NITROGENATED HETEROCYCLIC DERIVATIVE

Title:

NITROGENATED HETEROCYCLIC DERIVATIVE

Document Type and Number:

WIPO Patent Application WO/2006/137465

Kind Code:

A1

Abstract:

It is found that a nitrogenated heterocyclic derivative represented by the formula (I) can bind specifically to an NR1/NR2B receptor and can be used as an analgestic agent. A compound represented by the formula (I) or a pharmaceutically acceptable salt thereof or the like: (I) wherein A¹ represents a nitrogenated aromatic monocyclic group or nitrogenated aromatic fused-ring group which has at least one hydroxyl and/or amino and which may be substituted by other group or a nitrogenated aromatic monocyclic ring or nitrogenated aromatic fused-ring group which has -NH- in the ring and in which other ring-constituting atom may be substituted; A² represents an aromatic hydrocarbon cyclic group which may have a substituent or the like; R¹ and R² independently represent a hydrogen, hydroxyl or the like; m is 0 or 1; X represents a lower alkylene, -CO(CR³R⁴)n- or -A³-(CR³R⁴)n- which may have a substituent or the like; Y represents a single bond, a lower alkylene or the like; and R³ to R¹⁵ independently represent a hydrogen, a lower alkyl or the like.

Inventors:

MASUI MORIYASU (JP)
MATSUMURA AKIRA (JP)

Application Number:

PCT/JP2006/312466

Publication Date:

December 28, 2006

Filing Date:

June 22, 2006

Export Citation:

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Assignee:

SHIONOGI & CO (JP)
MASUI MORIYASU (JP)
MATSUMURA AKIRA (JP)

International Classes:

C07D401/12; A61K31/4439; A61K31/444; A61K31/454; A61K31/4545; A61K31/455; A61P9/10; A61P25/00; A61P25/04; A61P25/06; A61P25/08; A61P25/14; A61P25/16; A61P25/28; A61P25/32; A61P27/16; A61P43/00; C07D401/06; C07D401/10; C07D413/12; C07D413/14

Domestic Patent References:

WO2002085352A1	2002-10-31
WO2004048364A1	2004-06-10

Foreign References:

JP2003513069A	2003-04-08
JP2001525321A	2001-12-11
JP2004515544A	2004-05-27
US6124323A	2000-09-26
JP2004516295A	2004-06-03

Attorney, Agent or Firm:

Takayama, Hirotsugu (Ltd. Intellectual Property Department 12-4 Sagisu 5-chome, Fukushima-k, Osaka-shi Osaka 02, JP)

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