Title:
NEW RECOMBINANT BIFUNCTIONAL FUSION PROTEIN, PREPARATION METHOD THEREFOR AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2015/149708
Kind Code:
A1
Abstract:
Disclosed are a recombinant bifunctional fusion protein, the preparation method therefor and the use thereof. Specifically, disclosed is a fusion protein having an element A comprising TGF-β receptor extracellular domain, an element B comprising VEGFR1 second extracellular domain D2 and an immunoglobulin element C that are connected in series. The protein can simultaneously bind to two kinds of ligands: VEGF and TGF-β1, and inhibit the biological activity of the ligands. Also provided is the use of the new recombinant bifunctional fusion protein in treating diseases.
Inventors:
TIAN WENZHI (CN)
Application Number:
PCT/CN2015/075759
Publication Date:
October 08, 2015
Filing Date:
April 02, 2015
Export Citation:
Assignee:
HUABO BIOPHARM CO LTD (CN)
International Classes:
C07K19/00; A61K38/16; C07K14/00; C12N1/00; C12N15/00; C12P21/00
Domestic Patent References:
| WO2010003118A1 | 2010-01-07 |
Foreign References:
| CN102850458A | 2013-01-02 | |||
| CN103319610A | 2013-09-25 |
Attorney, Agent or Firm:
XU & PARTNERS, LLC. (CN)
上海一平知识产权代理有限公司 (CN)
上海一平知识产权代理有限公司 (CN)
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