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Title:
NITROGEN-CONTAINING HETEROCYCLIC COMPOUND, PREPARATION METHOD, INTERMEDIATE, PHARMACEUTICAL COMPOSITION AND USE
Document Type and Number:
WIPO Patent Application WO/2018/086593
Kind Code:
A1
Abstract:
Disclosed are a nitrogen-containing heterocyclic compound, a preparation method, an intermediate, a pharmaceutical composition and a use. The nitrogen-containing heterocyclic compound of the present invention has a novel structure, relatively high TLR7 agonist activity, high selectivity and good safety.

Inventors:
LIU XUEMEI (CN)
QIAN PENGFEI (CN)
Application Number:
PCT/CN2017/110493
Publication Date:
May 17, 2018
Filing Date:
November 10, 2017
Export Citation:
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Assignee:
LIVO SHANGHAI PHARMACEUTICAL CO LTD (CN)
International Classes:
A61K31/505; C07D473/28; A61K31/506; A61K31/522; A61K31/55; A61P35/00; C07D239/47; C07D239/48; C07D473/32; C07D473/36; C07D519/00
Domestic Patent References:
WO2017064675A12017-04-20
WO2016023511A12016-02-18
Foreign References:
CN101027295A2007-08-29
CN1114318A1996-01-03
US20070213361A12007-09-13
CN101784548A2010-07-21
Other References:
"Toll-like receptors", CURR BIOL, vol. 21, 2011, pages R488 - 93
"The role ofpattern recognition receptors in intestinal inflammation", MUCOSAL IMMUNOL, vol. 6, 2013, pages 451 - 63
"Synthetic TLR agonists reveal functional differences between human TLR7 and TLR8", J IMMUNOL, vol. 174, 2005, pages 1259 - 68
BERGE ET AL.: "Pharmaceutical Salts", JOURNAL OF PHARMACEUTICAL SCIENCE, vol. 66, 1977, pages 1 - 19, XP002675560, DOI: doi:10.1002/jps.2600660104
See also references of EP 3539963A4
Attorney, Agent or Firm:
SHANGHAI BESHINING LAW OFFICE (CN)
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