Title:
NITROGEN-CONTAINING HETEROCYCLIC COMPOUNDS AND MEDICINAL USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2004/052862
Kind Code:
A1
Abstract:
Because of having an effect of controlling CXCR4, compounds represented by the following general formulae (I) and (II), salts thereof, N-oxides thereof, solvates thereof or prodrugs of the same and medicinal compositions containing the same are useful as preventives and/or remedies for various inflammatory diseases, various allergic diseases, acquired immunodeficiency syndrome, infection with human immunodeficiency virus, etc. and agents for regeneration therapy: (I) (II) wherein the ring A represents an optionally substituted nitrogen-containing heterocycle; the ring B represents an optionally substituted homocycle or an optionally substituted heterocycle; Y represents an optionally substituted hydrocarbyl group, an optionally substituted heterocyclic group, an optionally protected amino group, an optionally protected hydroxyl group or an optionally protected mercapto group; and T represents the ring A or an optionally substituted amino group.
Inventors:
HABASHITA HIROMU (JP)
KOKUBO MASAYA (JP)
SHIBAYAMA SHIRO (JP)
TADA HIDEAKI (JP)
TANIHIRO TATSUYA (JP)
KOKUBO MASAYA (JP)
SHIBAYAMA SHIRO (JP)
TADA HIDEAKI (JP)
TANIHIRO TATSUYA (JP)
Application Number:
PCT/JP2003/015718
Publication Date:
June 24, 2004
Filing Date:
December 09, 2003
Export Citation:
Assignee:
ONO PHARMACEUTICAL CO (JP)
HABASHITA HIROMU (JP)
KOKUBO MASAYA (JP)
SHIBAYAMA SHIRO (JP)
TADA HIDEAKI (JP)
TANIHIRO TATSUYA (JP)
HABASHITA HIROMU (JP)
KOKUBO MASAYA (JP)
SHIBAYAMA SHIRO (JP)
TADA HIDEAKI (JP)
TANIHIRO TATSUYA (JP)
International Classes:
A61P3/00; A61P9/00; A61P25/00; A61P29/00; A61P31/00; A61P31/18; A61P35/00; A61P37/00; A61P37/08; A61P43/00; C07D221/22; C07D239/48; C07D239/95; C07D401/12; C07D401/14; C07D403/12; C07D403/14; C07D405/12; C07D493/10; (IPC1-7): C07D213/74; C07D401/14; C07D403/04; C07D403/14; C07D417/04; C07D401/12; C07D401/04; C07D403/12; C07D405/14; C07D409/14; C07D417/14; C07D405/12; C07D413/04; C07D413/12; C07D215/42; C07D493/04; C07D493/10; C07D495/04; C07D473/16; C07D251/50; C07D239/42; A61K31/55; A61K31/506; A61K31/551; A61K31/4725; A61K31/517; A61K315/53; A61K31/4709; A61K31/444; A61K31/519; A61P3/00; A61P9/00; A61P25/00; A61P29/00; A61P31/00; A61P31/18; A61P35/00; A61P37/00; A61P37/08; A61P43/00
Domestic Patent References:
| WO2000056729A1 | 2000-09-28 | |||
| WO2002022599A2 | 2002-03-21 | |||
| WO2001040227A1 | 2001-06-07 | |||
| WO2002045652A2 | 2002-06-13 | |||
| WO2003062236A1 | 2003-07-31 |
Foreign References:
| JP2002348288A | 2002-12-04 | |||
| GB1113918A | 1968-05-15 | |||
| DE1794396B1 | 1974-08-15 | |||
| JPS519759A | 1976-01-26 |
Other References:
GUPTA C ,, BHADURI A P, KHANNA N M: "DRUGS ACTING ON THE CENTRAL NERVOUS SYSTEM. SYNTHESIS OF SUBSTITUTED QUINAZOLINONES AND QUINAZOLINES AND TRIAZEPINO- AND TRIAZOCINOQUINAZOLINONES", JOURNAL OF MEDICINAL CHEMISTRY, vol. 11, no. 2, 1968, pages 392 - 395, XP002156695
See also references of EP 1571146A4
See also references of EP 1571146A4
Attorney, Agent or Firm:
Ohie, Kunihisa (Selva-Ningyocho 6F 14-6, Nihonbashi-Ningyocho,
2-chome, Chuo-k, Tokyo, JP)
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