NICOTINAMIDE-RIBOSIDE AND PTEROSTILBENE COMBINATIONS TO TREAT OSTEOARTHRITIS

WIPO Patent Application WO/2024/050120

A3

Compositions and methods of treatment for osteoarthritis and cartilage damage in a subject comprising administering to a subject in need thereof an effective amount of a nicotinamide-riboside (NR) and pterostilbene (PT) in a ratio of about 2:1.

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BRYAN RU LIU (US)
MIGAUD MARIE (US)

PCT/US2023/031900

April 04, 2024

September 01, 2023

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UNIV CALIFORNIA (US)
UNIV SOUTH ALABAMA (US)

A61K31/7042; A61K31/7052; A61K31/706; A61P19/02; A61P29/00; A61K45/06

US20210369750A1	2021-12-02
US20180362570A1	2018-12-20
US20170267709A1	2017-09-21
US20160272668A1	2016-09-22

R. STUDER, D. JAFFURS, M. STEFANOVIC-RACIC, P. D. ROBBINS, C. H. EVANS: "Nitric oxide in osteoarthritis", OSTEOARTHRITIS AND CARTILAGE, ELSEVIER, AMSTERDAM, NL, vol. 7, no. 4, 1 July 1999 (1999-07-01), AMSTERDAM, NL, pages 377 - 379, XP093158999, ISSN: 1063-4584, DOI: 10.1053/joca.1998.0216
DELLINGER R. W. ET AL.: "Repeat dose NRPT (nicotinamide riboside and pterostilbene) increases NAD, levels in humans safely and sustainably: a randomized, double-blind, placebo- controlled study", NPJ AGING AND MECHANISMS OF DISEASE, vol. 3, 2017, XP055482304, DOI: 10.1038/s41514-017-0016-9

WARREN, William L. et al. (US)

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