Title:
NITROGEN-CONTAINING FUSED RING COMPOUND AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2006/057460
Kind Code:
A1
Abstract:
An URAT1 activity inhibitor which contains a nitrogen-containing fused ring compound represented by the following general formula [1]: [1] wherein each symbol is as defined in the description. This URAT1 activity inhibitor is useful in, for example, treating pathological conditions in which uric acid participates such as hyperuricemia, gouty node, acute gouty arthritis, chronic gouty arthritis, gouty kidney, urinary calcus, renal dysfunction, coronary artery disease and ischemic heart disease.
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Inventors:
HIRATA KAZUYUKI (JP)
OGAWA NAOKI (JP)
SHINAGAWA YUKO (JP)
KIGUCHI TOSHIHIRO (JP)
INOUE TERUHIKO (JP)
MATSUO AKIRA (JP)
KOSUGI YOSHINORI (JP)
NOMURA YUKIHIRO (JP)
KAWAHARA IICHIRO (JP)
UEHARA HIDETO (JP)
OGAWA NAOKI (JP)
SHINAGAWA YUKO (JP)
KIGUCHI TOSHIHIRO (JP)
INOUE TERUHIKO (JP)
MATSUO AKIRA (JP)
KOSUGI YOSHINORI (JP)
NOMURA YUKIHIRO (JP)
KAWAHARA IICHIRO (JP)
UEHARA HIDETO (JP)
Application Number:
PCT/JP2005/022259
Publication Date:
June 01, 2006
Filing Date:
November 29, 2005
Export Citation:
Assignee:
JAPAN TOBACCO INC (JP)
HIRATA KAZUYUKI (JP)
OGAWA NAOKI (JP)
SHINAGAWA YUKO (JP)
KIGUCHI TOSHIHIRO (JP)
INOUE TERUHIKO (JP)
MATSUO AKIRA (JP)
KOSUGI YOSHINORI (JP)
NOMURA YUKIHIRO (JP)
KAWAHARA IICHIRO (JP)
UEHARA HIDETO (JP)
HIRATA KAZUYUKI (JP)
OGAWA NAOKI (JP)
SHINAGAWA YUKO (JP)
KIGUCHI TOSHIHIRO (JP)
INOUE TERUHIKO (JP)
MATSUO AKIRA (JP)
KOSUGI YOSHINORI (JP)
NOMURA YUKIHIRO (JP)
KAWAHARA IICHIRO (JP)
UEHARA HIDETO (JP)
International Classes:
A61K45/00; A61K31/404; A61K31/47; A61K31/498; A61K31/538; A61K31/5383; A61K31/5415; A61K31/55; A61K31/5513; A61P9/10; A61P13/02; A61P13/12; A61P19/02; A61P19/06; A61P43/00; C07D209/08; C07D215/08; C07D223/16; C07D241/42; C07D241/50; C07D243/12; C07D265/34; C07D265/36; C07D265/38; C07D279/16; C07D413/06; C07D498/04
Domestic Patent References:
| WO2004085401A1 | 2004-10-07 |
Foreign References:
| JPH04321669A | 1992-11-11 | |||
| JP2003513082A | 2003-04-08 | |||
| JPH08301848A | 1996-11-19 | |||
| JPH072800A | 1995-01-06 | |||
| JP2002513425A | 2002-05-08 | |||
| JPH04154765A | 1992-05-27 |
Other References:
OGAWA H ET AL: "ORALLY ACTIVE, NONPEPTIDE VASOPRESSIN V2 RECEPTOR ANTAGONIST: A NOVEL SERIES OF 1-[4-(BENZOYLAMINO) BENZOYL]-2,3,4,5-TETRAHYDRO-1H-BENZAZEPINES AND RELATED COMPOUNDS.", J MED CHEM., vol. 39, no. 18, 1996, pages 3547 - 3555, XP002148303
NAKAJIMA H ET AL: "STUDIES ON THE METABOLIC FATE OF M17055, A NOVEL DIURETIC (6). ASSESSMENT FOR DRUG-DRUG INTERACTIONS OF M17055 IN METABOLISM, DISTRIBUTION AND EXCRETION.", XENOBIOTICA., vol. 32, no. 12, 2002, pages 1161 - 1172, XP002999424
See also references of EP 1820515A4
NAKAJIMA H ET AL: "STUDIES ON THE METABOLIC FATE OF M17055, A NOVEL DIURETIC (6). ASSESSMENT FOR DRUG-DRUG INTERACTIONS OF M17055 IN METABOLISM, DISTRIBUTION AND EXCRETION.", XENOBIOTICA., vol. 32, no. 12, 2002, pages 1161 - 1172, XP002999424
See also references of EP 1820515A4
Attorney, Agent or Firm:
Takashima, Hajime (1-1 Fushimimachi 4-chome, Chuo-k, Osaka-shi Osaka, JP)
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