Title:
NEW UREA COMPOUND, MANUFACTURING METHOD AND APPLICATION THEREOF
Document Type and Number:
WIPO Patent Application WO/2015/090209
Kind Code:
A1
Abstract:
Provided in the present invention are a general formula I compound, the isomers, pharmaceutically-acceptable salt or solvate thereof, and application thereof to manufacturing medicine for preventing and/or treating drug-resistant tumours, or diseases or conditions caused by drug-resistant bacteria, or manufacturing medicine for preventing and/or treating tumours, neurodegenerative disease, allogeneic transplant rejection, infection-related diseases or symptoms; preferably, the tumour, neurodegenerative disease, allogeneic transplant rejection, infection-related disease or symptom is a disease or symptom caused by Heat shock protein 70 (Hsp70). The compound of the present invention is a highly-active Hsp70 inhibitor having an entirely new structure, used for overcoming the problem of drug-resistant tumours, improving the effects of tumour treatment, and providing a medical strategy for clinical oncology.
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Inventors:
ZHONG WU (CN)
LI SONG (CN)
ZENG YANQUN (CN)
XIAO JUNHAI (CN)
ZHOU XINBO (CN)
ZHENG ZHIBING (CN)
LI XINGZHOU (CN)
WANG XIAOKUI (CN)
LI SONG (CN)
ZENG YANQUN (CN)
XIAO JUNHAI (CN)
ZHOU XINBO (CN)
ZHENG ZHIBING (CN)
LI XINGZHOU (CN)
WANG XIAOKUI (CN)
Application Number:
PCT/CN2014/094162
Publication Date:
June 25, 2015
Filing Date:
December 18, 2014
Export Citation:
Assignee:
INST PHARM & TOXICOLOGY AMMS (CN)
International Classes:
C07C391/00; A61K31/165; A61K31/17; A61K31/4402; A61K31/4406; A61K31/4453; A61K31/5375; A61P25/28; A61P35/00; A61P37/06; C07C335/08; C07C335/14; C07C335/16; C07C335/18; C07D213/75; C07D295/16; A61P31/04
Domestic Patent References:
| WO2007015632A1 | 2007-02-08 | |||
| WO2005033288A2 | 2005-04-14 | |||
| WO2002022581A1 | 2002-03-21 | |||
| WO2004032716A2 | 2004-04-22 | |||
| WO2006110724A2 | 2006-10-19 | |||
| WO2008066576A2 | 2008-06-05 |
Foreign References:
| CN102241673A | 2011-11-16 | |||
| CN102241628A | 2011-11-16 | |||
| CN102028689A | 2011-04-27 | |||
| CN101489542A | 2009-07-22 |
Other References:
See also references of EP 3085690A4
None
None
Attorney, Agent or Firm:
CCPIT PATENT AND TRADEMARK LAW OFFICE (CN)
中国国际贸易促进委员会专利商标事务所 (CN)
中国国际贸易促进委员会专利商标事务所 (CN)
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