Title:
NITROGENATED HETEROCYCLIC COMPOUND
Document Type and Number:
WIPO Patent Application WO/2013/069765
Kind Code:
A1
Abstract:
Provided are: a nitrogenated heterocyclic compound represented by formula (I-A)(wherein R1A represents a lower alkyl group which may be substituted by a lower alkoxy group; R3A represents a fluorine-substituted lower alkyl group; and R4A represents an aromatic heterocyclic group which may have a substituent) or the like, or a pharmacologically acceptable salt thereof; and others.
Inventors:
KANAI TOSHIMI
UCHIDA KENJI
HONMA MASAKAZU
FUKUDA YUICHI
UCHIDA KENJI
HONMA MASAKAZU
FUKUDA YUICHI
Application Number:
PCT/JP2012/079109
Publication Date:
May 16, 2013
Filing Date:
November 09, 2012
Export Citation:
Assignee:
KYOWA HAKKO KIRIN CO LTD (JP)
International Classes:
C07D401/14; A61K31/498; A61K31/506; A61P25/00; A61P31/00; A61P35/00; A61P37/00; A61P43/00; C07D413/14; C07D417/12; C07D417/14
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WO2011142316A1 | 2011-11-17 | |||
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WO2004007472A1 | 2004-01-22 | |||
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J. CLIN. INVEST., vol. 117, no. 5, 1988, pages 1147 - 1154
J. CLIN. INVEST., vol. 117, 2007, pages 1147 - 1154
J. VIROL., vol. 81, 2007, pages 11593 - 11603
NEUROPATHOL. APPL. NEUROBIOL., vol. 31, 2005, pages 395 - 404
NEUROSCI. LETT., vol. 187, 1995, pages 9 - 12
SHELDRICK GM.: "A short history of SHELX", ACTA CRYSTALLOGR. SECT. A., vol. 64, no. 1, 2008, pages 112 - 22
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See also references of EP 2781517A4
J. EXP. MED., vol. 196, no. 4, 2002, pages 447 - 457
BLOOD, vol. 109, no. 7, 2007, pages 2871 - 2877
CLIN. CANCER RES., vol. 12, no. 4, 2006, pages 1144 - 1151
EUR. J. CANCER, vol. 44, no. 15, 2008, pages 2266 - 2275
LEUKEMIA, vol. 21, 2007, pages 353 - 355
BR. J. CANCER, vol. 95, no. 11, 2006, pages 1555 - 1561
J. CLIN. INVEST., vol. 114, no. 2, 2004, pages 280 - 290
CLIN. CANCER RES., vol. 11, no. 16, 2005, pages 6030 - 6039
LEUK. RES., vol. 33, no. 1, 2009, pages 39 - 45
LEUK. RES., vol. 33, no. 3, 2009, pages 490 - 494
DERMATOLOGY, vol. 214, no. 1, 2007, pages 8 - 14
CANCER RES., vol. 67, no. 2, 2007, pages 792 - 800
NAT. IMMUNOL., vol. 2, no. 1, 2001, pages 64 - 68
NAT. IMMUNOL., vol. 2, 2001, pages 64 - 68
BLOOD, vol. 109, 2007, pages 3351 - 3359
J VIROL., vol. 81, no. 7, 2007, pages 3662 - 3666
J CLIN INVEST., vol. 117, 2007, pages 1147 - 1154
J VIROL., vol. 81, 2007, pages 11593 - 11603
NEUROPATHOL APPL NEUROBIOL., vol. 31, 2005, pages 395 - 404
NEUROSCI LETT., vol. 187, 1995, pages 9 - 12
NEUROPSYCHOPHARMACOLOGY, vol. 33, 2008, pages 2341 - 2351
JOURNAL OF MEDICINAL CHEMISTRY, vol. 40, 1997, pages 996
T. W. GREENE: "Protective Groups in Organic Synthesis, 3rd edition,", 1999, JOHN WILEY & SONS INC.
JOURNAL OF MEDICINAL CHEMISTRY, vol. 24, 1981, pages 93 - 101
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, vol. 111, 1989, pages 393
J. BIOL. CHEM., vol. 263, 1988, pages 2041 - 2048
J. CLIN. INVEST., vol. 117, no. 5, 1988, pages 1147 - 1154
J. CLIN. INVEST., vol. 117, 2007, pages 1147 - 1154
J. VIROL., vol. 81, 2007, pages 11593 - 11603
NEUROPATHOL. APPL. NEUROBIOL., vol. 31, 2005, pages 395 - 404
NEUROSCI. LETT., vol. 187, 1995, pages 9 - 12
SHELDRICK GM.: "A short history of SHELX", ACTA CRYSTALLOGR. SECT. A., vol. 64, no. 1, 2008, pages 112 - 22
SHELDRICK GM.: "A short histry of SHELX", ACTA CRYSTALLOGR. SECT. A., vol. 64, no. 1, 2008, pages 112 - 22
FLACK HD.: "On enantiomorph-polarity estimation", ACTA CRYSTALLOGR. SECT. A., vol. 39, no. 6, 1983, pages 876 - 81
See also references of EP 2781517A4
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