to still another embodiment of formula I, it is substituted with R ^7b .

According to still another embodiment of formula I, R ⁷ is phenyl-Ci-C ₆ -alkyl, such as phenyl- CH ₂ , wherein the phenyl moiety in each case is unsubstituted or substituted with one, two or three identical or different groups R ^7b which independently of one another are selected from CN, halogen, Ci-C2-alkyl, Ci-C2-alkoxy, Ci-C2-halogenalkyl, Ci-C2-halogenalkoxy and S(0) _n -Ci-C ₆ - alkyl, in particular from CN, F, Cl, Br, CH3, OCH3, CF3, CHF2, OCHF2, OCF3 and S(0) ₂ CH ₃ .

According to still another embodiment of formula I, R ⁷ is aryl, in particular phenyl, wherein the aryl or phenyl moiety in each case is unsubstituted or substituted with identical or different groups R ^7b which independently of one another are selected from CN, halogen, Ci-C2-alkyl, C1- C2-alkoxy, Ci-C2-halogenalkyl, Ci-C2-halogenalkoxy and S(0) _n -Ci-C ₆ -alkyl, in particular from CN, F, Cl, Br, CH ₃ , OCH ₃ , CF ₃ , CHF ₂ , OCHF ₂ , OCF ₃ . According to one embodiment, R ⁷ is un- substituted phenyl. According to another embodiment, R ⁷ is phenyl, that is substituted with one, two or three, in particular one, halogen, in particular selected from F, Cl and Br, more specifi- cally selected from F and Cl.

According to still another embodiment of formula I, R ⁷ is a 5-membered heteroaryl such as pyr- rol-1-yl, pyrrol-2-yl, pyrrol-3-yl, thien-2-yl, thien-3-yl, furan-2-yl, furan-3-yl, pyrazol-1-yl, pyrazol- 3-yl, pyrazol-4-yl, pyrazol-5-yl, imidazol-1-yl, imidazol-2-yl, imidazol-4-yl, imidazol-5-yl, oxazol-2- yl, oxazol-4-yl, oxazol-5-yl, isoxazol-3-yl, isoxazol-4-yl, isoxazol-5-yl, thiazol-2-yl, thiazol-4-yl, thiazol-5-yl, isoth iazol-3-yl , isothiazol-4-yl, isoth iazol-5-y 1 , 1 ,2,4-triazolyl-1-yl, 1 ,2,4-triazol-3-yl 1 ,2,4-triazol-5-yl, 1 ,2,4-oxadiazol-3-yl, 1 ,2,4-oxadiazol-5-yl and 1 ,2,4-thiadiazol-3-yl, 1 ,2,4-thia- diazol-5-yl.

According to still another embodiment of formula I, R ⁷ is a 6-membered heteroaryl, such as pyri- din-2-yl, pyridin-3-yl, pyridin-4-yl, pyridazin-3-yl, pyridazin-4-yl, pyrimidin-2-yl, pyrimidin-4-yl, py- rimidin-5-yl, pyrazin-2-yl and 1 ,3,5-triazin-2-yl and 1 ,2,4-triazin-3-yl.

According to a further specific embodiment of formula I, R ⁷ is Ci-C ₆ -alkyl, especially CFh subsitited by a 5-membered saturated heteroaryl which contains 1 , 2 or 3, in particular 1 or 2, heteroatoms from the group consisting of N, O and S as ring members. According to one embodiment thereof, the heteroaryl is unsubstituted, i.e. it does not carry any substituent R ^7b . According to still another embodiment of formula I, it is substituted by R ^7b .

According to a further specific embodiment of formula I, R ⁷ is Ci-C ₆ -alkyl, especially CFh subsitited by a 5-membered saturated heteroaryl which contains one N as ring member.

According to one embodiment thereof, the heteroaryl is unsubstituted, i.e. it does not carry any substituent R ^7b . According to still another embodiment of formula I, it is substituted by R ^7b .

According to a further specific embodiment of formula I, R ⁷ is Ci-C ₆ -alkyl, especially CH ₂ subsitited by a 5-membered saturated heteroaryl which contains two N as ring members.

According to one embodiment thereof, the heteroaryl is unsubstituted, i.e. it does not carry any substituent R ^7b . According to still another embodiment of formula I, it is substituted by R ^7b .

According to a further specific embodiment of formula I, R ⁷ is Ci-C ₆ -alkyl, especially CFh subsitited by a 5-membered saturated heteroaryl which contains three N as ring members. According to one embodiment thereof, the heteroaryl is unsubstituted, i.e. it does not carry any substituent R ^7b . According to still another embodiment of formula I, it is substituted by R ^7b .

According to one specific embodiment thereof, said 5-membered saturated heterocycle contains 1 or 2, in particular 1 , heteroatom(s) O.

According to a further specific embodiment of formula I, R ⁷ is Ci-C ₆ -alkyl, especially CFh subsitited by a 5-membered saturated heteroaryl which contains one S as ring member.

According to one embodiment thereof, the heteroaryl is unsubstituted, i.e. it does not carry any substituent R ^7b . According to still another embodiment of formula I, it is substituted by R ^7b .

According to a further specific embodiment of formula I, R ⁷ is Ci-C ₆ -alkyl, especially CFh subsitited by a 5-membered saturated heteroaryl which contains one S and one N as ring mem- bers. According to one embodiment thereof, the heteroaryl is unsubstituted, i.e. it does not carry any substituent R ^7b . According to still another embodiment of formula I, it is substituted by R ^7b .

According to a further specific embodiment of formula I, R ⁷ is Ci-C ₆ -alkyl, especially CFh subsitited by a 5-membered saturated heteroaryl which contains one S and two N as ring mem- bers. According to one embodiment thereof, the heteroaryl is unsubstituted, i.e. it does not carry any substituent R ^7b . According to still another embodiment of formula I, it is substituted by R ^7b .

According to a further specific embodiment of formula I, R ⁷ is Ci-C ₆ -alkyl, especially CH ₂ subsitited by a 5-membered saturated heteroaryl which contains one oxygen and one N as ring members. According to one embodiment thereof, the heteroaryl is unsubstituted, i.e. it does not carry any substituent R ^7b . According to still another embodiment of formula I, it is substituted by R ^7b .

According to a further specific embodiment of formula I, R ⁷ is Ci-C ₆ -alkyl, especially CH ₂ subsitited by a 5-membered saturated heteroaryl which contains one oxygen and two N as ring members. According to one embodiment thereof, the heteroaryl is unsubstituted, i.e. it does not carry any substituent R ^7b . According to still another embodiment of formula I, it is substituted by R ^7b .

According to a further specific embodiment of formula I, R ⁷ is Ci-C ₆ -alkyl, especially CH ₂ subsitited by a 6-membered saturated heteroaryl which contains 1 , 2 or 3, in particular 1 or 2, heteroatoms from the group consisting of N, O and S as ring members. According to one embodiment thereof, the heteroaryl is unsubstituted, i.e. it does not carry any substituent R ^7b . According to still another embodiment of formula I, it is substituted by R ^7b .

According to a further specific embodiment of formula I, R ⁷ is Ci-C ₆ -alkyl, especially CH ₂ subsitited by a 6-membered saturated heteroaryl which one N as ring member. According to one embodiment thereof, the heteroaryl is unsubstituted, i.e. it does not carry any substituent R ^7b . According to still another embodiment of formula I, it is substituted by R ^7b .

According to a further specific embodiment of formula I, R ⁷ is Ci-C ₆ -alkyl, especially CH ₂ subsitited by a 6-membered saturated heteroaryl which two N as ring members. According to one embodiment thereof, the heteroaryl is unsubstituted, i.e. it does not carry any substituent R ^7b . According to still another embodiment of formula I, it is substituted by R ^7b .

According to a further specific embodiment of formula I, R ⁷ is Ci-C ₆ -alkyl, especially CH ₂ subsitited by a 10-membered saturated heteroaryl which contains 1 , 2 or 3, in particular 1 or 2, heteroatoms from the group consisting of N, O and S as ring members. According to one embodiment thereof, the heteroaryl is unsubstituted, i.e. it does not carry any substituent R ^7b . According to still another embodiment of formula I, it is substituted by R ^7b . According to one specific embodiment thereof, said 10-membered saturated heterocycle contains 1 or 2, in partic- ular 1 , heteroatom(s) N.

According to a further specific embodiment of formula I, R ⁷ is Ci-C ₆ -alkyl, especially CH ₂ subsitited by a 10-membered saturated heteroaryl which one N as ring members. According to one embodiment thereof, the heteroaryl is unsubstituted, i.e. it does not carry any substituent R ^7b . According to still another embodiment of formula I, it is substituted by R ^7b .

According to still another embodiment of formula I, R ⁷ is CH ₂ substituted by a 5-membered heteroaryl such as pyrrol-1 -yl, pyrrol-2-yl, pyrrol-3-yl, thien-2-yl, thien-3-yl, furan-2-yl, furan-3-yl, pyrazol-1-yl, pyrazol-3-yl, pyrazol-4-yl, pyrazol-5-yl, imidazol-1-yl, imidazol-2-yl, imidazol-4-yl, imidazol-5-yl, oxazol-2-yl, oxazol-4-yl, oxazol-5-yl, isoxazol-3-yl, isoxazol-4-yl, isoxazol-5-yl, thiazol-2-yl, thiazol-4-yl, thiazol-5-yl, isothiazol-3-yl, isothiazol-4-yl, isoth iazol-5-yl , 1 ,2,4-triazolyl- 1-yl, 1 ,2,4-triazol-3-yl 1 ,2,4-triazol-5-yl, 1 ,2,4-oxadiazol-3-yl, 1 ,2,4-oxadiazol-5-yl and 1 ,2,4- thiadiazol-3-yl, 1 ,2,4-thiadiazol-5-yl.

According to still another embodiment of formula I, R ⁷ is Chh substituted by a 6-membered het- eroaryl, such as pyridin-2-yl, pyridin-3-yl, pyridin-4-yl, pyridazin-3-yl, pyridazin-4-yl, pyrimidin-2- yl, pyrimidin-4-yl, pyrimidin-5-yl, pyrazin-2-yl and 1 ,3,5-triazin-2-yl and 1 ,2,4-triazin-3-yl.

According to a further particular embodiment, R ⁷ is selected from Ci-C ₆ -alkyl, Ci-C ₆ -halogen- alkyl, CN, C2-C6-alkenyl, C2-C6-halogenalkenyl, C3-C6-cycloalkenyl, C2-C6-alkynyl, C2-C6-halo- genalkynyl, CrC ₆ -alkoxy, C3-C6-cycloalkynyl, C(=0)Ci-C ₆ -alkyl, C(=0)0(Ci-C ₆ -alkyl),

CR’=NOR”, C3-C6-halogencycloalkyl a saturated three-, four-, five-, six-, membered carbocycle or heterocycle, a five- or six-membered heteroaryl or aryl;, and Ci-C ₆ -alkyl substituted by CN, Ci-C ₆ -alkoxy, Ci-C ₄ -halogenalkoxy, Ci-C ₆ -alkylthio, S(0) _n -Ci-C ₆ -alkyl, NH-SO2-RX, NH(CI-C ₆ - alkyl), N(Ci-C6-alkyl)2, C(=0)Ci-C ₆ -alkyl, C(=0)0(Ci-C ₆ -alkyl), a saturated three-, four-, five-, six-, membered carbocycle, heterocycle, aryl or heteroaryl; wherein the carbocycle, heterocycle, aryl and heteroaryl is unsubstituted or carries one, two, three or four substituents R ^7b as defined below. According to one embodiment thereof, the carbocycle, heterocycle, heteroaryl and aryl are unsubstituted. In a particular embodiment, R ⁷ is selected from CN, Ci-C ₆ -alkyl, CrC ₆ -halo- genalkyl, C2-C6-alkenyl, C2-C6-halogenalkenyl, C2-C6-alkynyl, C2-C6-halogenalkynyl, C1-C6- alkoxy, a saturated three-, four-, five-, six-, membered carbocycle or heterocycle, a five- or six- membered heteroaryl or aryl; and Ci-C ₆ -alkyl substituted by a saturated three-, four-, five-, six-, membered carbocycle, heterocycle, aryl or heteroaryl; wherein the carbocycle, heterocacle, aryl and heteroaryl are unsubstituted or carries one, two, three or four substituents R ^7b as defined below.

According to a further particular embodiment, R ⁷ is selected from Ci-C ₆ -halogenalkyl, CN, C2- C ₆ -alkenyl, C2-C6-halogenalkenyl, C3-C6-cycloalkenyl, C2-C6-alkynyl, C2-C6-halogenalkynyl, Cr C ₆ -alkoxy, C3-C6-cycloalkynyl, C(=0)Ci-C ₆ -alkyl, C(=0)0(Ci-C ₆ -alkyl), CR’=NOR”, C3-C6- halogencycloalkyl a saturated three-, four-, five-, six-, membered carbocycle or heterocycle, a five- or six-membered heteroaryl or aryl;, and Ci-C ₆ -alkyl substituted by CN, Ci-C ₆ -alkoxy, C1- C ₄ -halogenalkoxy, Ci-Ce-alkylthio, S(0) _n -Ci-C ₆ -alkyl, NH-SO2-RX, NH(Ci-C ₆ -alkyl), N(Ci-C ₆ -al- kyl)2, C(=0)Ci-C ₆ -alkyl, C(=0)0(Ci-C ₆ -alkyl), a saturated three-, four-, five-, six-, membered carbocycle, heterocycle, aryl or heteroaryl; wherein the carbocycle, heterocycle, aryl and het- eroaryl is unsubstituted or carries one, two, three or four substituents R ^7b as defined below. Ac- cording to one embodiment thereof, the carbocycle, heterocycle, heteroaryl and aryl are unsub- stituted. In a particular embodiment, R ⁷ is selected from CN, Ci-C ₆ -alkyl, Ci-C ₆ -halogenalkyl, C2-C6-alkenyl, C2-C6-halogenalkenyl, C2-C6-alkynyl, C2-C6-halogenalkynyl, Ci-C ₆ -alkoxy, a satu- rated three-, four-, five-, six-, membered carbocycle or heterocycle, a five- or six-membered het- eroaryl or aryl; and Ci-C ₆ -alkyl substituted by a saturated three-, four-, five-, six-, membered carbocycle, heterocycle, aryl or heteroaryl; wherein the carbocycle, heterocacle, aryl and het- eroaryl are unsubstituted or carries one, two, three or four substituents R ^7b as defined below.

Particularly preferred embodiments of R ⁷ according to the invention are in Table P6 below, wherein each line of lines P6-1 to P6-208 corresponds to one particular embodiment of the in- vention, wherein P6-1 to P6-208 are also in any combination with one another a preferred embodiment of the present invention. The connection point to the carbon atom, to which R ⁷ is bound is marked with“#” in the drawings.

Table P7 (py = pyridyl):

R ⁸ is independently selected from CN, Ci-C ₆ -alkyl, Ci-C ₆ -halogenalkyl, C2-C6-alkenyl, C2-C6-hal- ogenalkenyl, C2-C6-alkynyl, C2-C6-halogenalkynyl, CH(=0), C(=0)Ci-C ₆ -alkyl, C(=0)0(Ci-C ₆ - alkyl), C(=0)NH(Ci-C ₆ -alkyl), C(=0)N(Ci-C ₆ -alkyl) ₂ , CR’=NOR”, a saturated or partially unsatu- rated three-, four-, five-, six-, seven-, eight-, nine-, or ten-membered carbocycle or heterocycle, a five- or six-membered heteroaryl or aryl; wherein in each case one or two CFh groups of the carbo- and heterocycle may be replaced by a group independently selected from C(=0) and C(=S), and wherein the heterocycle and heteroaryl contain independently one, two, three or four heteroatoms selected from N, O and S, and wherein heterocycle and heteroaryl are connected via C atom; and wherein R’ and R” are independently selected from H, Ci-C ₄ -alkyl, C ₂ -C ₆ - alkenyl, C ₂ -C ₆ -alkynyl, saturated or partially unsaturated three-, four-, five-, six-, seven-, eight-, nine-, or ten-membered carbo- and heterocycle, five- or six-membered heteroaryl or aryl;

wherein the heterocycle or heteroaryl contains one, two or three heteroatoms selected from N,

O and S, and wherein R’ and R” are independently unsubstituted or substituted with R’” which is independently selected from halogen, OH, CN, NO ₂ , SH, NH _2, NH(Ci-C ₄ -alkyl), N(CrC ₄ -al- kyl)2, NH-S0 ₂ -R ^x , Ci-C ₆ -alkyl, Ci-C ₆ -halogenalkyl, C ₂ -C ₆ -alkenyl, C ₂ -C ₆ -halogenalkenyl, C ₂ -C ₆ - alkynyl, C ₂ -C ₆ -halogenalkynyl, Ci-C ₆ -alkoxy, Ci-C ₆ -halogenalkoxy, C ₃ -C ₆ -cycloalkyl, C ₃ -C ₆ - halogencycloalkyl and phenyl;

wherein R ^x is as defined above;

wherein the acyclic moieties of R ⁸ are independently not further substituted or carry one, two, three or up to the maximum possible number of identical or different groups R ^8a , which inde- pendently of one another are selected from:

R ^8a halogen, OH, CN, N0 ₂ , SH, NH ₂ , NH(Ci-C ₄ -alkyl), N(Ci-C ₄ -alkyl) ₂ , NH(C(=0)Ci-C ₄ -aikyl), N(C(=0)Ci-C4-alkyl)2, NH-S02-R ^X , Ci-C6-alkoxy, Ci-C4-halogenalkoxy, C3-C6-cycloalkyl, C3-C6- halogencycloalkyl, Ci-Ce-alkylthio, Ci-C ₆ -halogenalkylthio, S(0) _n -Ci-C ₆ -alkyl, S(0) _n -aryl,

CH(=0), C(=0)Ci-C ₆ -alkyl, C(=0)0(Ci-C ₆ -aikyl), C(=0)NH(Ci-C ₆ -aikyl), C(=0)N(Ci-C ₆ -alkyl) ₂ , CR’=NOR”, a saturated or partially unsaturated three-, four-, five-, six-, seven-, eight-, nine-, or ten-membered carbo- or heterocycle, a five-, six- or ten-membered heteroaryl, aryl or phenoxy, wherein in each case one or two CH ₂ groups of the carbo- and heterocycle may be replaced by a group independently selected from C(=0) and C(=S), and wherein the heterocycle and het- eroaryl contains independently one, two, three or four heteroatoms selected from N, O and S, and wherein heterocycle and heteroaryl are connected via C atom; wherein the carbo-, hetero- cyclic, heteroaryl and phenyl groups are independently unsubstituted or carry one, two, three, four or five substituents selected from the group consisting of halogen, OH, CN, NO ₂ , SH, NH ₂ , NH(Ci-C ₄ -alkyl), N(Ci-C ₄ -alkyl) ₂ , NH(C(=0)Ci-C ₄ -aikyl), N(C(=0)Ci-C ₄ -alkyl) ₂ , NH-S0 ₂ -R ^x , Ci- C ₆ -alkylthio, Ci-C ₄ -alkyl, Ci-C ₄ -halogenalkyl, Ci-C ₄ -alkoxy, Ci-C ₄ -halogenalkoxy, and S(0)n-Ci- C ₆ -alkyl; and wherein R ^x , R’ and R” are as defined above; n is 0, 1 , 2; and

wherein the carbo-, heterocyclic, heteroaryl and aryl moieties of R ⁸ are independently unsubsti- tuted or substituted with identical or different groups R ^8b , which independently of one another are selected from:

R ^8b halogen, OH, CN, N0 ₂ , SH, NH _2, NH(Ci-C ₄ -alkyl), N(Ci-C ₄ -alkyl) ₂ , NH(C(=0)Ci-C ₄ -aikyl), N(C(=0)Ci-C ₄ -alkyl) ₂ , NH-S0 ₂ -R ^X , Ci-C ₄ -alkyl, Ci-C ₄ -alkoxy, Ci-C ₄ -halogenalkyl, C ₃ -C ₆ -cycloal- kyl, C ₃ -C ₆ -halogencycloalkyl, Ci-C ₄ -halogenalkoxy, Ci-C ₆ -alkylthio, Ci-C ₆ -halogenalkylthio, S(0) _n -Ci-C ₆ -alkyl, Ci-C ₄ -alkoxy-Ci-C ₄ -alkyl, phenyl and phenoxy, wherein the phenyl groups are unsubstituted or carry one, two, three, four or five substituents selected from the group consist- ing of halogen, OH, CrC ₄ -alkyl, CrC ₄ -halogenalkyl, Ci-C ₄ -alkoxy and CrC ₄ -halogenalkoxy; and wherein R ^x and n are as defined above.

According to one embodiment of formula I, R ⁸ is selected from substituted Ci-C ₆ -alkyl, O-I-OQ- halogenalkyl, C ₂ -C ₆ -halogenalkyl, C ₂ -C ₆ -alkenyl, C ₂ -C ₆ -halogenalkenyl, C ₃ -C ₆ -cycloalkenyl, C ₂ - C ₆ -alkynyl, C ₂ -C ₆ -halogenalkynyl, C ₃ -C ₆ -cycloalkynyl, CN, CH(=0), C(=0)C ₂ -C ₆ -alkyl,

C(=0)0(C ₂ -C ₆ -alkyl), CR -NOR”, C ₃ -C ₆ -cycloalkyl, C ₃ -C ₆ -halogencycloalkyl, Ci-C ₆ -alkyl-five- and six-membered heteroaryl ,a five- or six-membered heteroaryl, benzyl, aryl; wherein R’ and R” are defined below; and wherein the acyclic moieties of R ⁸ are unsubstituted or substituted with identical or different groups R ^8a as defined below and wherein wherein the carbocycle, het- erocycle and heteroaryl and aryl moieties are unsubstituted or substituted with substituents R ^8b as defined below.

According to still another embodiment of formula I, R ⁸ is CN.

According to still another embodiment of formula I, R ⁸ is selected from CN, substituted C ₁ -C ₆ - alkyl, Ci-C ₆ -halogenalkyl or Ci-C ₆ -alkyl which is substituted, Ci-C ₆ -halogenalkyl, phenyl, halogenphenyl and three-, four-, five- or six-membered carbo- and heterocycle, wherein the carbo- and heterocycle is unsubstituted or is substituted with substituents R ^8b as defined below. According to one embodiment thereof, the carbocycle is unsubstituted. In a particular embodi- ment, R ⁸ is selected from Ci-C ₆ -halogenalkyl, phenyl-Chh, halogenphenyl-Chh, phenyl, halogenphenyl and three-, four-, five- or six-membered carbo- and heterocycle, wherein the carbo- and heterocycle is unsubstituted or is substituted with substituents R ^8b as defined below.

According to still another embodiment of formula I, R ⁸ is selected from CN, substituted C ₁ -C ₆ - alkyl, Ci-C ₆ -halogenalkyl or Ci-C ₆ -alkyl which is substituted, Ci-C ₆ -halogenalkyl, phenyl, halogenphenyl and three-, four-, five- or six-membered carbo- and heterocycle, wherein the carbo- and heterocycle is unsubstituted or substituted bysubstituents R ^8b as defined below. Ac- cording to one embodiment thereof, the carbo- and heterocycle is unsubstituted. In a particular embodiment, R ⁸ is selected from substituted Ci-C ₆ -halogenalkyl, phenyl, halogenphenyl and three-, four-, five- or six-membered carbo- and heterocycle, wherein the carbo- and heterocycle is unsubstituted or substituted bysubstituents R ^8b as defined below.