Title:
NEW-TYPE CORONAVIRUS VACCINE COMPOSITION AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2022/206954
Kind Code:
A1
Abstract:
Provided are a new-type coronavirus vaccine composition and the use thereof. The new-type coronavirus vaccine composition comprises an N-glycosylation-shielded new-type coronavirus spike protein mutant in an N-terminal domain or a receptor-binding domain, and can effectively induce an individual to generate an immune response towards different new-type coronavirus variants.
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Inventors:
WU SUH-CHIN (CN)
CHEN I-CHEN (CN)
LIN WEI-SHUO (CN)
LEE YI-CHIEN (CN)
HONG HAO-CHAN (CN)
CHEN I-CHEN (CN)
LIN WEI-SHUO (CN)
LEE YI-CHIEN (CN)
HONG HAO-CHAN (CN)
Application Number:
PCT/CN2022/084807
Publication Date:
October 06, 2022
Filing Date:
April 01, 2022
Export Citation:
Assignee:
WU SUH CHIN (CN)
FU JEN CATHOLIC UNIV (CN)
FU JEN CATHOLIC UNIV (CN)
International Classes:
C07K14/00; A61K38/00
Foreign References:
| CN105934441A | 2016-09-07 |
Other References:
HUANG HAN-YI, LIAO HSIN-YU, CHEN XIAORUI, WANG SZU-WEN, CHENG CHENG-WEI, SHAHED-AL-MAHMUD MD., LIU YO-MIN, MOHAPATRA ARPITA, CHEN : "Vaccination with SARS-CoV-2 spike protein lacking glycan shields elicits enhanced protective responses in animal models.", SCIENCE TRANSLATIONAL MEDICINE, vol. 14, no. 639, 1 March 2022 (2022-03-01), pages eabm0899, 1 - eabm0899, 13, XP009540166, ISSN: 1946-6234, DOI: 10.1126/scitranslmed.abm0899
CASALINO LORENZO, GAIEB ZIED, GOLDSMITH JORY A., HJORTH CHRISTY K., DOMMER ABIGAIL C., HARBISON AOIFE M., FOGARTY CARL A., BARROS : "Beyond Shielding: The Roles of Glycans in the SARS-CoV-2 Spike Protein", ACS CENTRAL SCIENCE, vol. 6, no. 10, 28 October 2020 (2020-10-28), pages 1722 - 1734, XP055973942, ISSN: 2374-7943, DOI: 10.1021/acscentsci.0c01056
WATANABE, Y. ET AL.: "Site-specific glycan analysis of the SARS-CoV-2 spike.", SCIENCE, vol. 369, no. 6501, 4 May 2020 (2020-05-04), XP055882284, DOI: 10.1126/science.abb9983
ZHAO, PENG ET AL.: "Virus-Receptor Interactions of Glycosylated SARS-CoV-2 Spike and Human ACE2 Receptor.", CELL HOST & MICROBE., vol. 28, no. 4, 24 August 2020 (2020-08-24), XP086284608, DOI: 10.1016/j.chom.2020.08.004
ZHANG TING, WANG ZHI-RONG, XU XUE-MEI: "Impact of glycosylation and length of ＲBD of SAＲS-CoV-2 S protein on the immunogenicity of ＲBD protein vaccines", BASIC & CLINICAL MEDICINE, vol. 40, no. 12, 31 December 2020 (2020-12-31), pages 1645 - 1650, XP055973941, ISSN: 1001-6325, DOI: 10.16352/j.issn.1001-6325.2020.12.009
JIANG MINGJIN, WEN JIN-HUA;PAN DE-CHENG;ZHOU JIAN;LYU YAN-NI;WEI XIAO-HUA: "Structure and Function of SARS-CoV-2 Spike Protein and its Receptor", ZHONGGUO YAOLIXUE TONGBAO - CHINESE PHARMACOLOGICAL BULLETIN, LINCHUANG YAOLI YANJIUSUO, HEFEI, CN, vol. 36, no. 11, 30 November 2020 (2020-11-30), CN , pages 1497 - 1501, XP055973939, ISSN: 1001-1978, DOI: 10.3969/j.issn.1001-1978.2020.11.004
CASALINO LORENZO, GAIEB ZIED, GOLDSMITH JORY A., HJORTH CHRISTY K., DOMMER ABIGAIL C., HARBISON AOIFE M., FOGARTY CARL A., BARROS : "Beyond Shielding: The Roles of Glycans in the SARS-CoV-2 Spike Protein", ACS CENTRAL SCIENCE, vol. 6, no. 10, 28 October 2020 (2020-10-28), pages 1722 - 1734, XP055973942, ISSN: 2374-7943, DOI: 10.1021/acscentsci.0c01056
WATANABE, Y. ET AL.: "Site-specific glycan analysis of the SARS-CoV-2 spike.", SCIENCE, vol. 369, no. 6501, 4 May 2020 (2020-05-04), XP055882284, DOI: 10.1126/science.abb9983
ZHAO, PENG ET AL.: "Virus-Receptor Interactions of Glycosylated SARS-CoV-2 Spike and Human ACE2 Receptor.", CELL HOST & MICROBE., vol. 28, no. 4, 24 August 2020 (2020-08-24), XP086284608, DOI: 10.1016/j.chom.2020.08.004
ZHANG TING, WANG ZHI-RONG, XU XUE-MEI: "Impact of glycosylation and length of ＲBD of SAＲS-CoV-2 S protein on the immunogenicity of ＲBD protein vaccines", BASIC & CLINICAL MEDICINE, vol. 40, no. 12, 31 December 2020 (2020-12-31), pages 1645 - 1650, XP055973941, ISSN: 1001-6325, DOI: 10.16352/j.issn.1001-6325.2020.12.009
JIANG MINGJIN, WEN JIN-HUA;PAN DE-CHENG;ZHOU JIAN;LYU YAN-NI;WEI XIAO-HUA: "Structure and Function of SARS-CoV-2 Spike Protein and its Receptor", ZHONGGUO YAOLIXUE TONGBAO - CHINESE PHARMACOLOGICAL BULLETIN, LINCHUANG YAOLI YANJIUSUO, HEFEI, CN, vol. 36, no. 11, 30 November 2020 (2020-11-30), CN , pages 1497 - 1501, XP055973939, ISSN: 1001-1978, DOI: 10.3969/j.issn.1001-1978.2020.11.004
Attorney, Agent or Firm:
DRAGON INTELLECTUAL PROPERTY LAW FIRM (CN)
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