Title:
NEW XYLENE-BASED AMPHIPATHIC COMPOUND AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2017/039107
Kind Code:
A1
Abstract:
The present invention relates to a xylene-based amphipathic compound, a method for preparing same, and a method for extracting, solubilizing, stabilizing, or crystallizing membrane proteins by using said compound. By using the xylene-based compound according to the present invention, membrane proteins can be stably kept in an aqueous solution for a long period of time and thus can be utilized in the analysis of the function and structure thereof. The analysis of the structure and function of membrane proteins is one of the fields that currently receive the most attention in biology and chemistry, and thus can be applied to protein structure research, which is closely related to the development of new drugs.
Inventors:
CHAE PIL SEOK (KR)
CHO KYUNG HO (KR)
CHO KYUNG HO (KR)
Application Number:
PCT/KR2016/003929
Publication Date:
March 09, 2017
Filing Date:
April 15, 2016
Export Citation:
Assignee:
INDUSTRY-UNIV COOP FOUND HANYANG UNIV ERICA CAMPUS (KR)
International Classes:
C07H15/00; C07C15/107; C07H3/04; C07K1/14; G01N1/28; G01N33/68
Domestic Patent References:
| WO2014182710A1 | 2014-11-13 |
Foreign References:
| US20090270598A1 | 2009-10-29 |
Other References:
CHAE, P. S. ET AL.: "Maltose-neopentyl Glycol (MNG) Amphiphiles for Solubilization, Stabilization and Crystallization of Membrane Proteins", NATURE METHODS, vol. 7, no. 12, 31 October 2010 (2010-10-31), pages 1003 - 1008, XP055377701
CHAE, P. S. ET AL.: "Tandem Facial Amphiphiles for Membrane Protein Stabilization", J. AM. CHEM. SOC., vol. 132, no. 47, 4 November 2010 (2010-11-04), pages 16750 - 16752, XP055377702
CHAE, P. S. ET AL.: "A New Class of Amphiphiles Bearing Rigid Hydrophobic Groups for Solubilization and Stabilization of Membrane Proteins", CHEMISTRY-A EUROPEAN JOURNAL, vol. 18, no. 31, 22 June 2012 (2012-06-22), pages 9485 - 9490, XP055377703
CHO, K. H. ET AL.: "Novel Xylene-linked. Maltoside Amphiphiles (XMAs) for Membrane Protein Stabilisation", CHEMISTRY-A EUROPEAN JOURNAL, vol. 21, no. 28, 26 May 2015 (2015-05-26), pages 10008 - 10013, XP055377704
CHO, K. H. ET AL.: "Novel Benzene-centered Maltoside Amphihiles (BMAs) for Membrane Protein Study", 115TH GENERAL MEETING AND CONFERENCE OF THE KOREAN CHEMICAL SOCIETY, vol. 55, no. 4, 15 April 2015 (2015-04-15)
CHAE, P. S. ET AL.: "Tandem Facial Amphiphiles for Membrane Protein Stabilization", J. AM. CHEM. SOC., vol. 132, no. 47, 4 November 2010 (2010-11-04), pages 16750 - 16752, XP055377702
CHAE, P. S. ET AL.: "A New Class of Amphiphiles Bearing Rigid Hydrophobic Groups for Solubilization and Stabilization of Membrane Proteins", CHEMISTRY-A EUROPEAN JOURNAL, vol. 18, no. 31, 22 June 2012 (2012-06-22), pages 9485 - 9490, XP055377703
CHO, K. H. ET AL.: "Novel Xylene-linked. Maltoside Amphiphiles (XMAs) for Membrane Protein Stabilisation", CHEMISTRY-A EUROPEAN JOURNAL, vol. 21, no. 28, 26 May 2015 (2015-05-26), pages 10008 - 10013, XP055377704
CHO, K. H. ET AL.: "Novel Benzene-centered Maltoside Amphihiles (BMAs) for Membrane Protein Study", 115TH GENERAL MEETING AND CONFERENCE OF THE KOREAN CHEMICAL SOCIETY, vol. 55, no. 4, 15 April 2015 (2015-04-15)
Attorney, Agent or Firm:
DANA PATENT LAW FIRM (KR)
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