Title:
NITROGEN-CONTAINING TETRACYCLIC COMPOUND, AND PREPARATION METHOD THEREFOR AND USE THEREOF IN MEDICINE
Document Type and Number:
WIPO Patent Application WO/2023/072297
Kind Code:
A1
Abstract:
The present disclosure relates to a nitrogen-containing tetracyclic compound, and a preparation method therefor and the use thereof in medicine. Specifically, the present disclosure relates to a nitrogen-containing tetracyclic compound represented by general formula (I) and a preparation method therefor, a pharmaceutical composition containing said compound, and the use of said compound as a therapeutic agent, in particular the use as a KRAS G12C inhibitor and the use in preparation of drugs for treating and/or preventing tumors.
Inventors:
LI XIN (CN)
SHEN FENG (CN)
DONG HUAIDE (CN)
HE FENG (CN)
TAO WEIKANG (CN)
SHEN FENG (CN)
DONG HUAIDE (CN)
HE FENG (CN)
TAO WEIKANG (CN)
Application Number:
PCT/CN2022/128914
Publication Date:
May 04, 2023
Filing Date:
November 01, 2022
Export Citation:
Assignee:
JIANGSU HENGRUI PHARMACEUTICALS CO LTD (CN)
SHANGHAI HENGRUI PHARMACEUTICAL CO LTD (CN)
SHANGHAI HENGRUI PHARMACEUTICAL CO LTD (CN)
International Classes:
C07D498/14; A61K31/4985; A61K31/55; A61K31/553; A61P35/00; C07D487/14
Foreign References:
CN110603258A | 2019-12-20 | |||
CN112074520A | 2020-12-11 | |||
CN112300195A | 2021-02-02 | |||
CN113508118A | 2021-10-15 | |||
CN112300194A | 2021-02-02 | |||
US20190177338A1 | 2019-06-13 |
Attorney, Agent or Firm:
GE CHENG & CO., LTD (CN)
Download PDF: