Title:
NITROGEN HETEROARYL DERIVATIVE HAVING CSF1R INHIBITORY ACTIVITY, AND PREPARATION METHOD THEREFOR AND APPLICATION THEREOF
Document Type and Number:
WIPO Patent Application WO/2018/233527
Kind Code:
A1
Abstract:
The present invention provides a nitrogen heteroaryl derivative having CSF1R inhibitory activity, and a preparation method therefor and an application thereof. Compounds in the present invention has a structure represented by formula (I) as below, and the definition on substituents is as stated in the description and the claims. The compounds in the present invention can be widely applied to preparation of drugs for treating cancers, tumors, autoimmune diseases, metabolic diseases, or metastatic diseases, in particular ovarian cancer, pancreatic cancer, prostate cancer, breast cancer, cervical cancer, glioblastoma, multiple myeloma, metabolic diseases, neurodegenerative diseases, metastasis of primary tumor sites, or bone metastatic cancer, and a new generation of CSF1R inhibitor drugs is expected to be developed.
Inventors:
ZHANG MINGMING (CN)
ZHAO BAOWEI (CN)
YU HONGPING (CN)
CHEN ZHUI (CN)
XU YAOCHANG (CN)
ZHAO BAOWEI (CN)
YU HONGPING (CN)
CHEN ZHUI (CN)
XU YAOCHANG (CN)
Application Number:
PCT/CN2018/091045
Publication Date:
December 27, 2018
Filing Date:
June 13, 2018
Export Citation:
Assignee:
ABBISKO THERAPEUTICS CO LTD (CN)
International Classes:
C07D471/04; A61K31/4375
Domestic Patent References:
| WO2014145023A1 | 2014-09-18 |
Foreign References:
| CN105120864A | 2015-12-02 | |||
| CN101223169A | 2008-07-16 |
Other References:
See also references of EP 3643715A4
Attorney, Agent or Firm:
XU & PARTNERS, LLC. (CN)
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