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Title:
NITROGEN-CONTAINING COMPOUND AND PHARMACEUTICAL COMPOSITION
Document Type and Number:
WIPO Patent Application WO/2011/021726
Kind Code:
A2
Abstract:
The present invention provides a novel diazepine compound that blocks the IKur current or the Kv1.5 channel potently and more selectively than other K+ channels. The present invention relates to a diazepine compound represented by General Formula (1) or a salt thereof, wherein R1, R2, R3, and R4 are each independently hydrogen, lower alkyl, cyclo lower alkyl or lower alkoxy lower alkyl; R2 and R3 may be linked to form lower alkylene; A1 is lower alkylene optionally substituted with one or more substituents selected from the group consisting of hydroxyl and oxo; Y1 and Y2 are each independently -N= or -CH=; and R5 is group represented by (2) wherein R6 and R7 are each independently hydrogen or organic group; R6 and R7 may be linked to form a ring together with the neighboring group -XA-N-XB-; XA and XB are each independently a bond, lower alkylene, etc.

Inventors:
OSHIMA KUNIO (JP)
MATSUMURA SHUUJI (JP)
YAMABE HOKUTO (JP)
ISONO NAOHIRO (JP)
TAKEMURA NORIAKI (JP)
TAIRA SHINICHI (JP)
OSHIYAMA TAKASHI (JP)
MENJO YASUHIRO (JP)
NAGASE TSUYOSHI (JP)
UEDA MASATAKA (JP)
KOGA YASUO (JP)
NAKAYAMA SUNAO (JP)
TSUJIMAE KENJI (JP)
ONOGAWA TOSHIYUKI (JP)
TAI KUNINORI (JP)
ITOTANI MOTOHIRO (JP)
Application Number:
PCT/JP2010/064545
Publication Date:
February 24, 2011
Filing Date:
August 20, 2010
Export Citation:
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Assignee:
OTSUKA PHARMA CO LTD (JP)
OSHIMA KUNIO (JP)
MATSUMURA SHUUJI (JP)
YAMABE HOKUTO (JP)
ISONO NAOHIRO (JP)
TAKEMURA NORIAKI (JP)
TAIRA SHINICHI (JP)
OSHIYAMA TAKASHI (JP)
MENJO YASUHIRO (JP)
NAGASE TSUYOSHI (JP)
UEDA MASATAKA (JP)
KOGA YASUO (JP)
NAKAYAMA SUNAO (JP)
TSUJIMAE KENJI (JP)
ONOGAWA TOSHIYUKI (JP)
TAI KUNINORI (JP)
ITOTANI MOTOHIRO (JP)
International Classes:
A61K31/4704; C07D243/12; A61K31/496; A61K31/498; A61K31/4985; A61K31/506; A61K31/517; A61K31/551; A61K31/553; A61K31/554; C07D215/227; C07D401/06; C07D401/12; C07D401/14; C07D403/06; C07D403/12; C07D403/14; C07D405/14; C07D407/14; C07D409/12; C07D409/14; C07D413/06; C07D413/12; C07D413/14; C07D417/14; C07D471/04; C07D491/048; C07D495/04; C07D519/00
Domestic Patent References:
WO2007026959A22007-03-08
WO1996040655A11996-12-19
WO2001010216A12001-02-15
WO2009104819A12009-08-27
Foreign References:
EP0504695A11992-09-23
Other References:
THE JOURNAL OF AMERICAN MEDICAL ASSOCIATION, vol. 285, 2001, pages 2370 - 2375
CIRCULATION, vol. 114, 2006, pages 119 - 123
AM. J. CARDIOL., vol. 72, 1993, pages B44 - B49
NATURE REVIEWS DRUG DISCOVERY, vol. 4, 2005, pages 899 - 910
NATURE REVIEWS DRUG DISCOVERY, vol. 5, 2006, pages 1034 - 49
TRENDS PHANNACOL. SOC., vol. 22, 2001, pages 240 - 246
CRIC. RES., vol. 73, 1993, pages 1061 - 1076
J. PHYSIOL., vol. 491, 1996, pages 31 - 50
CRIC. RES., vol. 80, 1997, pages 572 - 579
NATURE, vol. 374, 1995, pages 135 - 141
Attorney, Agent or Firm:
Saegusa & Partners (1-7-1 Doshomachi, Chuo-ku, Osaka-sh, Osaka 45, JP)
Download PDF:
Claims:
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Description:
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