Title:
NEW USE OF PQQ AND DERIVATIVE THEREOF
Document Type and Number:
WIPO Patent Application WO/2022/166599
Kind Code:
A1
Abstract:
A new use of PQQ and a derivative thereof. PQQ can effectively alleviate or treat primary dysmenorrhea, secondary dysmenorrhea and abnormal menstruation. After being treated with PQQ, the following effects can be achieved for patients: 1. the dysmenorrhea alleviation rate is 100%; 2. the average duration of a menstrual period in each month is reduced from about 2 weeks to about 1 week, and is returned to the normal average duration of a menstrual period; 3. the menstrual blood volume in each month is reduced by more than 30% on average, and is substantially returned to the normal average level of menstrual blood volume; and 4. two patients suffering from years of infertility caused by secondary dysmenorrhea are pregnant within a treatment period of 3 months.
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Inventors:
GUO LING (CN)
ZHANG XIAOWEN (CN)
ZHANG XIAOWEN (CN)
Application Number:
PCT/CN2022/072881
Publication Date:
August 11, 2022
Filing Date:
January 20, 2022
Export Citation:
Assignee:
GUANGZHOU HUTONGYOUWU BIOTECHNOLOGY CO LTD (CN)
International Classes:
A61K31/4745; C07D471/04; A61K36/534; A61P15/00
Foreign References:
| CN104856996A | 2015-08-26 | |||
| CN105853502A | 2016-08-17 | |||
| CN102665707A | 2012-09-12 | |||
| CN110870866A | 2020-03-10 | |||
| CN110151764A | 2019-08-23 | |||
| CN106265730A | 2017-01-04 | |||
| CN105963297A | 2016-09-28 | |||
| CN103191115A | 2013-07-10 |
Other References:
RUCKER, R. ET AL.: "Potential Physiological Importance of Pyrroloquinoline Quinone", ALTERNATIVE MEDICINE REVIEW, vol. 14, no. 3, 31 December 2009 (2009-12-31), XP055325799
DURAK, YILDIRIM ET AL.: "Effect of vitamin C on the growth of experimentally induced endometriotic cysts", JOURNAL OF OBSTETRICS AND GYNAECOLOGY RESEARCH, vol. 39, no. 7, 2013, pages 1253 - 1258, XP055325865, DOI: 10.1111/jog.12050
CAS , no. 72909-34-3
"Pharmaceutical Salts: Properties, Selection, and Use", August 2002, pages: 388
DURAK, YILDIRIM ET AL.: "Effect of vitamin C on the growth of experimentally induced endometriotic cysts", JOURNAL OF OBSTETRICS AND GYNAECOLOGY RESEARCH, vol. 39, no. 7, 2013, pages 1253 - 1258, XP055325865, DOI: 10.1111/jog.12050
CAS , no. 72909-34-3
"Pharmaceutical Salts: Properties, Selection, and Use", August 2002, pages: 388
Attorney, Agent or Firm:
GUANGZHOU NUOFENG INTELLECTUAL PROPERTY AGENT (CN)
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