NICKEL-BASED REAGENTS FOR DETECTING DNA AND DNA-PROTEIN CONTACTS

Title:

NICKEL-BASED REAGENTS FOR DETECTING DNA AND DNA-PROTEIN CONTACTS

Document Type and Number:

WIPO Patent Application WO2001002370

Kind Code:

A9

Abstract:

The invention relates to a compound comprising a labeled nickel complex (Figure 1) that is used to detect and purify nucleic acid sequences by forming an adduct between a specific nucleic acid base and the labeled nickel complex. The adduct can also be purified through a separation process, such as affinity chromatography.

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Inventors:

ROKITA STEVEN E (US)
BURROWS CYNTHIA J (US)

Application Number:

PCT/US2000/018325

Publication Date:

July 12, 2001

Filing Date:

July 03, 2000

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Assignee:

UNIV MARYLAND (US)
UNIV UTAH (US)
ROKITA STEVEN E (US)
BURROWS CYNTHIA J (US)

International Classes:

C07C251/24; C07C271/20; C07D233/64; C07D487/22; C07D495/04; C07K14/795; G01N33/531; G01N33/58; (IPC1-7): C07D233/64; C07D235/02; C07D487/22; C07F15/04; C07K2/00; C07K14/795; G01N33/52; G01N33/58; G01N33/60; G01N33/68

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