Title:
NEW THERAPY AND PREVENTION FOR SUPPRESSING AGING-RELATED DISORDERS INCLUDING SARCOPENIA
Document Type and Number:
WIPO Patent Application WO/2023/145735
Kind Code:
A1
Abstract:
Provided is a new therapy/prevention for aging-related disorders including sarcopenia. The present invention pertains to a pharmaceutical composition that contains an expectorant (examples thereof include compounds, or pharmaceutically acceptable salts thereof or solvates of same) and that is for controlling, delaying progression of, preventing, or treating aging-related disorders including sarcopenia.
Inventors:
HAYANO MOTOSHI (JP)
TSUBOTA KAZUO (JP)
TSUBOTA KAZUO (JP)
Application Number:
PCT/JP2023/002118
Publication Date:
August 03, 2023
Filing Date:
January 24, 2023
Export Citation:
Assignee:
HAYANO MOTOSHI (JP)
International Classes:
A61K45/00; A61K31/136; A61K31/198; A61K31/223; A61P1/00; A61P3/00; A61P9/00; A61P11/00; A61P13/00; A61P15/00; A61P19/00; A61P21/00; A61P25/00; A61P27/00; A61P31/00; A61P35/00
Foreign References:
| US20200215089A1 | 2020-07-09 | |||
| JP2021511388A | 2021-05-06 |
Other References:
ZUO SHI QI, LI CAN, LIU YI LUN, TAN YUE HAO, WAN XING, XU TIAN, LI QIANG, WANG LI, WU YONG LI, DENG FENG MEI, TANG BIN: "Cordycepin inhibits cell senescence by ameliorating lysosomal dysfunction and inducing autophagy through the AMPK and mTOR–p70S6K pathway", FEBS OPEN BIO, ELSEVIER, US, vol. 11, no. 10, 1 October 2021 (2021-10-01), US , pages 2705 - 2714, XP093082425, ISSN: 2211-5463, DOI: 10.1002/2211-5463.13263
MISHRA AKANKSHA; KRISHNAMURTHY SAIRAM: "Neurorestorative effects of sub-chronic administration of ambroxol in rodent model of Parkinson’s disease", NAUNYN-SCHMIEDEBERG'S ARCHIVES OF PHARMACOLOGY, SPRINGER, DE, vol. 393, no. 3, 25 October 2019 (2019-10-25), DE , pages 429 - 444, XP037170306, ISSN: 0028-1298, DOI: 10.1007/s00210-019-01737-9
BOUSCARY ALEXANDRA, QUESSADA CYRIL, MOSBACH ALTHÉA, CALLIZOT NOËLLE, SPEDDING MICHAEL, LOEFFLER JEAN-PHILIPPE, HENRIQUES ALEXANDRE: "Ambroxol Hydrochloride Improves Motor Functions and Extends Survival in a Mouse Model of Familial Amyotrophic Lateral Sclerosis", FRONTIERS IN PHARMACOLOGY, vol. 10, XP093082424, DOI: 10.3389/fphar.2019.00883
PEARSON IONA, GLASMACHER STELLA A., NEWTON JUDITH, BESWICK EMILY, MEHTA ARPAN R., DAVENPORT RICHARD, CHANDRAN SIDDHARTHAN, PAL SUV: "The Prevalence and Management of Saliva Problems in Motor Neuron Disease: A 4-Year Analysis of the Scottish Motor Neuron Disease Register", NEURODEGENERATIVE DISEASES, KARGER, CH, vol. 20, no. 4, 1 January 2020 (2020-01-01), CH , pages 147 - 152, XP093082426, ISSN: 1660-2854, DOI: 10.1159/000514615
MISHRA AKANKSHA; KRISHNAMURTHY SAIRAM: "Neurorestorative effects of sub-chronic administration of ambroxol in rodent model of Parkinson’s disease", NAUNYN-SCHMIEDEBERG'S ARCHIVES OF PHARMACOLOGY, SPRINGER, DE, vol. 393, no. 3, 25 October 2019 (2019-10-25), DE , pages 429 - 444, XP037170306, ISSN: 0028-1298, DOI: 10.1007/s00210-019-01737-9
BOUSCARY ALEXANDRA, QUESSADA CYRIL, MOSBACH ALTHÉA, CALLIZOT NOËLLE, SPEDDING MICHAEL, LOEFFLER JEAN-PHILIPPE, HENRIQUES ALEXANDRE: "Ambroxol Hydrochloride Improves Motor Functions and Extends Survival in a Mouse Model of Familial Amyotrophic Lateral Sclerosis", FRONTIERS IN PHARMACOLOGY, vol. 10, XP093082424, DOI: 10.3389/fphar.2019.00883
PEARSON IONA, GLASMACHER STELLA A., NEWTON JUDITH, BESWICK EMILY, MEHTA ARPAN R., DAVENPORT RICHARD, CHANDRAN SIDDHARTHAN, PAL SUV: "The Prevalence and Management of Saliva Problems in Motor Neuron Disease: A 4-Year Analysis of the Scottish Motor Neuron Disease Register", NEURODEGENERATIVE DISEASES, KARGER, CH, vol. 20, no. 4, 1 January 2020 (2020-01-01), CH , pages 147 - 152, XP093082426, ISSN: 1660-2854, DOI: 10.1159/000514615
Attorney, Agent or Firm:
IPR CONSULTANT PPC (JP)
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