Title:
NITROGEN-CONTAINING HETEROCYCLIC DERIVATIVES AND MEDICINAL COMPOSITIONS COMPRISING SAME
Document Type and Number:
WIPO Patent Application WO/2016/010108
Kind Code:
A1
Abstract:
A compound represented by formula (I) [in the formula: (1) represents (2), (3), etc.; R2a represents optionally substituted alkyl, etc.; R2b, R3a, R3b, R4a, R4b, R5a and R5b independently represent a hydrogen atom, etc.; and R1 represents (4), etc., (wherein: ring B represents a 6-membered aromatic carbon ring, etc.; ring D represents a 6-membered aromatic carbon ring, etc.; R11 represents optionally substituted alkyl, etc.; R12s independently represent a halogen, etc.; r is 0 or 1; and p is an integer of 0 to 3)] or a pharmaceutically acceptable salt thereof.
Inventors:
TACHIBANA YUKI (JP)
KANO KAZUYA (JP)
TONOGAKI KEISUKE (JP)
YONEHARA MITSUHIRO (JP)
JIKIHARA SAE (JP)
KANO KAZUYA (JP)
TONOGAKI KEISUKE (JP)
YONEHARA MITSUHIRO (JP)
JIKIHARA SAE (JP)
Application Number:
PCT/JP2015/070376
Publication Date:
January 21, 2016
Filing Date:
July 16, 2015
Export Citation:
Assignee:
SHIONOGI & CO (JP)
International Classes:
C07D231/56; A61K31/416; A61K31/4196; A61K31/42; A61K31/427; A61K31/428; A61K31/437; A61K31/454; A61K31/4545; A61K31/497; A61K31/506; A61K31/519; A61K31/5377; A61K31/538; A61K31/5383; A61K31/541; A61P1/04; A61P1/16; A61P3/10; A61P7/06; A61P9/00; A61P11/00; A61P11/02; A61P11/06; A61P17/00; A61P17/04; A61P17/06; A61P19/02; A61P25/00; A61P25/04; A61P27/02; A61P29/00; A61P31/18; A61P35/00; A61P37/00; A61P37/02; A61P37/06; A61P37/08; A61P43/00; C07D401/04; C07D401/10; C07D401/14; C07D403/04; C07D403/14; C07D405/06; C07D405/10; C07D405/12; C07D405/14; C07D409/12; C07D409/14; C07D413/04; C07D413/06; C07D413/12; C07D413/14; C07D417/04; C07D417/12; C07D417/14; C07D471/04; C07D487/04; C07D491/052; C07D491/107; C07D491/113; C07D498/04; C07D519/00; C12N9/12; C12N9/99
Domestic Patent References:
WO2011065402A1 | 2011-06-03 | |||
WO2014041518A1 | 2014-03-20 | |||
WO2014175370A1 | 2014-10-30 |
Foreign References:
JP2007505038A | 2007-03-08 | |||
JP2011246389A | 2011-12-08 |
Other References:
BURCH, J. D. ET AL.: "Property- and Structure- Guided Discovery of a Tetrahydroindazole Series of Interleukin-2 Inducible T- Cell Kinase Inhibitors", JOURNAL OF MEDICINAL CHEMISTRY, vol. 57, 2014, pages 5714 - 5727, XP055227886, DOI: doi:10.1021/jm500550e
ZYK, N. V. ET AL.: "Synthesis Of Novel Condensed Binuclear Heterocycles Based On 1,3- And 1,5- Dicarbonyl Derivatives Of 2,2- Dimethyltetrahydropyran", CHEMISTRY OF HETEROCYCLIC COMPOUNDS, vol. 40, no. 1, 2004, pages 70 - 74
ZYK, N. V. ET AL.: "Synthesis Of Novel Condensed Binuclear Heterocycles Based On 1,3- And 1,5- Dicarbonyl Derivatives Of 2,2- Dimethyltetrahydropyran", CHEMISTRY OF HETEROCYCLIC COMPOUNDS, vol. 40, no. 1, 2004, pages 70 - 74
Attorney, Agent or Firm:
TAKAYAMA, Hirotsugu et al. (JP)
Hiromitsu Takayama (JP)
Hiromitsu Takayama (JP)
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