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Title:
NITROGEN-CONTAINING HETEROCYCLIC COMPOUND, PREPARATION METHOD THEREFOR, INTERMEDIATE THEREOF, AND APPLICATION THEREOF
Document Type and Number:
WIPO Patent Application WO/2023/046034
Kind Code:
A1
Abstract:
A nitrogen-containing heterocyclic compound, a preparation method therefor, an intermediate thereof, and an application thereof. A nitrogen-containing heterocyclic compounds as shown in formula II-a, II-b, I-c, or I-d, a preparation method therefor, an intermediate thereof, and an application thereof. The compound has strong inhibitory activity on PARP1, particularly has a significant advantage in PARP1/PARP2 selectivity over the positive controls Olaparib and AZD5305, and can effectively reduce blood toxicity caused by PARP2.

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Inventors:
LI AO (CN)
JADHAV PRABHAKARKONDAJI (CN)
CHEN YILE (CN)
CAO GUOQING (CN)
Application Number:
PCT/CN2022/120655
Publication Date:
March 30, 2023
Filing Date:
September 22, 2022
Export Citation:
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Assignee:
MINGHUI PHARMACEUTICAL HANGZHOU LTD (CN)
MINGHUI PHARMACEUTICAL SHANGHAI LTD (CN)
International Classes:
C07D471/04; A61K31/4375; A61P35/00; C07D487/04; C07D491/052
Domestic Patent References:
WO2021260092A12021-12-30
WO2022225934A12022-10-27
WO2022222921A12022-10-27
WO2009053373A12009-04-30
WO2011014681A12011-02-03
WO2021013735A12021-01-28
Foreign References:
CN102341394A2012-02-01
CN107849040A2018-03-27
Attorney, Agent or Firm:
SHANGHAI BESINGIP INTELLECTUAL PROPERTY AGENCY CO., LTD (CN)
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