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Title:
NEW TYPE OF CYTIDINE DERIVATIVE DIMER AND APPLICATION THEREOF
Document Type and Number:
WIPO Patent Application WO/2016/078399
Kind Code:
A1
Abstract:
Disclosed are a new type of cytidine derivative dimer, having the general formula (I), and an application thereof. By means of the optimized molecular design of a cytidine compound, the cytidine derivative dimer of the present invention has a significant inhibitory effect on human colon cancer HCT-116 tumor cells, while at the same time having a strong growth inhibitory effect on a transplanted human colon cancer HCT-116 tumor borne by nude mice; the new type of cytidine derivative dimer compound of the present invention has very high antitumor activity, while the toxicity of the compound is low.

Inventors:
YANG, Daria (NO.108 Hehai Road, Xinbei districtChangzhou city, Jiangsu 2, 213022, CN)
WANG, Haidong (NO.108 Hehai Road, Xinbei districtChangzhou city, Jiangsu 2, 213022, CN)
WANG, Huijuan (NO.108 Hehai Road, Xinbei districtChangzhou city, Jiangsu 2, 213022, CN)
LIEW, Siong Tern (NO.108 Hehai Road, Xinbei districtChangzhou city, Jiangsu 2, 213022, CN)
Application Number:
CN2015/081138
Publication Date:
May 26, 2016
Filing Date:
June 10, 2015
Export Citation:
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Assignee:
CHANGZHOU FANGYUAN PHARMACEUTICAL CO.,LTD (NO.108 Hehai Road, Xinbei districtChangzhou city, Jiangsu 2, 213022, CN)
CHANGZHOU UPER BIOPHARMACEUTICAL CO.,LTD (NO.106 Hehai Road, Xinbei districtChangzhou city, Jiangsu 2, 213022, CN)
International Classes:
C07H19/073; A61K31/7068; A61P35/00; A61P35/02; A61P35/04; C07H1/00
Domestic Patent References:
WO2014078295A12014-05-22
WO2004041203A22004-05-21
Other References:
KAZUHIKO KONDO ET AL.: "Studies on Biologically Active Nucleosides and Nucleotides. 5. Synthesis and Antitumor Activity of Some 2, 2'-Anhydro-1-(3', 5'-di-O-acyl- beta -D-arabinofuranosyl)cytosine Salts and 2, 2'-Anhydro-1-(3'-O-acyl- beta -D-arabinofuranosyl)cytosine 5'-Phosphates", JOURNAL OF MEDICINAL CHEMISTRY, vol. 22, no. 6, 1 June 1979 (1979-06-01), pages 639 - 646, XP000573809, DOI: doi:10.1021/jm00192a007
THEODOROS KARAMPELAS ET AL.: "GnRH-Gemcitabine Conjugates for the Treatment of Androgen-Independent Prostate Cancer: Pharmacokinetic Enhancements Combined with Targeted Drug Delivery", BIOCONJUGATE CHEMISTRY, vol. 25, no. 4, 24 March 2014 (2014-03-24), pages 813 - 823, XP055396050
Attorney, Agent or Firm:
CHANGZHOU JIANGHAI YANGGUANG INTELLECTUAL PROPERTY AGENCY LTD. (Room 503, Guotai Xindu Business CenterNO.1 Heping North Road, Tianning Distric, Changzhou city Jiangsu 3, 213003, CN)
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