Title:
NITROGEN-CONTAINING CONDENSED HETEROCYCLIC COMPOUND
Document Type and Number:
WIPO Patent Application WO/2017/069270
Kind Code:
A1
Abstract:
Provided is a novel compound or a pharmaceutically acceptable salt thereof that is useful for treating or preventing, on the basis of the PAM effects of the GABAB receptor, diseases such as autism spectrum disorder, fragile X syndrome, schizophrenia, bipolar disorder, depression, anxiety disorder, dementia, pain, drug/alcohol addiction, convulsion, cerebrovascular disorder, cerebral palsy, spinal palsy, external-injury posttraumatic complication, multiple sclerosis, amyotrophic lateral sclerosis, stiff-person syndrome, essential tremor, overactive bladder, gastroesophageal reflux disease, Charcot-Marie-Tooth disease, and so forth. Specifically, provided is a compound indicated by formula (I) or a pharmaceutically acceptable salt thereof.
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Inventors:
SHIMONO RIE (JP)
MATSUDA DAISUKE (JP)
MASUDA SEIJI (JP)
YAMAMOTO SHUJI (JP)
MATSUDA DAISUKE (JP)
MASUDA SEIJI (JP)
YAMAMOTO SHUJI (JP)
Application Number:
PCT/JP2016/081355
Publication Date:
April 27, 2017
Filing Date:
October 21, 2016
Export Citation:
Assignee:
TAISHO PHARMACEUTICAL CO LTD (JP)
International Classes:
C07D487/04; A61K31/519; A61K31/53; A61K31/5377; A61K31/5383; A61K31/541; A61P9/00; A61P21/02; A61P25/00; A61P25/04; A61P25/08; A61P25/18; A61P25/22; A61P25/24; A61P25/28; A61P25/30; A61P25/32; A61P43/00; C07D519/00
Domestic Patent References:
| WO2000044754A1 | 2000-08-03 | |||
| WO2006136530A1 | 2006-12-28 | |||
| WO2005084439A1 | 2005-09-15 | |||
| WO2001077111A1 | 2001-10-18 | |||
| WO2016169995A1 | 2016-10-27 |
Foreign References:
| CN101147741A | 2008-03-26 | |||
| JPS5019769A | 1975-03-01 |
Other References:
DATABASE REGISTRY [o] 14 January 2014 (2014-01-14), retrieved from STN Database accession no. 1519911-04-6
DATABASE REGISTRY 21 November 2013 (2013-11-21), Database accession no. 1478173-34-0
ZHANG X. ET AL.: "Highly facile and regio-selective synthesis of pyrazolo[1,5-a] pyrimidines via reactions of 1,2-allenic ketones with aminopyrazoles", ORGANIC & BIOMOLECULAR CHEMISTRY, vol. 12, 2014, pages 2099 - 107, XP055377462, ISSN: 1477-0520
PERDONA E. ET AL.: "In vitro and in vivo characterization of the novel GABAB receptor positive allosteric modulator, 2-{1-[2-(4- chlorophenyl)-5-methylpyrazolo[1,5-a] pyrimidin-7-yl]-2-piperidinyl}ethanol(CMPPE)", NEUROPHARMACOLOGY, vol. 61, 2011, pages 957 - 66, XP028268260, ISSN: 0028-3908
SORBERA L.A. ET AL.: "Indiplon: Treatment of insomnia GABA-A agonist", DRUGS OF THE FUTURE, vol. 28, no. 8, 2003, pages 739 - 46, XP008045127, ISSN: 0377-8282
DATABASE REGISTRY 21 November 2013 (2013-11-21), Database accession no. 1478173-34-0
ZHANG X. ET AL.: "Highly facile and regio-selective synthesis of pyrazolo[1,5-a] pyrimidines via reactions of 1,2-allenic ketones with aminopyrazoles", ORGANIC & BIOMOLECULAR CHEMISTRY, vol. 12, 2014, pages 2099 - 107, XP055377462, ISSN: 1477-0520
PERDONA E. ET AL.: "In vitro and in vivo characterization of the novel GABAB receptor positive allosteric modulator, 2-{1-[2-(4- chlorophenyl)-5-methylpyrazolo[1,5-a] pyrimidin-7-yl]-2-piperidinyl}ethanol(CMPPE)", NEUROPHARMACOLOGY, vol. 61, 2011, pages 957 - 66, XP028268260, ISSN: 0028-3908
SORBERA L.A. ET AL.: "Indiplon: Treatment of insomnia GABA-A agonist", DRUGS OF THE FUTURE, vol. 28, no. 8, 2003, pages 739 - 46, XP008045127, ISSN: 0377-8282
Attorney, Agent or Firm:
ONO, SHINJIRO et al. (JP)
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