NICOTINE RECEPTOR AGONISTS IN STEM CELL AND PROGENITOR CELL RECRUITMENT

WIPO Patent Application WO2005079344

A3

The present invention features methods for recruitment of bone marrow-derived stem cells (e.g., endothelial cell precursors, hematopoietic stem cells) by administration of nicotine or other nicotine receptor agonist. The methods of the invention can be used in, for example, treatment of conditions amenable to treatment by recruitment of bone marrow-derived stem cells (e.g., neutropenia).

JP5484490	A bactericidal composition containing Fluopyram and 5-ethyl-6-octyl- [1,2,4] triazolo [1,5-a] pyrimidin-7-ylamine.
WO/1998/016522	AMINOPHENOL DERIVATES WITH FUNGICIDAL PROPERTY,

COOKE JOHN P (US)
JOHNSON FRANCES LAURI (US)
PATHAK ANJALI (US)
JANG JAMES (US)
TSAO PHILIP (US)
HEESCHEN CHRISTOPHER (DE)

PCT/US2005/004550

July 20, 2006

February 11, 2005

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UNIV LELAND STANFORD JUNIOR (US)
COOKE JOHN P (US)
JOHNSON FRANCES LAURI (US)
PATHAK ANJALI (US)
JANG JAMES (US)
TSAO PHILIP (US)
HEESCHEN CHRISTOPHER (DE)

A01N43/40; A61K31/40; A61K31/44; A61K31/445; A61K31/465

WO2001008683A1

2001-02-08

US5695755A

1997-12-09

VILLABLANCA A.C.: "Nicotine Stimulates DNA Synthesis and Proliferation in Vascular Endothelial Cells in Vitro", J. APPL. PHYSIOL., vol. 84, no. 6, 1998, pages 2089 - 2098, XP002315260
CARTY ET AL.: "Nicotine and Cotinine Stimulate Secretion of Basic Fibroblast Growth Factor and Affect Expression of Matrix Metalloproteinases in Cultured Human Smooth Muscle Cells", J. VASC. SURG., vol. 24, 1996, pages 927 - 935, XP005141809

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