Title:
NICORANDIL-CONTAINING PHARMACEUTICAL COMPOSITION
Document Type and Number:
WIPO Patent Application WO/2013/002382
Kind Code:
A1
Abstract:
A pharmaceutical composition containing nicorandil, mannitol, and the alkali metal salt of an organic carboxylic acid, wherein (1) "the peak value of the δ crystals of mannitol at 9.8° ±0.3°(2θ) in X-ray diffraction "/"the peak value of nicorandil crystals at 10.6°±0.3°(2θ) in X-ray diffraction" is 2.0 or less or (2) "the peak intensity at 1.01 THz ±0.2 THz of the secondary derivative spectrum in the absorption spectrum of the δ crystals of mannitol measured by means of terahertz transmission spectroscopy"/" the peak intensity at 0.95 THz ±0.2 THz of the secondary derivative spectrum in the absorption spectrum of nicorandil crystals measured by means of terahertz transmission spectroscopy" is 1.5 or less. This pharmaceutical composition exhibits excellent storage stability.
Inventors:
YURA TAKAYUKI (JP)
HASHIMOTO YUKI (JP)
KANEHIRO HIDEO (JP)
HASHIMOTO YUKI (JP)
KANEHIRO HIDEO (JP)
Application Number:
PCT/JP2012/066743
Publication Date:
January 03, 2013
Filing Date:
June 29, 2012
Export Citation:
Assignee:
MOCHIDA PHARM CO LTD (JP)
YURA TAKAYUKI (JP)
HASHIMOTO YUKI (JP)
KANEHIRO HIDEO (JP)
YURA TAKAYUKI (JP)
HASHIMOTO YUKI (JP)
KANEHIRO HIDEO (JP)
International Classes:
A61K31/455; A61K9/19; A61K47/10; A61K47/12; A61P9/04; A61P9/10
Foreign References:
| JPS62252722A | 1987-11-04 | |||
| CN101474161A | 2009-07-08 |
Other References:
See also references of EP 2727593A4
Attorney, Agent or Firm:
TSUJII Koichi et al. (JP)
辻居 Koichi (JP)
辻居 Koichi (JP)
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Claims: