Title:
NEW SYNTHETIC DRUGS FOR TREATING ALZHEIMER'S DISEASE
Document Type and Number:
WIPO Patent Application WO/2024/058196
Kind Code:
A1
Abstract:
The present invention aims to provide a novel agent for treating Alzheimer's disease, a method for treating Alzheimer's disease, a method for screening for a candidate substance for a therapeutic drug for Alzheimer's disease, and the like. The present invention is a prophylactic and/or therapeutic agent for Alzheimer's disease comprising a peptide corresponding to dynamin 1. The peptide preferably corresponds to dynamin 1-pleckstrin-homology domain or dynamin 1-proline rich domain. In addition, the peptide is preferably encapsulated in nano-particles or linked to a peptide sequence that improve delivery of the peptide into the brain.
Inventors:
HORI TETSUYA (JP)
TAKAHASHI TOMOYUKI (JP)
TAOUFIQ ZACHARIE (JP)
TAKEI KOHJI (JP)
YAMADA HIROSHI (JP)
TAKAHASHI TOMOYUKI (JP)
TAOUFIQ ZACHARIE (JP)
TAKEI KOHJI (JP)
YAMADA HIROSHI (JP)
Application Number:
PCT/JP2023/033289
Publication Date:
March 21, 2024
Filing Date:
September 13, 2023
Export Citation:
Assignee:
OKINAWA INST SCIENCE & TECH SCHOOL CORP (JP)
International Classes:
A61K38/10; A61K9/51; A61K38/08; A61K39/395; A61K47/51; A61K47/62; A61P25/28
Foreign References:
| US20070105803A1 | 2007-05-10 | |||
| US20160058838A1 | 2016-03-03 |
Other References:
WARNOCK D.E., TERLECKY L.J., SCHMID S.L.: "Dynamin GTPase is stimulated by crosslinking through the C-terminal proline-rich domain.", THE EMBO JOURNAL / EUROPEAN MOLECULAR BIOLOGY ORGANIZATION, IRL PRESS, OXFORD, vol. 14, no. 7, 1 April 1995 (1995-04-01), Oxford , pages 1322 - 1328, XP093146521, ISSN: 0261-4189, DOI: 10.1002/j.1460-2075.1995.tb07118.x
ARTALEJO CRISTINA R, LEMMON MARK A, SCHLESSINGER JOSEPH, PALFREY H CLIVE: "Specific role for the PH domain of dynamin-1 in the regulation of rapid endocytosis in adrenal chromaffin cells gesting that other forms of endocytosis are also dependent", THE EMBO JOURNAL / EUROPEAN MOLECULAR BIOLOGY ORGANIZATION., vol. 16, no. 7, 1 April 1997 (1997-04-01), pages 1565 - 1574, XP093146524
L. SAAVEDRA, A. MOHAMED, V. MA, S. KAR, E. P. DE CHAVES: "Internalization of -Amyloid Peptide by Primary Neurons in the Absence of Apolipoprotein E", JOURNAL OF BIOLOGICAL CHEMISTRY, AMERICAN SOCIETY FOR BIOCHEMISTRY AND MOLECULAR BIOLOGY, vol. 282, no. 49, 1 January 2007 (2007-01-01), pages 35722 - 35732, XP055046996, ISSN: 00219258, DOI: 10.1074/jbc.M701823200
HORI TETSUYA, EGUCHI KOHGAKU, WANG HAN-YING, MIYASAKA TOMOHIRO, GUILLAUD LAURENT, TAOUFIQ ZACHARIE, MAHAPATRA SATYAJIT, YAMADA HIR: "Microtubule assembly by tau impairs endocytosis and neurotransmission via dynamin sequestration in Alzheimer’s disease synapse model", ELIFE, ELIFE SCIENCES PUBLICATIONS LTD., GB, vol. 11, 20 April 2022 (2022-04-20), GB , pages e73542, XP093146527, ISSN: 2050-084X, DOI: 10.7554/eLife.73542
HORI TETSUYA, EGUCHI KOHGAKU, WANG HAN-YING, MIYASAKA TOMOHIRO, GUILLAUD LAURENT, TAOUFIQ ZACHARIE, YAMADA HIROSHI, TAKEI KOHJI, T: "Microtubule assembly by soluble tau impairs vesicle endocytosis and excitatory neurotransmission via dynamin sequestration in Alzheimer’s disease synapse model", BIORXIV, 14 September 2021 (2021-09-14), XP093146528, [retrieved on 20240328], DOI: 10.1101/2021.09.13.460074
ARTALEJO CRISTINA R, LEMMON MARK A, SCHLESSINGER JOSEPH, PALFREY H CLIVE: "Specific role for the PH domain of dynamin-1 in the regulation of rapid endocytosis in adrenal chromaffin cells gesting that other forms of endocytosis are also dependent", THE EMBO JOURNAL / EUROPEAN MOLECULAR BIOLOGY ORGANIZATION., vol. 16, no. 7, 1 April 1997 (1997-04-01), pages 1565 - 1574, XP093146524
L. SAAVEDRA, A. MOHAMED, V. MA, S. KAR, E. P. DE CHAVES: "Internalization of -Amyloid Peptide by Primary Neurons in the Absence of Apolipoprotein E", JOURNAL OF BIOLOGICAL CHEMISTRY, AMERICAN SOCIETY FOR BIOCHEMISTRY AND MOLECULAR BIOLOGY, vol. 282, no. 49, 1 January 2007 (2007-01-01), pages 35722 - 35732, XP055046996, ISSN: 00219258, DOI: 10.1074/jbc.M701823200
HORI TETSUYA, EGUCHI KOHGAKU, WANG HAN-YING, MIYASAKA TOMOHIRO, GUILLAUD LAURENT, TAOUFIQ ZACHARIE, MAHAPATRA SATYAJIT, YAMADA HIR: "Microtubule assembly by tau impairs endocytosis and neurotransmission via dynamin sequestration in Alzheimer’s disease synapse model", ELIFE, ELIFE SCIENCES PUBLICATIONS LTD., GB, vol. 11, 20 April 2022 (2022-04-20), GB , pages e73542, XP093146527, ISSN: 2050-084X, DOI: 10.7554/eLife.73542
HORI TETSUYA, EGUCHI KOHGAKU, WANG HAN-YING, MIYASAKA TOMOHIRO, GUILLAUD LAURENT, TAOUFIQ ZACHARIE, YAMADA HIROSHI, TAKEI KOHJI, T: "Microtubule assembly by soluble tau impairs vesicle endocytosis and excitatory neurotransmission via dynamin sequestration in Alzheimer’s disease synapse model", BIORXIV, 14 September 2021 (2021-09-14), XP093146528, [retrieved on 20240328], DOI: 10.1101/2021.09.13.460074
Attorney, Agent or Firm:
TSUKUNI & ASSOCIATES (JP)
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