NITROGEN-CONTAINING CONDENSED HETEROCYCLIC COMPOUND

Title:

NITROGEN-CONTAINING CONDENSED HETEROCYCLIC COMPOUND

Document Type and Number:

WIPO Patent Application WO/2012/124744

Kind Code:

A1

Abstract:

Provided is a compound represented by general formula (I), or a pharmaceutically acceptable salt thereof, having superior monoacylglycerol acyltransferase-2 inhibitory activity. In formula (I), ring (A) represents a partially saturated heteroaryl group, an aryl group, or a heteroaryl group; RB represents a C4-18 alkyl group, a C3-8 cycloalkyl group, a partially saturated aryl group, an aryl group, or formula (II) (in formula (II), V represents the formula -CR11R12-, the formula -CO-, the formula -CO-O-, or the formula -CO-NH-; W represents a single bond or a C1-3 alkylene group; and the ring (B) represents a C3-8 cycloalkyl group, a C3-8 cycloalkenyl group, a partially saturated heteroaryl group, a saturated heterocyclyl group, an aryl group, or a heteroaryl group); Y represents a nitrogen atom or formula N+(RF); RF represents a C1-4 alkyl group; and m and n may be the same or different and each independently represent an integer 0 or 1.

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Inventors:

BUSUJIMA TSUYOSHI (JP)
OI TAKAHIRO (JP)
TANAKA HIROAKI (JP)
SHIRASAKI YOSHIHISA (JP)
IWAKIRI KANAKO (JP)
SATO NAGAAKI (JP)
TOKITA SHIGERU (JP)

Application Number:

PCT/JP2012/056600

Publication Date:

September 20, 2012

Filing Date:

March 14, 2012

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Assignee:

TAISHO PHARMACEUTICAL CO LTD (JP)
BUSUJIMA TSUYOSHI (JP)
OI TAKAHIRO (JP)
TANAKA HIROAKI (JP)
SHIRASAKI YOSHIHISA (JP)
IWAKIRI KANAKO (JP)
SATO NAGAAKI (JP)
TOKITA SHIGERU (JP)

International Classes:

C07D209/44; A61K31/4035; A61K31/454; A61K31/472; A61K31/4725; A61K31/497; A61K31/498; A61K31/506; A61K31/538; A61K31/55; A61P1/16; A61P3/04; A61P3/06; A61P3/10; A61P9/10; A61P9/12; A61P43/00; C07D217/04; C07D217/06; C07D217/22; C07D223/16; C07D401/06; C07D401/10; C07D401/12; C07D403/12; C07D405/06; C07D405/12; C07D413/12; C07D417/06

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WO2010095767A1	2010-08-26
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Foreign References:

JP2008540539A	2008-11-20
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See also references of EP 2687507A4

Attorney, Agent or Firm:

ONO, Shinjiro et al. (JP)
Ono Shinjiro (JP)

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