Title:
NEW PYRIDOPYRIMIDINE DERIVATIVE
Document Type and Number:
WIPO Patent Application WO/2023/001123
Kind Code:
A1
Abstract:
Provided in the present invention are a new pyridopyrimidine derivative, a pharmaceutically acceptable salt, an ester, a stereoisomer or a tautomer, and a pharmaceutical composition containing same and the use thereof. The compound of the present invention shows an excellent inhibitory effect on KRAS mutations (particularly a KRAS G12D mutation and a KRAS G12V mutation).
Inventors:
LUO HUIBING (CN)
JIANG JIAJUN (CN)
JIANG JIAJUN (CN)
Application Number:
PCT/CN2022/106363
Publication Date:
January 26, 2023
Filing Date:
July 19, 2022
Export Citation:
Assignee:
SHANGHAI ALLIST PHARMACEUTICALS CO LTD (CN)
International Classes:
C07D498/22; A61K31/551; A61K31/553; A61P35/00; C07D471/22; C07D519/00
Domestic Patent References:
| WO2022199587A1 | 2022-09-29 | |||
| WO2022194245A1 | 2022-09-22 | |||
| WO2022188729A1 | 2022-09-15 | |||
| WO2020239123A1 | 2020-12-03 | |||
| WO2021108683A1 | 2021-06-03 |
Foreign References:
| CN110603258A | 2019-12-20 | |||
| CN112074520A | 2020-12-11 | |||
| CN112390818A | 2021-02-23 |
Attorney, Agent or Firm:
CHINA PATENT AGENT (H.K.) LTD. (CN)
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