Title:
NICOTINE EUTECTIC CRYSTAL, PREPARATION METHOD THEREFOR AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2020/038238
Kind Code:
A1
Abstract:
Provided is a nicotine eutectic crystal, which is obtained by self-assembling nicotine and 2,6-dihydroxybenzoic acid in a molar ratio of 1 : 1 to 1 : 5 and has a melting point of 159ºC-163ºC. Further provided are a preparation method for the nicotine eutectic crystal and the use thereof in an electronic cigarette liquid. The nicotine eutectic crystal is obtained for the first time, and applied in an electronic cigarette liquid to make the tobacco thereof provide a strong aroma, a soft aroma, and a stronger sense of satisfaction. The problem that a free state nicotine is unstable and volatile is solved, and the strong irritation to the throat of a smoker is reduced. The preparation method has a simple process, and the obtained nicotine eutectic crystal has a higher yield and purity, and a low cost, and is suited for mass production.
Inventors:
HAN JINGMEI (CN)
ZHAO XIAOQING (CN)
LI HANGXING (CN)
TANG JIANGUO (CN)
ZHENG XUDONG (CN)
LEI PING (CN)
SHANG SHANZHAI (CN)
LI ZHIQIANG (CN)
WANG CHENGYA (CN)
SUN ZHIYONG (CN)
DU LIN (CN)
CHEN YONGKUAN (CN)
ZHAO XIAOQING (CN)
LI HANGXING (CN)
TANG JIANGUO (CN)
ZHENG XUDONG (CN)
LEI PING (CN)
SHANG SHANZHAI (CN)
LI ZHIQIANG (CN)
WANG CHENGYA (CN)
SUN ZHIYONG (CN)
DU LIN (CN)
CHEN YONGKUAN (CN)
Application Number:
PCT/CN2019/099824
Publication Date:
February 27, 2020
Filing Date:
August 08, 2019
Export Citation:
Assignee:
CHINA TOBACCO YUNNAN IND CO LTD (CN)
International Classes:
C07D401/04; A24B15/16; C07C65/05
Domestic Patent References:
| WO2017089931A1 | 2017-06-01 |
Foreign References:
| CN106536501A | 2017-03-22 | |||
| US20180051002A1 | 2018-02-22 | |||
| CN108323792A | 2018-07-27 | |||
| CN108329296A | 2018-07-27 | |||
| CN108285441A | 2018-07-17 |
Other References:
PERFETTI THOMAS A.: "Structural Study of Nicotine Salts", BEITRAGE ZUR TABAKFORSCHUNG INTERNATIONAL, vol. 12, no. 2, 30 June 1983 (1983-06-30), XP009185158, ISSN: 0173-783X, DOI: 20191025142716X
Attorney, Agent or Firm:
BEIJING LINGZHUAN INTELLECTUAL PROPERTY AGENCY CO., LTD (CN)
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