NITRO COMPOUNDS HAVING VASODILATOR ACTIVITY - FUJISAWA PHARMACEUTICAL CO

Title:

NITRO COMPOUNDS HAVING VASODILATOR ACTIVITY

Document Type and Number:

WIPO Patent Application WO/1993/010097

Kind Code:

A1

Abstract:

A few nitro compound of formula (I), wherein R?1¿ and R?2¿ are each lower alkyl or lower alkoxy(lower)-alkyl, or (a) is cyclized to form (b), X is -O-, -S- or -NH-, m is an integer 0 or 1, and R?3¿ is carbamoyl, lower alkylcarbamoyl, lower alkanoyl, di-lower alkylaminosulfonyl, lower alkylsulfonyl, oxamoyl or a group of the formula: -(Y)¿n?-R?4¿, wherein Y is -CO-, -SO¿2?-, -COCH¿2? or (c), n is an integer of 0 or 1, and R?4¿ is heterocyclic group which is optionally substituted with one or more substituents selected from lower alkyl, lower alkoxy, phenyl, carbamoyl, halogen, amino, lower alkylthio, hydroxy, lower alkylsulfonylamino and carbamoylmethyl, and pharmaceutically acceptable salt thereof, which are useful for vasodilator.

Inventors:

KATO MASAYUKI (JP)
NISHINO SHIGETAKA (JP)
HAMANO MITSUKO (JP)
TAKASUGI HISASHI (JP)

Application Number:

PCT/JP1992/001414

Publication Date:

May 27, 1993

Filing Date:

November 02, 1992

Export Citation:

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Assignee:

FUJISAWA PHARMACEUTICAL CO (JP)

International Classes:

A61K31/165; A61K31/215; A61K31/40; A61K31/403; A61K31/404; A61K31/41; A61K31/415; A61K31/4164; A61K31/12; A61K31/42; A61K31/423; A61K31/433; A61K31/44; A61K31/4402; A61K31/4406; A61K31/4409; A61K31/4418; A61K31/47; A61P7/02; A61P9/08; C07C249/06; C07C251/40; C07C271/12; C07C275/20; C07C307/06; C07C311/05; C07C319/20; C07C323/23; C07D209/34; C07D209/38; C07D209/48; C07D213/56; C07D213/71; C07D213/78; C07D213/80; C07D213/81; C07D213/82; C07D215/54; C07D231/14; C07D233/84; C07D233/90; C07D233/92; C07D239/38; C07D241/14; C07D241/24; C07D249/10; C07D253/00; C07D257/04; C07D261/18; C07D277/56; C07D277/70; C07D277/74; C07D285/125; C07D471/04; C07D473/38; C07D285/12; (IPC1-7): A61K31/00; C07D209/48; C07D213/54; C07D213/71; C07D213/78; C07D213/80; C07D213/82; C07D473/38

Foreign References:

EP0113106A1	1984-07-11
EP0168921A2	1986-01-22

Attorney, Agent or Firm:

Seki, Hideo (Ltd., Osaka Factory, 1-6, Kashima 2-chome, Yodogawa-ku, Osaka-shi, Osaka 532, JP)

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