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Title:
NF-κB ACTIVATION INHIBITORS
Document Type and Number:
WIPO Patent Application WO/2003/103654
Kind Code:
A1
Abstract:
Drugs having an inhibitory activity against NF-κB activation, which contain as the active ingredient substances selected from the group consisting of compounds represented by the general formula (I), pharmacologically acceptable salts thereof, and hydrates and solvates of both: (I) wherein A is hydrogen or acetyl; E is 2,5- or 3,5-disubstituted phenyl or an optionally substituted monocyclic or fused-polycyclic heteroaryl group (exclusive of (1) fused -polycyclic heteroaryl whose benzene ring is bonded directly to the -CONH- group, (2) unsubstituted thiazol-2-yl, and (3) unsubstituted benzothiazol-2-yl); and Z is arene which may have a substituent in addition to the groups represented by the general formulae: -O-A (wherein A is as defined above) and -CONH-E (wherein E is as defined above) or heteroarene which may have a substituent in addition to the groups represented by the general formulae: -O-A (wherein A is as defined above) and -CONH-E (wherein E is as defined above).

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Inventors:
MUTO SUSUMU (JP)
ITAI AKIKO (JP)
Application Number:
PCT/JP2003/007119
Publication Date:
December 18, 2003
Filing Date:
June 05, 2003
Export Citation:
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Assignee:
INST MED MOLECULAR DESIGN INC (JP)
MUTO SUSUMU (JP)
ITAI AKIKO (JP)
International Classes:
A61K31/00; A61K31/167; A61K31/18; A61K31/222; A61K31/275; A61K31/381; A61K31/40; A61K31/404; A61K31/4164; A61K31/421; A61K31/422; A61K31/426; A61K31/433; A61K31/437; A61K31/4402; A61K31/445; A61K31/451; A61K31/455; A61K31/47; A61K31/498; A61K31/505; A61K31/5375; A61K31/5377; A61P29/00; A61P37/06; A61P43/00; (IPC1-7): A61K31/167; A61K31/18; A61K31/275; A61K31/381; A61K31/40; A61K31/404; A61K31/4164; A61K31/421; A61K31/422; A61K31/426; A61K31/433; A61K31/437; A61K31/4402; A61K31/445; A61K31/451; A61K31/455; A61K31/47; A61K31/498; A61K31/505; A61K31/5375; A61K31/5377; A61P29/00; A61P37/06; A61P43/00; A61K31/222
Domestic Patent References:
WO2001012588A12001-02-22
WO2002049632A12002-06-27
WO2002076918A12002-10-03
WO1999065449A21999-12-23
WO2002028819A12002-04-11
WO2001010865A12001-02-15
WO1999024404A11999-05-20
Foreign References:
JPH04217916A1992-08-07
EP0317991A21989-05-31
EP0198456A21986-10-22
Other References:
MORI T. ET AL.: "Inhibitory effect of amino-benzoic acid derivatives on hemolytic reaction in vitro", YAKUGAKU ZASSHI, vol. 95, no. 12, 1975, pages 1477 - 1482, XP002971396
OHSUGI Y. ET AL.: "Inhibitory effect of bis (2-hydroxybenzamido) benzoic acid derivatives on reagin-mediated passive cutaneous anaphylaxis (PCA) in rats", YAKUGAKU ZASSHI, vol. 96, no. 2, 1976, pages 165 - 169, XP002971397
DATABASE CAS [online] ROBERT-PIESSARD S. ET AL.: "Synthesis and anti-inflammatory activity of N-(4,6-dimethylpyridin-2-yl) beta-ketoamides and derivatives", XP002971398, accession no. STN Database accession no. 127.257114
DAIDONE C. ET AL.: "Synthesis and evaluation of the analgesic and antiinflammatory activities of N-substituted salicylamides", FARMACO, vol. 44, no. 5, 1989, pages 465 - 473, XP001053114
See also references of EP 1535609A4
Attorney, Agent or Firm:
SIKS & CO. (Kyobashi-Nisshoku Bldg. 8-7, Kyobashi 1-chom, Chuo-ku Tokyo, JP)
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