Title:
NITROGEN-CONTAINING HETEROCYCLIC PYRIDINE COMPOUND
Document Type and Number:
WIPO Patent Application WO/2022/233286
Kind Code:
A1
Abstract:
A nitrogen-containing heterocyclic protein inhibitor compound, and a stereoisomer, a tautomer or a pharmaceutically acceptable salt thereof. Also provided are a preparation method for the nitrogen-containing heterocyclic compound, and a use thereof. A drug prepared from the compound is widely used for treating diseases, the diseases comprising multiple types of autoimmune diseases, such as multiple sclerosis, rheumatoid arthritis, inflammatory bowel disease, lupus erythematosus, neurodermatitis, dermatitis, psoriasis, psoriatic arthritis, Crohn's disease, dry syndrome, and scleroderma.
Inventors:
ZHANG QIANG (CN)
DU FENGTIAN (CN)
YANG XIANGYU (CN)
DU FENGTIAN (CN)
YANG XIANGYU (CN)
Application Number:
PCT/CN2022/090847
Publication Date:
November 10, 2022
Filing Date:
May 04, 2022
Export Citation:
Assignee:
SHANGHAI ZHEYE BIOTECHNOLOGY CO LTD (CN)
International Classes:
A61K31/501; A61K31/4439; A61K31/444; A61K31/53; A61P1/00; A61P17/00; A61P17/06; A61P19/02; A61P29/00; A61P35/00; A61P37/00; C07D403/12
Domestic Patent References:
| WO2020156311A1 | 2020-08-06 | |||
| WO2020159904A1 | 2020-08-06 | |||
| WO2020086616A1 | 2020-04-30 | |||
| WO2021180072A1 | 2021-09-16 | |||
| WO2017181918A1 | 2017-10-26 | |||
| WO2014074661A1 | 2014-05-15 |
Foreign References:
| CN111936486A | 2020-11-13 | |||
| CN106660960A | 2017-05-10 | |||
| CN111484480A | 2020-08-04 | |||
| CN111909140A | 2020-11-10 | |||
| CN113563309A | 2021-10-29 |
Other References:
STEPHEN T. WROBLESKI, RYAN MOSLIN, SHUQUN LIN, YANLEI ZHANG, STEVEN SPERGEL, JAMES KEMPSON, JOHN S. TOKARSKI, JOANN STRNAD, ADRIAN: "Highly Selective Inhibition of Tyrosine Kinase 2 (TYK2) for the Treatment of Autoimmune Diseases: Discovery of the Allosteric Inhibitor BMS-986165", JOURNAL OF MEDICINAL CHEMISTRY, vol. 62, no. 20, 24 October 2019 (2019-10-24), US , pages 1 - 23, XP055629848, ISSN: 0022-2623, DOI: 10.1021/acs.jmedchem.9b00444
JOURNAL OF MEDICINAL CHEMISTRY, vol. 47, no. 2, 2004, pages 400 - 410
JOURNAL OF THE CHINESE CHEMICAL SOCIETY (TAIPEI, vol. 45, no. 2, 1998, pages 307 - 312
BIOORGANIC & MEDICINAL CHEMISTRY, vol. 21, no. 21, 2013, pages 6634 - 6641
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, vol. 112, no. 8, 1990, pages 3156 - 3162
JOURNAL OF ORGANIC CHEMISTRY, vol. 53, no. 20, 1988, pages 4748 - 4758
ORGANIC LETTERS, vol. 9, no. 16, 2007, pages 2981 - 2984
BULLETIN OF THE CHEMICAL SOCIETY OF JAPAN, vol. 76, no. 2, 2003, pages 347 - 353
ANGEWANDTE CHEMIE, INTERNATIONAL EDITION, vol. 55, no. 9, 2016, pages 3171 - 3175
JOURNAL OF MEDICINAL CHEMISTRY, vol. 47, no. 2, 2004, pages 400 - 410
JOURNAL OF THE CHINESE CHEMICAL SOCIETY (TAIPEI, vol. 45, no. 2, 1998, pages 307 - 312
BIOORGANIC & MEDICINAL CHEMISTRY, vol. 21, no. 21, 2013, pages 6634 - 6641
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, vol. 112, no. 8, 1990, pages 3156 - 3162
JOURNAL OF ORGANIC CHEMISTRY, vol. 53, no. 20, 1988, pages 4748 - 4758
ORGANIC LETTERS, vol. 9, no. 16, 2007, pages 2981 - 2984
BULLETIN OF THE CHEMICAL SOCIETY OF JAPAN, vol. 76, no. 2, 2003, pages 347 - 353
ANGEWANDTE CHEMIE, INTERNATIONAL EDITION, vol. 55, no. 9, 2016, pages 3171 - 3175
Attorney, Agent or Firm:
SINO-CREATIVITY INTELLECTUAL PROPERTY LAW FIRM (CN)
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