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Title:
NEW TYPE OF CYTIDINE DERIVATIVE AND APPLICATION THEREOF
Document Type and Number:
WIPO Patent Application WO/2016/078397
Kind Code:
A1
Abstract:
Disclosed are a new type of cytidine derivative, having the general formula (I), and an application thereof. The new type of cytidine derivative of the present invention has a growth inhibitory effect, confirmed by testing, on transplanted colon cancer HCT-116 tumors borne by nude mice; the antitumor activity of the compound of the present invention is high, while the impact on the body weight of the colon cancer HCT-116 tumor-bearing mice, as well as mortality rate data, prove the low toxicity of the compound.

Inventors:
YANG, Daria (No. 108 Hehai Road, Xinbei DistrictChangzhou, Jiangsu 2, 213022, CN)
WANG, Haidong (No. 108 Hehai Road, Xinbei DistrictChangzhou, Jiangsu 2, 213022, CN)
LIU, Xin (No. 108 Hehai Road, Xinbei DistrictChangzhou, Jiangsu 2, 213022, CN)
WANG, Huijuan (No. 108 Hehai Road, Xinbei DistrictChangzhou, Jiangsu 2, 213022, CN)
LIEW, Siong Tern (No. 108 Hehai Road, Xinbei DistrictChangzhou, Jiangsu 2, 213022, CN)
Application Number:
CN2015/081047
Publication Date:
May 26, 2016
Filing Date:
June 09, 2015
Export Citation:
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Assignee:
CHANGZHOU FANGYUAN PHARMACEUTICAL CO., LTD (No. 108 Hehai Road, Xinbei DistrictChangzhou, Jiangsu 2, 213022, CN)
CHANGZHOU UPER BIOPHARMACEUTICAL CO., LTD (No. 106 Hehai Road, Xinbei DistrictChangzhou, Jiangsu 2, 213022, CN)
International Classes:
C07H19/06; A61K31/7068
Domestic Patent References:
WO1991015498A21991-10-17
Foreign References:
US20140134160A12014-05-15
Other References:
See also references of EP 3210992A4
Attorney, Agent or Firm:
CHANGZHOU JIANGHAI YANGGUANG INTELLECTUAL PROPERTY AGENCY LTD. (Room 503, Guotai Xindu Business CenterNo. 1 Heping North Road,Tianning Distric, Changzhou Jiangsu 3, 213003, CN)
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