Title:
NITROGEN-CONTAINING HETEROCYCLIC COMPOUND, AND PREPARATION METHOD THEREFOR, INTERMEDIATE THEREOF, AND APPLICATION THEREOF
Document Type and Number:
WIPO Patent Application WO/2023/274324
Kind Code:
A9
Abstract:
Disclosed in the present invention are a nitrogen-containing heterocyclic compound, and a preparation method therefor, an intermediate thereof, and an application thereof. The present invention provides a nitrogen-containing heterocyclic compound as represented by formula (I), a stereoisomer thereof, or a pharmaceutically acceptable salt thereof. The nitrogen-containing heterocyclic compound as represented by formula (I), the stereoisomer thereof, or the pharmaceutically acceptable salt thereof provided by the present invention has the activity of inhibiting proliferation of Ba/F3 KRAS-G12D cells, AGS cells, Ba/F3 KRAS-G12V cells expressing KRAS G12D and/or KRAS G12V mutant proteins, and also shows good in vivo tumor suppression activity; the present invention is expected to treat and/or prevent a variety of diseases mediated by KRAS G12D and/or KRAS G12V.
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Inventors:
LUO HUIBING (CN)
JIANG JIAJUN (CN)
WANG JIAPO (CN)
ZHOU HUAYONG (CN)
JIANG JIAJUN (CN)
WANG JIAPO (CN)
ZHOU HUAYONG (CN)
Application Number:
PCT/CN2022/102497
Publication Date:
October 26, 2023
Filing Date:
June 29, 2022
Export Citation:
Assignee:
SHANGHAI ALLIST PHARMACEUTICALS CO LTD (CN)
International Classes:
C07D519/00; A61K31/519; A61P35/00; A61P35/02; C07C51/41; C07C53/18; C07D471/04; C07F7/18
Attorney, Agent or Firm:
SHANGHAI BESHINING LAW OFFICE (CN)
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